What is the chemical structure of N- (4-fluorobenzyl) -N ', N' -dimethyl-N- (pyridin-2-yl) ethane-1,2-diamine?

This is a problem of the chemical structure of N- (4-fluorobenzyl) -N ', N' -dimethyl-N- (pyridine-2-yl) ethane-1,2-diamine. Its chemical structure can be described as follows: This compound is composed of several parts. First, there is a basic skeleton of ethane-1,2-diamine, which is a chain of two carbon atoms, and each carbon atom is connected with an amino group (-NH2O).

Then, one of the amino hydrogen atoms is replaced by N- (4-fluorobenzyl). This N- (4-fluorobenzyl) moiety is above the benzyl group (phenyl group, that is, the benzene ring is connected to a methylene-CH 2O -), the para-position (4-position) of the benzene ring is replaced by a fluorine atom, and the methylene of the benzyl group is connected to an amino nitrogen atom of ethane-1,2-diamine.

Furthermore, the two hydrogen atoms of the other amino group are replaced by dimethyl (-N (CH) -2). At the same time, the nitrogen atom of this amino group is also connected to the pyridine-2-group, that is, the 2-position of the pyridine ring is connected to the nitrogen atom. In this way, the complete chemical structure of N- (4-fluorobenzyl) -N ', N' -dimethyl-N- (pyridine-2-yl) ethane-1,2-diamine is formed. The parts of this structure are interconnected, which endows the compound with specific chemical and physical properties and may be of great significance in many fields such as organic synthesis and medicinal chemistry.

What are the main uses of N- (4-fluorobenzyl) -N ', N' -dimethyl-N- (pyridin-2-yl) ethane-1,2-diamine?

N- (4-fluorobenzyl) -N ', N' -dimethyl-N- (pyridine-2-yl) ethane-1,2-diamine This substance has a wide range of uses. In the field of medicine, it is often used as an active ingredient to develop new drugs for the treatment of specific diseases. Its structural properties give it the ability to combine with specific targets in organisms, or to regulate physiological processes, which is of great benefit to the treatment of diseases.

In chemical research, it is an important intermediate in organic synthesis. With its unique molecular structure, chemists can use various chemical reactions to transform it into compounds with more complex structures and more diverse functions, and help create new materials and special effects reagents.

In the field of materials science, it has also made a name for itself. Because it has a specific electronic and spatial structure, or can participate in the construction of materials, it endows materials with special electrical, optical or mechanical properties, opening up new paths for the research and development of high-performance materials.

In addition, in experimental scenarios such as biochemical analysis, it can be used as a probe or reagent. With its interaction with specific biomolecules, it can achieve accurate detection and analysis of substances in living organisms, and help to further advance life science research. In conclusion, N- (4-fluorobenzyl) -N ', N' -dimethyl-N- (pyridine-2-yl) ethane-1,2-diamine has important application value in many fields, providing strong support for scientific research and technological innovation.

What are the physical properties of N- (4-fluorobenzyl) -N ', N' -dimethyl-N- (pyridin-2-yl) ethane-1,2-diamine?

N- (4-fluorobenzyl) -N ', N' -dimethyl-N- (pyridine-2-yl) ethane-1,2-diamine This substance has many physical properties. Its properties are often solid, and the color may be white to off-white, which is determined by the interaction of atoms in its molecular structure.

When it comes to the melting point, due to the specific interatomic force within the molecule, it is about a certain temperature range. This temperature range is accurately determined by experiments, reflecting the molecular lattice energy and the strength of the intermolecular force.

In terms of solubility, it has a certain solubility in common organic solvents such as ethanol and dichloromethane. Due to the fact that its molecules have both polar and non-polar parts, polar amine groups and pyridyl groups can form hydrogen bonds with polar solvents, and non-polar fluorobenzyl groups and dimethyl groups can interact with non-polar organic solvents, so they exhibit unique dissolution characteristics in different solvents.

Its density is also an important physical property, which is determined by the molecular weight and the way of molecular accumulation. This value reflects the degree of molecular compactness, which is of great significance for its practical application in material measurement and other aspects.

In addition, the refractive index of the compound also has a specific value, which is related to the distribution of electron clouds in the molecule and the characteristics of chemical bonds, reflecting the degree of refraction when light passes through the substance, which is very helpful for identification and purity analysis. Overall, the physical properties of this compound are derived from its unique molecular structure, which has far-reaching impact on its application in chemical, pharmaceutical and other fields.

What is the synthesis method of N- (4-fluorobenzyl) -N ', N' -dimethyl-N- (pyridin-2-yl) ethane-1,2-diamine?

The preparation of N- (4-fluorobenzyl) -N ', N' -dimethyl-N- (pyridine-2-yl) ethane-1,2-diamine is an important task in organic synthesis. First, choose the appropriate starting material, usually 4-fluorobenzyl halide, N, N-dimethylethylenediamine and 2-halogenated pyridine.

First take 4-fluorobenzyl halide, such as 4-fluorobenzyl chloride or 4-fluorobenzyl bromide, whose activity is suitable for nucleophilic substitution reactions. In a suitable solvent, such as dichloromethane, N, N-dimethylformamide (DMF), an appropriate amount of alkali, such as potassium carbonate and triethylamine, is added to create a suitable reaction environment. The action of the base is to grab the hydrogen on the nitrogen atom in N, N-dimethylethylenediamine and make it a nucleophilic reagent.

The nitrogen atom of N, N-dimethylethylenediamine is nucleophilic and can attack the benzyl carbon of 4-fluorobenzyl halide. The halogen atom leaves to form an intermediate of N- (4-fluorobenzyl) -N, N-dimethylethylenediamine. This step requires temperature control and reaction time. Generally, the reaction is between room temperature and 50 ° C. The reaction process is monitored by thin layer chromatography (TLC) or gas chromatography (GC) for several hours until the raw materials are exhausted.

After obtaining the intermediate, react it with 2-halopyridine. This step is also carried out under similar solvent and base conditions. The halogen atom of 2-halopyridine undergoes nucleophilic substitution with the nitrogen atom of the intermediate to form the target product N- (4-fluorobenzyl) -N ', N' -dimethyl-N- (pyridine-2-yl) ethane-1,2-diamine.

The reaction is over, and the product needs to be isolated and purified. First, the reaction mixture is extracted with an organic solvent such as ethyl acetate by a conventional extraction method to separate the organic phase. Then, by column chromatography, a suitable silica gel column and eluent, such as the mixture of petroleum ether and ethyl acetate, are selected. According to the polarity of the product, it is separated from impurities to obtain pure N- (4-fluorobenzyl) -N ', N' -dimethyl-N- (pyridine-2-yl) ethane-1,2-diamine, and then its structure is confirmed by nuclear magnetic resonance (NMR) and mass spectrometry (MS).

What are the safety precautions for N- (4-fluorobenzyl) -N ', N' -dimethyl-N- (pyridin-2-yl) ethane-1,2-diamine?

N- (4-fluorobenzyl) -N ', N' -dimethyl-N- (pyridine-2-yl) ethane-1,2-diamine is an organic compound that may be used in chemical, pharmaceutical and other fields. There are many matters to pay attention to regarding the safety of this substance:
- ** Toxicity **: This compound may be toxic and may cause damage to the human body after contact. If ingested orally, or cause digestive tract discomfort, such as nausea, vomiting, abdominal pain, etc.; through skin contact, or cause skin allergies, itching, redness and swelling; if inhaling its dust or volatile gas, or irritating the respiratory tract, causing cough, asthma, and even damage to lung function. Strict protection must be taken during operation to avoid direct contact with the body.
- ** Explosion hazard **: Although there is no exact information indicating that it is highly flammable, as an organic compound, under certain conditions, in case of open flame, hot topic, or risk of combustion. When storing and using, it should be kept away from fire and heat sources, and the environment should be well ventilated to prevent the formation of explosive mixed gases.
- ** Chemical stability **: The compound may react chemically with certain substances. For example, when encountering strong oxidizing agents, or causing violent reactions, resulting in dangerous conditions. When using, it is necessary to clarify its chemical properties and avoid mixing with incompatible substances to prevent the generation of harmful gases or other hazards.
- ** Environmental impact **: If it enters the environment, or affects the ecology. It may remain in soil and water, affecting the survival of animals and plants. Therefore, during use, it is necessary to follow environmental protection regulations, properly dispose of waste, and prevent pollution of the environment.

In conclusion, when operating N- (4-fluorobenzyl) -N ', N' -dimethyl-N- (pyridine-2-yl) ethane-1,2-diamine, you should fully understand its safety characteristics, operate in strict accordance with safety procedures, and take protective measures to ensure personal safety and environmental safety.