Ethyl 2-amino-6- [ (4-fluorobenzyl) amino] pyridine-3-carbamate, compound with maleic acid (1:1)

The chemical structure of a compound formed by ethyl 2-amino-6- [ (4-fluorobenzyl) amino] pyridine-3-carbamate and maleic acid (1:1) is as follows.

In this compound, the main structure is a pyridine ring with an amino group at 2 positions, a carbamate ethyl group at 3 positions, and a 4-fluorobenzyl group connected by an imino group at 6 positions. That is, the nitrogen atom at position 2 of the pyridine ring is connected to the nitrogen of the amino group; the carbon atom at position 3 is connected to the carbonyl carbon atom of ethyl carbamate, where the ethoxy group of ethyl carbamate is connected to the carbonyl group through the oxygen atom; the carbon atom at position 6 is connected to the imino group (-NH-), and the other end of the imino group is connected to the benzyl carbon atom of 4-fluorobenzyl group. The 4-position of the benzene ring in the 4-fluorobenzyl group is connected with a fluorine atom. This host structure binds to maleic acid in a ratio of 1:1 through a specific interaction. Maleic acid has a cis-double bond, and two carboxyl groups are located on The whole compound combines the main pyridine derivative with maleic acid through intermolecular forces, such as hydrogen bonds, to form a stable structure. In this way, the compound structure of ethyl 2-amino-6- [ (4-fluorobenzyl) amino] pyridine-3-carbamate and maleic acid (1:1) is formed.

What are the physical properties of ethyl 2-amino-6- [ (4-fluorobenzyl) amino] pyridine-3-carbamate, compound with maleic acid (1:1)

The compound of ethyl-2-amino-6- [ (4-fluorobenzyl) amino] pyridine-3-carbamate and maleic acid (1:1) is an organic compound. Its physical properties are of great research value.

Looking at its properties, at room temperature and pressure, this compound is mostly in a solid state, and the specific form is a crystalline powder. The appearance is white and the texture is fine, like the first snow in winter, pure and regular. This form benefits from the interaction force between molecules, which makes the molecules arranged in an orderly manner, so it appears like this.

When it comes to the melting point, it has a specific value, about [X] ℃. When the temperature gradually rises, the molecule obtains enough energy, the lattice structure begins to disintegrate, and the solid state transitions to the liquid state. This melting point characteristic is of great significance for its stability and processing applications under different temperature environments.

In terms of solubility, it exhibits certain solubility in organic solvents such as ethanol and dichloromethane. Ethanol is like a friendly medium and can interact with the compound molecules. By virtue of the similar miscibility principle, some molecules are dispersed in the ethanol system. In water, its solubility is relatively limited. Due to the weak force between water molecules and the compound molecules, it is difficult to promote the uniform dispersion of a large number of molecules.

In addition, the density of the compound is also an important physical property, which is about [X] g/cm ³. This density value reflects the mass of the substance in a unit volume, affects its sedimentation and suspension behavior in various media, and is of great significance to related chemical processes and product design. These physical properties are interrelated, and together outline the unique physical appearance of the compound, laying the foundation for its application in chemical, pharmaceutical and other fields.

Ethyl 2-amino-6- [ (4-fluorobenzyl) amino] pyridine-3-carbamate, compound with maleic acid (1:1)

Ethyl + 2 - amino - 6 - [ (4 - fluorobenzyl) amino] pyridine - 3 - carbamate, compound with maleic acid (1:1), Chinese name or 2 - amino - 6 - [ (4 - fluorobenzyl) amino] pyridine - 3 - carbamate ethyl ester maleate. This compound may have unique uses in the field of medicine.

According to previous medical investigations, such compounds containing pyridine structures are often unique in biological activity display due to the special electron cloud distribution and conjugation effect of pyridine rings. 2-Amino-6- [ (4-fluorobenzyl) amino] pyridine-3-carbamate ethyl maleate, in which the pyridine ring is cleverly connected to groups such as fluorobenzyl and carbamate, giving it a specific molecular shape and electronic properties.

In drug development, or by virtue of its structural characteristics, it can precisely bind to specific targets in organisms. For example, some disease-related receptors, enzymes, etc., this compound may be used as a ligand to bind to it with suitable affinity, or regulate receptor activity, or inhibit the catalytic action of enzymes, thereby interfering with the disease process. The salts formed with maleic acid may improve the solubility, stability and other physical and chemical properties of the original compound, which is conducive to the development of pharmaceutical preparations, making the drug more easily absorbed and distributed by the body, improving the efficacy, and being of great benefit to the treatment of diseases.

What is the synthesis method of ethyl 2-amino-6- [ (4-fluorobenzyl) amino] pyridine-3-carbamate, compound with maleic acid (1:1)

Nowadays, there are compounds formed by ethyl + 2-amino-6- [ (4-fluorobenzyl) amino] pyridine-3-carbamate and maleic acid in a 1:1 ratio. The synthesis method is as follows.

First take an appropriate amount of 2-amino-6-chloropyridine-3-carboxylic acid ethyl, place it in a reactor, use anhydrous ethanol as a solvent, add potassium carbonate as a base, and stir well. Then slowly add 4 - fluorobenzylamine, heated to an appropriate temperature, such as 60 - 80 ℃, stirring the reaction number, about 6 - 8 hours, this step is designed to make the 6 - position chlorine atom is 4 - fluorobenzylamino substituted to give ethyl 2 - amino - 6 - [ (4 - fluorobenzyl) amino] pyridine - 3 - carboxylate.

The resulting product ethyl 2 - amino - 6 - [ (4 - fluorobenzyl) amino] pyridine - 3 - carboxylate, with dichloromethane as a solvent, cooled to 0 - 5 ℃, ethyl chloroformate was added dropwise, while adding triethylamine as an acid binding agent, the reaction for 2 - 3 hours, the amino group and ethyl chloroformate react to form ethyl 2 - amino - 6 - [ (4 - fluorobenzyl) amino] pyridine - 3 - carbamate.

Finally, take an equal amount of ethyl 2 - amino - 6 - [ (4 - fluorobenzyl) amino] pyridine - 3 - carbamate and maleic acid, use an appropriate amount of ethyl acetate as a solvent, heat to reflux, so that the two fully react, after cooling, filter and dry to obtain ethyl + 2 - amino - 6 - [ (4 - fluorobenzyl) amino] pyridine - 3 - carbamate, compound with maleic acid (1:1) product. The whole process needs to pay attention to the control of reaction temperature, time, and the amount of each reagent to ensure the purity and yield of the product.

Ethyl 2-amino-6- [ (4-fluorobenzyl) amino] pyridine-3-carbamate, compound with maleic acid (1:1)

I don't know if there is any relevant clinical research in the ethyl+2-amino-6-%5B%284-fluorobenzyl%29amino%5Dpyridine-3-carbamate%2C+compound+with+maleic+acid+%281%3A1%29. However, if you want to know this, you should follow the rules of medical practice and widely search medical canons, classics and various research reports.

Looking at ancient medical affairs emphasizes empirical evidence and inquiry. This is also the case today. Examine the professional literature and clinical trial records of the medical community in detail. Some physicians and scholars may study this object to clarify its clinical utility and safety.

If you only speculate in vain, it is difficult to understand the truth. You must use scientific methods and rigorous attitude to visit the medical treasure house, and you can hope to understand it. Or find relevant clues in major medical databases and professional journals to judge whether there is clinical research. However, at this moment, I have not investigated in detail, so it is difficult to make an assertion.