What is the chemical structure of ethyl {2 - amino - 4 - [ (4 - fluorobenzyl) amino] phenyl} carbamate?

The chemical structure of ethyl {2-amino-4- [ (4-fluorobenzyl) amino] phenyl} carbamate, let me explain in detail.

In this compound structure, ethyl is a simple alkyl group connected by a single carbon-carbon bond. The carbamate part is formed by an amino group forming an ester bond with formic acid. Among them, the nitrogen atom is connected to the ethyl group at one end, and the other end is connected to the part containing the benzene ring.

On the benzene ring, there is an amino group at the 2nd position, which is a nitrogen-containing basic group. The 4th position is connected to a complex substituent, namely [ (4-fluorobenzyl) amino]. In the 4-fluorobenzyl group, the benzyl group is a benzyl group structure, and the fourth position of the benzene ring is replaced by a fluorine atom, and the benzyl group is then connected to the benzene ring through a nitrogen atom.

Overall view, the compound fuses structural fragments such as alkyl, amino, benzene ring, fluorine atom and carbamate, and each part is connected to each other to construct a unique chemical structure. Different functional groups endow it with diverse chemical properties and potential reactivity, and may have specific uses and research value in organic synthesis, medicinal chemistry and other fields.

What are the main uses of ethyl {2 - amino - 4 - [ (4 - fluorobenzyl) amino] phenyl} carbamate?

Ethyl {2-amino-4- [ (4-fluorobenzyl) amino] phenyl} carbamate, often referred to as ethoxybenzoamine in Chinese, is a herbicide widely used in the field of agriculture. Its main uses are as follows:

One, to prevent annual grasses weeds. In many crop fields, annual grasses such as barnyard grass, matang, and chickweed thrive, ethoxybenzoamine can effectively inhibit the growth of such weeds. By hindering specific physiological and biochemical processes in weeds, such as inhibiting weed seed germination, root development, and photosynthesis, it can achieve the purpose of prevention, create a good growth environment for crops, reduce the competition between weeds and crops for nutrients, water, and light resources, and ensure the normal growth of crops. < Br >
Both, to control some broad-leaved weeds. In addition to annual grasses, ethoxyfenachlor also has a certain control effect on some broad-leaved weeds, such as quinoa, amaranth, etc. Its mechanism of action is similar to that of controlling grasses. By interfering with the physiological activities of broad-leaved weeds, it inhibits their growth and even causes their death, further broadens the scope of weed control in the field, maintains the ecological balance of farmland, and improves crop yield and quality.

All three are suitable for a wide range of applications. Ethoxyfenachlor can be used for a variety of dry field crops, such as peanuts, soybeans, cotton, corn, etc. The use of these crops before sowing or after sowing can effectively control weed growth without significant adverse effects on crop seed germination and seedling growth, so they are widely used in agricultural production to help farmers reduce weed control labor intensity, reduce production costs, and ensure crop yield and quality.

What is the synthesis of ethyl {2 - amino - 4 - [ (4 - fluorobenzyl) amino] phenyl} carbamate?

To make ethyl {2 - amino - 4 - [ (4 - fluorobenzyl) amino] phenyl} carbamate, follow the following ancient method.

First take an appropriate amount of 2 - amino - 4 - nitrobenzoic acid and place it in a clean reactor. Dissolve it in an alcohol solvent such as ethanol. Slowly add thionyl chloride, the amount of which needs to be accurately weighed. In this reaction, the molar ratio of thionyl chloride to 2 - amino - 4 - nitrobenzoic acid is about 1.2:1. Heat to a moderate temperature, about 60-70 ° C, stir the reaction number, until the reaction solution no longer escapes hydrogen chloride gas, to obtain 2-amino-4-nitrobenzoyl chloride.

Dissolve the resulting 2-amino-4-nitrobenzoyl chloride in a suitable organic solvent, such as dichloromethane. Take another 4-fluorobenzylamine, press the molar ratio of 1.1:1, and slowly drop into the above solution while maintaining a low temperature environment, about 0-5 ° C. After dropping, raising to room temperature, stirring for a number of reaction times, purified by column chromatography to obtain 2-amino-4- [ (4-fluorobenzyl) amino] -nitrobenzene.

Then 2-amino-4- [ (4-fluorobenzyl) amino] -nitrobenzene is placed in a reaction system containing palladium-carbon catalyst, methanol is used as a solvent, hydrogen is introduced, and the hydrogen pressure is maintained in a moderate range of about 1-2 atm. The reaction is stirred at room temperature until the reaction system no longer absorbs hydrogen. This step is a key step in the reduction of nitro groups to amino groups to obtain 2-amino-4- [ (4-fluorobenzyl) amino] aniline.

Finally, take 2-amino-4- [ (4-fluorobenzyl) amino] aniline and dissolve it in an appropriate amount of acetone. Add ethyl chloroformate, which has a molar ratio of about 1.2:1 to 2-amino-4- [ (4-fluorobenzyl) amino] aniline, and add an appropriate amount of acid binding agent, such as triethylamine. Ethyl {2-amino-4 - [ (4-fluorobenzyl) amino] phenyl} carbamate can be obtained by recrystallization after stirring the reaction at room temperature. Careful monitoring is required at each step to ensure that the reaction is complete and the product is pure before the desired compound can be obtained.

What are the physicochemical properties of ethyl {2 - amino - 4 - [ (4 - fluorobenzyl) amino] phenyl} carbamate?

Ethyl {2-amino-4- [ (4-fluorobenzyl) amino] phenyl} carbamate, which has various physical and chemical properties. Its appearance is often white to off-white crystalline powder, which is slightly shiny when viewed in sunlight.

When it comes to solubility, it has a certain solubility in organic solvents such as methanol, ethanol, and dichloromethane, but it has little solubility in water. This property is related to the lipophilic group contained in the molecular structure, which makes it easier to disperse in organic solvents with weaker polarities.

The melting point is about a specific temperature range, which is of great significance for determining its purity and stability. When heated near the melting point, the state of the substance gradually changes, from the solid state to the liquid state, the process is relatively stable, reflecting the characteristics of intermolecular forces.

Stability is also an important property. It can maintain stability in a normal temperature, dry and dark environment. In the case of strong acid, strong alkali environment, or high temperature and high humidity conditions, it is easy to undergo chemical reactions and cause structural changes. Due to the active groups such as amino groups and ester groups in the molecule, it is easy to react with acid and alkali, which affects its chemical stability.

In addition, the spectral properties are also worthy of attention. In the infrared spectrum, there are characteristic absorption peaks at specific wavenumbers, which are related to the vibration of chemical bonds within the molecule, which can help to confirm the structure. In the ultraviolet spectrum, there is absorption in a specific wavelength range, which is related to its conjugate structure, and its analysis and detection are of great significance.

What is the market outlook for ethyl {2 - amino - 4 - [ (4 - fluorobenzyl) amino] phenyl} carbamate?

Today there is a product named ethyl {2-amino-4 - [ (4-fluorobenzyl) amino] phenyl} carbamate. The prospect of this product in the market is like the rise and fall of the ancient merchants, which is related to many variables.

Looking at the current field of medicine, the research is deepening, and the search for novel compounds. ethyl {2-amino-4 - [ (4-fluorobenzyl) amino] phenyl} carbamate If it has unique pharmacological activity and can break the problem of disease treatment, such as a sharp blade breaking the ice, it will definitely attract pharmaceutical companies to look at it, gather funds, and make rapid progress in research and development. It may become the cornerstone of innovative drugs, opening up a new era in the market, like a businessperson exploring a new path, and the future is bright.

However, the market is changing, and the battlefield of ancient times is full of fog. Similar competing products are like Lin, if there are drugs that have achieved similar curative effects and have a solid foundation, it is difficult for this compound to break through. And regulatory regulations, such as ancient laws, are strict, and the road to approval is long. It is necessary to prove that it is safe and effective before it can enter the market. If there is a slight mistake, it will be like a boat going against the current, and all previous achievements will be lost.

Furthermore, cost is also the key. If the preparation method is complicated, the raw materials are scarce and expensive, and even if the drug effect is miraculous, the price is high and difficult to sell, and it is still trapped in the market.

To sum up, the market prospects of ethyl {2-amino-4 - [ (4-fluorobenzyl) amino] phenyl} carbamate, opportunities and challenges coexist. If the ancient walkers go astray and make the right choice, they can go through the road. If they misjudge the situation, they may fall into a quagmire. It all depends on understanding the situation and making good use of resources to seek development.