What is the main use of 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-carbonitrile

1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formonitrile has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate to help create new drugs. This is because of its specific chemical structure, which can interact with specific targets in organisms. For example, in the development of anti-tumor drugs, scientists modify the structure of this compound in the hope of enhancing its targeting and inhibitory activity against tumor cells.

In the field of materials science, 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formonitrile may be used to prepare special functional materials. Due to its unique optoelectronic properties, it is expected to be applied to optoelectronic devices such as organic Light Emitting Diodes (OLEDs) to improve the luminous efficiency and stability of the devices.

Furthermore, in the field of organic synthetic chemistry, it is an extremely important synthetic building block. Chemists can build more complex and unique organic compounds through various chemical reactions, expand the boundaries of organic synthesis chemistry, and provide a rich material foundation for the development of many fields such as materials science and medicinal chemistry. In short, 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formonitrile plays a key role in many scientific fields, promoting technological innovation and development in various fields.

What are the synthesis methods of 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-carbonitrile

The synthesis of 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formonitrile is an important topic in the field of organic synthetic chemistry. To synthesize this compound, there are several common methods as follows.

First, the compound containing the structure of pyridine and pyrazole is used as the starting material. First, the pyridine ring is properly modified, and a halogen atom is introduced at a specific position through a halogenation reaction. This halogen atom can be used as an active check point in subsequent reactions. At the same time, the pyrazole ring is functionalized to make it have the conditions for connecting to the pyridine ring. Subsequently, the coupling reaction catalyzed by transition metals, such as the coupling reaction catalyzed by palladium, is used to connect the pyridine to the pyrazole structure, and then the core skeleton of pyrazolo [3,4-b] pyridine is constructed. After that, through benzylation, 2-fluorobenzyl is introduced at a specific position. In this step, the appropriate base and reaction conditions need to be selected to ensure the selectivity of the reaction. Finally, the nitrile group is introduced through the nitrile reaction to achieve the synthesis of 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formonitrile. < Br >
Second, we can start from the perspective of constructing pyrazolo [3,4-b] pyridine rings. Using suitable bifunctional compounds as raw materials, the pyrazolo [3,4-b] pyridine skeleton is constructed by intramolecular cyclization reaction. During the cyclization reaction, the reaction conditions, such as temperature, solvent and catalyst dosage, need to be carefully regulated to promote the reaction to proceed in the desired direction. After the skeleton is formed, 2-fluorobenzyl is also introduced through benzylation reaction, and then methylnitrile is added through nitrile reaction to complete the synthesis of the target product.

Furthermore, the idea of reverse synthesis analysis can also be considered to disassemble the target molecule into multiple simple fragments. These fragments are synthesized separately, and then finally converged into the target product through a strategy of stepwise splicing. This method requires in-depth understanding and precise control of the synthesis and ligation reactions of each fragment to ensure the efficiency and accuracy of each step of the reaction, so as to successfully prepare 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formonitrile.

What are the physical properties of 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-carbonitrile

1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formonitrile is a kind of organic compound. Its physical properties are particularly important, and it is related to its application in many fields.

Looking at its appearance, it may be white to light yellow crystalline powder at room temperature and pressure. This form is easy to store and transport, and it also has certain advantages in subsequent chemical reaction operations because it is easy to weigh, mix and other treatments.

When it comes to melting point, the melting point of this compound may be within a specific range. Melting point is an important indicator for identifying the purity and characteristics of a compound. If the purity is quite high, the melting point range is narrow and similar to the theoretical value; if it contains impurities, the melting point may decrease and the melting range becomes wider. By measuring the melting point, the purity status of the compound can be preliminarily judged.

In terms of solubility, 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formonitrile behaves differently in different solvents. In common organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), or with certain solubility, this property makes it suitable for organic synthesis reactions, and suitable solvents can be selected to promote the reaction. In water, its solubility or poor, which is related to the hydrophilicity of the functional groups contained in the molecular structure of the compound. Most of its structures are hydrophobic groups, so it is difficult to dissolve in water.

Furthermore, its density is also a key physical property. The size of the density affects its distribution in solution and the proportional relationship when mixed with other substances. Accurately knowing its density is of great significance to the proportion and volume calculation of materials in actual production and experimental operations.

As for its stability, under normal storage conditions, without the influence of extreme environmental factors such as light, high temperature, and high humidity, 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formonitrile may remain relatively stable. When exposed to strong oxidizing agents, strong acids, strong bases and other chemicals, chemical reactions may occur, causing changes in its structure and properties.

What are the chemical properties of 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-carbonitrile

1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formonitrile, this is an organic compound. Its chemical properties are rich and unique.

Looking at its structure, the skeleton of pyrazolo [3,4-b] pyridine endows it with certain stability and special electron cloud distribution. Nitrogen atoms in this skeleton can participate in a variety of chemical reactions due to their electronegativity. Pyrazole rings are conjugated to pyridine rings, enhancing the conjugated system of molecules, affecting their electron transfer and spectral properties.

Its nitrile (-CN) activity is quite high. Nitrile groups can undergo hydrolysis reactions. Under acidic or basic conditions, they can be converted into carboxyl groups (-COOH), or partially hydrolyzed to form amide groups (-CONH ³). This property makes them an important intermediate in organic synthesis, and can be used to construct a variety of compounds containing carboxyl groups or amide groups.

Furthermore, the fluorine atom of the 2-fluorobenzyl part, due to the strong electronegativity of fluorine, affects the electron cloud density of benzyl groups, making the hydrogen atom on benzyl groups have different activities. At the same time, fluorine atoms also affect molecular fat solubility and biological activity, which is of great significance in the field of medicinal chemistry.

The 1-position nitrogen atom in this compound can be used as a nucleophilic check point to react with electrophilic reagents such as halogenated hydrocarbons, introduce more substituents, and expand the diversity of molecular structures.

Due to the interaction of various parts in the molecule, 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formonitrile has shown potential application value in many fields such as organic synthesis and drug development. Chemists can use its chemical properties to design and synthesize new functional compounds.

What is the price of 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-carbonitrile in the market?

I haven't heard of "1- (2 - fluorobenzyl) -1H - pyrazolo [3,4 - b] pyridine - 3 - carbonitrile" at the market price. This is a fine chemical, and its price often varies depending on quality, purity, supply and demand, and the amount purchased.

If it has high purity, and the preparation process is complicated, it requires multiple reactions and fine purification, the price may be high. If the market demand is small and the production supply is stable, the price may be relatively stable. If the purchase volume is large, the seller may give a discount due to small profits but quick turnover; if the purchase quantity is rare, the unit price may be higher.

However, we have not found the exact price information. If you want to know the price, you can consult chemical product suppliers, chemical trading platforms, or industry reports. These channels may provide more accurate price intelligence to help you know its market price.