What is the chemical structure of [5- [4- [4- [ (3-Fluorobenzyl) oxy] -3-chloroanilino] -6-quinazolinyl] -2-furancarboxaldehyde

This is a description of the chemical structure of an organic compound, described in the classical Chinese style of Tiangong Kaiwu as follows:

This compound is named [5- [4- [4- [ (3 -fluorobenzyl) oxy] -3 -ketaniline] -6 -quinazolinyl] -2 -furanaldehyde]. Its chemical structure is based on quinazoline as the core skeleton. At the 6th position of quinazoline, there is a group containing a specific substituent. In this group, there is a 3-chlorphenylamine group modified by [ (3-fluorobenzyl) oxy] at the 4th position, and this [ (3-fluorobenzyl) oxy] is due to the fluorine atom substitution at the 3rd position of the benzyl group, and after the benzyl group is connected to the oxygen atom, it is connected to the 3-chlorphenylamine group. The quinazoline position 5 is connected to 2-furanaldehyde, and the furan ring is connected to the formyl group at the 2nd position, forming the overall chemical structure of this complex organic compound. Such a delicate structure must have its unique properties and uses in the field of organic chemistry.

What are the main uses of [5- [4- [4- [ (3-Fluorobenzyl) oxy] -3-chloroanilino] -6-quinazolinyl] -2-furancarboxaldehyde

%5B5-%5B4-%5B4-%5B%283 - Fluorobenzyl%29oxy%5D - 3 - chloroanilino% 5D - 6 - quinazolinyl% 5D - 2 - furancarboxaldehyde, an organic compound, is widely used in the field of pharmaceutical research and development and chemical industry.

In pharmaceutical research and development, it may be a key intermediate. Pharmaceutical development often requires multi-step reactions to synthesize complex compounds, which can be used as starting materials or important intermediaries. After specific chemical reactions, its structure can be modified to obtain substances with specific pharmacological activities. Or by adjusting its surrounding chemical groups, the interaction with specific biological targets can be optimized, such as acting on some disease-related protein receptors, laying the foundation for the development of new therapeutic drugs.

In the chemical industry, or involved in the study of organic synthesis reactions. Chemists expand the methodology of organic synthesis by exploring the reaction conditions and reaction mechanisms in which they participate. For example, studying the reaction selectivity and reaction rate between it and other reagents helps to improve the efficiency and accuracy of organic synthesis, and provides ideas and methods for the synthesis of new materials and the preparation of fine chemicals. In addition, its structural properties may endow some unique physical and chemical properties. In the field of materials science, after rational design and application, it may be possible to prepare materials with special properties, such as optical materials, electrical materials, etc.

What is the synthesis method of [5- [4- [4- [ (3-Fluorobenzyl) oxy] -3-chloroanilino] -6-quinazolinyl] -2-furancarboxaldehyde

To obtain the synthesis method of [5- [4- [4- [ (3-fluorobenzyl) oxy] - 3-ketaniline] - 6-quinazolinyl] - 2-furanaldehyde, you can follow the following steps.

First, start with 3-fluorobenzyl alcohol, and work with appropriate halogenating reagents, such as sulfoxide chloride or phosphorus tribromide, under suitable reaction conditions to convert hydroxyl groups into halogen atoms to obtain 3-fluorobenzyl halides. This step requires attention to the reaction temperature and reagent dosage to prevent side reactions from breeding.

Second, take 3-chloro-4-nitroaniline and make it with the above-mentioned 3-fluorobenzyl halide. In the presence of a base, such as potassium carbonate or sodium carbonate, in an organic solvent, such as N, N-dimethylformamide (DMF). The amino nucleophilic group of nitroaniline attacks the halogen atom of the halide and forms a C-N bond to obtain a 3-chloro-4-nitroaniline derivative containing 3-fluorobenzyl oxide. In this process, the choice of solvent and the amount of base have a great impact on the reaction process and yield. Then, the above-mentioned nitro derivatives are reduced with suitable reducing agents, such as iron powder and hydrochloric acid or hydrogen and palladium carbon, etc., to convert the nitro group into an amino group, and obtain the key intermediate 3-chloro-4- [ (3-fluorobenzyl) oxy] aniline. The control of the conditions of this reduction step, such as temperature, pressure (when reducing hydrogen), is crucial.

Then take 2-chloro-6-formyl quinazoline, and 3-chloro-4-[ (3-fluorobenzyl) oxy] aniline prepared above, in a suitable organic solvent, such as toluene or xylene, heated and refluxed. The two are reacted through a series of reactions such as nucleophilic substitution to generate [5- [4- [4- [ (3-fluorobenzyl) oxy] -3-chlorophenamido] -6-quinazolinyl] -2-furanaldehyde. During the reaction process, factors such as solvent boiling point and reaction time need to be finely regulated to achieve high yield and purity.

During the whole synthesis process, the reaction products in each step need to be purified, such as column chromatography, recrystallization and other means to remove impurities, ensure the smooth progress of the reaction and the quality of the final product.

What are the physical and chemical properties of [5- [4- [4- [ (3-Fluorobenzyl) oxy] -3-chloroanilino] -6-quinazolinyl] -2-furancarboxaldehyde

[5- [4- [4- [ (3 -fluorobenzyl) oxy] -3 -ketaniline] -6 -quinazolinyl] -2 -furanaldehyde, this material has complex properties and many physical and chemical properties. Its color may be light plain, or slightly yellow, often in the form of crystals in the world, fine and regular texture.

Looking at its melting point, due to the attractive force between molecules, it often melts in a specific temperature range, just like ice and snow melting when they are warm. This temperature is about [specific melting point value], and its melting range is narrow and narrow, just like a precise rule, indicating its high purity. As for the boiling point, if you want to gasify it into steam, you need to apply a temperature of [specific boiling point value] to cause its molecules to break free from the shackles of the liquid phase and shake and rise.

Solubility is also important. In organic solvents, such as ethanol and acetone, it is quite soluble, just like salt melts in water, and it is seamless. However, in water, it is insoluble, just like oil floats in water, and it is distinct. This is because of the hydrophobic groups in the molecular structure, which cause it to have little affinity with water.

In terms of stability, it can be relatively stable under normal temperature and humidity. If it is exposed to strong light and hot topics, or when it encounters active reagents, the molecular structure is easy to move and a chemical reaction occurs, just like a delicate flower in the face of strong wind and rain, it is difficult to maintain its original state. Due to its unique physical and chemical properties, this substance has potential in many fields, such as medicine and chemical industry, or it has become a good prescription for the world, or it is a new chemical material. It is waiting for the world to explore in depth and make the best use of it.

What is the market outlook for [5- [4- [4- [ (3-Fluorobenzyl) oxy] -3-chloroanilino] -6-quinazolinyl] -2-furancarboxaldehyde

Today, there are [5- [4- [4- [ (3-fluorobenzyl) oxy] - 3-ketaniline] - 6-quinazolinyl] - 2-furanaldehyde, which is a specific organic compound. Its market prospect is related to many aspects.

Looking at the field of medicine and chemical industry today, organic compounds are widely used. This compound may have potential uses in drug research and development, fine chemical product manufacturing and other fields due to its unique chemical structure. If it has unique biological activity, it can be used in the creation of new drugs, or become a key intermediate to help pharmaceutical developers develop new drugs to solve the suffering of patients, so the market demand may be very considerable.

However, its market prospects are not entirely clear. If the process of synthesizing this compound is complicated and expensive, it will limit its large-scale production and application. And the market competition is fierce. If there are alternatives with similar efficacy and low cost, its promotion will also be hindered.

Furthermore, regulations and policies are increasingly strict in the supervision of chemical products. If this compound wants to enter the market, it must meet various strict standards and safety requirements. If it fails to meet the standards, even if it has potential application value, it will be difficult to gain market recognition.

In conclusion, the market prospect of [5- [4- [4- [ (3 -fluorobenzyl) oxy] - 3 -ketaniline] - 6 -quinazolinyl] - 2 -furanaldehyde has both opportunities and challenges. Only by overcoming the problems of synthesis process, cost control and regulatory compliance can it be expected to emerge in the market and achieve good development.