3- (4-chloro-2-fluorobenzyl) -2-Methyl-N- (3-Methyl-1H-pyrazol-5-yl) -8- (MorpholinoMethyl) iMidazo [1,2-b] pyridazin-6-aMine What is the chemical structure of

The name of this compound is "3- (4-chloro-2-fluorobenzyl) -2-methyl-N- (3-methyl-1H-pyrazole-5-yl) -8- (morpholinomethyl) imidazolo [1,2-b] pyridazine-6-amine", which is composed of multi-part structural fragments.

Looking at its name, "imidazolo [1,2-b] pyridazine" is the core mother ring structure, which is like the cornerstone of the building and lays the basic framework of the whole molecule. Above the parent ring, the 6-position connecting amino group (-NH2O), which is like an outstretched tentacle, can participate in many chemical reactions and endow the molecule with unique chemical activity.

8-position is connected with morpholine methyl group, which seems to add a different "decoration" to the molecule, affecting the spatial configuration and physicochemical properties of the molecule. The methyl group at 2-position changes the electron cloud distribution around the parent ring, causing subtle changes in the hydrophilicity and hydrophobicity of the molecule.

4-chloro-2-fluorobenzyl at the 3rd position, in which the benzyl group is a benzene ring-linked methylene (-CH -2 -) structure, the chlorine atom and the fluorine atom are substituted at a specific position in the benzene ring, which further enriches the chemical diversity of the molecule. The N - (3-methyl-1H-pyrazole-5-yl) part, the pyrazole ring, as a nitrogen-containing heterocycle, is connected to the nitrogen atom at the 5th position, and the presence of the methyl group at the 3rd position also affects the activity and properties of the part of the structure.

Overall, the chemical structure of this compound is composed of these specific structural fragments, which interact with each other to give the molecule unique chemical and physical properties.

What are the physical properties of 3- (4-chloro-2-fluorobenzyl) -2-Methyl-N- (3-Methyl-1H-pyrazol-5-yl) -8- (MorpholinoMethyl) iMidazo [1,2-b] pyridazin-6-aMine

This is a chemical substance named 3- (4-chloro-2-fluorobenzyl) -2-methyl-N- (3-methyl-1H-pyrazole-5-yl) -8- (morpholinomethyl) imidazolo [1,2-b] pyridazine-6-amine. Looking at this substance, its physical properties have various characteristics.

First, the appearance, under room temperature and pressure, or a white to off-white solid powder. The formation of this morphology is closely related to the interaction force between molecules. The molecules are arranged in an orderly manner through van der Waals forces, hydrogen bonds, etc., resulting in this morphology.

Melting point is also an important physical property. Experiments have determined that its melting point is within a certain range, and the melting point value depends on the stability of the molecular structure and the strength of the intermolecular force. Halogen atoms such as chlorine and fluorine in the molecule, as well as heterocyclic structures such as pyrazole and imidazole-pyridazine, enhance the intermolecular force, which in turn affects the melting point.

In terms of solubility, this substance exhibits certain characteristics in organic solvents. In common organic solvents such as dichloromethane, N, N-dimethylformamide, it has good solubility. This is due to the polar groups contained in its molecular structure, such as morpholine groups, amine groups, etc., which can form hydrogen bonds or other intermolecular forces with organic solvent molecules to promote dissolution. However, the solubility in water is poor, because the whole molecule is relatively hydrophobic, and the force between water molecules and the molecules of the substance is weak, making it difficult to overcome the intermolecular cohesion and disperse it in water.

Furthermore, the density of the substance is also a specific value. The density depends on the mass of the molecule and the degree of compaction of the molecule. The molecular structure of this substance is relatively complex, the number of atoms is large and the arrangement is orderly, which makes it have a certain density.

In addition, the substance has its characteristics of light and thermal stability. Under light or heating conditions, the molecular structure may change. Due to the heterocyclic and unsaturated bonds contained in the molecule, photochemical reactions or thermal decomposition reactions may be triggered. Therefore, during storage and use, care should be taken to control environmental conditions and avoid direct light and high temperatures to maintain its chemical stability.

3- (4-chloro-2-fluorobenzyl) -2-Methyl-N- (3-Methyl-1H-pyrazol-5-yl) -8- (MorpholinoMethyl) iMidazo [1,2-b] pyridazin-6-aWhat is the main use of Mine

3- (4-chloro-2-fluorobenzyl) -2-methyl-N- (3-methyl-1H-pyrazole-5-yl) -8- (morpholinomethyl) imidazolo [1,2-b] pyrazine-6-amine, this compound has important uses in many fields.

In the context of pharmaceutical research and development, it may be used as a lead compound. Due to its unique structure, it can specifically interact with specific biological targets in vivo. Such as some disease-related protein receptors, enzymes, etc., by binding to the compound, its biological activity may be modulated, and then it can play a therapeutic effect. For example, in the development of anti-tumor drugs, it may be able to target abnormally expressed proteins in tumor cells, inhibit the proliferation and metastasis of tumor cells, and provide new hope for the fight against cancer.

In the field of pesticide creation, this compound also has great potential. It may exhibit biological activity against specific pests or pathogens. For example, for some crop pests, it can interfere with their physiological functions such as nervous system and digestive system, achieve efficient pest control, and have lower toxicity and better environmental compatibility than traditional pesticides, contributing to the development of green agriculture.

In the field of materials science, if the compound can participate in the construction of materials, it may endow materials with novel properties. For example, in optoelectronic materials, its unique molecular structure may affect the electronic transport, optical absorption and other properties of materials, providing new options for the development of new optoelectronic materials and promoting the progress of display technology, optoelectronic devices and other fields.

What are the synthesis methods of 3- (4-chloro-2-fluorobenzyl) -2-Methyl-N- (3-Methyl-1H-pyrazol-5-yl) -8- (MorpholinoMethyl) iMidazo [1,2-b] pyridazin-6-aMine

To prepare 3 - (4 - chloro - 2 - fluorobenzyl) - 2 - methyl - N - (3 - methyl - 1H - pyrazole - 5 - yl) - 8 - (morpholinomethyl) imidazolo [1,2 - b] pyridazine - 6 - amine, the synthesis method is as follows:

starting material, 4 - chloro - 2 - fluorobenzyl chloride and imidazolo [1,2 - b] pyridazine derivatives containing specific substituents can be selected as groups. First, the appropriate activity check point in 4-chloro-2-fluorobenzyl chloride and imidazolo [1,2-b] pyridazine derivatives is made, and the nucleophilic substitution reaction is carried out in the presence of bases. For bases, such as potassium carbonate, sodium carbonate, etc., to assist the reaction, the solvent can be acetonitrile, N, N-dimethylformamide, etc. Such solvents can dissolve the reactants and are relatively stable, and do not side-react with the reactants. At a suitable temperature, such as 50-80 ° C, when the number of reactions, this step aims to introduce 4-chloro-2-fluorobenzyl.

Furthermore, for the introduction of N- (3-methyl-1H-pyrazole-5-yl) moiety, a reagent containing 3-methyl-1H-pyrazole-5-amine can be prepared first, and then combined with imidazolo [1,2-b] pyridazine derivatives that have introduced 4-chloro-2-fluorobenzyl, in the presence of a condensing agent such as 1 - (3-dimethylaminopropyl) - 3-ethylcarbodiimide hydrochloride (EDC · HCl) and a catalyst 4-dimethylaminopyridine (DMAP), in a suitable solvent For example, in dichloromethane, it reacts at room temperature to about 40 ° C to achieve the connection of N- (3-methyl-1H-pyrazole-5-yl).

As for the addition of 8- (morpholinomethyl), the product of the above two-step reaction can be combined with morpholinomethylation reagents, such as morpholinomethylhalide, under alkali catalysis, in an appropriate solvent such as tetrahydrofuran, under the reaction number of 40-60 ℃, the final target product can be obtained 3- (4-chloro-2-fluorobenzyl) -2-methyl-N- (3-methyl-1H-pyrazole-5-yl) -8- (morpholinomethyl) imidazolo [1,2-b] pyridazin- 6 - amine. After the reaction is completed, it needs to be separated and purified, such as column chromatography, to obtain a purified product.

3- (4-chloro-2-fluorobenzyl) -2-Methyl-N- (3-Methyl-1H-pyrazol-5-yl) -8- (MorpholinoMethyl) iMidazo [1,2-b] pyridazin-6-aMine

In today's world, the market prospect of 3- (4-chloro-2-fluorobenzyl) - 2-methyl-N- (3-methyl-1H-pyrazole-5-yl) -8- (morpholinomethyl) imidazolo [1,2-b] pyridazine-6-amine is quite intriguing.

In the field of Guanfu medicine, such compounds often have unique pharmacological activities. Or can emerge in the process of new drug creation. Because modern medicine is eager for high-efficiency and low-toxicity therapeutic drugs, if this compound has significant biological activity, can target specific disease targets, and has good safety, it will attract the attention of pharmaceutical companies and researchers. Such as cancer, neurodegenerative diseases and other difficult diseases, its drug research and development progress is difficult, and if this substance can be the key to breakthrough, the market potential is limitless.

Furthermore, there are also opportunities in the field of pesticides. If it has efficient killing or repelling effects on pests, is environmentally friendly, and conforms to the general trend of green environmental protection, it is expected to become the choice of new pesticides and gain a place in the vast agricultural market.

However, its market prospects are not smooth. The complexity of the synthetic process, if it is difficult to optimize, the cost remains high, which may hinder its large-scale production and application. And the research and development of new drugs must undergo strict clinical trials, the cycle is long, and the risk is quite high. The competition of similar competitors should not be underestimated. If other similar compounds occupy the market first, they need to find another way to highlight their own advantages and gain market favor.

In summary, the market prospects, opportunities and challenges of 3 - (4 - chloro - 2 - fluorobenzyl) - 2 - methyl - N - (3 - methyl - 1H - pyrazole - 5 - yl) - 8 - (morpholinomethyl) imidazolo [1,2 - b] pyridazine - 6 - amine coexist, and it needs to be honed many times before it can be understood.