What is the chemical structure of N- (4-fluorobenzyl) -1-methylpiperidin-4-amine?

N- (4-fluorobenzyl) -1-methylpiperidine-4-amine is an organic compound. To understand its chemical structure, its name should be analyzed to know the outline of its structure.

"N- (4-fluorobenzyl) " means that at the nitrogen (N) atom, there is a 4-fluorobenzyl group. This 4-fluorobenzyl group is above the benzyl group (phenyl) and has a fluorine atom substituted at the para (4 position). The structure of the benzyl group is that the benzene ring is connected to a methylene (-CH 2O -), and the methylene is then connected to the nitrogen atom, and there is a fluorine atom at the 4th position of the benzene ring.

"1-methylpiperidine-4-amine", piperidine is a nitrogen-containing hexamembered heterocycle, and the nitrogen atom occupies one place in the ring. 1-methyl, shown in the 1st position of the piperidine ring (the carbon position connected to the nitrogen atom) has a methyl (-CH 2O) substitution. 4-amine, represented in the 4th position of the piperidine ring, is connected with an amino group (-NH 2O).

Overall, the chemical structure of N- (4-fluorobenzyl) -1-methylpiperidine-4-amine is based on a piperidine ring with a methyl group at the first position, an amino group at the fourth position, and a nitrogen atom connected to a 4-fluorobenzyl group. This structure fuses a variety of groups such as aromatic rings, heterocycles, alkyl groups and amino groups, and has unique chemical properties. It may be important in many fields such as organic synthesis and medicinal chemistry.

What are the physical properties of N- (4-fluorobenzyl) -1-methylpiperidin-4-amine?

N- (4-fluorobenzyl) -1-methylpiperidine-4-amine is an organic compound. It has many physical properties and is closely related to its chemical structure.

Looking at its morphology, it is mostly white to off-white crystalline powder under normal conditions, which is easy to store and use. When it comes to the melting point, it is in a specific temperature range, and the specific value will vary slightly due to factors such as purity, but it is roughly about [X] ° C. The melting point can help determine its purity. When it is high purity, the melting point range is narrower, and when there are many impurities, the melting point decreases and the range becomes wider.

Solubility is also an important property. In organic solvents, such as ethanol, chloroform, etc., there is a certain solubility. Because the molecular structure contains polar and non-polar parts, it can interact with organic solvent molecules. However, the solubility in water is relatively small, because the non-polar part accounts for a large proportion, and the interaction with water molecules is weak.

The density of this compound is moderate. Although the exact value needs to be determined experimentally, it is estimated to be about [X] g/cm ³ according to the structure and similar compounds. The density is of great significance for material separation, purification and process design, which can help to judge its distribution and behavior in the mixed system.

In addition, N- (4-fluorobenzyl) -1-methylpiperidine-4-amine is volatile to a certain extent, but the volatility is not strong. This makes it less likely to be lost due to volatilization when stored under conventional conditions. However, in high temperatures or specific environments, it is still necessary to pay attention to its volatilization to prevent it from affecting the content and quality.

The physical properties of this compound have a profound impact on its application in chemical synthesis, drug development and other fields. According to these properties, researchers can choose suitable reaction conditions, separation methods and preparation forms to achieve the desired goals.

What are the common synthesis methods of N- (4-fluorobenzyl) -1-methylpiperidin-4-amine?

N- (4-fluorobenzyl) -1-methylpiperidine-4-amine is also an organic compound. There are several methods for its common synthesis.

First, 1-methylpiperidine-4-one can be started. First, 1-methylpiperidine-4-one is reduced to 1-methylpiperidine-4-ol with a suitable reducing agent, such as sodium borohydride. This step needs to be carried out in a suitable solvent, such as methanol or ethanol, under mild temperature conditions to ensure a smooth reaction. After obtaining 1-methylpiperidine-4-ol, it reacts with p-fluorobenzyl halide, such as p-fluorobenzyl chloride or p-fluorobenzyl bromide, in the presence of a base, such as potassium carbonate, in a solvent such as acetonitrile. The action of the base is to capture the hydrogen of the alcohol hydroxyl group, which enhances the nucleophilicity of the oxygen anion, and then undergoes a nucleophilic substitution reaction with the p-fluorobenzyl halide to obtain the target product precursor. Finally, with a suitable reagent, such as phosphorus tribromide or sulfoxide chloride, the alcohol hydroxyl group is converted into a halogen atom, which is then reacted with ammonia or amine compounds to replace the halogen atom, and then N - (4-fluorobenzyl) -1-methylpiperidine-4-amine is obtained.

Second, 1-methyl-4-piperidinecarboxylic acid can also be used as a raw material. First, its carboxyl group is converted into an acyl chloride, which can be reacted with sulfoxide chloride to generate 1-methyl-4-piperidinecarboxylic chloride. Then, the acid chloride is reacted with p-fluorobenzyl amine to form an Then through strong reducing agents such as lithium aluminum hydride, in anhydrous ether or tetrahydrofuran and other solvents, the amide is reduced to amine to obtain N- (4-fluorobenzyl) -1-methylpiperidine-4-amine. In this process, the use of lithium aluminum hydride needs to be extra careful, because it reacts violently with water, and the operation must be carried out in an anhydrous and oxygen-free environment.

Or starting from 1-methylpiperidine, first halogenate its 4-position, such as N-bromosuccinimide (NBS) in the presence of an initiator, react in a suitable solvent to obtain 4-halo-1-methylpiperidine. Then the halogen is coupled with p-fluorobenzylboronic acid or its ester under palladium catalysis by Suzuki, which can introduce p-fluorobenzyl. Finally, N - (4 -fluorobenzyl) -1 -methylpiperidine-4 -amine can be obtained by aminating the halogen atom on the piperidine ring, for example, by reacting with the alcohol solution of methamine under heating conditions.

Synthesis methods have their own advantages and disadvantages, and need to be carefully selected according to actual needs, such as the availability of raw materials, reaction conditions, and product purity.

What are the applications of N- (4-fluorobenzyl) -1-methylpiperidin-4-amine?

N- (4-fluorobenzyl) -1-methylpiperidin-4-amine has considerable applications in the fields of pharmaceutical research and development and organic synthesis.

In the field of pharmaceutical research and development, such compounds are often the key intermediates for the creation of new drugs. Because of their unique chemical structure or specific biological activity, they can bind to specific targets in organisms. Or they can regulate some biological signaling pathways and affect cell physiological functions, so they may play an important role in the development of many drugs such as antidepressant, analgesic, and anti-anxiety. Scientists can modify their structures to explore the effects of different substituents on their activity in order to find potential drug molecules with better activity and fewer side effects.

In the field of organic synthesis, N- (4-fluorobenzyl) -1-methylpiperidine-4-amine is an important building block for the construction of complex organic molecules. The piperidine ring and benzyl structure contained in it provide a variety of reaction check points. Chemists can use various organic reactions, such as nucleophilic substitution, reduction, oxidation, etc., to derivatize them. Through this, a series of organic compounds with different structures can be synthesized, providing rich raw materials for materials science, total synthesis of natural products and other fields. For example, when synthesizing organic materials with special photoelectric properties, they can be introduced into the molecular structure to endow the material with unique electronic properties to meet specific application requirements.

What is the market outlook for N- (4-fluorobenzyl) -1-methylpiperidin-4-amine?

The market prospect of N- (4-fluorobenzyl) -1-methylpiperidine-4-amine is related to many aspects. Looking at its chemical properties, this compound may have unique uses in the field of organic synthesis. In the field of pharmaceutical research and development, due to its specific molecular structure, it may become a key intermediate for exploring new drugs. If it can be used to construct unique pharmacophore, or it is expected to lead to innovative therapies for specific diseases, it will open up a new path for the pharmaceutical market, with unlimited prospects.

Looking at the field of materials science, such fluorinated organic amine compounds may endow materials with novel properties. For example, in the modification of polymer materials, adding an appropriate amount of this substance may improve the heat resistance and chemical corrosion resistance of the material, thereby broadening the application range of the material, finding a place for use in high-end fields such as aerospace and electronic devices, and the market demand will also increase.

However, the road to market expansion is not smooth. The complexity of the synthesis process may lead to high production costs, which is a bottleneck hindering its large-scale application. To open up the market, it is necessary to develop efficient and economical synthesis routes to reduce costs. And marketing activities also take time, and the relevant industries need to fully recognize its advantages and potential. Although the current challenges still exist, with time, if the technical and market difficulties can be overcome, N- (4-fluorobenzyl) -1-methylpiperidine-4-amine will be able to emerge in many fields, gain considerable market share, and have broad prospects.