What is the chemical structure of 5- [4- ((3-Chloro-4- ((3-fluorobenzyl) oxy) phenyl) amino) quinazolin-6-yl] -2-furaldehyde?

This is the naming of an organic compound. To clarify its chemical structure, it is necessary to analyze it according to the naming rules of organic chemistry. "5- [4- ((3-chloro-4- ((3-fluorobenzyl) oxy) phenyl) amino) quinazoline-6-yl] -2 -furfural", first look at "furfural", which is a structure containing a furan ring and an aldehyde group on the ring. "2-furfural" indicates that the aldehyde group is attached to the second position of the furan ring.

Look at the "5- [4- ((3-chloro-4- ((3-fluorobenzyl) oxy) phenyl) amino) quinazoline-6-yl]" part again, "quinazoline" is a fused heterocyclic structure. "6-yl" indicates that a specific position of this fused ring is the connection check point. "4- ((3-chloro-4- ((3-fluorobenzyl) oxy) phenyl) amino) ", indicating that there is a substituent containing a benzene ring connected at the 4 position of the quinazoline ring. On the benzene ring, there is a chlorine atom at the 3rd position, and a " (3-fluorobenzyl) oxy group" at the 4th position, and the benzene ring is connected to the quinazoline ring through an amino group. "3-fluorobenzyl", that is, the benzyl (benzyl) benzene ring has a fluorine atom substituted at the 3rd position.

In summary, the structure of this compound is formed by connecting the furfural part with the quinazoline part containing a specific substituent, and each substituent is connected to the corresponding position in an orderly manner according to the naming rules, which constructs its unique chemical structure.

What are the physical properties of 5- [4- ((3-Chloro-4- ((3-fluorobenzyl) oxy) phenyl) amino) quinazolin-6-yl] -2-furaldehyde?

5- [4- ((3-chloro-4- ((3-fluorobenzyl) oxy) phenyl) amino) quinazoline-6-yl] -2-furanaldehyde, which is an organic compound. Its physical properties are as follows:

From the perspective of normal temperature and pressure, it is mostly in a solid state, but it may vary slightly due to the characteristics of the substituent, its appearance may vary slightly due to differences in purity and crystal form, or it is a white to light yellow powdery solid, or a crystalline solid. The color of this compound is due to the existence of a conjugated system in the molecular structure. The electronic transition of the conjugated system causes it to absorb visible light, so it presents a certain color.

When it comes to melting point, this compound contains a variety of polar groups, such as amino groups, aldehyde groups, etc. The intermolecular forces are more complex, including hydrogen bonds, van der Waals forces, etc., resulting in a relatively high melting point. However, due to the lack of specific experimental data, it is difficult to accurately give the melting point value. However, it can be inferred that the melting point is in a certain high temperature range to maintain the intermolecular forces.

In terms of solubility, the compound molecule contains hydrophobic parts such as furan rings and quinazoline rings, as well as polar groups such as chlorine atoms, fluorine atoms, amino groups, and aldehyde groups. In organic solvents, such as dichloromethane, chloroform, N, N-dimethylformamide (DMF), etc., due to the interaction between the hydrophobic ring and the organic solvent and the weak interaction between some polar groups and the organic solvent, there may be a certain solubility. However, in water, due to the large proportion of the overall hydrophobic part, only a small number of polar groups are difficult to overcome the hydrophobic effect, so its solubility in water is poor.

Volatility, because of its relatively large molecular mass and strong intermolecular force, volatility is very weak. At room temperature and pressure, it is difficult to volatilize to the gas phase, and most stability remains in the solid or liquid phase.

What is the synthesis method of 5- [4- ((3-Chloro-4- ((3-fluorobenzyl) oxy) phenyl) amino) quinazolin-6-yl] -2-furaldehyde?

To prepare 5- [4- ((3 - chloro - 4- ((3 - fluorobenzyl) oxy) phenyl) amino) quinazoline - 6 - yl] -2 - furfural, the method is as follows:
first take an appropriate amount of 3 - chloro - 4 - hydroxyaniline, which with 3 - fluorobenzyl halide, in a suitable solvent, such as N, N - dimethylformamide, adding a base, such as potassium carbonate, heating and stirring, so that a substitution reaction occurs to give 3 - chloro - 4 - ((3 - fluorobenzyl) oxy) aniline. This step requires temperature control and regular monitoring of the reaction process to achieve the best degree of reaction.
Take 4,6-dichloroquinazoline at times, and the 3-chloro-4- ((3-fluorobenzyl) oxy) aniline obtained above, in an organic solvent such as toluene, add an acid binding agent such as triethylamine, heat and reflux, so that the amino group and the chlorine atom undergo nucleophilic substitution to obtain 4- ((3-chloro-4- ((3-fluorobenzyl) oxy) phenyl) amino) -6-chloroquinazoline. During this period, attention should be paid to the tightness of the reaction device to prevent the material from escaping. < Br > Then 4- ((3-chloro-4- ((3-fluorobenzyl) oxy) phenyl) amino) -6-chloroquinazoline and 2-furfural derivatives, in a suitable solvent, such as dioxane, adding a base and a catalyst, such as a copper catalyst, heating the reaction, so that the two are coupled, then 5 - [4- ((3-chloro-4- ((3-fluorobenzyl) oxy) phenyl) amino) quinazoline-6-yl] -2 -furfural. After the reaction is completed, the pure product is obtained by separation and purification methods, such as column chromatography. The whole process and the reaction conditions of each step need to be precisely controlled in order to achieve good yield and purity.

What are the application fields of 5- [4- ((3-Chloro-4- ((3-fluorobenzyl) oxy) phenyl) amino) quinazolin-6-yl] -2-furaldehyde?

5- [4- ((3-chloro-4- ((3-fluorobenzyl) oxy) phenyl) amino) quinazoline-6-yl] -2-furfural, this is an organic compound with a wide range of application fields.

In the field of pharmaceutical research and development, it shows potential pharmacological activity. It may be used as a lead compound to provide a cornerstone for the creation of new drugs. Because the structure of quinazoline and furfural has key activities in many drugs, this compound may have anti-tumor, antiviral, anti-inflammatory and many other biological activities. By modifying and optimizing its structure, it is expected to develop innovative drugs with excellent efficacy and minor side effects.

In the field of materials science, this compound may be used to synthesize functional materials. With its unique molecular structure and chemical properties, it may endow materials with special optical, electrical or magnetic properties, such as for the preparation of organic Light Emitting Diode (OLED) materials to improve their luminous efficiency and stability; or for the manufacture of sensor materials to achieve high sensitivity detection of specific substances.

In the field of agricultural chemistry, it also has potential applications. It may have biological activities such as insecticidal, bactericidal or weeding. After research and development, it may become an active ingredient in new pesticides, helping to prevent and control agricultural pests and diseases, and ensuring the yield and quality of crops. In addition, in organic synthesis chemistry, this compound can be used as an important intermediate to construct more complex organic molecular structures, promoting the development and innovation of organic synthesis methodologies, and providing new paths and strategies for the synthesis of many organic compounds.

What is the market outlook for 5- [4- ((3-Chloro-4- ((3-fluorobenzyl) oxy) phenyl) amino) quinazolin-6-yl] -2-furaldehyde?

The name of the compound today is "5- [4- ((3-chloro-4- ((3-fluorobenzyl) oxy) phenyl) amino) quinazoline-6-yl] -2-furfural", and its market prospect is related to many parties.

Looking at this compound, its unique and complex structure may have potential opportunities in the field of medicinal chemistry. Drug development is like exploring secrets, and novel structures are often the key to unlocking new therapeutic effects. If this compound can accurately fit a specific disease target, it can be used as a key lock, or it can be developed into a good medicine for treating difficult diseases. Nowadays, there is a strong demand for drugs for the treatment of difficult diseases, and the exploration of new targets and new compounds has never stopped. This compound may emerge in the fierce competition, and if it is successfully developed, the market potential is considerable.

However, its prospects are not entirely bright. Synthesizing this compound, or building a delicate pavilion, involves complicated steps and high costs. The optimization of the synthetic route is like carving beautiful jade, which requires careful study by chemists, otherwise the cost will become a roadblock for commercialization. Furthermore, the market competition is like a race of sails, with many similar or potential replacement compounds. If other competitors have already gained market share, new compounds need to demonstrate excellent advantages, such as better curative effect and fewer side effects.

And the journey of drug research and development is full of dangers, from the laboratory to the clinic, it is like crossing many obstacles. The safety and effectiveness verification is rigorous, and if it cannot be passed, the previous efforts will be in vain. However, if it can be successfully launched through thorns, it may be able to get a share of the pharmaceutical market and bring good news to enterprises and patients.

To sum up, the market prospect of this compound is like a fog, with opportunities and challenges coexisting. If you can overcome the synthesis problem, highlight your own advantages, and pass the R & D hurdle, you may be able to gain a place in the market and shine.