What are the main uses of 2- [ (4-Fluorobenzyl) amino] ethanol?

2-% 5B% 284 - Fluorobenzyl%29amino%5Dethanol is a kind of organic compound. It has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry.

In the process of drug development, this compound can lay the foundation for the creation of new drugs. Because of its specific structure, it can interact with targets in organisms or have the potential to regulate physiological functions. Chemists can obtain a variety of derivatives by chemically modifying it to search for drug molecules with better pharmacological activity and selectivity.

In the field of materials science, 2-% 5B% 284 - Fluorobenzyl%29amino%5Dethanol is also useful. Or can participate in the preparation of special materials, such as materials with special optical and electrical properties. The fluorine atoms in its structure can endow the material with unique properties, such as enhancing the stability of the material and changing the surface properties of the material.

In addition, in the field of organic synthesis, this compound can be used as an important starting material or reaction intermediate. Organic chemists can use various chemical reactions to modify and expand its structure, synthesize more complex organic molecules, and contribute to the development of organic synthetic chemistry. From this point of view, 2-% 5B% 284 - Fluorobenzyl%29amino%5Dethanol has important uses in many scientific fields and plays an indispensable role in promoting progress in related fields.

What are the physical properties of 2- [ (4-Fluorobenzyl) amino] ethanol

2-%5B%284-Fluorobenzyl%29amino%5Dethanol, the Chinese name is often 2- [ (4-fluorobenzyl) amino] ethanol. The physical properties of this substance are as follows:

Under normal temperature, it is mostly colorless to light yellow liquid. If you have a sense of smell or a weak special smell, the smell is not strong and pungent.

When it comes to solubility, it shows a certain solubility in water and common organic solvents such as ethanol and acetone. It can be partially dissolved in water because the molecular structure contains hydroxyl groups, which can form hydrogen bonds with water molecules to enhance its affinity with water; for organic solvents such as ethanol and acetone, based on the principle of similar miscibility, its solubility is better, because the molecular structure of these organic solvents has certain similarities with 2- [ (4-fluorobenzyl) amino] ethanol, and can be miscible with each other.

Besides its melting point and boiling point, the melting point is relatively low, and it is not solid at room temperature. The boiling point varies according to specific pressure conditions, usually within a certain pressure range, and the boiling point is in a relatively moderate temperature range. However, the exact value needs to be determined by accurate experimental determination. In general, the boiling point of organic compounds is affected by intermolecular forces. There are hydrogen bonds and van der Waals forces between 2- [ (4-fluorobenzyl) amino] ethanol molecules, which together affect the boiling point.

As for the density, compared with water, its density is slightly higher than that of water, so if it is mixed with water and left to stand for a period of time, it will sink to the bottom of the water. This density characteristic is also closely related to the composition and structure of its molecules. The relative mass and spatial arrangement of carbon, hydrogen, oxygen, fluorine and other atoms in the molecule determine the density of the whole.

What are the chemical properties of 2- [ (4-Fluorobenzyl) amino] ethanol

2 - [ (4 -fluorobenzyl) amino] ethanol, this is an organic compound with specific chemical properties. Looking at its structure, fluorobenzyl and ethanolamine structural fragments, this structure gives it unique properties.

In terms of physical properties, under normal temperature and pressure, or liquid, due to the presence of certain forces between molecules, its specific melting boiling point is finely regulated by the forces between molecules. Intramolecular hydrogen bonding, or its boiling point is increased, is higher than that of non-hydrogen-bonded compounds with similar relative molecular masses.

In terms of chemical properties, amino groups are nucleophilic and can undergo nucleophilic substitution reactions with electrophilic reagents such as halogenated hydrocarbons and acid anhydrides. When encountering halogenated hydrocarbons, amino nitrogen atoms can attack the carbon atoms of halogenated hydrocarbons, and the halogen atoms leave to form new nitrogen-containing compounds. The hydroxyl group on the ethanol group has a certain acidity, although it is weak, but in a strong alkali environment, it can lose protons and form alkoxide anions. At the same time, the hydroxyl group can participate in the esterification reaction, and under the catalysis of acid with carboxylic acid, the corresponding ester compounds are formed.

Furthermore, the presence of fluorine atoms significantly affects the electron cloud distribution of the molecule. Fluorine has a large electronegativity and a strong electron-absorbing induction effect, which decreases the density of the benzyl electron cloud connected to it, thereby affecting the reactivity of the amino group and the ethanol group connected to it. In some reactions, or make the reaction check point more inclined to the relatively high electron cloud density.

In summary, 2 - [ (4 -fluorobenzyl) amino] ethanol has a unique structure and rich chemical properties, which may be widely used in organic synthesis and other fields.

What are the synthesis methods of 2- [ (4-Fluorobenzyl) amino] ethanol

To prepare 2 - [ (4 - fluorobenzyl) amino] ethanol, there are three methods.

First, 4 - fluorobenzyl amine and ethylene oxide are used as materials. The two are heated and reconciled in a suitable reactor, and are promoted by a specific catalyst, such as some acidic or alkaline catalysts, so that the nucleophilic addition of the two is made. The ring of ethylene oxide is opened by the attack of the nucleophilic reagent 4 - fluorobenzyl amine, and the final product is 2 - [ (4 - fluorobenzyl) amino] ethanol. The raw materials in this way are easy to buy, but ethylene oxide is active, and the reaction needs to be carefully controlled to avoid side reactions. < Br >
Second, start with 4-fluorobenzyl chloride and ethanolamine. In suitable solvents, such as ethanol, acetone, etc., add acid binding agents, such as potassium carbonate, triethylamine, etc., so that the chlorine atom of 4-fluorobenzyl chloride is replaced by the amino nucleophilic of ethanolamine. The acid binding agent can remove the acid generated by the reaction, promote the right shift of the reaction, and increase the yield of the product. Although the raw materials of this method are common, 4-fluorobenzyl chloride is corrosive, and the operation needs to be careful, and the side reactions also need to be paid attention to.

Third, 4-fluorobenzaldehyde, ethanolamine and reducing agents are used as materials. First, 4-fluorobenzaldehyde is condensed with ethanolamine to form an imine intermediate, and then the imine is reduced to the target 2 - [ (4-fluorobenzyl) amino] ethanol with a reducing agent, such as sodium borohydride, lithium aluminum hydride, etc. Sodium borohydride is mild and easy to operate; lithium aluminum hydride has strong reducing power, so it needs an anhydrous environment and harsh operation. There are slightly more steps in this path, but the reaction of each step is more controllable, and the purity of the product may be good.

What are the precautions for 2- [ (4-Fluorobenzyl) amino] ethanol during use

2-% 5B% 284 - Fluorobenzyl%29amino%5Dethanol, it is an organic compound. When using, all kinds of precautions should not be ignored.

First, safety protection is essential. This compound may have certain chemical activity, and appropriate protective equipment must be worn when exposed. Wear protective gloves to avoid direct contact with the skin, covering skin contact or irritation, or even absorption and endangering health. And wear protective glasses to prevent it from accidentally splashing into the eyes and damaging eye tissue. If there is a risk of inhalation, suitable respiratory protective equipment should also be prepared to prevent its volatile gas from entering the respiratory tract and causing respiratory discomfort.

Second, the operating environment should also be paid attention to. It is suitable to operate in a well-ventilated place, so that the volatile gas can be dissipated in time and will not accumulate. This helps to maintain fresh air and reduce the risk of inhalation hazards. And the operation area should be kept away from fire and heat sources, which may be flammable. In case of open flames, hot topics, it may cause danger, fire or even explosion.

Third, storage should also be paid attention to. It should be stored in a cool, dry and ventilated place away from direct sunlight. At the same time, it should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed to prevent chemical reactions, deterioration of compounds, or safety accidents.

Fourth, during use, accurate measurement and operation steps cannot be ignored. It is necessary to measure the required amount accurately according to the requirements of the experiment or production, and cannot be increased or decreased at will. The operation steps must follow the established specifications and must not be changed without authorization to ensure the accuracy and safety of the experiment or production. A slight mistake may cause the experiment to fail or lead to safety hazards.

When using 2-% 5B% 284-Fluorobenzyl%29amino%5Dethanol, it should be treated with caution in terms of safety protection, operating environment, storage and operation steps, and should not be slack at all, so as to ensure the safety and effectiveness of use.