What is the chemical structure of 5- (3,5-difluorobenzyl) -1H-indazole-3-amine?

I am looking at this question, but I am looking for the chemical structure of "5- (3,5-diethylamino) -1H-indole-3-formaldehyde". This substance is based on an indole ring, with a hydrogen atom at position 1, an aldehyde group at position 3, and a substituent at position 5 with 3,5-diethylamino.

The indole ring is a nitrogen-containing heterocyclic aromatic hydrocarbon, which is aromatic. The aldehyde group is -CHO, which is a functional group with high reactivity. The 3,5-diethylamino group is formed above the amino group (-NH ²), and is connected to an ethyl group (-C ² H) at positions 3 and 5.

The structure of this compound is based on the indole ring as the core skeleton, and the aldehyde group is connected to the diethylamino group in a specific position. The existence of the aldehyde group endows it with electrophilicity and can participate in various nucleophilic additions and other reactions. And 3,5-diethylamino, because the nitrogen atom has a lone pair of electrons, can exhibit a certain alkalinity, and because of its steric hindrance and electronic effect, it affects the physical and chemical properties of the molecule as a whole. The uniqueness of its structure may have specific uses and research value in the fields of organic synthesis, medicinal chemistry, etc.

What are the main uses of 5- (3,5-difluorobenzyl) -1H-indazole-3-amine?

5- (3,5-divinylamino) -1H-pyrrole-3-formaldehyde, this substance has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate to help synthesize a variety of biologically active compounds. Because of its unique chemical structure, it can undergo a variety of chemical reactions and be cleverly connected with other molecules to derive substances with specific pharmacological functions, or as antibacterial drugs, or as anti-cancer pioneers.

In the field of materials science, it also plays a pivotal role. It can participate in the preparation of organic materials with special properties, such as optoelectronic materials. With its own structural characteristics, the material is endowed with excellent optical and electrical properties, or it can be used to manufacture high-efficiency Light Emitting Diodes to make the light efficiency and color of display devices better; or it can be applied to solar cells to improve the efficiency of light energy conversion and promote the development of renewable energy.

In scientific research and exploration, as an important chemical reagent, it provides a key cornerstone for the study of organic synthesis methodologies. Through in-depth exploration of its reaction properties, researchers have developed novel synthesis paths and strategies, injecting vitality into the innovation and development of organic chemistry, leading chemical synthesis to a more efficient and accurate environment.

What is the synthesis method of 5- (3,5-difluorobenzyl) -1H-indazole-3-amine?

To prepare 5- (3,5-difluorobenzyl) -1H-indole-3-formaldehyde, the method is as follows:

First take an appropriate amount of 3,5-difluorobenzyl halide, place it in a reaction kettle with indole derivatives, dissolve it in an appropriate organic solvent, such as N, N-dimethylformamide (DMF), add an appropriate amount of base, such as potassium carbonate, to promote the nucleophilic substitution reaction between the two. Control the temperature within a certain range, such as 60-80 ° C, and continue to stir for a number of times to make the reaction sufficient. This step aims to introduce 3,5-difluorobenzyl into the indole structure.

After the reaction is completed, the product containing the target intermediate is obtained by conventional post-treatment methods such as extraction, liquid separation, and drying.

Then, the obtained intermediate is oxidized with a suitable oxidant. Mild manganese dioxide can be selected, and the reaction is stirred at room temperature in an organic solvent such as dichloromethane. The amount of oxidant needs to be precisely controlled to oxidize the indole 3-position side chain to an aldehyde group without damaging other groups.

After the reaction is completed, the impurities can be removed by column chromatography or recrystallization to obtain a pure 5- (3,5-difluorobenzyl) -1H-indole-3-formaldehyde product. During the operation, it is necessary to pay attention to the reaction conditions at each step, accurately control the temperature and quantity, and ensure the smooth reaction and improve the yield and purity of the product.

What are the physical and chemical properties of 5- (3,5-difluorobenzyl) -1H-indazole-3-amine?

5- (3,5-diethylamino) -1H-indole-3-formaldehyde, this is an organic compound with many unique physical and chemical properties.

In terms of physical properties, it is mostly solid at room temperature and pressure, due to factors such as intermolecular forces. Its melting point and boiling point are of great significance to its phase transition, but the exact value varies according to its purity and measurement conditions. In terms of solubility, the compound has good solubility in organic solvents such as ethanol and chloroform. Due to the principle of similarity and compatibility, its organic structure is compatible with organic solvents. However, its solubility in water is poor, because its molecular polarity is quite different from that of water.

Chemically, the compound contains an indole ring and an aldehyde group, and the aldehyde group has typical aldehyde chemical activity. Oxidation reactions can occur. Under the action of appropriate oxidants, aldehyde groups are easily oxidized to carboxyl groups. In case of weak oxidants such as Torun reagent, silver mirror reactions can occur; in case of strong oxidants such as potassium permanganate, the degree of oxidation may be even greater. At the same time, aldehyde groups can participate in nucleophilic addition reactions, such as acid-catalyzed formation of acetals with alcohols. This reaction is often used to protect aldehyde groups in organic synthesis. In addition, the indole ring also has a certain reactivity, and a substitution reaction can occur at a specific position on the ring, such as electrophilic substitution, because of its ring electron cloud density distribution characteristics, the specific position has a high reactivity for electrophilic reagents, which can be used as an important reaction check point when constructing complex organic molecular structures.

What is the price range of 5- (3,5-difluorobenzyl) -1H-indazole-3-amine in the market?

I don't know what the market price of "5 -% 283% 2C5 - diethylamino - 1H - pyrrole - 3 - aldehyde" is. This is a fine chemical, and its price often varies depending on factors such as quality, purity, supply and demand, purchase quantity, season, and region.

If its quality is good and its purity is very high, when demand is strong and supply is low, the price may be high; if the quality is normal, the purity is not top-notch, and the market is oversupplied and the purchase volume is large, the price may be slightly lower.

However, if you want to know the exact price range, you need to consult chemical raw material suppliers, chemical trading platforms, or communicate with industry insiders at relevant industry exhibitions and forums to obtain a more accurate price range. I lack real-time market information here, so it is difficult to determine the price.