Chemical Formula | C7H4F3I |
Molar Mass | 270.009 g/mol |
Appearance | Colorless to light yellow liquid |
Boiling Point | 185 - 187 °C |
Density | 1.845 g/mL at 25 °C |
Solubility In Water | Insoluble |
Solubility In Organic Solvents | Soluble in many organic solvents like ethanol, ether |
Flash Point | 79 °C |
Vapor Pressure | Low at room temperature |
What are the main uses of M-IODO TRIFLUORO TOLUENE?
M-IODO+TRIFLUORO+TOLUENE, m-iodine trifluorotoluene, which has a wide range of uses.
In the field of organic synthesis, it is a key intermediate. It can be converted into other organic compounds through various chemical reactions. For example, in many nucleophilic substitution reactions, iodine atoms are active and can be replaced by other nucleophiles, thereby forming novel carbon-carbon and carbon-heteroatom bonds, which facilitate the construction of complex organic molecules.
In the field of medicinal chemistry, m-iodine trifluorotoluene also plays an important role. It will be used as the starting material or key structural fragment in the design and synthesis of many drug molecules. Due to its trifluoromethyl content, this group has unique electronic effects and hydrophobicity, which can significantly improve the physicochemical properties of drug molecules, such as improving fat solubility, facilitating drug penetration through biofilms, and enhancing the interaction between drugs and targets, thereby enhancing drug activity and selectivity.
In the field of materials science, m-iodotrifluorotoluene is also useful. It can participate in the preparation of functional materials with special properties, such as optoelectronic materials. The introduction of fluorinated groups can optimize the optical and electrical properties of materials, making them unique in organic Light Emitting Diodes, solar cells and other devices.
In addition, in the field of pesticide chemistry, compounds derived from m-iodotrifluorotoluene can be used as highly efficient pesticide ingredients. Its unique chemical structure endows the compound with good biological activity and environmental stability, which can effectively control various pests and diseases, and ensure the yield and quality of crops. In short, m-iodotrifluorotoluene plays an indispensable role in many chemical-related industries.
What are the physical properties of M-IODO TRIFLUORO TOLUENE?
M-IODO+TRIFLUORO+TOLUENE, that is, m-iodine trifluorotoluene. Its physical properties are as follows:
In appearance, it often appears as a colorless to light yellow liquid, with a clear and elegant color.
In terms of melting point, the value is about -29 ° C, and it can solidify into a solid state at a lower temperature.
In terms of boiling point, it is roughly between 148 and 150 ° C. In this temperature range, the liquid will transform into a gaseous state.
The density is about 1.84g/cm ³, which is more than double that of common water. Therefore, if it coexists with an insoluble liquid such as water, it must sink at the bottom.
Its vapor pressure has a corresponding value under specific temperature conditions, and has a certain volatility, which can slowly evaporate in the air. < Br > In terms of solubility, slightly soluble in water, it can be miscible with many organic solvents, such as ethanol, ether, acetone, etc., and can be evenly dispersed in organic solvents to form a uniform system.
Refractive index is also one of its important physical properties, with a specific value. When light passes through the substance, the propagation direction will be correspondingly deflected according to its refractive index.
The many physical properties of m-iodotrifluorotoluene make it widely used in chemical, pharmaceutical and other fields, providing an important foundation for the development of related industries.
What are the chemical properties of M-IODO TRIFLUORO TOLUENE?
M-iodotrifluorotoluene, an organic compound, has interesting chemical properties, especially for chemical research and industrial applications.
In its structure, both iodine atoms and trifluoromethyl are connected to the benzene ring of toluene, which gives it special chemical properties. Iodine atoms are highly active and easily participate in many chemical reactions. For example, nucleophilic substitution reactions, iodine atoms can be replaced by other nucleophiles, because the carbon-iodine bond energy is relatively low, it is easy to break. This property can be used as an important reaction check point when constructing complex organic molecules, providing the possibility for the synthesis of new organic materials and pharmaceutical intermediates.
The presence of trifluoromethyl also affects its chemical properties. Trifluoromethyl has strong electron absorption, which can reduce the electron cloud density of the benzene ring, making it difficult to occur electrophilic substitution reaction on the benzene ring, and selectively changing the check point of the reaction. In electrophilic substitution reactions, the reaction tends to be carried out at a relatively high electron cloud density position. In addition, the strong electron absorption of trifluoromethyl also enhances the molecular polarity, which affects its physical properties such as solubility and boiling point.
M-iodotrifluorotoluene The stability of oxidants and reducing agents varies depending on the reaction conditions. Under specific conditions, iodine atoms can be oxidized or reduced, causing molecular structure changes. At the same time, its chemical properties are also different in different solvents, and solvent polarity, acidity and alkalinity may affect the relevant reaction rate and selectivity.
In short, M-iodotrifluorotoluene has important applications and research values in the fields of organic synthesis, medicinal chemistry and materials science due to its structural characteristics, complex and unique chemical properties.
What is the production method of M-IODO TRIFLUORO TOLUENE?
The preparation method of M-iodotrifluorotoluene often follows several paths. One is to use trifluorotoluene as the starting material and use halogenation to form it. In this method, it is usually necessary to choose an appropriate halogenating reagent, and temperature control, time control and good solvent selection are all key elements.
In terms of halogenating reagents, common ones are iodine elemental ($I_ {2} $), but its activity or insufficiency, so catalysts such as iron powder ($Fe $) or ferric chloride ($FeCl_ {3} $) are often used. Taking iron powder as an example, it can interact with iodine to form catalytically active species, which makes the reaction more likely to occur.
Temperature control is also very important. This reaction often requires heating, but the temperature is too high or causes a cluster of side reactions, such as the formation of polyhalogenated products, so it often needs to be reacted in a moderate temperature range, generally between about 80-120 ° C.
The solvent of choice is preferably one with good solubility to the reactants and does not react violently with halogenated reagents and products. Common organic solvents such as dichloromethane and chloroform can be considered. However, the boiling point of dichloromethane is low, and a reflux device may be required to maintain the stability of the reaction system during the reaction.
Another preparation route, or starting from compounds containing iodine and with suitable substituents, is to obtain M-iodotrifluorotoluene by functional group conversion. For example, an iodine-containing aromatic hydrocarbon can be achieved if its substituent can be converted into trifluoromethyl by an appropriate reaction. In this way, the choice of conversion reaction is very important, such as nucleophilic substitution reaction or metal-catalyzed coupling reaction.
For nucleophilic substitution reactions, appropriate nucleophilic reagents should be selected, and the spatial resistance and electronic effects of the substrate should be considered. For metal-catalyzed coupling reactions, suitable metal catalysts, such as palladium ($Pd $) catalysts, and their ligands, are often selected to improve the selectivity and efficiency of the reaction. In short, the methods for preparing M-iodotrifluorotoluene have their own advantages and disadvantages, and they need to be carefully selected and optimized according to actual needs and conditions.
What to pay attention to when storing and transporting M-IODO TRIFLUORO TOLUENE
M-iodotrifluorotoluene is also an organic compound. When storing and transporting, it is necessary to pay attention to many matters.
One is related to storage. This compound should be stored in a cool, dry and well-ventilated place. Because the substance is easily decomposed when heated, if the ambient temperature is too high, it may cause changes in its chemical properties, so a cool environment is essential. Dry conditions are also indispensable, because it may react with moisture, resulting in quality damage. Good ventilation can prevent the accumulation of volatile gases and avoid potential hazards such as explosion or poisoning.
Second, packaging. Good sealing performance packaging containers must be used. This can effectively prevent the compound from leaking, and at the same time avoid contact with outside air, moisture, etc. Packaging materials should be compatible with M-iodotrifluorotoluene and do not chemically react with it to ensure the stability of the substance.
Third, during transportation. Transportation vehicles should have corresponding protective measures to ensure a smooth transportation process, avoid violent vibration and collision, and prevent package damage. Transportation personnel also need to undergo professional training, familiar with the characteristics of the substance and emergency treatment methods. If there is an accident during transportation, such as leakage, they can respond in time and properly to reduce hazards.
Fourth, storage and transportation places should be kept away from fire sources, heat sources and oxidants. M-iodotrifluorotoluene may cause combustion and explosion in case of open flame, hot topic or contact with oxidant. Therefore, fireworks are strictly prohibited in the place of storage and transportation, and should be stored separately from oxidant, and must not be mixed in storage and transportation.
All of these are to be paid attention to when storing and transporting M-iodotrifluorotoluene, so as to ensure its safety and stability.