2- (1-Amino-1-methylethyl) -N- (4-fluorobenzyl) -5-hydroxy-1-methyl-6-oxo-1, what is the chemical structure of 6-dihydropyrimidine-4-carbox

The Chinese name of this compound is 2 - (1 - amino - 1 - methylethyl) -N - (4 - fluorobenzyl) -5 - hydroxy - 1 - methyl - 6 - oxo - 1,6 - dihydropyrimidine - 4 - formamide. Its chemical structure can be explained from the following parts.

The pyrimidine ring is the core structure, with a methyl group connected at the 1st position, a hydroxyl group introduced at the 5th position, and a carbonyl oxygen at the 6th position, which constitutes the basic structure of 1,6-dihydropyrimidine-5-hydroxy-1-methyl-6-oxo. On the side chain at the 2nd position, there is a (1-amino-1-methethyl) group, that is, the form of isopropylamino group. At the 4th position, a formamide group is connected, and (4-fluorobenzyl) is connected to the nitrogen atom of the formamide group. In this way, each substituent is associated with the core structure of pyrimidine to form the chemical structure of this complex compound. The different groups in this structure endow the compound with specific chemical properties and potential biological activities, and each part interacts to jointly determine its performance in chemical reactions and biological systems.

What are the physical properties of 2- (1-Amino-1-methylethyl) -N- (4-fluorobenzyl) -5-hydroxy-1-methyl-6-oxo-1, 6-dihydropyrimidine-4-carbox

2-%281-Amino-1-methylethyl%29-N-%284-fluorobenzyl%29-5-hydroxy-1-methyl-6-oxo-1%2C6-dihydropyrimidine-4-carbox this is the chemical name of an organic compound, according to this name, it may be slightly imprecise (key suffixes such as -amide indicating specific functional groups may be missing), making it difficult to clarify its specific structure. However, its physical properties can be slightly deduced from existing fragments.

Its structure contains a pyrimidine ring, which is often rigid and planar, which affects the overall configuration of the compound and the intermolecular forces. 1 - methyl - 6 - oxo - 1,6 - dihydropyrimidine - 4 - carbox - moiety, carbonyl (6 - oxo) is polar, which can participate in the formation of hydrogen bonds, or affect the solubility and melting point of compounds. Hydroxy (5-hydroxy) is also a polar group, which can form hydrogen bonds with water or other molecules containing hydrogen bond receptors, or make the compound have a certain solubility in polar solvents.

1-Amino-1-methylethyl and N- (4-fluorobenzyl) parts, amino groups are basic groups, which can form salts with acids; fluorobenzyl increases the hydrophobicity of molecules. The introduction of fluorine atoms affects its chemical and physical properties due to the large electronegativity of fluorine, or changes the distribution of molecular electron clouds, such as enhancing molecular stability and changing lipophilicity.

In general, the compound may have a certain polarity. Due to the existence of many polar groups, it may have a certain solubility in water or polar organic solvents. And because it contains hydrophobic benzyl moieties, it may also have a certain solubility in non-polar solvents. Its melting point may be affected by intermolecular hydrogen bonds and van der Waals forces. Because the polar groups in the molecule can form hydrogen bonds, the melting point may not be low. The rigid structure of the molecule or its conformational change in solution also affects its physical properties.

2- (1-Amino-1-methylethyl) -N- (4-fluorobenzyl) -5-hydroxy-1-methyl-6-oxo-1, what are the application fields of 6-dihydropyrimidine-4-carbox

2-% 281-Amino-1-methylethyl% 29-N-% 284-fluorobenzyl% 29-5-hydroxy-1-methyl-6-oxo-1% 2C6-dihydropyrimidine-4-carboxylic acid, this compound is widely used in medicine.

In the field of antimalarial, this compound may show unique effects. Malaria pathogens ravage in the complex physiological environment of the human body, and the special chemical structure of this compound may interfere with the metabolic pathway of Plasmodium. Specific functional groups in its molecules, such as 5-hydroxy and 6-oxo structures, may interact with key enzymes in the malaria parasite, inhibiting its activity, thereby hindering the growth and reproduction of the malaria parasite, adding a weapon for the prevention and treatment of malaria.

In the field of antibacterial, it also has potential value. Important physiological processes such as cell wall synthesis and protein synthesis of bacteria may be affected by this compound. The existence of 2 - (1-amino-1-methethyl) part may enable it to accurately target specific targets of bacteria, destroy the normal physiological function of bacteria, and achieve the purpose of antibacterial, providing new ideas and possibilities for responding to bacterial infections. < Br >
This compound may play an important role in regulating immunity. The human immune system is like a sophisticated defense network. The compound may regulate the activity and function of immune cells by binding to receptors on the surface of immune cells. Or promote the proliferation and differentiation of immune cells, enhance the body's immune response ability; or inhibit excessive immune responses and prevent the occurrence of immune-related diseases, showing broad application prospects in the field of immune regulation.

What is the synthesis method of 2- (1-Amino-1-methylethyl) -N- (4-fluorobenzyl) -5-hydroxy-1-methyl-6-oxo-1, 6-dihydropyrimidine-4-carbox

To prepare 2 - (1 - amino - 1 - methylethyl) - N - (4 - fluorobenzyl) - 5 - hydroxy - 1 - methyl - 6 - oxo - 1,6 - dihydropyrimidine - 4 - carboxylic acid, the synthesis method is covered by the following steps. < Br >
First, the raw materials must be prepared, that is, compounds containing 1-amino-1-methylethyl, 4-fluorobenzyl related reagents, 5-hydroxy-1-methyl-6-oxo-1, 6-dihydropyrimidine-4-carboxylic acid starting materials, etc. All raw materials must be pure, which is the basis for synthesis.

Then, in a suitable reaction vessel, dissolve the raw materials in a suitable solvent. The selected solvent must be able to dissolve the reactants well and do not react with the reactants. Common organic solvents such as ethanol and dichloromethane are selected according to the specific needs of the reaction.

After the raw materials are uniformly dispersed in the solvent, slowly add a catalyst. The choice of catalyst is related to the reaction rate and yield, and it should be done with caution. For example, some acidic or basic catalysts can be determined according to the reaction mechanism. When adding, the dosage and rate must be controlled to avoid overreaction.

Subsequently, the reaction temperature and time are regulated. Different reaction stages require different temperatures. The initial temperature may be required to make the raw materials initially function, and then gradually increase the temperature to promote the complete reaction. The reaction time must also be accurately controlled. If it is too short, the reaction will not be completed, and if it is too long, it will cause side reactions to breed. The reaction process can be monitored by means of thin-layer chromatography (TLC).

When the reaction reaches the expected level, the separation and purification are performed. First, the reaction solution and impurities are preliminarily separated by filtration and extraction. After that, the pure target product 2- (1-amino-1-methylethyl) -N- (4-fluorobenzyl) -5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid is obtained by fine methods such as column chromatography and recrystallization. Every step of the operation requires careful attention to ensure the purity and yield of the product.

2- (1-Amino-1-methylethyl) -N- (4-fluorobenzyl) -5-hydroxy-1-methyl-6-oxo-1, 6-dihydropyrimidine-4-carbox

There are currently 2- (1-amino-1-methylethyl) -N- (4-fluorobenzyl) -5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid products. The market prospects are discussed as follows.

In the field of medicine, the development of innovative drugs is the trend. This compound has a unique structure or potential activity in specific disease targets. Medical researchers often seek molecules with novel structures to open up new therapeutic pathways. If this compound is studied in depth and proves that it has a definite curative effect on certain diseases, such as inflammation-related diseases, tumor diseases, etc., and the toxic and side effects are mild, it is expected to open a new chapter of medicine.

In the field of pesticides, it may also have opportunities. Modern pesticides are increasingly demanding, requiring high efficiency, low toxicity and environmental friendliness. If the properties of this compound can meet the functional requirements of insecticides, sterilization or weeding, it will definitely win market favor. However, the pesticide market is highly competitive, and many new pesticides are emerging one after another. If you want to stand out, you need to demonstrate excellent performance in the research and development stage.

Re-examine the field of chemical materials. Although it is not its traditional application, science and technology are developing rapidly. The unique chemical structure of this compound may provide an opportunity for the research and development of new materials. If it can be combined with materials science to develop materials with special properties, such as special adsorption, optical properties, etc., it can also gain a place in the chemical materials market.

However, its market prospects are not smooth. The complexity of the synthesis process or the high cost of production limit large-scale production and marketing activities. And the development of new drugs or new pesticides requires a long and strict approval process, which requires a lot of manpower, material resources and time. If the research and development process encounters technical bottlenecks, such as substandard biological activity and poor stability, it will also collapse.

In summary, 2- (1-amino-1-methylethyl) - N- (4-fluorobenzyl) - 5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid has potential opportunities in the fields of medicine, pesticides, chemical materials, etc., but also faces many challenges. Only with exquisite technology, strong funds and firm determination can it be expected to emerge in the market.