What is the chemical structure of N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodo-4-quinazolinamine

This is the naming of an organic compound, and its chemical structure is inferred from the naming, and the naming rules of organic chemistry need to be followed. "N - {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodine-4-quinazolinamine" can be disassembled and analyzed.

"Quinazolinamine" indicates that the parent nucleus is quinazoline, and the amino group is connected at the 4th position. "6-iodine" means the introduction of an iodine atom at the 6th position of the quinazoline parent nucleus.

Look again at the "N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl}" part, which is the substituent attached to the nitrogen atom. Where "3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl" means that on the benzene ring, there is a chlorine atom at the 3rd position, and a 3-fluorobenzyl group at the 4th position is connected through an oxygen atom. 3-fluorobenzyl, that is, benzyl (phenyl), has a fluorine atom at the 3rd position on the benzene ring.

In general, the chemical structure of the compound is quinazoline as the parent nucleus, with amino group at the 4th position and iodine atom at the 6th position. The benzene ring connected to the nitrogen atom has chlorine at the 3rd position and 3-fluorobenzyl at the 4th position through oxygen. Thus, its chemical structure is reconstructed according to the nomenclature.

What are the main uses of N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodo-4-quinazolinamine

N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodine-4-quinazolinamide, this is an organic compound. Its main use is more common in the research and development of medicinal chemistry.

In the process of drug development, such compounds may have unique biological activities and can be used as lead compounds to help scientists explore new drugs. Due to their specific chemical structure, they may interact with specific targets in organisms, such as specific enzymes or receptors. For example, to explore its impact on certain disease-related signaling pathways, if these pathways can be precisely regulated, it may provide new strategies for disease treatment.

In the field of organic synthesis, it can be used as a key intermediate. Chemists modify its structure through various organic reactions and derive many structural analogs. By studying the relationship between structure and activity, we can gain a deeper understanding of the impact of compound structure changes on biological activities, laying the foundation for the design and synthesis of more efficient and safe drugs.

In addition, in the field of materials science, such quinazoline amines containing special substituents may have unique photoelectric properties due to their structure. Potential applications in the research and development of new organic materials, such as the exploration of organic Light Emitting Diodes or sensor materials.

What is the synthesis method of N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodo-4-quinazolinamine

The method of preparing N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodine-4-quinazolinamide is quite delicate. First, an appropriate 3-chloro-4-hydroxybenzoic acid is taken, and a specific halogenation reagent is used to obtain the corresponding halogenate under a suitable reaction environment, such as a suitable solvent and temperature. This halogen is then combined with 3-fluorobenzyl alcohol under the catalysis of a base, and undergoes a nucleophilic substitution reaction in a suitable reaction system to obtain 3-chloro-4- [ (3-fluorobenzyl) oxy] benzoic acid.

Thereafter, the acid is converted into an acid chloride, which is often treated with sulfoxide chloride and other reagents. The resulting acid chloride is amidated with suitable amines, such as 2-amino-5-iodobenzoic acid amides, under suitable conditions, such as suitable acid binding agents and temperature ranges, to obtain key intermediates.

Under the action of specific cyclic reagents, such as polyphosphoric acid, this intermediate undergoes an intramolecular cyclization reaction within the corresponding reaction temperature and time to construct a quinazoline ring, and finally obtains N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6 -iodine-4-quinazolinamide. Each step of the reaction requires precise control of the reaction conditions, such as temperature, reagent dosage, reaction time, etc., and the reaction products need to be properly separated and purified to obtain high-purity target products.

What are the physicochemical properties of N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodo-4-quinazolinamine

N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodine-4-quinazolinamine, this is an organic compound. Its physical properties contain several key aspects.

Looking at its properties, it usually takes a solid form, which is due to the relatively strong force between molecules, which promotes the orderly arrangement of molecules. In terms of melting point, the compound has a specific melting point, which depends on the interaction between atoms in the molecular structure and the way the molecules are deposited. Halogen atoms such as chlorine, fluorine, and iodine in the molecule can enhance the intermolecular force due to their high electronegativity, which in turn increases the melting point.

Solubility is also an important property. Due to the presence of hydrophobic groups such as benzene ring and quinazoline ring in the molecule, the solubility in water is low. However, in organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF), it has a certain solubility due to the interaction between molecules and solvents. The nitrogen-containing quinazolinamine part can interact with some organic solvents such as hydrogen bonds to improve its solubility.

The density of this compound is closely related to the relative molecular weight and molecular accumulation. The relative molecular weight increases due to the presence of chlorine, iodine, fluorine and other atoms, and the compactness of the molecular structure also affects the density. The precise arrangement of each atom in its molecular structure determines its density characteristics.

In addition, the compound may have a certain degree of volatility, but due to the strong intermolecular forces, the volatility is relatively weak. Halogen atoms and cyclic structures in the molecule have inhibitory effects on volatility.

In summary, the physical properties of N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodine-4-quinazolinamines are determined by their unique molecular structures, which are of great significance in the separation, purification and application of compounds.

What is the market price of N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodo-4-quinazolinamine

I don't know what the price of "N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6-iodine-4-quinazolinamide" is on the market. This is a rather professional chemical substance, and its price is determined by many factors.

First, the difficulty of preparing this compound is the key factor. If its synthesis steps are complicated, rare or expensive raw materials are required, and it can be prepared after multiple precise reactions, the price will be high. On the contrary, if the synthesis path is relatively simple, the raw materials are common and inexpensive, the price may be slightly lower.

Second, the market demand situation also affects its price. If there is strong demand for this substance in the fields of pharmaceutical research and development, chemical production, etc., and the supply is limited, the price will rise according to the reason of supply and demand. If there is little demand and sufficient supply, the price may stabilize or even decline.

Third, different manufacturers will also cause price differences. Different manufacturers may have different prices for this compound due to differences in technical level, production costs, and business strategies.

I have not personally seen the transaction of this substance in the market, and there is no detailed market survey, so it is difficult to determine its price. To know the exact price, you may need to consult a professional chemical reagent supplier or consult the quotation information of the relevant chemical product trading platform to obtain a more accurate price.