What are the chemical properties of 3-Bromo-4-fluorobenzylamine hydrochloride?

3-Bromo-4-fluorobenzyl amine hydrochloride is one of the organic compounds. Its properties are often white to off-white solid powder, which acts as a key intermediate in many organic synthesis reactions.

This compound has unique chemical properties. From its structural point of view, the amino group of the benzyl amine part is basic and can react with acids, and the state of hydrochloride is obtained by its reaction with hydrochloric acid. The bromine and fluorine atoms contained in it can participate in many nucleophilic substitution reactions due to the characteristics of halogen atoms. For example, bromine atoms can be replaced by other nucleophiles under suitable conditions, such as by hydroxyl substitutions to form corresponding alcohols, or by cyanyl substitutions to introduce cyanyl functional groups, which is very important in the construction of complex organic molecular structures. Fluorine atoms, because of their large electronegativity, can have a significant impact on the distribution of molecular electron clouds, change the physical and chemical properties of compounds, such as enhancing molecular fat solubility, etc., are of great significance in the field of medicinal chemistry, because they can affect the ability of drugs to bind to targets and metabolic processes in vivo.

In addition, the stability of 3-bromo-4-fluorobenzamine hydrochloride is also characterized. In conventional environments, it is relatively stable, but under extreme conditions such as strong oxidizing agents and strong acids and bases, the structure may be damaged. When storing and using, it is necessary to avoid contact with such substances. It should be stored in a dry and cool place to prevent moisture decomposition and deterioration. In terms of solubility, it generally has a certain solubility in polar organic solvents such as methanol and ethanol, and can also be dissolved in water, which is convenient for its application in different reaction systems.

What are the main uses of 3-Bromo-4-fluorobenzylamine hydrochloride?

3-Bromo-4-fluorobenzylamine hydrochloride has a wide range of uses. In the field of pharmaceutical synthesis, it is often a key intermediate. The molecular design of drugs requires the introduction of specific functional groups to adjust pharmacological activities. The structure of bromine, fluorine and benzylamine hydrochloride in this compound can participate in the reaction by organic synthesis to construct drug molecules with unique physiological activities. For example, when developing antibacterial, anti-tumor and other drugs, or by reacting with other reagents to generate new compounds containing specific pharmacoactive groups, which are expected to become clinically available drugs after subsequent optimization.

In materials science, it also has its uses. Organic electronic materials have developed rapidly, containing halogen atoms and amine-based compounds, which can be appropriately modified for the preparation of organic Light Emitting Diodes (OLEDs), organic field effect transistors (OFETs) and other materials. 3-Bromo-4-fluorobenzamine hydrochloride can impart special electrical and optical properties to materials, such as adjusting molecular energy levels, affecting material luminous efficiency, carrier transport properties, etc., thereby optimizing material properties and meeting different device requirements.

Furthermore, it is a commonly used reagent in organic synthetic chemistry research. Organic chemists use its functional group properties to carry out various reaction studies, such as nucleophilic substitution, coupling reactions, etc. In order to explore new synthetic methods and strategies, enrich the content of organic synthetic chemistry, lay the foundation for the synthesis of more complex and diverse organic compounds, and promote the development of organic chemistry.

What is the synthesis method of 3-Bromo-4-fluorobenzylamine hydrochloride?

To prepare 3-bromo-4-fluorobenzyl amine hydrochloride, the following ancient method can be used.

First, 3-bromo-4-fluorobenzoic acid is used as the starting material, and dichlorosulfoxide is often co-heated with it. This step is intended to convert the carboxyl group into an acid chloride. Dichlorosulfoxide has strong activity. When encountering the carboxyl group, the hydroxyl group in the carboxyl group is replaced by chlorine to form 3-bromo-4-fluorobenzoyl chloride, and sulfur dioxide and hydrogen chloride gas escape at the same time. After the reaction is completed, the unreacted reagents and by-products are removed by distillation to obtain pure 3-bromo-4-fluorobenzoyl chloride.

times, 3-bromo-4-fluorobenzoyl chloride is mixed with excess ammonia water, the active chlorine of the acyl chloride is nucleophilic substituted with the amino group in the ammonia, the hydrogen of the ammonia and the chlorine form ammonium chloride, and the rest is 3-bromo-4-fluorobenzamide. After the reaction system is properly treated, such as removing ammonium chloride and other salts with water polyester, the organic phase is dried to obtain 3-bromo-4-fluorobenzamide. Next, 3-bromo-4-fluorobenzamide was reduced with lithium aluminum hydride as a reducing agent in anhydrous ether and other inert solvents. The hydrogen anion in lithium aluminum hydride has strong reductivity, and the carbonyl group of the amide group can be reduced to methylene, so 3-bromo-4-fluorobenzyl amine is obtained. After the reaction, carefully hydrolyze the excess aluminum hydride, and extract, dry, and distill to separate 3-bromo-4-fluorobenzyl amine.

Finally, 3-bromo-4-fluorobenzyl amine is dissolved in an appropriate amount of organic solvent, such as ether or dichloromethane, and dried hydrogen chloride gas is introduced. The amino group of benzyl amine is alkaline and forms a salt with hydrogen chloride to obtain the target product 3-bromo-4-fluorobenzyl amine hydrochloride. After the reaction is completed, the precipitated solid is filtered, washed with cold solvent, and dried in vacuum to obtain a pure 3-bromo-4-fluorobenzyl amine hydrochloride.

3-Bromo-4-fluorobenzylamine the market price of hydrochloride

3-Bromo-4-fluorobenzyl amine hydrochloride, the price of this product in the market is difficult to hide. The price of the cover often changes for many reasons, and it cannot be determined.

The first to bear the brunt is the cost of production. The price of raw materials fluctuates from time to time. If the various raw materials required for the synthesis of this compound are either dilute or abundant, the price will rise and fall accordingly. The process of preparing 3-bromo-4-fluorobenzyl amine hydrochloride requires quite a lot of process requirements. The simplicity of the process is also related to the cost, which in turn affects its market price.

Furthermore, the state of market supply and demand is also the key. If many pharmaceutical companies or scientific research institutions have strong demand for it, but limited supply, the price will rise; on the contrary, if the market is oversupplied, the merchant may sell their goods at a lower price.

The difference in origin also results in price differences. In different places, due to differences in policies, labor costs, transportation conditions, etc., the cost of producing and selling this compound is different, and its selling price is also different.

Ordinarily speaking, in the fine chemical product market, the price may range from a few yuan per gram to a few tens of yuan. However, this is only an approximate number, and the actual price depends on the specific time, place and transaction situation. When purchasing, you must carefully check the quotations of each supplier and measure its quality before you can get a suitable price.

3-Bromo-4-fluorobenzylamine hydrochloride during storage and transportation

3-Bromo-4-fluorobenzyl amine hydrochloride is a chemical substance, and many things should be paid attention to when storing and transporting.

Bear the brunt of it. When storing, you must find a cool, dry and well-ventilated place. This substance is quite sensitive to humidity and temperature, and high temperature or high humidity can easily cause it to deteriorate. Therefore, the warehouse temperature should be controlled within a specific range, and the humidity should also be kept at an appropriate level to prevent moisture dissolution or other chemical reactions.

Furthermore, during transportation, ensure that the packaging is intact. This chemical is dangerous. If the packaging is damaged or leaks, it will endanger the safety of transporters and the environment. Packaging materials should have good sealing and corrosion resistance, and can resist general vibration, collision and friction.

In addition, fireworks are strictly prohibited in storage and transportation places. 3-Bromo-4-fluorobenzyl amine hydrochloride may be flammable, in case of open fire, hot topic, or cause serious accidents such as combustion or even explosion.

At the same time, the storage area should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed. Because of its active chemical properties, contact with these substances, or trigger violent chemical reactions, causing danger.

Furthermore, whether it is storage or transportation, it needs to be managed and operated by professionals. They should be familiar with the characteristics of the substance, safety precautions and emergency treatment methods. In the event of an accident, it can be disposed of quickly and properly to minimize losses and hazards.

Also, the storage place should be equipped with suitable materials to contain possible leaks. In the event of a leak, it can be collected in time to prevent the spread of pollution.

In short, the storage and transportation of 3-bromo-4-fluorobenzyl amine hydrochloride should be treated with caution and strict safety guidelines should be followed to ensure that personnel safety and the environment are not endangered.