What is the chemical structure of N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6- [5- ({[2- (methylsulfonyl) ethyl] amino} methyl) furan-2-yl] quinazolin-4-amine

This is a rather complex organic compound named "N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6- [5- ({[2 - (methylsulfonyl) ethyl] amino} methyl) furan-2-yl] quinazoline-4-amine". To clarify its chemical structure, it is necessary to analyze it one by one from each part.

"Quinazoline-4-amine" is the core parent structure of this compound, which is like the cornerstone of a building. An amino group is attached to the fourth position of the quinazoline ring, which is an important part of the structure.

"6- [5- ({[2- (methylsulfonyl) ethyl] amino} methyl) furan-2-yl]" indicates that there is a furan group attached to the sixth position of the quinazoline ring. The fifth position of this furan group is connected to an amino group through methylene, which in turn is connected to 2- (methylsulfonyl) ethyl, and extends outward like a branch.

"N - {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl}" is shown to be connected to a phenyl group on the nitrogen atom of quinazoline-4-amine. The third position of the phenyl group is substituted with a chlorine atom, and the fourth position is connected to a 3-fluorobenzyl group through an oxygen atom.

In summary, the structure of this compound is composed of quinazoline parent nucleus, furan group, phenyl group and its many substituents. The interaction of each part jointly determines the chemical properties and biological activities of the compound.

What are the physical properties of N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6- [5- ({[2- (methylsulfonyl) ethyl] amino} methyl) furan-2-yl] quinazolin-4-amine

N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6- [5 - ({[2 - (methylsulfonyl) ethyl] amino} methyl) furan-2-yl] quinazoline-4-amine, this is a complex organic compound. Looking at its structure, it can be seen that it has unique physical properties.

In terms of solubility, because the molecule contains many polar groups, such as sulfonyl, amino, etc., it should have a certain solubility in polar solvents such as methanol, ethanol, and dimethyl sulfoxide (DMSO). However, its aromatic ring structure and furan ring and other non-polar parts make it less soluble in non-polar solvents such as n-hexane and benzene.

In terms of melting point, the compound has a relatively stable structure due to the interaction of hydrogen bonds and van der Waals forces between molecules, and is expected to have a high melting point. However, the exact value still needs to be accurately determined by experiments.

The appearance is mostly solid, because of its large molecular weight and strong intermolecular force, it is easy to aggregate into a solid state at room temperature and pressure. And because the molecular structure contains multiple conjugated systems, such as quinazoline rings, benzene rings, etc., or has a certain color, or is light yellow to brown solid. The density of

is related to the relative molecular weight and the degree of molecular accumulation. Due to the complex structure and large relative molecular weight, the estimated density is higher than that of common organic compounds. However, the specific density also needs to be accurately measured by experiments.

What is the use of N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6- [5- ({[2- (methylsulfonyl) ethyl] amino} methyl) furan-2-yl] quinazolin-4-amine

N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6 - [5 - ({[2 - (methylsulfonyl) ethyl] amino} methyl) furan-2-yl] quinazoline-4-amine, which is an organic compound. In the era of Tiangong Kaiji, there is no knowledge of such compounds, but from today's perspective, such compounds are quite useful in many fields.

In the field of medicine, it may be developed into drugs through research. Many compounds containing quinazoline structures have anti-tumor, antiviral and other pharmacological activities. The complex substituents in this compound may endow it with unique biological activities, or can interact with specific biological targets to regulate physiological processes in organisms, and may have potential value in the treatment of specific diseases.

In the field of materials science, compounds containing such structures, or due to their unique electronic structure and spatial configuration, exhibit specific physicochemical properties, such as fluorescence properties, electrical properties, etc. After rational design and modification, they may be applied to the preparation of new functional materials, such as organic Light Emitting Diodes, sensor materials, etc., injecting new vitality into the development of materials science.

Although this object is not contained in "Tiangong Kaiwu", in today's era of technological development, such compounds, with their unique structures, may open up a vast world in fields such as medicine and materials, contributing to the progress and development of mankind.

What is the synthesis method of N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6- [5- ({[2- (methylsulfonyl) ethyl] amino} methyl) furan-2-yl] quinazolin-4-amine

To prepare N - {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6 - [5 - ({[2 - (methylsulfonyl) ethyl] amino} methyl) furan-2-yl] quinazoline-4-amine, the following method can be followed.

First take the appropriate 3-chloro-4-hydroxybenzoic acid as the starting material, and treat it with a suitable base agent to form the corresponding phenate. After adding 3-fluorobenzyl halide, in a suitable solvent, such as N, N-dimethylformamide, heating and stirring for nucleophilic substitution reaction, 3-chloro-4- [ (3-fluorobenzyl) oxy] benzoic acid can be obtained.

React this product with a suitable reagent, such as sulfinyl chloride, to convert it into the corresponding acid chloride. Then amidation with 2-amino-5-methylfuran can be carried out in a suitable solvent, such as dichloromethane, in the presence of acid binding agents, such as triethylamine, to obtain amide compounds containing furan groups.

Another suitable 4,6-dichloroquinazoline is taken, reacted with the amide compound containing the above furan group, and reacted in a suitable base agent and solvent system, such as potassium carbonate and N, N-dimethylformamide system, heated to replace the 4-chlorine of the quinazoline to form the quinazoline intermediate containing the furan group.

Finally, the chlorine substitution reaction of quinazoline 6-position in the intermediate is carried out with 2- (methylsulfonyl) ethylamine. Under suitable reaction conditions, such as heating the reaction in a suitable base and solvent, after separation, purification and other steps, the target product N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6- [5- ({[2 - (methylsulfonyl) ethyl] amino} methyl) furan-2-yl] quinazoline-4-amine can be obtained. Each step of the reaction requires attention to the control of the reaction conditions and the separation and purification of the product to enhance the yield and purity.

N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6- [5- ({[2- (methylsulfonyl) ethyl] amino} methyl) furan-2-yl] quinazolin-4-amine What is the relevant safety information

This is a compound named N- {3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl} -6- [5- ({[2 - (methylsulfonyl) ethyl] amino} methyl) furan-2-yl] quinazoline-4-amine. However, there is no conclusive ancient record for its safety information. This compound may be a newly synthesized chemical substance. The ancient books are old, and the chemical synthesis technology at that time was not as developed as it is today, so it is difficult to have its relevant safety records.

If viewed from the perspective of current research, organic compounds containing chlorine, fluorine, sulfonyl groups and other groups may have certain chemical activities. Chlorine atoms may affect the toxicity of compounds, and they may be metabolized in the body or participate in chemical reactions to generate toxic metabolites. Although fluorine atoms often enhance the stability of compounds, they may also change their lipid solubility and biological activity, affecting the absorption and distribution of human bodies. Methylsulfonyl groups affect the polarity of compounds, or affect their transport and excretion in vivo.

From the structure, it is speculated that this compound may have certain chemical stability, but it may meet various substances in living organisms or cause complex biochemical reactions. However, these are all speculations based on modern chemical theories, which are not confirmed in ancient books. For accurate safety information, modern experimental studies and toxicological assessments should prevail.