What is the chemical structure of 2-Aminomethy-4- (4-fluorobenzyl) morpholine?

2-Aminomethyl-4- (4-fluorobenzyl) morpholine, this is a kind of organic compound. Looking at its name, it can be seen that its structure is composed of several parts.

First of all, the morpholine ring is the core structure of the compound, which is ring-like and quite stable. The nitrogen atom on the ring has good chemical activity and can be connected with many groups.

At the 4th position of the morpholine ring, there are 4-fluorobenzyl groups. Benzyl, benzyl, is also connected with a benzene ring and a methylene ring. And the benzyl ring of the benzyl ring is connected with a fluorine atom. The introduction of fluorine atoms, due to its high electronegativity, will significantly affect the electron cloud distribution and spatial structure of the molecule, and then affect the physical and chemical properties of the compound.

Furthermore, at the second position of the morpholine ring, there is an amino methyl group connected. Amino-NH ² is basic and can participate in many chemical reactions. The connection of methyl groups changes the electronic effect and steric resistance of amino groups.

The structure of this compound and the interaction of its parts give it unique chemical properties and may have important uses in organic synthesis, medicinal chemistry and other fields. Due to the combination of the characteristics of each group, it may be used as an intermediate to participate in the construction of more complex organic molecules, providing a key foundation for the creation of new drugs and the development of new materials.

What are the main uses of 2-Aminomethy-4- (4-fluorobenzyl) morpholine?

2-Aminomethyl-4- (4-fluorobenzyl) morpholine is an organic compound. This compound has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry. Due to its unique structure, it can be derived from various biologically active substances through various chemical reactions, which is particularly important in the process of new drug creation.

In drug development, compounds with high affinity and selectivity for specific biological targets can be obtained by modifying their structures. For example, new drugs with good efficacy and low side effects may be developed for receptors and enzymes related to certain diseases.

In the field of materials science, it may also have applications. Due to its molecular structural properties, it may participate in material synthesis reactions, endowing materials with specific properties, such as improving the solubility and stability of materials, or making materials have certain special physical and chemical properties, thereby expanding the scope of material applications.

In addition, in the field of organic synthetic chemistry, this compound, as an intermediate, can participate in the construction of various complex organic molecules. With its unique functional groups, it can react with many reagents, providing an effective way for the synthesis of organic compounds with diverse structures, contributing to the development of organic synthetic chemistry, and promoting the creation and research of new organic compounds.

What are the synthesis methods of 2-Aminomethy-4- (4-fluorobenzyl) morpholine?

The synthesis method of 2-aminomethyl-4- (4-fluorobenzyl) morpholine covers a variety of paths. In the past, various experts in organic synthesis have tried to explore it in different ways.

One method is to take the morpholine as the base first and make it react with a suitable halogenated benzyl derivative by nucleophilic substitution. This halogenated benzyl, if 4-fluorobenzyl halide is mixed in a suitable solvent with an alkali agent, such as potassium carbonate, sodium carbonate, etc., can be promoted. The action of the base agent grabs the hydrogen on the morpholine nitrogen, making it negatively charged, and is more likely to attack the carbon position of the halogen atom of halobenzyl, causing a carbon-nitrogen bond to form a 4 - (4 - fluorobenzyl) morpholine intermediate.

Then, this intermediate is co-placed in the reaction system with formaldehyde and ammonia (or its equivalent, such as ammonium formate). Formaldehyde and ammonia first form an imine intermediate, and then undergo nucleophilic addition with the nitrogen atom of 4 - (4 - fluorobenzyl) morpholine. After the reduction step, 2-aminomethyl-4 - (4 - fluorobenzyl) morpholine can be obtained. This method of reduction, or using reducing agents such as sodium borohydride, can reduce imino groups to aminomethyl groups under mild conditions.

Another way is to prepare carboxylic acid esters containing 4-fluorobenzyl and morpholine structures first, and then perform aminolysis to convert the ester groups into amides. The amide is treated with strong reducing agents such as lithium aluminum hydride, and the amide group can be reduced to aminomethyl groups, and the final product can be obtained. In this process, the amount of lithium aluminum hydride, the reaction temperature and time need to be carefully controlled to avoid excessive reduction or other side reactions.

Or there may be a protective group strategy. The nitrogen atom of the morpholine is first shielded with a suitable protective group, and then the 4-fluorobenzylation reaction is carried out. After deprotection, amino methyl is introduced. This can avoid unnecessary side reactions in the reaction and improve the selectivity and yield of the reaction. However, the selection of protective groups and the steps of deprotection also need to be considered in detail to make the overall synthesis convenient and efficient.

What are the physical properties of 2-Aminomethy-4- (4-fluorobenzyl) morpholine?

2-Aminomethyl-4- (4-fluorobenzyl) morpholine, which is an organic compound. According to its physical properties, under room temperature and pressure, it is mostly colorless to pale yellow liquid. This is due to the interaction between atoms in the molecular structure, which causes the intermolecular forces to be in a specific range, thus presenting this aggregated state.

Its boiling point is usually in a specific temperature range, about [X] ° C. This is due to the existence of interactions such as van der Waals forces and hydrogen bonds between molecules. A specific energy is required to overcome these forces and convert the liquid into a gas.

The density of this compound is also an important physical property, which is about [X] g/cm ³. This value reflects the mass of the substance per unit volume and is closely related to the size and structure of the molecule. The degree of molecular arrangement determines the density.

As for solubility, it shows good solubility in common organic solvents, such as ethanol and dichloromethane. This is due to the fact that its molecular structure can form similar interactions with organic solvent molecules, such as van der Waals force, hydrogen bonds, etc., following the principle of "similar miscibility". However, the solubility in water is relatively limited, and the ratio and structural characteristics of the hydrophilic part to the hydrophobic part of the molecule make it difficult to fully interact with water molecules, thus limiting its solubility in water.

The above physical properties are all determined by the unique molecular structure of the compound. The existence of atoms such as nitrogen and oxygen in the molecule, as well as the characteristics of functional groups such as fluorobenzyl and aminomethyl groups, together shape the characteristics of its physical properties.

What is the price range for 2-Aminomethy-4- (4-fluorobenzyl) morpholine in the market?

I am not aware of the market price range for "2 - Aminomethy - 4 - (4 - fluorobenzyl) morpholine". The price of this product or a common product that is not widely known is subject to many factors.

First, purity is the key. For high purity, the price must be higher than for low purity. Because purification requires more refined processes and more costs. If used in fine chemical synthesis or pharmaceutical research and development, the purity requirements are strict and the price is high.

Second, supply and demand have a great impact. If demand is strong and supply is limited, the price will rise; conversely, if supply exceeds demand, the price may drop. If many pharmaceutical companies compete to make new drugs at some time, the price will rise.

Third, the source channel is related to the price. Buy directly from the manufacturer, or because there is no intermediate link and the price is excellent; resell through multi-level dealers, each pass, the cost is accumulated, and the price is higher.

Fourth, the market competition situation also plays a role. If there is multiple competition in the market, it is difficult to determine the price range. For the exact price, you can consult a chemical raw material supplier, a pharmaceutical intermediate seller, or a professional chemical product trading platform.