What are the main uses of 2-Cyano-5-fluorobenzyl alcohol?

2-Cyano-5-fluorobenzyl alcohol is an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of pharmaceutical synthesis. The cyano and fluorine atoms of this compound can be converted into various functional groups through various chemical reactions, and then complex drug molecules can be synthesized. For example, in the development process of anti-cancer drugs, it may be able to integrate into the drug molecular structure through specific reaction steps, giving the drug a unique biological activity, which helps to improve the targeting and inhibitory effect on cancer cells.

In the field of materials science, 2-cyano-5-fluorobenzyl alcohol is also used. New polymer materials can be constructed by means of polymerization reaction. Its special chemical structure may endow the material with characteristics such as excellent stability and optical properties. For example, it can be used to prepare optical materials with special response to specific wavelengths of light, showing unique advantages in optoelectronic devices.

Furthermore, in the field of organic synthesis chemistry, as an important starting material, it can participate in the construction of many complex organic compounds. With its chemical activity of cyanyl group and benzyl alcohol part, a series of organic compounds with different functions and structures can be derived through many classic organic reactions such as nucleophilic substitution and oxidation reduction, providing a rich material basis and research direction for the development of organic synthesis chemistry.

2-Cyano-5-fluorobenzyl the physical properties of alcohol

2-Cyano-5-fluorobenzyl alcohol is one of the organic compounds. Its physical properties are quite impressive, so let me explain in detail.

First of all, its properties are mostly white to light yellow crystalline powder at room temperature, which is easy to observe and process. Looking at its color, it is white and yellowish, just like the first light of the morning, pure and simple.

When it comes to the melting point, it is about 62-66 ° C. The melting point is the critical temperature at which the substance changes from solid to liquid. This temperature range indicates that 2-cyano-5-fluorobenzyl alcohol can undergo phase changes at relatively mild temperatures. When heated, it gradually melts, just like spring ice when warm, and turns into a flowing state.

As for solubility, this compound has good solubility in organic solvents, such as methanol, ethanol, dichloromethane, etc. Just like a fish entering water, it can blend with various organic solvents. However, in water, its solubility is poor, just like the incompatibility of oil and water, and it is distinct.

Furthermore, its density is also one of the important physical properties. Although the exact value is not detailed, its density may be similar to that of common organic compounds based on its chemical structure and the properties of similar compounds. Density is related to the mass per unit volume of a substance, and in practical applications, it affects operations such as mixing and separation.

In addition, the stability of 2-cyano-5-fluorobenzyl alcohol also needs attention. Under normal conditions, if there are no special factors to interfere, it can still maintain a relatively stable state. However, in case of extreme conditions such as high temperature and strong oxidants, its structure and properties may change, just like a building in case of strong earthquakes, which will inevitably shake.

To sum up, the physical properties of 2-cyano-5-fluorobenzyl alcohol are of great significance in the fields of organic synthesis and drug development. Its properties, melting point, solubility and other characteristics provide a key basis for relevant workers to use this substance.

2-Cyano-5-fluorobenzyl the chemistry of alcohol

2-Cyano-5-fluorobenzyl alcohol, this is an organic compound with unique chemical properties. Its appearance is usually white to light yellow solid or liquid, and its properties vary according to specific conditions.

From the perspective of chemical structure, the molecule contains cyanide group (-CN) and fluorine atom (-F), as well as benzyl alcohol structure. Cyanyl groups have high reactivity and can participate in a variety of organic reactions, such as nucleophilic substitution, addition, etc. Due to their strong electronegativity, fluorine atoms can significantly affect the distribution and spatial structure of molecular electron clouds, resulting in unique chemical properties and reactivity. The benzyl alcohol part provides hydroxyl groups (-OH), which can undergo esterification, oxidation and other reactions.

In chemical reactions, the cyanyl group of 2-cyano-5-fluorobenzyl alcohol can undergo nucleophilic addition reaction with nucleophilic reagents to form nitrogen-containing heterocycles or other derivatives. Although fluorine atoms are stable in carbon-fluorine bonds, they can also be replaced under specific conditions, such as strong nucleophilic reagents or high temperatures. Hydroxyl groups can react with acids to form esters, or oxidize to alaldehyde or carboxylic acids under the action of appropriate oxidants.

In addition, its solubility and stability are also important properties. Solubility in organic solvents or varies depending on molecular polarity, and is generally soluble in common organic solvents such as ethanol, dichloromethane, etc. In terms of stability, it is necessary to pay attention to its storage conditions, avoid high temperature, strong light and contact with active reagents to prevent decomposition or unnecessary reactions.

In summary, 2-cyano-5-fluorobenzyl alcohol has potential application value in the field of organic synthesis due to its unique structure and rich chemical properties. It can be used as an intermediate for the preparation of drugs, pesticides and functional materials.

2-Cyano-5-fluorobenzyl the synthesis of alcohol

There are several ways to synthesize 2-cyano-5-fluorobenzyl alcohol. One is to use 2-cyano-5-fluorobenzoic acid as the starting material and prepare it by reduction reaction. This process requires a suitable reducing agent, such as lithium aluminum hydride (LiAlH). In an anhydrous organic solvent, such as anhydrous tetrahydrofuran (THF), 2-cyano-5-fluorobenzoic acid is slowly added to the solution containing lithium aluminum hydride. The reaction needs to be carefully controlled at temperature, usually starting at a low temperature environment, such as 0 ° C, and gradually rising to room temperature to ensure a smooth reaction. After the reaction is complete, 2-cyano-5-fluorobenzyl alcohol can be obtained after hydrolysis.

The second can be obtained from 2-cyano-5-fluorobenzyl halide through nucleophilic substitution reaction. Select halides such as 2-cyano-5-fluorobenzyl chloride or 2-cyano-5-fluorobenzyl bromide to react with nucleophilic reagents such as aqueous or alcoholic solutions of sodium hydroxide (NaOH). The reaction temperature and time should be controlled during the reaction. Moderate heating can promote the reaction rate. The hydroxyl anion (OH) in the nucleophilic reagent attacks the carbon atom of the benzyl halide, and the halogen ion leaves to obtain 2-cyano-5-fluorobenzyl alcohol.

Furthermore, 2-cyano-5-fluorobenzaldehyde can also be obtained as a raw material. Using a mild reducing agent, such as sodium borohydride (NaBH). In alcoholic solvents such as methanol or ethanol, 2-cyano-5-fluorobenzaldehyde reacts with sodium borohydride. Sodium borohydride provides hydrogen negative ions to attack the carbon atom of the aldehyde group to form an alkoxide intermediate. After acidification, the target product 2-cyano-5-fluorobenzyl alcohol is obtained. This method is relatively mild, with few side reactions, and the purity of the product is easy to control.

What is the price range of 2-Cyano-5-fluorobenzyl alcohol in the market?

The price range of 2-cyano-5-fluorobenzyl alcohol in the market is difficult to determine. This is due to many reasons, which affect its price.

First, the situation of supply and demand has a deep impact. If there are many people in the market, but the supply is small, the price will rise; on the contrary, if the demand is scarce and the supply is abundant, the price may drop.

Second, the cost of production is also a major factor. The price of raw materials, the method of production, and the cost of labor are all related to cost. If the price of raw materials is high, or the craftsmanship is complicated, it requires more manpower and material resources, and the cost will increase, and the price will also rise.

Furthermore, the difference in quality also leads to the price difference. The price of the superior quality is often higher than that of the inferior. Because of its purity, the amount of impurities, etc., there is strict control.

There is competition in the market, which also affects its price. Competing with the industry, or adjusting its price to occupy the market.

According to past market conditions, the price of 2-cyano-5-fluorobenzyl alcohol may vary from time to time, ranging from tens of yuan to hundreds of yuan per gram. However, this is only an approximate number and is not an exact value. If you want to know the current accurate price, you should consult a supplier of chemical raw materials or a professional chemical price information platform to obtain the exact number.