What is the chemical structure of 9- (2-chloro-6-fluorobenzyl) -9H-purine-6-amine?

The chemical structure of 9- (2-cyano-6-bromobenzyl) -9H-carbazole-6-amine is an important research object in the field of organic chemistry. The structure of this compound is based on the parent structure of carbazole.

Carbazole is a nitrogen-containing heterocyclic compound with unique electronic properties and rigid planar structure. A specific substituent (2-cyanogen-6-bromobenzyl) is introduced at the 9-position. Among this substituent, benzyl is benzyl, which is often used as a linking group in organic synthesis; while cyanyl (-CN) has strong electron-absorbing properties, which can change the distribution of molecular electron clouds and affect its physical and chemical properties; bromine atoms (-Br) can participate in a variety of chemical reactions, such as nucleophilic substitution, coupling reactions, etc., to increase the reactivity of compounds.

is connected to an amine group (-NH -2) at the 6-position. Amine groups have electron-giving properties, which can further adjust the electronic structure of molecules, affecting their solubility, acidity and alkalinity, and interactions with other molecules. Overall, the chemical structure of 9- (2-cyano- 6-bromobenzyl) -9H-carbazole-6-amine, through the ingenious combination of different functional groups, endows the compound with diverse chemical properties and potential application value, and may have important uses in materials science, medicinal chemistry and other fields.

What are the physical properties of 9- (2-chloro-6-fluorobenzyl) -9H-purine-6-amine?

9- (2-cyanogen-6-ethoxyphenyl) -9H-carbazole-6-aldehyde, this is an organic compound. Its physical properties are very critical, and it is related to its performance in various chemical processes and practical applications.

Looking at its appearance, it is often in a solid state, mostly white to light yellow crystalline powder, which is easy to distinguish and deal with in experiments and production.

When it comes to melting point, it has a specific melting point range, about [X] ℃ to [X] ℃. Melting point, as a key physical property, is of great significance for the determination of its purity. If the purity of the sample is high, the melting point should be close to the theoretical value; if impurities are mixed in, the melting point will tend to decrease and the melting range will also become wider.

The solubility of this compound also has characteristics, and it shows good solubility in common organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF). This property is extremely important in the selection of reaction solvents and product separation in organic synthesis. With the help of its solubility differences in different solvents, effective purification and separation can be achieved.

In addition, its density is also an important physical property, about [X] g/cm ³. Density data is indispensable in accurate stoichiometry and reaction system design, and can assist chemists in accurately controlling the dosage and proportion of reaction materials.

In the field of chemistry, understanding the physical properties of 9- (2-cyanogen-6-ethoxyphenyl) -9H-carbazole-6-aldehyde is the cornerstone for in-depth study of its chemical properties and applications. Whether it is organic synthesis, materials science, or drug development, many fields need to take its physical properties as the starting point to carry out subsequent scientific exploration and practice.

What are the common methods for synthesizing 9- (2-chloro-6-fluorobenzyl) -9H-purine-6-amine?

The common synthesis methods of 9- (2-cyanogen-6-ethoxybenzyl) -9H-carbazole-6-carboxylic acid are as follows:

###Take 2-cyanogen-6-ethoxybenzyl chloride and carbazole as the starting material
1. ** First step: nucleophilic substitution reaction **
- Take an appropriate amount of carbazole, place it in the reaction vessel, add an appropriate amount of basic reagents, such as potassium carbonate, etc., to provide an alkaline environment, which is conducive to the formation of nucleophilic reagents by carbazole nitrogen atoms. < Br > - Slowly add 2-cyanogen-6-ethoxybenzyl chloride, stir the reaction in a suitable organic solvent such as N, N-dimethylformamide (DMF) at a suitable temperature (e.g. 80-100 ° C) for several hours. During this process, the lone pair electron of the carbazole nitrogen atom attacks the benzyl carbon of 2-cyanogen-6-ethoxybenzyl chloride, and the chloride ions leave to form 9- (2-cyanogen-6-ethoxybenzyl) -9H-carbazole. < Br > - After the reaction is completed, the reaction solution is poured into an appropriate amount of water and extracted with an organic solvent such as dichloromethane. After the organic phase is dried with anhydrous sodium sulfate, the solvent is removed by rotary evaporation to obtain a crude product, which is further purified by column chromatography.
2. ** The second step: carboxylation reaction **
- the purified 9- (2-cyanogen-6-ethoxybenzyl) -9H-carbazole is placed in the reaction bottle, and an appropriate amount of strong base, such as n-butyl lithium, is added. React at low temperature (such as -78 ° C) for a period of time, so that the ortho-hydrogen of the benzyl group connected to carbazole is replaced by lithium to form a lithium intermediate.
- Slowly introduce carbon dioxide gas and keep the low temperature reaction for a period of time, so that the lithium intermediate and carbon dioxide carboxylation reaction occurs to form a carboxylate. < Br > - After the reaction is completed, carefully acidify the reaction solution with dilute acid (such as dilute hydrochloric acid) to convert the carboxylate into 9- (2-cyanogen-6-ethoxybenzyl) -9H-carbazole-6-carboxylic acid, and further purify the product by filtration, recrystallization, etc.

###With 2-cyanogen-6-ethoxybenzoic acid and carbazole as starting materials
1. ** Step 1: Activate the carboxyl group **
- Add 2-cyanogen-6-ethoxybenzoic acid with appropriate reagents, such as oxalyl chloride, etc., in an organic solvent (such as dichloromethane), add a small amount of N, N-dimethylformamide (DMF) as a catalyst, and react at room temperature for a period of time to convert the carboxyl group into an acyl chloride to form 2-cyanogen-6-ethoxybenzoyl chloride.
2. ** Step 2: Amidization and Cyclization Reaction **
- Add carbazole to the above reaction system, and add an organic base such as triethylamine, etc., at the same time, for neutralizing the hydrogen chloride generated by the reaction. At the appropriate temperature (e.g. 50-70 ℃), the nitrogen atom of carbazole attacks the carbonyl carbon of the acyl chloride to form an amide intermediate.
- Then under suitable conditions, such as high temperature (150-180 ℃) or under the catalysis of Lewis acid (such as aluminum trichloride, etc.), an intramolecular cyclization reaction occurs to form 9- (2-cyanogen-6-ethoxybenzyl) -9H-carbazole-6-carboxylic acid, and finally the pure product is obtained by conventional separation and purification methods, such as column chromatography, recrystallization, etc.

What are the applications of 9- (2-chloro-6-fluorobenzyl) -9H-purine-6-amine in the field of medicine?

9- (2-tritium-6-deuteryl) -9H-purine-6-amine, this compound is widely used in the field of medicine.

First, it plays a significant role in the development of anti-tumor drugs. Tumor cells proliferate rapidly and have a high demand for nucleic acid synthesis. The compound's structure is similar to that of key raw materials for nucleic acid synthesis, and it can inhibit the growth and division of tumor cells by interfering with nucleic acid metabolism. For example, some purine analogs can be incorporated into the DNA or RNA synthesis process of tumor cells, resulting in abnormal synthesis, thereby hindering the reproduction of tumor cells and providing an effective way for tumor treatment.

Second, it has made outstanding contributions to antiviral drugs. Virus replication depends on the nucleic acid synthesis mechanism of the host cell, and this compound can specifically act on the synthesis of virus-related nucleic acids. Taking influenza virus as an example, its replication process involves many nucleic acid synthesis steps. The compound can interfere with viral nucleic acid replication, prevent a large number of virus proliferation, and then reduce the symptoms of viral infection, achieving the purpose of treating viral infection diseases.

Third, it is also used in the development of immunomodulators. Immune system regulation relies on complex signaling between cells and nucleic acid-related activities. The compound can regulate immune cell activity and function by affecting immune cell nucleic acid metabolism. For example, in the treatment of autoimmune diseases, it can adjust the immune system overreaction, restore the balance of immune function, and relieve the disease.

Fourth, it is used to treat neurological diseases. Nervous system cell metabolism and signaling involve nucleic acid-related physiological processes. The compound regulates nucleic acid metabolism in nervous system cells and improves nerve cell function. For example, in some neurodegenerative diseases, it helps to maintain the normal structure and function of nerve cells and delay the progression of the disease.

What is the market outlook for 9- (2-chloro-6-fluorobenzyl) -9H-purine-6-amine?

As a specific organic compound, 9- (2-tritium-6-deuteryl) -9H-carbazole-6-aldehyde has a multi-faceted market prospect.

Since today's world, science and technology have flourished, and the field of chemical industry has developed rapidly. This compound is quite useful in the genus of optoelectronic materials. Today, the electronic display industry is booming, such as OLED technology is in the ascendant, and there is a growing demand for materials with unique optoelectronic properties. 9- (2-tritium-6-deuteryl) -9H-carbazole-6-aldehyde is expected to gain a place in the display materials market due to its unique structure, which may endow materials with better luminous efficiency, stability and other characteristics.

Furthermore, in the field of organic synthesis, as a key intermediate, it can be derived from many fine chemicals with high added value. With the increase in demand for novel structural compounds in the pharmaceutical, pesticide and other industries, this compound may provide an opportunity for the synthesis of novel active molecules, and then open up a broad market space.

However, its market prospects also face challenges. The process of preparing this compound may be complicated and costly. If the production process cannot be effectively optimized and the cost is reduced, it may be difficult to gain an advantage in the market competition. And today's environmental protection regulations are becoming increasingly stringent. If the production process fails to conform to the concept of green chemistry, it will also hinder its marketing activities.

In summary, although the market prospect of 9- (2-tritium-6-deuteryl) -9H-carbazole-6-aldehyde is broad, it also needs to overcome the problems of cost and environmental protection in order to emerge in the market and seek long-term development.