What are the main application fields of 1- (2-Fluoro-benzyl) -1H-pyrazolo [3,4-b] pyridine-3-carboxamidine

1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formamidine has a wide range of main application fields. In the field of medicinal chemistry, this compound may have significant pharmacological activity or can be used as a key intermediate for the creation of new drugs. Because of its unique chemical structure, it may interact with specific targets in organisms, such as specific proteins, enzymes, etc., by regulating its function, or it is expected to develop therapeutic drugs for specific diseases, such as anti-tumor, anti-viral and other drugs.

In the field of organic synthesis, it can be used as a key synthetic building block. Organic synthesis aims to construct complex organic molecules. This compound can participate in various chemical reactions, such as nucleophilic substitution, electrophilic addition, etc., to help synthesize more complex and special functional organic molecules, and contribute to the development of organic synthetic chemistry.

In the field of materials science, after appropriate modification or modification, it may exhibit unique physical and chemical properties, such as optical and electrical properties, and then be applied to the research and development of new materials, such as optoelectronic materials, providing new directions and possibilities for the progress of materials science.

From this point of view, 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formamidine has potential application value and development prospects in many fields such as medicine, organic synthesis and materials science.

What are the synthesis methods of 1- (2-Fluoro-benzyl) -1H-pyrazolo [3,4-b] pyridine-3-carboxamidine

The synthesis method of 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formamidine is not directly described in Tiangong Kaiwu, but it can be derived from the principles of organic synthesis chemistry today, with reference to the wisdom of ancient books.

It is first necessary to prepare 2-fluorobenzyl halide, or it can be obtained by halogenation of 2-fluorotoluene. For example, with halogen elementals (chlorine, bromine, etc.), under the action of light or initiators, the hydrogen on the methyl group is replaced by a halogen atom to form 2-fluorobenzyl halide.

The synthesis of pyrazolo [3,4-b] pyridine-3-formonitrile is also key. It can be prepared by nitrile reaction of compounds containing the structure of pyridine ring and pyridine ring. For example, a suitable pyridine derivative is introduced into the pyrazole ring through a multi-step reaction, and then a cyano group is introduced at a specific position in the pyridine ring.

Then, 2-fluorobenzyl halide is reacted with pyrazolo [3,4-b] pyridine-3-formonitrile, which may be a nucleophilic substitution reaction. The halogen atom is replaced by the nucleophilic group in pyrazolo [3,4-b] pyridine-3-formonitrile to form 1- (2-fluorobenzyl) -pyrazolo [3,4-b] pyridine-3-formonitrile.

Finally, the formonitrile compound is converted to formamidine. Under the action of ammonia and appropriate catalysts, the cyano group can be aminolyzed, and the cyano group can be gradually converted to formamidine, resulting in 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formamidine. Although this specific synthesis is not contained in "Tiangong Kaiwu", the principles of synthetic chemistry today are also similar to the cognition of material transformation in ancient methods, and they all follow the laws of material properties and reactions to form the desired thing.

What are the physicochemical properties of 1- (2-Fluoro-benzyl) -1H-pyrazolo [3,4-b] pyridine-3-carboxamidine

1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formamidine, this is an organic compound. Its physicochemical properties are quite important for its application in many fields.

First, the appearance is usually solid, which is caused by intermolecular forces to appear solid at room temperature and pressure. Looking at its color, it may be white to off-white. This pure state is common in high-purity samples and changes in color due to impurities or causes.

In terms of melting point, it is a specific temperature range, which is the key physical property for identifying the compound. When the melting point is reached, the lattice structure is destroyed, and the molecules gain enough energy to leave the fixed position and turn from solid to liquid. The precise melting point is of great significance to quality control and purity evaluation, and can be accurately determined by differential scanning calorimetry or capillary melting point determination.

Solubility is also a key property. In organic solvents such as dichloromethane, N, N-dimethylformamide, it has a certain solubility. Because its molecular structure contains lipophilic groups, it can interact with organic solvent molecules. However, the solubility in water is limited, because of its strong overall hydrophobicity, the force between water molecules and compound molecules is weak, and it is difficult to overcome the force between compound molecules to disperse.

In terms of stability, it is relatively stable under normal storage conditions. However, when exposed to strong oxidizing agents, strong acids and bases, or chemical reactions cause structural changes. In high temperature and light environments, decomposition or other reactions may also be triggered, so it needs to be stored in a cool, dry and dark place.

The physicochemical properties of this compound provide an important basis for its synthesis, purification, analysis and practical application, and are of great significance in the fields of medicinal chemistry and materials science.

What is the price range of 1- (2-Fluoro-benzyl) -1H-pyrazolo [3,4-b] pyridine-3-carboxamidine in the market?

I have not obtained the exact information on the price range of 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formamidine in the market. If you want to know the price of this product, you can explore it from many ways.

First, you can visit various chemical trading platforms. Nowadays, many online platforms gather many chemical suppliers, and the prices of various compounds are often listed on them. Search for 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formamidine on such platforms under the name of fine, or you can get its price clue, and different suppliers have different prices depending on product purity and packaging specifications.

Second, consult chemical suppliers. Many professional suppliers specialize in the supply of various chemicals, and can be contacted directly by fax, mail or telephone to inquire about the price of 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formamidine. They can quote the exact price according to factors such as demand quantity and purity requirements.

Third, refer to relevant industry reports and literature. Some chemical industry reports or research literature, or market price analysis of specific chemicals. Although it may not be accurate to 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formamidine, the price trend of similar compounds may be useful for reference to help predict their price range.

It is unfortunate that I cannot directly state its price range today. I hope you can follow these paths to obtain the exact price information you need.

What is the stability of 1- (2-Fluoro-benzyl) -1H-pyrazolo [3,4-b] pyridine-3-carboxamidine

The stability of 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formamidine depends on its chemical structure, environment and many other factors.

Looking at its chemical structure, this compound contains the core structure of pyrazolopyridine, which is connected to fluorobenzyl and formamidine. In the structure of pyrazolopyridine, the nitrogen atom is bonded in a specific way to give it a certain stability, but the heterocyclic structure or active check point exists, which is easy to lead to chemical reactions. The fluorine atom on fluorobenzyl has strong electronegativity, which can affect the distribution of molecular electron clouds, make benzyl carbons more positively charged, or increase their reactivity, and then affect the overall stability. The nitrogen atom in formamidine has a solitary pair electron, which is nucleophilic and is also a potential reaction check point.

Due to environmental factors, the temperature increases, the molecular thermal motion intensifies, the energy increases, and the activation energy required for the reaction is easily reached, making the compound more reactive and the stability decreases. Under light, or lead to luminescent chemical reactions, destroy the molecular structure, such as the photoinduced defluorination reaction of fluorine atoms, and damage its stability. When the humidity is high, if the compound contains hydrolyzable groups, water may react with it to cause structural changes. In acidic and alkaline environments, check points such as formamidine groups are acidic and alkaline, and can react with acids and bases to cause stability changes. In case of oxidizing agents or reducing agents, compounds with redox activity check points can react, affecting stability.

In summary, the stability of 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formamidine is complex due to its own structural complexity and the changeable external environment. When using and storing, various factors need to be comprehensively considered to ensure its stability.