What is the chemical structure of 2- [1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridin-3-yl] -5- [ (E) -phenylhydrazinyl] -4,6-pyrimidine diamine

The chemical structure of 2-% [1- (2-cyanoethyl) -1H-pyrrolido [3,4-b] pyridin-3-yl] -5- [ (E) -phenylacryloyl] -4,6-pyrimidinedione is a complex organic compound structure analysis problem. The following is based on the ancient Chinese saying of "Tiangong Kaiwu", which will be described in detail for you.

Looking at this compound, its core structure is 4,6-pyrimidinedione. This pyrimidinedione is a six-membered nitrogen-containing heterocycle with biscarbonyl based on the 4,6 position, which lays the basic framework and reactivity of the molecule. The (E) -phenylacryloyl group at the 5 position of

is connected by a phenyl group and an acryloyl group by a double bond of formula (E). The phenyl group is aromatic, and the electron cloud conjugation increases the molecular stability and affects the physical and chemical properties of the compound. The double bond of the acryloyl group is electrophilic, and can undergo addition and polymerization reactions. Its (E) configuration determines the spatial arrangement of molecules and affects the interaction with other molecules. The substituent at the

2 position is more complex, containing 1- (2-cyanoethyl) -1H-pyrrolido [3,4-b] pyridine-3-yl. 1H-pyrrolido [3,4-b] pyridine is a fused heterocyclic system, which is formed by fusing pyrrole ring with pyridine ring, contains multiple nitrogen atoms, and has rich electronic properties and alkalinity. The 1-position linked 2-cyanoethyl group has strong electron-absorbing properties and affects the electron cloud distribution of pyrrolido-pyridine ring. And this long chain substituent changes the spatial structure and solubility of the molecule.

In summary, the chemical structure of 2-% [1- (2-cyanoethyl) -1H-pyrrolo [3,4-b] pyridine-3-yl] -5- [ (E) -phenylacryloyl] -4,6-pyrimidinedione is integrated with a variety of functional groups and heterocycles, and each part affects each other, endowing the compound with unique physical and chemical properties and potential biological activities. It has important research value in the fields of organic synthesis, medicinal chemistry, etc.

What are the physical properties of 2- [1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridin-3-yl] -5- [ (E) -phenylhydrazinyl] -4,6-pyrimidine diamine

This is a question related to complex organic compounds. The structure of the substance is extremely complex, containing many specific groups and ring systems. 2 - [1 - (2 - furanyl) -1H - pyrrolio [3,4 - b] pyridine - 3 - yl] - 5 - [ (E) -phenylvinylene] - 4,6 - pyridine dimethylonitrile, the physical properties of this compound are rich and diverse.

In terms of appearance, it is mostly solid, due to strong intermolecular forces, and the molecular arrangement is orderly. Its color may be affected by the conjugated system and substituents. The conjugated system is large or deepened in color. If it contains a specific chromophore, or it shows a specific color.

In terms of melting point, the intermolecular force and structural regularity have significant effects. The compound contains polar groups such as nitrile groups and pyridine rings, which can increase the intermolecular force and increase the melting point; and the structure has certain rigidity and symmetry, which is also conducive to the increase of the melting point, or is in a higher temperature range.

In terms of solubility, in organic solvents, because they contain some polar groups and larger conjugated systems, in polar organic solvents such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), due to the principle of similar phase solubility, or have good solubility, because polar groups can form intermolecular forces with solvents; in non-polar organic solvents such as n-hexane, solubility or poor, due to the weak interaction between non-polar solvents and polar groups.

At the stability level, the structures of nitrile groups, pyridine rings and furan groups in the molecule are relatively stable, but under specific conditions, such as strong acids, strong bases or high temperature environments, some chemical bonds may react. Nitrile groups can be hydrolyzed into carboxyl groups or amide groups, and pyridine ring nitrogen atoms can undergo protonation and other reactions. And although the conjugated system is stable, strong light and strong oxidants may affect the distribution of its electron cloud and cause structural changes.

This compound may have potential applications in materials science, medicinal chemistry and other fields due to its unique physical properties. For example, as an organic semiconductor material, the conjugated system is used to transport charges; or modified to develop drugs with specific biological activities.

What is the synthesis method of 2- [1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridin-3-yl] -5- [ (E) -phenylhydrazinyl] -4,6-pyrimidine diamine

To prepare 2- [1- (2-cyanoethyl) -1H-pyrrolido [3,4-b] pyridine-3-yl] -5 - [ (E) -phenylvinylene] -4,6 -pyrimidinedione, the synthesis method is as follows:

The starting material selects suitable nitrogen-containing heterocyclic compounds and reagents with cyanoethyl structure, and uses specific organic reaction conditions, such as in an appropriate solvent, adding an appropriate amount of base or catalyst to promote its substitution reaction to generate 1- (2-cyanoethyl) -1H-pyrrolido [3,4-b] Pyridine-3-based related intermediates. This process requires careful control of the reaction temperature and time to make the reaction sufficient and accurate.

Then, choose a reagent containing phenylvinyl structure, react with the above intermediates under specific conditions, or use a condensation reaction method to form a key intermediate containing phenylvinyl. The choice of solvent in this step, the pH of the reaction system and other factors have a great impact on the reaction process and product purity.

Finally, the above key intermediates, in a suitable reaction environment, through a specific cyclization reaction, generate the target product 2- [1- (2-cyanoethyl) -1H-pyrrolido [3,4-b] pyridine-3-yl] -5 - [ (E) -phenylvinylene] -4,6 -pyrimidinedione. After the reaction, it is often necessary to separate and purify the product, such as column chromatography, recrystallization, etc., to obtain high-purity products. < Br >
The whole process of synthesis requires rigorous planning and fine operation of the reaction conditions, the proportion of materials, and the sequence of reactions in each step to achieve the goal of efficient and high-purity synthesis.

2- [1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridin-3-yl] -5- [ (E) -phenylhydrazinyl] -4,6-pyrimidinediamine What are the application fields

2-% [1- (2-furyl) -1H-pyrrolido [3,4-b] pyridine-3-yl] -5- [ (E) -phenylvinylene] -4,6-pyrimidinedione is a relatively complex organic compound. Such compounds have shown important application value in many fields, as detailed below:
1. ** Field of pharmaceutical research and development **: The structural characteristics of this compound make it have potential biological activity. In pharmaceutical chemistry research, it is often used as a lead compound for the development of new drugs. For example, its structure is similar to some substances with anti-cancer activity, or its effect on specific targets of cancer cells can be optimized by adjusting the structure to develop new anti-cancer drugs; for nervous system diseases, it may also be possible to develop drugs for treating related diseases by virtue of its effect on neurotransmitter receptors.
2. ** Materials Science Field **: The compound's unique conjugate structure gives it special optical and electrical properties. In organic optoelectronic materials, it can be used to prepare organic Light Emitting Diodes (OLEDs). Because it can emit light efficiently, it can improve the brightness and color saturation of OLED display; in the field of organic solar cells, it may be used as a light-absorbing material to enhance the absorption of sunlight and improve the photoelectric conversion efficiency of batteries.
3. ** Agricultural field **: Some compounds containing similar structures have antibacterial, antiviral or herbicidal activities. 2-% [1- (2-furyl) -1H-pyrrolido [3,4-b] pyridine-3-yl] -5- [ (E) -phenylvinylene] -4,6-pyrimidinedione has been researched and developed, or can be used as a new type of pesticide to prevent and control crop diseases and insect pests, and compared with traditional pesticides, or has low toxicity, environmental protection and other advantages.

What is the market outlook for 2- [1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridin-3-yl] -5- [ (E) -phenylhydrazinyl] -4,6-pyrimidine diamine?

What is the market prospect of 2- [1- (2-furyl) -1H-pyrrolido [3,4-b] pyridine-3-yl] -5 - [ (E) -phenylpropenyl] -4,6-pyrimidinedione? Let me tell you in detail.

This compound is used in the field of medicinal chemistry and may have unique pharmacological activities. Furyl, pyrrolidine and pyrimidinedione are often key components of many biologically active molecules. Among them, furyl, as a heterocyclic structure, exists in many natural products and synthetic drugs, which can affect the lipophilicity of molecules, the distribution of electron clouds, and then affect their interaction with biological targets.

1H-pyrrolido [3,4-b] pyridine structure has attracted much attention in many drug development because it can provide a variety of hydrogen bond donor and receptor sites, which is conducive to the formation of specific binding with biological macromolecules. The introduction of (E) -phenylpropenyl may enhance the hydrophobicity of molecules, change their transmembrane ability and distribution characteristics in vivo.

In the drug research and development market, if this compound is confirmed to have significant activity against specific diseases, such as tumors, neurological diseases and other related targets after in-depth research, its prospects are quite promising. In the field of cancer, the research and development of small molecule inhibitors targeting abnormal signaling pathway targets is in the ascendant. If this compound can precisely act on a key target and block key links such as tumor cell proliferation and metastasis, it is expected to become a new type of anti-cancer drug.

In neurological diseases, due to the existence of the blood-brain barrier, the structure and properties of drug molecules are strictly required. If this compound has a suitable lipid-water partition coefficient and polarity, it may cross the blood-brain barrier and act on neurotransmitter receptors or related enzymes, bringing new opportunities for the treatment of neurological diseases.

However, its market prospects also face challenges. Drug research and development needs to go through multiple stages of rigorous testing, from cell experiments, animal experiments to human clinical trials. Failure in any link may lead to disruption of research and development. And competition is intense. Many pharmaceutical companies and scientific research institutions are committed to the development of new drugs. If they cannot stand out, they will not be favored by the market.

Overall, if 2- [1- (2-furanyl) -1H-pyrrolido [3,4-b] pyridine-3-yl] -5 - [ (E) -phenylpropenyl] -4,6-pyrimidinedione can perform well in terms of pharmacological activity and safety, and break through the research and development dilemma, it is necessary to gain a place in the market.