What is the chemical structure of N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodoquinazolin-4-amine

This is the structural description of an organic compound, which is called by the professional chemical nomenclature. Its structure is complex and can be disassembled.
- ** Core skeleton **: It is a quinazoline structure, which is a nitrogen-containing dicyclic heterocyclic compound composed of a benzene ring fused with a pyrimidine ring. In this compound, quinazoline is connected to an amine group at position 4 and an iodine atom at position 6.
- ** Benzene ring substituent **: On the benzene ring connected to the amine group, there is a chlorine atom at position 3, and an oxygen atom at position 4 is connected to a 3-fluorobenzyl group. In the case of 3-fluorobenzyl, the benzyl ring of benzyl group (benzyl) has a structure of fluorine atom substitution at position 3.
- ** The overall structure is presented **: quinazoline is used as the core, and one side is connected to the benzene ring and amine group containing chlorine and 3-fluorobenzoxy group, and the other side is an iodine atom. This structure endows the compound with specific physical and chemical properties, which may be of great significance in organic synthesis, medicinal chemistry and other fields, or can be used to develop new drugs. Due to its unique structure or ability to interact with specific targets in organisms, it exhibits pharmacological activity.

What are the physical properties of N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodoquinazolin-4-amine

N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodoquinazoline-4-amine, this is an organic compound. Its physical properties are related to the state, melting point, solubility, density, color and odor, etc., which are of great significance to chemical research and practical applications.

Let's talk about the state first, because there is no relevant experimental data and literature reference, it is difficult to determine its normal state. However, it can be inferred from similar structural compounds that it may be a solid. Such organic compounds containing benzene ring and quinazoline structure have strong intermolecular forces and are often solid.

In addition to the melting boiling point, the structure of benzene ring and quinazoline in the molecule increases the intermolecular force, and the halogen atoms such as chlorine, fluorine, and iodine are also affected. Organic compounds containing halogen atoms, due to the large electronegativity of halogen atoms, there is a strong dipole-dipole interaction between molecules, and the melting boiling point increases. Therefore, it is speculated that the melting boiling point of this compound is high, but the exact value needs to be determined experimentally.

In terms of solubility, the compound contains polar groups, such as amino groups and halogen atoms, and also has non-polar benzene ring and quinazoline structures. According to the principle of "similar miscibility", it may have a certain solubility in polar organic solvents, such as ethanol and acetone, and its solubility in water may be limited. Due to the strong polarity of water molecules, the non-polar part of < Br >
Density is also affected by molecular structure and atomic mass. The relative atomic mass of chlorine, fluorine and iodine atoms is relatively large, which increases the molecular mass or increases the density. But the exact density still needs to be measured experimentally.

Color and odor, iodine-containing atomic compounds or with color, but the specific color is difficult to determine only according to the structure. And the odor is also difficult to judge according to the structure alone, and the actual smell and smell perception is required.

In conclusion, although the physical properties of N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6 -iodoquinazoline-4 -amine can be speculated according to the structure, accurate data need to be experimentally determined and reviewed in the literature.

What is the main use of N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodoquinazolin-4-amine

N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodoquinazoline-4-amine, this is an organic compound. Its main use involves drug development in the field of pharmaceutical chemistry.

In the process of drug development, such compounds are often used as lead compounds. The cover contains specific functional groups and structural units in its structure, or has specific biological activities. For example, quinazoline structures are common in many drugs, or can interact with specific targets in organisms, such as certain kinases. The chlorine, fluorine, iodine and other halogen atoms of this compound, as well as the benzyloxy group and other substituents, may adjust its physical and chemical properties and biological activities, such as lipophilicity, water solubility, and binding affinity with targets.

Or by structural modification and optimization of this compound, new drug molecules with better activity, higher selectivity, and lower toxicity can be explored. Furthermore, in biological activity research, it may be used to construct biological activity models to help in-depth understanding of physiological and pathological processes in organisms, as well as drug action mechanisms. It can also provide structural templates for pharmaceutical chemists to create a series of derivatives by introducing different substituents and changing connection methods, expanding the scope of drug development.

What are the synthesis methods of N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodoquinazolin-4-amine

To prepare N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodoquinazoline-4-amine, organic synthesis is often followed. The method may have multiple ends, which are briefly described here.

First, it can be obtained by nucleophilic substitution reaction between aniline derivatives containing corresponding substituents and halogenated quinazoline compounds. First, 3-chloro-4- [ (3-fluorobenzyl) oxy] aniline is used as the starting material, and it is heated and stirred with the appropriately activated 6-iodine-4-haloquinazoline in the presence of suitable bases and solvents to promote nucleophilic substitution. Alkalis, such as potassium carbonate, sodium carbonate, etc., can maintain the alkaline environment of the reaction system and assist in the formation of nucleophilic reagents; the solvent can be selected as N, N-dimethylformamide (DMF), dimethylsulfoxide (DMSO) and other polar aprotic solvents, which have good solubility to the reactants and can stabilize the transition state and improve the reaction rate and yield.

Second, we can also start from the construction of quinazoline rings. The derivatives of anthranilic acid containing suitable substituents are prepared by a series of reactions such as condensation and cyclization with iodoaromatic hydrocarbons. First, the anthranilic acid is reacted with appropriate reagents, and 3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl is introduced. Then, under the action of iodide reagents, it is cyclized to form quinazoline rings under specific conditions, and then appropriately modified to obtain the target product. Commonly used iodide reagents include iodine elemental substance, N-iodosuccinimide (NIS), etc. The reaction conditions need to be carefully regulated, such as temperature, reaction time, reactant ratio, etc., to achieve the best effect.

There may be other synthetic routes, all of which depend on the activity of the reactants, the precise control of the reaction conditions, and the clever design of the synthesis strategy. When synthesizing, it is necessary to pay attention to the selectivity and yield of each step of the reaction, and carefully purify the product to obtain high-purity N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodoquinazoline-4-amine.

N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodoquinazolin-4-amine

Nowadays, there is N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodoquinazoline-4-amine. The market prospect of this substance is quite attractive. Looking at the field of pharmaceutical chemistry today, such compounds may have unique pharmacological activities. In the process of new drug development, they may be potential stocks.

The ingenious combination of halogen atoms and phenyl ring and quinazoline structures may endow the compound with excellent biological activity and pharmacokinetic properties. In the field of anti-cancer drug development, many compounds containing quinazoline structures have emerged, which are effective in inhibiting the growth of specific cancer cells. This N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-ioquinazoline-4-amine, or due to the introduction of iodine atoms and fluorine atoms, changes the electron cloud distribution of the molecule and enhances the interaction with biological targets.

However, its market prospects are not completely smooth. The road of new drug development is full of risks. Strict pharmacological and toxicological tests are required to prove its safety and effectiveness. And the market competition is fierce, and drugs of the same or similar mechanism of action may already be numerous. To stand out, it is necessary to demonstrate unique advantages, such as higher efficacy and fewer side effects.

If it can overcome difficulties in research and development and demonstrate excellent performance, its market prospect may be extremely broad. It can be applied to clinical treatment, bringing good news to patients, and also creating rich profits for pharmaceutical companies. But before comprehensive research and verification, its market prospect is still in the fog, waiting for explorers to clear the clouds with wisdom and perseverance and see the light.