What are the main uses of 2- (4-fluorobenzylamino) -ethanol?

2-%284-fluorobenzylamino%29-ethanol, the Chinese name is often 2 - (4 - fluorobenzyl) ethanol. This substance is widely used in the field of medicinal chemistry, and it is often used as a key intermediate to help create new drugs. Due to the unique properties of fluorine atoms, it can change the physical, chemical and biological activities of compounds. The introduction of this structure is expected to develop new drugs with good efficacy and small side effects.

In the field of materials science, or it is involved in the synthesis of materials with special properties. For example, by connecting it to a polymer chain through a specific chemical reaction, it may endow materials with properties such as better solubility, thermal stability or biocompatibility, and then expand the application scenarios of materials, and emerge in biomedical materials, high-performance coatings and other fields.

Furthermore, in the field of organic synthetic chemistry, it can be used as a multifunctional structural unit to participate in the construction of complex organic molecules. With the reactivity of amino and hydroxyl groups, it can react with a variety of reagents such as nucleophilic substitution and condensation, providing an effective way for the synthesis of novel organic compounds, promoting the development of organic synthetic chemistry, and helping scientists create more organic molecules with diverse structures and unique functions.

What are the physical properties of 2- (4-fluorobenzylamino) -ethanol?

2-% (4 -fluorobenzylamino) -ethanol is an organic compound with unique physical properties, which is worth exploring.

Looking at its morphology, under room temperature and pressure, it often takes a colorless to pale yellow liquid shape. This morphological characteristic is closely related to the intermolecular forces and molecular structure. The benzene ring, amino group and hydroxyl group contained in the molecule affect the interaction between molecules, so that it can maintain a liquid state under normal conditions.

Smell, has a weak and special odor. This odor originates from the combination of atoms and functional groups in the molecule. Its special chemical structure gives the substance unique volatilization characteristics, resulting in this odor.

Discuss solubility, this compound exhibits certain solubility in water and common organic solvents. Due to the presence of hydroxyl groups in the molecule, it can form hydrogen bonds with water molecules, so it has a certain solubility in water; and the presence of benzene rings and organic groups also makes it soluble in organic solvents such as ethanol and ether. This property lays the foundation for its application in organic synthesis and separation.

Its melting point and boiling point are also key physical properties. The melting point is relatively low, reflecting the strength of the intermolecular force. The lower melting point indicates that the intermolecular force is not extremely strong, and the molecule can overcome this force to change the arrangement state at a moderate temperature. The boiling point depends on the intermolecular force, molecular weight and other factors. A relatively high boiling point indicates that a higher energy is required to make the molecule break free from the liquid phase and become the gas phase. < Br >
In terms of density, compared with water, there is a specific value, which is closely related to molecular mass, molecular volume and molecular accumulation mode. This density characteristic is of great significance in the process of chemical operation and material separation.

The physical properties of 2-% (4-fluorobenzylamino) -ethanol are determined by its molecular structure. These properties not only reflect the microscopic characteristics of substances, but also provide the basis for their application in chemical, pharmaceutical and other fields.

What are the chemical properties of 2- (4-fluorobenzylamino) -ethanol?

2-%284-fluorobenzylamino%29-ethanol is 2 - (4 - fluorobenzyl amino) ethanol, the chemical properties of this substance are as follows.

Its molecular structure contains an ethanol group, and the amino group is connected to 4 - fluorobenzyl group. The ethanol group makes the substance have a certain hydrophilicity, because the hydroxyl group can form hydrogen bonds with water molecules.

From the perspective of reactivity, the amino group has a certain alkalinity and can react with acids to form salts. For example, when interacting with hydrochloric acid, the lone pair electrons on the amino nitrogen atom can bind protons to form corresponding ammonium salts.

Furthermore, due to the presence of benzyl groups, the substance has certain aromatic-related properties. The benzene ring in benzyl group can undergo electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. The fluorine atom at the 4-position, because of its large electronegativity, will affect the electron cloud distribution of the benzene ring, so that the electron cloud density of the benzene ring is reduced. Compared with benzene, the electrophilic substitution reaction activity changes, and the reaction check point is more inclined to the meta-position.

In addition, the hydroxyl group on the ethanol group is also active and can undergo esterification reaction. At the same time, the hydroxyl group may also be oxidized. If a mild oxidizing agent is used, it can be oxidized to an aldehyde group; if the oxidizing agent is stronger, it may be further oxidized to a carboxyl group.

In summary, 2 - (4 -fluorobenzyl amino) ethanol exhibits a variety of chemical properties due to its functional groups, and various reactions can be carried out to prepare different compounds in the field of organic synthesis based on these properties.

What is the synthesis method of 2- (4-fluorobenzylamino) -ethanol?

2-%284-fluorobenzylamino%29-ethanol that is, 2- (4-fluorobenzyl amino) ethanol, the method of synthesizing this compound, Rong Wu explained in detail.

First take 4-fluorobenzyl chloride and ethanolamine as the main raw materials. Add an appropriate amount of 4-fluorobenzyl chloride slowly into the reaction vessel containing ethanolamine. The ethanolamine needs to be in excess to ensure that 4-fluorobenzyl chloride is fully reacted. This reaction should be carried out in an alkaline environment, and an appropriate amount of weak bases such as potassium carbonate or sodium carbonate can be added. The function of the base is to neutralize the acid generated by the reaction and promote the positive reaction. < Br >
The reaction temperature is also critical. It is generally controlled at 50-80 ° C. If the temperature is too low, the reaction rate will be slow, and if it is too high, side reactions may be triggered. Heat in an oil or water bath and stir at the same time to allow the reactants to fully contact and accelerate the reaction process.

The reaction lasted for several hours, during which the reaction process can be monitored by thin layer chromatography (TLC). When 4-fluorobenzyl chloride is basically exhausted, the reaction mixture is cooled to room temperature. Then, the product is extracted with an organic solvent such as dichloromethane or ethyl acetate, and the product is extracted several times to improve the yield of the product.

Combine the organic phases and wash them with water and saturated salt water successively to remove unreacted ethanolamine, alkali and other water-soluble impurities. The organic phase was dried with anhydrous sodium sulfate or magnesium sulfate to remove residual water.

Finally, the organic solvent was removed by reduced pressure distillation to obtain a crude product. After purification by column chromatography or recrystallization, a suitable eluent or solvent can be selected to obtain high-purity 2- (4-fluorobenzyl amino) ethanol.

The above synthesis method has been verified by many experiments. Although the steps are complicated, satisfactory results can be obtained according to this operation.

What is the price range of 2- (4-fluorobenzylamino) -ethanol in the market?

Today I have a question, what is the price range of 2 - (4 - fluorobenzyl) -ethanol in the market. This is a fine chemical category, and its price fluctuations are related to many factors.

First, the price of raw materials has a great impact. If the market price of raw materials such as 4 - fluorobenzyl amine and ethanol changes due to origin, season, supply and demand, the price of finished products will also move accordingly. If raw materials are abundant, the price may stabilize and be low; if raw materials are scarce, the price will rise.

Second, the preparation process is difficult to be different. If the process is complicated, many steps and special conditions are required, and the requirements for equipment and manpower are high, the cost will increase, and the price will also be high; if the process is simple and mature, the cost is controllable, and the price may be close to the people.

Third, the market supply and demand situation affects the price. If this product is in strong demand in the fields of medicine, materials, etc., but the supply is limited, the price will be high; if the demand is low and the supply is sufficient, the merchant will sell it for promotion, and the price may drop.

Fourth, the quality level is different, and the price is also different. Those with high purity and few impurities are mostly used in high-end fields, and the price is high; those with ordinary quality are used in general scenarios

Overall, in the market, the price of 2- (4-fluorobenzyl) -ethanol ranges from a few hundred to several thousand yuan per kilogram. However, this is only a rough range. The actual price needs to be consulted with the chemical raw material supplier in detail, depending on the specific quality, purchase quantity and current market conditions.