What is the chemical structure of N- (3-chloro-4- (3-fluorobenzyloxy) phenyl) -6-iodoquinazolin-4-amine

The name of this organic compound is N- (3-chloro-4- (3-fluorobenzyloxy) phenyl) -6-iodoquinazoline-4-amine. To clarify its chemical structure, it should be analyzed according to the naming rules of organic chemistry.

"quinazoline" is a kind of nitrogen-containing heterocyclic parent nucleus structure with specific atomic arrangement and chemical bonding. "6-iodine" is shown on the 6-position carbon of the quinazoline parent nucleus, and there are iodine atoms connected by covalent bonds.

"N- (3-chloro-4- (3-fluorobenzyloxy) phenyl) ", this section lists the substituents attached to the nitrogen atom at the 4th position of the quinazoline parent nucleus. Among them, "3-chloro-4- (3-fluorobenzyloxy) phenyl" is a complex aryl substituent. "Phenyl" is a hexamembered carbon ring with a conjugated π electronic system. "3-chloro" means that the 3-position of the benzene ring has a chlorine atom substituted; "4 - (3-fluorobenzyloxy) " means that the 4-position of the benzene ring is connected with a group, which is "3-fluorobenzyloxy". " Benzyl "is benzyl, that is, benzene ring-linked methylene (- CH 2O -)," 3-fluorobenzyl "is benzyl benzene ring with fluorine atom substitution at 3 position, and" 3-fluorobenzyl "is 3-fluorobenzyl benzyl group connected to the oxygen atom, and then connected to the above-mentioned benzene ring at 4 position.

In summary, the chemical structure of this compound is based on quinazoline as the core, with iodine substitution at 6 positions, and nitrogen atom at 4 positions connected to a complex aromoxy substituent containing chlorine and fluorine. Each atom is arranged according to a specific space and valence bond relationship, resulting in this unique chemical structure.

What are the main uses of N- (3-chloro-4- (3-fluorobenzyloxy) phenyl) -6-iodoquinazolin-4-amine

N- (3-chloro-4- (3-fluorobenzyloxy) phenyl) -6-iodoquinazoline-4-amine is often the core research material in the field of medical exploration. Because of its unique chemical structure, it can accurately target specific biological targets in the creation of targeted drugs, thus paving the way for the treatment of various diseases.

Watching the cancer raging, this compound may be able to target the unique proteins and receptors presented by cancer cells, and use subtle molecular mechanisms to block their proliferation and promote their apoptosis, paving the way for the development of anti-cancer drugs. Furthermore, in the field of immune regulation, it may affect the signaling of immune cells, opening up different ideas for the treatment of immune-related diseases.

It can also be seen in the study of neurological diseases. It may act on the metabolism of neurotransmitters and the signal transduction of nerve cells, and find potential solutions for the treatment of intractable neurological diseases such as epilepsy and Parkinson's disease.

In the field of agriculture, this compound may be modified and transformed into a pesticide. By its regulation of specific biological activities, it can prevent pests and diseases, protect the robust growth of crops, and ensure the harvest of agriculture.

In summary, N- (3-chloro-4- (3-fluorobenzoxy) phenyl) -6-iodoquinazoline-4-amine has broad application prospects in various fields such as medicine and agriculture, and it is a treasure that researchers urgently need to dig deeper.

What are the synthesis methods of N- (3-chloro-4- (3-fluorobenzyloxy) phenyl) -6-iodoquinazolin-4-amine

There are many methods for synthesizing N- (3-chloro-4- (3-fluorobenzyloxy) phenyl) -6-iodoquinazoline-4-amine. One method is to first take 4-chloro-6-iodoquinazoline, which is the starting material, make it with 3-chloro-4-hydroxybenzaldehyde, under the catalysis of alkali, such as potassium carbonate, in a suitable solvent, such as N, N-dimethylformamide (DMF), heat and stir to make the two condensate to obtain an intermediate. Then, this intermediate is reacted with 3-fluorobenzyl halide, such as 3-fluorobenzyl bromide, under similar base and solvent conditions, and then the target product can be obtained through the substitution step.

Another method is to use 3-chloro-4- (3-fluorobenzoxy) aniline as the starting material, and combine it with a suitable iodine substitution reagent, such as N-iodosuccinimide (NIS), in a suitable solvent, such as dichloromethane, under mild conditions, introduce an iodine atom to obtain an iodine-containing aniline derivative. Afterwards, the derivative is condensed with formamide and triethyl orthoformate through cyclization to form a quinazoline ring, which can also achieve the synthesis of the target product.

Furthermore, the quinazoline ring can be constructed first, starting with 6-iodine-4-hydroxyquinazoline, and it can be combined with 3-chloro-4- (3-fluorobenzoxy) chlorobenzene in a base and a suitable solvent system. N- (3-chloro-4- (3-fluorobenzoxy) phenyl) -6-iodoquinazoline-4-amine can also be successfully prepared by nucleophilic substitution reaction. Each method has its own advantages and disadvantages, and it is necessary to choose carefully according to many factors such as the availability of raw materials, the conditions of reaction, and the high or low yield.

What are the physical properties of N- (3-chloro-4- (3-fluorobenzyloxy) phenyl) -6-iodoquinazolin-4-amine

N- (3-chloro-4- (3-fluorobenzyloxy) phenyl) -6-iodoquinazoline-4-amine, this is an organic compound. Its physical properties are very important, related to its performance in various chemical processes and practical applications.

Looking at its appearance, it is usually in a solid state, mostly white or off-white crystalline powder, which is easy to store and operate. Its melting point is also a key physical property, but the exact value varies depending on the purity and measurement conditions, and is roughly in a specific temperature range. This temperature range is of great significance for its thermal stability and processing technology.

In terms of solubility, the compound exhibits some solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), while its solubility in water is relatively low. This difference in solubility requires chemists to consider carefully when selecting the reaction system, separating and purifying the product.

In addition, the density of the compound is a fixed value under certain conditions. Although there are few reports in the relevant literature, it cannot be ignored when it comes to precise measurement and reaction system design.

Furthermore, its stability is good under conventional conditions, but due to the presence of iodine atoms in the structure, there is a certain sensitivity to light and heat. Light or high temperature environments may cause iodine atoms to react, causing structural changes in compounds. Therefore, it is necessary to store them at low temperatures and away from light to ensure their quality and stability.

What is the safety of N- (3-chloro-4- (3-fluorobenzyloxy) phenyl) -6-iodoquinazolin-4-amine?

N- (3-chloro-4- (3-fluorobenzyloxy) phenyl) -6-iodoquinazoline-4-amine, this is an organic compound. When it comes to safety, it needs to be explored in detail from multiple aspects.

In terms of toxicity, the compound structure contains halogen atoms such as chlorine, fluorine, and iodine. Halogen atoms often increase the lipid solubility of the compound, easily penetrate the biofilm, or concentrate in the organism, leading to potential toxicity. And the quinazoline structure has biological activity in some analogs, or interferes with the normal biochemical process in the organism, such as affecting enzyme activity, receptor binding, etc., causing cytotoxicity, genetic toxicity, etc.

Its chemical stability is also related to safety. Different functional groups in the molecule sometimes react chemically, especially under extreme conditions such as high temperature, strong acid, and strong base. For example, benzyloxy groups under specific conditions or hydrolysis cause the structure of the compound to change, which not only affects its own properties, but also produces products with different toxicity and reactivity.

Furthermore, if the compound is involved in the production process, its raw materials, intermediates, and production waste may pose environmental and health risks. Organic solvents, catalysts, etc. are used in production. If they are not handled properly, they may evaporate into the atmosphere or flow into water and soil, polluting the environment and threatening ecological and human health.

From the perspective of fire safety, although there is no direct information indicating its flammability, it contains elements such as carbon, hydrogen, nitrogen, and many organic compounds are flammable. When heated or exposed to open flames, or burned or even exploded, attention should be paid to fire and explosion protection when storing and using.

In summary, N- (3-chloro-4- (3-fluorobenzoxy) phenyl) -6-iodoquinazoline-4-amine has complex safety and requires rigorous testing and evaluation. It should be operated according to specifications in all aspects of use, storage and production to ensure safety.