What is the chemical structure of 1- (2-fluorobenzyl) -1h-pyrazolo (3,4-b) pyridine-3-carboximidamide hydrochloride?

1- (2-fluorobenzyl) -1H-pyrazolo (3,4-b) pyridine-3-formamidine hydrochloride, this is an organic compound. According to its name, its chemical structure can be roughly analyzed. "1- (2-fluorobenzyl) " means that at position 1 of the molecular structure, there is a 2-fluorobenzyl group attached. This 2-fluorobenzyl group has a fluorine atom substituted at position 2 of the benzene ring, and the benzyl group is connected to the main structure. And "1H-pyrazolo (3,4-b) pyridine" indicates that the main structure is formed by fusing the pyrazole ring with the pyridine ring, and the fusing mode of the two is according to the (3,4-b) rule. Furthermore, "-3-formamidine" refers to the presence of a formamidine group at position 3 of the fused ring structure. Finally, "hydrochloride" means that this compound forms a salt of hydrochloric acid, and there will be corresponding ionic bonds in the structure. The chemical structure of this compound is composed of different groups with specific connection relationships, and each group affects each other, giving the compound specific chemical properties and reactivity.

What are the main uses of 1- (2-fluorobenzyl) -1h-pyrazolo (3,4-b) pyridine-3-carboximidamide hydrochloride?

1- (2-fluorobenzyl) -1H-pyrazolo (3,4-b) pyridine-3-formamidine hydrochloride has a wide range of uses. In the field of medicine, it is often used as a key intermediate to assist in the development of new drugs. Due to its specific chemical structure and biological activity, compounds with unique pharmacological properties can be chemically modified to treat various diseases such as inflammation, tumors and the nervous system.

In the field of organic synthesis, it is an important building block. With its special functional groups, it can participate in a variety of chemical reactions to build complex organic molecular structures, such as through condensation, substitution and other reactions, to synthesize organic materials with specific functions and structures, for use in photoelectric materials and other fields.

Furthermore, in biochemical research, it may serve as a tool molecule. With the help of specific interactions with biological macromolecules, researchers can explore biochemical processes and mechanisms in organisms, providing key clues for revealing the mysteries of life. In short, 1- (2-fluorobenzyl) -1H-pyrazolo (3,4-b) pyridine-3-formamidine hydrochloride is of great significance in many fields, promoting the development of medicine, materials and scientific research.

What is the preparation method of 1- (2-fluorobenzyl) -1h-pyrazolo (3,4-b) pyridine-3-carboximidamide hydrochloride?

The preparation of 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formamidine hydrochloride is an important step in chemical synthesis.

The selection of starting materials is crucial. Usually 2-fluorobenzyl halide and raw materials containing pyrazolo [3,4-b] pyridine structure are used as bases. First, 2-fluorobenzyl halide and pyrazolo [3,4-b] pyridine derivatives undergo nucleophilic substitution in organic solvents in the presence of suitable bases. For alkalis, such as potassium carbonate, sodium carbonate, etc., acetonitrile, N, N-dimethylformamide, etc. can be selected for organic solvents. This reaction requires temperature control, usually between 50 and 80 ° C. After several reactions, 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine intermediates can be obtained.

Then, this intermediate reacts with cyanamide or cyanamide derivatives under acid catalysis in a suitable solvent to form 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-carbamidine. The acid can be selected from hydrochloric acid, sulfuric acid, etc. The solvent is preferably ethanol and methanol, the temperature is maintained in the reflux state, and the reaction is carried out over time.

Finally, the obtained 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formamidine is treated with hydrochloric acid to obtain 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formamidine hydrochloride. During treatment, 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formamidine can be dissolved into an appropriate amount of organic solvent, an alcohol solution of hydrochloric acid is added dropwise, precipitated, filtered, and dried to obtain the target product. Throughout the preparation process, it is necessary to pay attention to the precise control of the reaction conditions and the appropriate proportion of materials, so as to obtain a higher yield and purity of 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formamidine hydrochloride.

What are the physicochemical properties of 1- (2-fluorobenzyl) -1h-pyrazolo (3,4-b) pyridine-3-carboximidamide hydrochloride?

1- (2-fluorobenzyl) -1H-pyrazolo (3,4-b) pyridine-3-formamidine hydrochloride, which is an organic compound. Its physical and chemical properties are as follows:

Looking at it, it may be a solid at room temperature, but the specific color and crystal form need to be observed by experiments. Its solubility, because it has a variety of polar groups, may have a certain solubility in polar solvents such as water and alcohols. However, due to hydrophobic structures such as benzene rings, its solubility in non-polar solvents such as alkanes may be limited.

When it comes to melting point, the melting point of organic amidine hydrochloride compounds is usually higher. The structure of this compound contains pyrazolopyridine ring and benzyl group, or further enhances the intermolecular force, and the melting point may be in a higher temperature range. However, the exact value needs to be accurately determined experimentally.

In terms of boiling point, in view of its relatively complex molecular structure and certain molecular weight, coupled with the existence of hydrogen bonds, van der Waals forces and other interactions between molecules, the boiling point may be higher.

In terms of stability, due to the existence of nitrogen-hydrogen bonds and carbon-nitrogen bonds in the molecule, it may be relatively stable under conventional conditions. However, in the case of strong acid, strong alkali environment, or special conditions such as high temperature and light, some chemical bonds may break, triggering chemical reactions. For example, in strong acids, the amido group or protonation causes chemical properties to change; in strong alkali environments, the substituents on the benzyl or pyridine ring may be replaced by nucleophiles.

Spectral properties also have characteristics. In infrared spectroscopy, nitrogen-hydrogen bonds, carbon-nitrogen bonds, carbon-hydrogen bonds, etc. will all produce absorption peaks at specific wavenumbers, which can be used for structural characterization; nuclear magnetic resonance spectroscopy, hydrogen and carbon atoms in different chemical environments will appear at the corresponding chemical shifts, which helps to determine the connection mode of each atom in the molecule and the chemical environment.

What is the market price of 1- (2-fluorobenzyl) -1h-pyrazolo (3,4-b) pyridine-3-carboximidamide hydrochloride?

I look at your question, but I am inquiring about the market price of 1- (2-fluorobenzyl) -1H-pyrazolo (3,4-b) pyridine-3-formamidine hydrochloride. However, the market situation of this drug is fickle, and the price also changes with many factors.

The determination of its price is primarily related to quality. If the quality is good, the purified essence, and the impurities are small, the price is high; the quality is the opposite. Furthermore, the source of production is also heavy. Different origins have different prices due to the difficulty of obtaining raw materials and the simplicity of the process. Large factories often rely on regulations and quality control to produce high-quality products, and the price is high; small factories have low costs, and the price is low, but the quality is unstable.

The amount of purchase also affects the price. If the purchase volume is huge, the supplier may give discounts in order to promote sales; if the quantity is small, it is difficult to enjoy discounts, and the unit price tends to rise. Market supply and demand are also critical. Demand is prosperous and supply is small, and prices are rising; if supply exceeds demand, prices will drop.

In addition, the number of circulation links and the level of transportation costs all affect the price. Multiple links increase costs, leading to price increases; efficient logistics reduces costs, which is beneficial to price stability.

To sum up, if you want to know the exact market price of this product, you need to consult pharmaceutical merchants, chemical raw material suppliers, or check relevant trading platforms. However, it is difficult to determine the number at the moment, because its price is in a dynamic change, and it is subject to various factors.