1- (3-chloro-4-fluorobenzyl) -5, what is the main purpose of 6-dihydro-1H-pyridin-2-one?

1- (3-chloro-4-fluorobenzyl) -5,6-dihydro-1H-pyridine-2-one, this is an organic compound. Its main uses are quite extensive, and it is often used as a key intermediate in the field of medicinal chemistry. In the process of drug development, the specific chemical structure has a profound impact on drug activity and targeting, and the unique structure of this compound can be converted into drug molecules with specific pharmacological activity through a series of chemical reactions.

For example, in the creation of some new antibacterial drugs, with the help of its structural characteristics, combined with other chemical groups, drugs with strong inhibitory effects on specific pathogens are constructed. In the field of materials science, it also has potential uses. The unique electronic structure and physical properties of organic compounds make it possible to apply them to the preparation of new functional materials. For example, in the field of optoelectronic materials, by chemically modifying and modifying them, the materials may be endowed with special optical and electrical properties, such as good fluorescence properties or charge transport ability, and then applied to the manufacture of organic Light Emitting Diode (OLED), solar cells and other devices.

In addition, in the field of agricultural chemistry, through rational design and modification, it may become a pesticide active ingredient with high efficiency and low toxicity, which can be used for the control of crop diseases and pests, contributing to the sustainable development of agriculture. Overall, 1 - (3 - chloro - 4 - fluorobenzyl) - 5,6 - dihydro - 1H - pyridine - 2 - one has shown important application value in many fields due to its unique structure, providing a key material basis for technological innovation and development in related fields.

What are the synthesis methods of 1- (3-chloro-4-fluorobenzyl) -5 6-dihydro-1H-pyridin-2-one

To prepare 1- (3-chloro-4-fluorobenzyl) -5,6-dihydro-1H-pyridine-2-one, there are various methods. The common method is to take 3-chloro-4-fluorobenzyl halide and 5,6-dihydro-1H-pyridine-2-one in a suitable solvent, add base catalysis, and make the two undergo nucleophilic substitution reaction. Among them, the solvent can be selected as an aprotic polar solvent such as N, N-dimethylformamide and dimethylsulfoxide, and the base can be an inorganic base such as potassium carbonate and sodium carbonate, or an organic base such as triethylamine and pyridine. During the reaction, control the temperature to a suitable range, usually between room temperature and 80 ° C, and the product can be obtained when the number of reactions is numbered.

Another method is to prepare an intermediate containing 3-chloro-4-fluorobenzyl first, and then to obtain the target by cyclization reaction. For example, 3-chloro-4-fluorobenzyl amine and a suitable dicarbonyl compound are obtained by condensation and cyclization under acid catalysis. This acid can be selected as p-toluenesulfonic acid and other organic acids, and the reaction is carried out in high boiling point solvents such as toluene and xylene to promote the reaction to move towards the formation of products.

can start from pyridine derivatives and introduce 3-chloro-4-fluorobenzyl through halogenation. First, pyridine is properly protected to make the nitrogen atom of pyridine appropriately active, and then reacts with 3-chloro-4-fluorobenzyl halogen under the action of metal catalyst, and then deprotects to obtain the target product. Metal catalysts can be selected from complexes such as palladium and copper, which are relatively mild in conditions and have good selectivity. All methods have their own advantages and disadvantages. The actual preparation needs to be comprehensively considered according to the availability of raw materials, cost, yield and purity requirements, and the optimal method should be selected.

1- (3-chloro-4-fluorobenzyl) -5, what are the physical properties of 6-dihydro-1H-pyridin-2-one

1 - (3-chloro-4-fluorobenzyl) -5,6-dihydro-1H-pyridine-2-one is an organic compound with unique physical properties.

Looking at its appearance, it may be a white to off-white crystalline powder under normal conditions. This morphology is common in many organic compounds. It is crystalline because of the orderly arrangement of molecular structures and the stability of intermolecular forces. This appearance characteristic is not only easy to identify, but also has a great impact on its storage and transportation, because the powder morphology is more conducive to packaging and dispersion.

When it comes to melting point, the melting point of this compound may be in a specific temperature range. Melting point is an important physical property of compounds, which is determined by factors such as intermolecular forces and lattice energy. Accurate melting point determination is of great significance for the purity identification of compounds. If impurities are contained, the melting point often decreases and the melting range becomes wider. Therefore, knowing its melting point is extremely helpful for quality control and purity detection.

In terms of solubility, 1- (3-chloro-4-fluorobenzyl) -5,6-dihydro-1H-pyridine-2-one may have certain solubility in organic solvents such as ethanol and dichloromethane. This is because the molecular structure of the compound contains groups that can form intermolecular forces with organic solvents, such as van der Waals forces, hydrogen bonds, etc. The solubility or poor in water, because of its strong structural hydrophobicity, the interaction between water molecules and compounds is weak. Its solubility characteristics determine the solvent selection in synthesis, separation and application.

Furthermore, the density of the compound is also a specific value. Density reflects the unit volume mass of the substance and is related to the molecular structure and stacking method. Accurate density data are indispensable for operations involving mass and volume conversion, such as solution preparation, reaction material measurement, etc.

In addition, 1- (3-chloro-4-fluorobenzyl) -5,6-dihydro-1H-pyridine-2-one may have certain stability. Stability is affected by factors such as chemical bond strength and steric resistance in the molecular structure. The stable structure makes the compound less susceptible to chemical reactions under conventional storage and use conditions, which is conducive to long-term storage and application. However, under specific conditions, such as high temperature, strong acid and alkali environment, its stability may be affected and chemical changes occur.

1- (3-chloro-4-fluorobenzyl) -5, what are the chemical properties of 6-dihydro-1H-pyridin-2-one

1 - (3-chloro-4-fluorobenzyl) - 5,6-dihydro-1H-pyridine-2-one, this is an organic compound, its chemical properties are unique, and it is worth in-depth investigation.

First talk about its physical properties. It may be a solid under normal conditions, but the specific melting and boiling point is difficult to determine due to lack of data. Its solubility is closely related to the molecular structure. The polar groups and benzene ring structures it contains make it have a certain solubility in polar solvents such as ethanol and acetone, or in non-polar solvents such as n-hexane. The solubility may be limited.

Re-discussion of chemical properties, chlorine atoms and fluorine atoms in the molecule are both halogen atoms, which have high reactivity. Chlorine atoms can participate in nucleophilic substitution reactions. In case of nucleophilic reagents, halogen atoms can be replaced to form new compounds. Although fluorine atoms have strong electronegativity, they also have high reactivity. Due to their small atomic radius and large C-F bond energy, they participate in the reaction conditions or are more severe.

The carbonyl group in the molecule, that is, the C = O double bond of the pyridine-2-one part, is the active center of electrophilic reaction. It can react with nucleophilic reagents such as alcohols and amines to generate corresponding acetals, Schiff bases and other derivatives. In addition, the 5,6-dihydropyridine ring part, due to its unsaturation, can participate in the addition reaction, such as hydrogenation reaction with hydrogen under the action of appropriate catalyst, so that the pyridine ring is further saturated.

Furthermore, the methylene of the benzyl part is affected by the benzene ring and the pyridine ring, and α-hydrogen has a certain acidity. Under the action of a strong base, it can be taken away, triggering a subsequent series of reactions. The chemical properties of this compound are diverse, providing a broad application space for the field of organic synthesis, which can be used to prepare more complex and special functional organic compounds.

1- (3-chloro-4-fluorobenzyl) -5, what is the price of 6-dihydro-1H-pyridin-2-one in the market?

I haven't heard the market price of "1- (3-chloro-4-fluorobenzyl) -5,6-dihydro-1H-pyridine-2-one". This is a fine chemical, and its price often varies depending on quality, quantity, and supply.

If it is a high-purity high-quality product for scientific research, its price will be high due to the difficulty of preparation and the need for high-tech refining. Small purchases can reach hundreds of gold or even thousands of gold per gram.

If it is an industrial mass-produced product, and the quantity is quite large, the price may drop slightly. However, it also depends on the cost of production, such as raw materials, labor, equipment, etc. If the raw materials are easily available, the process is mature, and the large quantities are purchased, the price per kilogram or thousands of gold.

In addition, the demand and supply of the market also affect its price. If there are many people who want it, the supply will be few, and the price will rise; on the contrary, if the supply exceeds the demand, the price will tend to fall.

Furthermore, different places and different merchants have different prices. To know the exact price, you should consult the chemical raw material supplier, reagent supplier, or visit the chemical product trading platform to get a near-real price.