What is the chemical structure of 5- (4- ((3-chloro-4- ((3-fluorobenzyl) oxy) phenyl) amino) quinazolin-6-yl) -2-furaldehyde?

The name of this compound is 5- (4- ((3-chloro-4- ((3-fluorobenzyl) oxy) phenyl) amino) quinazoline-6-yl) -2-furfural. To clarify its chemical structure, the chemical nomenclature and structural knowledge should be used as the basis.

"5- (4- ((3-chloro-4- ((3-fluorobenzyl) oxy) phenyl) amino) quinazoline-6-yl) ", this section indicates that the quinazoline ring is the core structure. The quinazoline ring has nitrogen atoms and carbon atoms connected in a specific way to form a ring. At the 6-position, there is a structure containing a complex substituent, which is analyzed from the outside to the inside: "4- ((3-chloro-4- (3-fluorobenzyl) oxy) phenyl) amino) ", where 3-chloro-4- ((3-fluorobenzyl) oxy) phenyl means that there is a chlorine atom at the 3-position on the benzene ring, and the 4-position is connected to 3-fluorobenzyl through the oxygen atom; and this phenyl group is connected to the 6-position of the quinazoline ring with an amino group.

"-2-furfural" indicates that the 5-position of the quinazoline ring is connected to the furfural structure, and furfural is a compound with an aldehyde group at the 2-position of the furan ring.

Overall, this compound has a quinazoline ring as the core, a substituent containing a specific substituted benzene ring at the 6-position, and a furfural structure at the 5-position. Each part is connected by chemical bonds to form a unique chemical structure. The structure is complex and is cleverly combined by a variety of groups.

What are the physical properties of 5- (4- ((3-chloro-4- ((3-fluorobenzyl) oxy) phenyl) amino) quinazolin-6-yl) -2-furaldehyde?

5- (4- ((3-chloro-4- ((3-fluorobenzyl) oxy) phenyl) amino) quinazoline-6-yl) -2-furfural, the physical properties of this substance are as follows:

Looking at its morphology, it may be a solid under normal conditions. Because of the organic compounds containing polycyclic and heterocyclic rings, the structure has certain complexity and rigidity, and tends to form a solid state. As for the color, it may be white to light yellow, due to the lack of strong chromophore groups in the molecular structure, which causes it to develop significantly. However, some conjugated systems may cause it to be slightly yellowish.

When it comes to melting point, the estimated melting point is relatively high due to the existence of various interactions between molecules, such as van der Waals forces, hydrogen bonds, etc. The π-π stacking between aromatic rings and heterocycles in the molecule, as well as the potential hydrogen bonding between polar groups such as amino groups and aldehyde groups, all make the molecules tightly arranged, and more energy is required to overcome the interaction and cause them to melt.

In terms of solubility, because the molecule has a certain polarity, it may have good solubility in polar organic solvents such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), because the polarities of the two can interact with the polar groups of the compound. However, in non-polar solvents such as n-hexane, the solubility is poor, because it is difficult to dissolve with the polar part of the compound because of its non-polar.

In addition, the density of the compound may be higher than that of water, and the molecular structure is rich in heavy atoms such as chlorine and fluorine, and the relative molecular weight is large, which increases the unit volume mass. Its stability may be acceptable under conventional conditions. However, when encountering high temperature, strong acid-base or strong oxidant, some bonds in the molecular structure may be affected, such as aldehyde groups are easily oxidized, amino groups may participate in acid-base reactions, etc.

What are the main uses of 5- (4- ((3-chloro-4- ((3-fluorobenzyl) oxy) phenyl) amino) quinazolin-6-yl) -2-furaldehyde?

5- (4- ((3-chloro-4- ((3-fluorobenzyl) oxy) phenyl) amino) quinazoline-6-yl) -2 -furfural, which is mostly used in the field of medicinal chemistry research. Looking at its structure, the organic heterocycle is connected to the aryl group, and this special structure gives it unique chemical activity, which has great potential in the process of drug development.

In the process of creating new drugs, researchers often explore its interaction with biological targets. Because of its delicate structure, it may specifically bind to certain protein receptors, thereby regulating the signal transduction pathway in organisms. For example, in the field of anti-tumor drug development, after in-depth research, it has been found that some compounds with similar structures can effectively inhibit the proliferation of tumor cells, or interfere with the metabolic process of tumor cells, or block their division cycle. This compound may also follow a similar mechanism and is expected to become a lead compound for new anti-tumor drugs.

Furthermore, in the development of antibacterial drugs, the chlorine and fluorine atoms in its structure may enhance its affinity with bacterial targets, destroy bacterial cell walls, cell membranes or interfere with bacterial nucleic acid synthesis, showing antibacterial activity. Therefore, 5- (4- ((3-chloro-4- ((3-fluorobenzyl) oxy) phenyl) amino) quinazoline-6-yl) -2 -furfural is mainly used in the field of pharmaceutical research and development, bringing new hope and opportunity for conquering diseases and improving human health.

What are the synthesis methods of 5- (4- ((3-chloro-4- ((3-fluorobenzyl) oxy) phenyl) amino) quinazolin-6-yl) -2-furaldehyde?

The synthesis method of 5- {4- [ (3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl) amino] quinazoline-6-yl} -2 -furfural covers all kinds of ways. The paradigm of "Tiangong Kaiwu" can be studied in detail, and it is described in the ancient method as follows.

First, all kinds of raw materials need to be prepared, such as 3-chloro-4-hydroxyaniline, 3-fluorobenzyl halide, 2-furfural, etc., all of which should be pure and free of impurities. This is the foundation of synthesis.

First, 3-chloro-4-hydroxyaniline and 3-fluorobenzyl halide can undergo nucleophilic substitution reaction. In this reaction, a suitable solvent, such as dimethylformamide (DMF) or acetonitrile, should be selected to help the reaction smooth. And a base, such as potassium carbonate or sodium carbonate, needs to be added to grab the hydrogen halide generated in the reaction and cause the reaction equilibrium to shift to the right. Control the temperature at an appropriate degree, or 50-80 degrees Celsius. After several times of reaction, 3-chloro-4-[ (3-fluorobenzyl) oxy] aniline can be obtained. < Br >
times, react with a suitable quinazoline derivative with 3-chloro-4- [ (3-fluorobenzyl) oxy] aniline. This step may require a condensing agent, such as 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (EDC · HCl) and 1-hydroxybenzotriazole (HOBt), to condensate the two to form an intermediate of the target product. The reaction should also be temperature-controlled, or between room temperature and 50 degrees Celsius, through a certain process, to obtain the key intermediate. At the end of

, the intermediate is reacted with 2-furfural, or through condensation or other suitable reaction paths, and the final product is 5 - {4- [ (3-chloro-4- [ (3-fluorobenzyl) oxy] phenyl) amino] quinazoline-6-yl} -2 -furfural. In this step of the reaction, attention should also be paid to the control of the reaction conditions, such as solvent, temperature, reaction time, etc., so that the yield and purity of the product can be improved.

The synthesis method is interconnected, and the purity of the raw material and the precise control of the reaction conditions are all essential to obtain this target compound.

What are the precautions for using 5- (4- ((3-chloro-4- ((3-fluorobenzyl) oxy) phenyl) amino) quinazolin-6-yl) -2-furaldehyde?

5- (4- ((3-chloro-4- ((3-fluorobenzyl) oxy) phenyl) amino) quinazoline-6-yl) -2 -furfural, this is a rather complex organic compound. When using, many things need to be paid attention to.

First of all, this substance has specific chemical activities and reaction characteristics. During operation, it is necessary to strictly follow the established chemical experimental procedures to prevent accidental reactions. Because its structure contains chlorine, fluorine and other halogen atoms, as well as quinazoline, furfural and other specific functional groups, these groups may initiate different chemical reactions under different conditions, such as halogenation reactions, nucleophilic substitution reactions, etc. Therefore, the control of the reaction conditions is extremely critical. Factors such as temperature, pH, reaction time, etc. need to be precisely controlled, otherwise the product may be impure or cause side reactions.

Secondly, safety should not be underestimated. Some organic compounds may be toxic, irritating, or flammable and explosive. Although the relevant characteristics of this compound are not clear, it is inferred from similar structural compounds that the operation should be carried out in a well-ventilated environment, preferably in a fume hood, to prevent the inhalation of harmful gases. At the same time, it is necessary to wear appropriate protective equipment, such as gloves, goggles, etc., to avoid contact between the skin and the eyes.

Furthermore, storage conditions should not be ignored. It should be stored in a suitable environment according to its chemical properties. Due to the complexity of its structure, or sensitive to light, heat, humidity and other factors. Generally, it should be placed in a cool, dry, dark place, and properly isolated from other chemicals to prevent mutual reaction.

In short, when using this compound, it is necessary to have a deep understanding of its chemical properties, strictly abide by the operating specifications, and pay attention to safety and storage to ensure the smooth operation or production process.