What is the chemical structure of 1- (2,6-difluorobenzyl) -3- (6-methoxypyridazine-3-yl) -5-methyl-6- (4-aminophenyl) thieno [2,3-d] pyrimidine-2,4 (1H, 3H) -dione

Today, there is a chemical problem related to the chemical structure of 1- (2,6-diethylamino) -3- (6-methoxypyridine-3-yl) -5-methyl-6- (4-hydroxybenzyl) imidazolo [2,3-d] pyrimidine-2,4 (1H, 3H) -dione. This is a rather complex organic compound. The analysis of its structure depends on the rules and principles of organic chemistry.

First look at its main structure, imidazolo [2,3-d] pyrimidine-2,4 (1H, 3H) -dione, which is a fused ring system, formed by fusing imidazolo ring and pyrimidine ring, and connected with carbonyl groups at positions 2 and 4, respectively. This is the core structure of the compound, giving it specific chemical activity and stability.

Looking at each substituent, there is 2,6-diethylamino in one position. This substituent is connected to the host by a nitrogen atom, and the ethylamino group has a certain electron-giving effect, or affects the electron cloud distribution and reactivity of the host. The 3-position 6-methoxypyridine-3-yl, the pyridine ring is a nitrogen-containing aromatic ring, the methoxy group is connected to the 6-position of the pyridine, and the 3-position of the pyridine is connected to the main body. The presence of this substituent will also affect the electronic properties and spatial configuration of the overall structure. The 5-position methyl group is a simple alkyl substituent. Although the structure is relatively simple, it also contributes to the physical and chemical properties of the compound, such as affecting the lipophilic properties of the molecule. The 6-position 4-hydroxybenzyl group, benzyl is benzyl, and the 4-position is connected with a hydroxyl group. This substituent contains both the aromatic properties of the benzene ring and the active hydrogen of the hydroxyl group, which can participate in a variety of chemical reactions.

In summary, the chemical structure of this compound is composed of a core fused ring structure and multiple different substituents, and the interaction of each part determines its unique chemical and physical properties.

What are the main physical properties of 1- (2,6-difluorobenzyl) -3- (6-methoxypyridazine-3-yl) -5-methyl-6- (4-aminophenyl) thieno [2,3-d] pyrimidine-2,4 (1H, 3H) -dione

2,4-Dinitro has various important physical properties. Its properties are mostly yellow crystals, which are relatively stable at room temperature, but have high chemical activity.

When it comes to the melting point, 2,4-dinitro is about 118 ° C, which makes it change state under specific temperature conditions. In terms of boiling point, it is easy to decompose due to heat, and there is no exact boiling point. It decomposes into many products when heated.

2,4-dinitro has a density greater than that of water, about 1.594g/cm ³. It is insoluble in water, but easily soluble in organic solvents such as acetone and benzene. Its solubility brings convenience to separation and purification.

Furthermore, 2,4-dinitro is volatile to a certain extent and will slowly evaporate in the air, emitting a special odor. Because of the nitro group in its chemical structure, it is oxidizing and can react with reducing substances.

In addition, 2,4-dinitro is flammable and explosive. In case of open flames and hot topics, it is easy to burn and explode. Strict safety regulations must be followed for storage and use to ensure safety.

What is the synthesis method of 1- (2,6-difluorobenzyl) -3- (6-methoxypyridazine-3-yl) -5-methyl-6- (4-aminophenyl) thieno [2,3-d] pyrimidine-2,4 (1H, 3H) -dione?

To make 1-%282%2C6-%E4%BA%8C%E6%B0%9F%E8%8B%84%E5%9F%BA%29-3-%286-%E7%94%B2%E6%B0%A7%E5%9F%BA%E5%93%92%E5%97%AA-3-%E5%9F%BA%29-5-%E7%94%B2%E5%9F%BA-6-%284-%E6%B0%A8%E5%9F%BA%E8%8B%AF%E5%9F%BA%29%E5%99%BB%E5%90%A9%E5%B9%B6%5B2%2C3-d%5D%E5%98%A7%E5%95%B6-2%2C4%281H%2C3H%29-%E4%BA%8C%E9%85%AE, you can follow the following methods.

First take an appropriate amount of 2,6-diethylamino raw material, and through specific reaction conditions, make it work ingeniously with related reagents. In this process, it is necessary to precisely control the temperature, time and the ratio of reactants to promote the reaction in the desired direction.

Furthermore, properly handle the 6-methoxypyridine-3-based raw material, so that it reacts with specific reagents in a suitable environment. The key to this step is to fine-tune the reaction conditions, such as pH and reaction time, to ensure the smooth progress of the reaction.

Then, the raw materials such as 5-methyl and 4-hydroxybenzyl are integrated into the reaction system in the appropriate proportion. At this time, the reaction is like a delicate dance. The raw materials are intertwined and reacted under specific conditions, and the basic structure of the target product is gradually constructed.

During the reaction, it is necessary to use modern analytical methods, such as chromatography and spectroscopy, to monitor the reaction process in real time to gain insight into the depth of the reaction and the purity of the product. If there is any deviation, immediately adjust the reaction conditions, such as fine-tuning the temperature and increasing or decreasing the amount of reagents, so that the reaction can return to the right track.

After the reaction is generally completed, multiple purification processes are required. Methods such as extraction, crystallization, column chromatography, etc. remove impurities and improve the purity of the product. This is an act of excellence to make the product meet the required high standards.

The whole synthesis process requires the experimenter to have exquisite skills, rigorous attitude, and insight into each step to obtain a pure 1-%282%2C6-%E4%BA%8C%E6%B0%9F%E8%8B%84%E5%9F%BA%29-3-%286-%E7%94%B2%E6%B0%A7%E5%9F%BA%E5%93%92%E5%97%AA-3-%E5%9F%BA%29-5-%E7%94%B2%E5%9F%BA-6-%284-%E6%B0%A8%E5%9F%BA%E8%8B%AF%E5%9F%BA%29%E5%99%BB%E5%90%A9%E5%B9%B6%5B2%2C3-d%5D%E5%98%A7%E5%95%B6-2%2C4%281H%2C3H%29-%E4%BA%8C%E9%85%AE product.

1- (2,6-difluorobenzyl) -3- (6-methoxypyridazine-3-yl) -5-methyl-6- (4-aminophenyl) thieno [2,3-d] pyrimidine-2,4 (1H, 3H) -dione What are the applications in the field of medicine

1-%282%2C6-%E4%BA%8C%E6%B0%9F%E8%8B%84%E5%9F%BA%29-3-%286-%E7%94%B2%E6%B0%A7%E5%9F%BA%E5%93%92%E5%97%AA-3-%E5%9F%BA%29-5-%E7%94%B2%E5%9F%BA-6-%284-%E6%B0%A8%E5%9F%BA%E8%8B%AF%E5%9F%BA%29%E5%99%BB%E5%90%A9%E5%B9%B6%5B2%2C3-d%5D%E5%98%A7%E5%95%B6-2%2C4%281H%2C3H%29-%E4%BA%8C%E9%85%AE%E7%9F%A5%E4%B9%8E%E8%80%85, this is the expression of a class of chemical substances, which is widely used in the field of medicine.

The structure of such compounds contains many specific chemical groups, which endow them with unique chemical properties and biological activities. In terms of its medical applications, one of them can be used as a pharmaceutical active ingredient. Because specific groups interact with human biological macromolecules, such as proteins, nucleic acids, etc., or can regulate physiological and biochemical processes in organisms, and then treat related diseases.

Furthermore, such compounds may be used as lead compounds for drug development. Researchers can modify and optimize their structures based on their structural characteristics to improve their pharmacological activity and reduce toxic and side effects, so as to develop safer and more effective new drugs.

In addition, in the field of drug synthesis, it may be used as an important intermediate. Through a series of organic synthesis reactions, combined with other chemical substances, more complex drug molecular structures are constructed to help create new drugs.

In short, 1-%282%2C6-%E4%BA%8C%E6%B0%9F%E8%8B%84%E5%9F%BA%29-3-%286-%E7%94%B2%E6%B0%A7%E5%9F%BA%E5%93%92%E5%97%AA-3-%E5%9F%BA%29-5-%E7%94%B2%E5%9F%BA-6-%284-%E6%B0%A8%E5%9F%BA%E8%8B%AF%E5%9F%BA%29%E5%99%BB%E5%90%A9%E5%B9%B6%5B2%2C3-d%5D%E5%98%A7%E5%95%B6-2%2C4%281H%2C3H%29-%E4%BA%8C%E9%85%AE in the field of medicine is like a jade, which has been carved and developed, and is expected to bring many benefits to human health and promote the progress and development of medical science.

What are the precautions in the preparation of 1- (2,6-difluorobenzyl) -3- (6-methoxypyridazine-3-yl) -5-methyl-6- (4-aminophenyl) thieno [2,3-d] pyrimidine-2,4 (1H, 3H) -dione?

In the process of preparing 2,4 (1H, 3H) -dione, many key matters need to be paid attention to.

First, the quality of the raw materials is of paramount importance. Raw materials such as 2,6-diethylamino and 6-methoxy-3-pyridyl-3-yl must meet the purity standard, and impurities will seriously interfere with the reaction process, resulting in poor product purity. When purchasing, high-quality suppliers should be selected, and the purity of raw materials should be strictly tested.

Second, precise control of reaction conditions is indispensable. In terms of temperature, different stages of reaction have strict temperature requirements. If there is a slight deviation, the reaction rate and product generation will be affected, or side reactions will occur frequently. Taking a similar reaction as an example, the temperature is too high, the by-products increase, and the target yield decreases. The pressure cannot be ignored either. The appropriate pressure ensures the smooth progress of the reaction, and it needs to be adjusted reasonably according to the reaction characteristics and equipment conditions.

Third, the use of catalysts needs to be cautious. Suitable catalysts can speed up the reaction rate and increase the yield, and should be carefully selected according to the reaction mechanism and characteristics. At the same time, the amount of catalyst is exquisite. Too much or too little is not conducive to the reaction, and the best amount needs to be determined by experiment.

Fourth, the monitoring of the reaction process is extremely critical. With the help of modern analytical methods, such as chromatography, spectroscopy, etc., the reaction process can be monitored in real time to detect whether the reaction is going as expected. If there is an abnormality, the reaction conditions can be adjusted in a timely manner to avoid resource waste and product loss.

Fifth, safety issues should not be underestimated. A variety of chemical substances are involved, some of which are toxic, corrosive or flammable and explosive. Be sure to strictly follow safety procedures when operating, wear protective equipment, ensure that the experimental environment is well ventilated, properly dispose of waste, and prevent environmental pollution and safety accidents.