SAFINAMIDE: (S) - (+) -2- [4- (3-FLUOROBENZYLOXY) BENZYLAMINO] PROPANA MIDE METHANSULFONATE

Safamide (SAFINAMIDE), namely (S) - (+) -2- [4- (3-fluorobenzyloxy) benzylamino] propionamide methanesulfonate, has unique functions in modern medical practice.

It is mainly used to treat Parkinson's disease. Parkinson's disease is caused by the degeneration and death of dopaminergic nerve cells in the brain, resulting in reduced dopamine secretion, which can lead to motor retardation, tremor, myotonia and other diseases. Safamide can improve the symptoms of Parkinson's disease through multiple pathways.

First, this drug can inhibit monoamine oxidase B (MAO-B). MAO-B degrades dopamine, and serafenamide inhibits this enzyme, which slows down dopamine degradation, increases the concentration of dopamine in the synaptic space, enhances dopaminergic nerve transmission, and reduces motor symptoms in Parkinson's disease patients, such as more flexible movements and reduced tremor.

Second, serafenamide can also regulate voltage-gated sodium ion channels. This channel plays a key role in the generation and propagation of nerve cell action potentials. Salfenamide regulates this channel, which can stabilize the excitability of nerve cells, avoid excessive excitation of nerve cells, and then reduce the excessive release of neurotransmitters. It also improves the motor symptoms of Parkinson's disease patients and helps to reduce the side effects of dyskinesia caused by dopaminergic drug therapy.

Salfenamide uses mechanisms such as inhibition of MAO-B and regulation of sodium ion channels to help patients relieve symptoms and improve quality of life in the treatment of Parkinson's disease.

SAFINAMIDE: (S) - (+) -2- [4- (3-FLUOROBENZYLOXY) BENZYLAMINO] PROPANA MIDE METHANSULFONATE

Shalfenamide, which is (S) - (+) -2- [4- (3-fluorobenzyloxy) benzylamino] propionamide methanesulfonate, is a good medicine for the treatment of Parkinson's disease, but it also has several side effects.

One of its common side effects is to affect the stomach. The user may experience nausea, like the upwelling of turbid air in the abdomen, and epigastric discomfort. Or there may be a feeling of vomiting, the stomach is reversed, and he wants to spit out the contents of the abdomen. Diarrhea may also occur, and the intestinal transportation and transformation are abnormal, such as dilute water, several times a day, which is quite troublesome for the user. This is because the drug enters the body, which affects the normal acceptance and conduction function of the stomach.

It also affects the nervous system. Some people will have dizziness after taking the medicine, just like being in a cloud and fog, the head is dizzy, and the body feels unstable when walking and standing, and the direction is difficult to distinguish. And it is easy to fatigue, mental fatigue, weakness of limbs, and fatigue after a while, and daily labor and activities are affected. This may be that the drug interferes with the regulation of the nervous system and causes neurological imbalance.

Cardiovascular aspects should not be ignored. It may cause blood pressure to fluctuate, or rise or fall. When blood pressure rises, the head is swollen and painful, and the face is red and red; when blood pressure drops, the head is dizzy and the eyes are black. It may also cause heart palpitations, self-conscious panic, and disorderly heartbeat. This is the stimulation of the drug to the cardiovascular system, which affects the normal beating of the heart and the regulation of vascular pressure.

Although sprinkling finamide plays an important role in the treatment of Parkinson's disease, when taking medication, doctors need to carefully observe the patient's reaction, weigh the pros and cons, and patients should also pay close attention to their own physical changes. If there is any abnormality, inform the doctor immediately to ensure the safety of medication.

SAFINAMIDE: (S) - (+) -2- [4- (3-FLUOROBENZYLOXY) BENZYLAMINO] PROPANA MIDE METHANSULFONATE

Safinamide, which is (S) - (+) -2- [4- (3-fluorobenzyloxy) benzylamino] propanamide methanesulfonate, is suitable for patients with intermediate and advanced Parkinson's disease.

Parkinson's disease is a neurodegenerative disease common in the elderly. As the disease progresses, the symptoms of patients will gradually intensify, which has a serious impact on daily life and motor function. Safinamide, a new anti-Parkinson's disease drug, mainly inhibits the reuptake of dopamine by nerve cells to increase dopamine levels in the brain, thereby alleviating the motor symptoms of Parkinson's disease patients, such as tremor, myotonia and motor retardation.

For patients with intermediate and advanced Parkinson's disease who are receiving levodopa treatment but have symptom fluctuations, saffinamide can significantly improve their motor function, reduce the "off" period time, prolong the "on" period and do not cause adverse reactions such as dyskinesia. This drug is suitable for patients who have gradually reduced the efficacy after levodopa treatment, and have sports complications such as "end-of-dose phenomenon" and "on-off phenomenon", which can help optimize the therapeutic effect and improve the quality of life. However, if the patient has severe hepatic and renal insufficiency, allergies to saffinamide or its excipients, etc., it should not be used. Be sure to strictly follow the doctor's instructions when taking medicine, and do not increase or decrease the dose at will.

SAFINAMIDE: (S) - (+) -2- [4- (3-FLUOROBENZYLOXY) BENZYLAMINO] PROPANA MIDE METHANSULFONATE

Sefolamide (SAFINAMIDE), namely (S) - (+) -2- [4- (3-fluorobenzyloxy) benzylamino] propionamide methanesulfonate, is a good medicine for the treatment of Parkinson's disease. Its usage and dosage are crucial, related to the efficacy and safety of the patient.

Usually at the beginning, the daily dose is 50 mg, which can be gradually increased with the progress of the disease and the patient's tolerance. Generally speaking, the maximum dose can reach 200 mg a day. Usage is oral, and it is recommended to take it at the same time every day to maintain the stability of blood drug concentration and maximize the efficacy.

When taking medication, many things should be paid attention to. The doctor should accurately weigh and determine the appropriate dose according to the patient's specific disease, age, physical condition and other factors. During the medication period, the patient's reaction should be closely monitored. If there are adverse reactions or poor curative effect, the dose should be adjusted or stopped in time. For the elderly and frail or hepatic and renal insufficiency, the medication should be especially cautious, and the dose may need to be adjusted accordingly.

The usage and dosage of cyfomide must follow the doctor's advice. It is not allowed to increase or decrease the dose without authorization to ensure that the medication is safe and effective, and to help patients relieve the symptoms of Parkinson's disease and improve the quality of life.

SAFINAMIDE: (S) - (+) -2- [4- (3-FLUOROBENZYLOXY) BENZYLAMINO] PROPANA MIDE METHANSULFONATE Does it interact with other drugs?

Fusafenamide, that is, (S) - (+) -2- [4- (3-fluorobenzyloxy) benzylamino] propionamide methanesulfonate. Among the various drugs, does it interact with each other? This matter is related to the safety of drug use and cannot be ignored.

Observe the principle of drug interaction, when many drugs are taken together, or due to the interference of metabolic pathways, protein binding competition, etc., the effect of the drug changes and the toxicity increases or decreases. The metabolism of safenamide in the body must go through a specific biochemical pathway. If it is used with other drugs, it may cause congestion or excessive passage of the pathway, which will affect its pharmacological effects.

If some liver drug enzyme inducers or inhibitors are taken together with them, or accelerate the metabolism of safenamide, it is difficult for the blood drug concentration to reach an effective level, and the efficacy is damaged; or slow down its metabolism, resulting in drug accumulation and increased toxicity. For example, if it is used with drugs with strong plasma protein binding, or due to competition for binding check points, the free concentration of safenamide is increased, and the pharmacological effects and adverse reactions may be exacerbated.

To determine whether safenamide interacts with other drugs, rigorous clinical research and experimental data are needed. Although the compatibility of all drugs with safenamide has not been studied in detail today, when taking medication, doctors must carefully review the drugs taken by patients and weigh the pros and cons to ensure the safety and effectiveness of the medication. They must not be negligent and cause patients to suffer from drug harm.