What is the chemical structure of N- [3- [5- (2-aminopyrimidin-4-yl) -2-tert-butyl-1,3-thiazol-4-yl] -2-fluorophenyl] -2, 6-difluorobenzenesulfonamide?

This is a rather complex organic compound. Its name is lengthy and has many specific group descriptions. To clarify its chemical structure, it should be disassembled and dissected by self-naming.

"N - [3- [5- (2-aminopyrimidine-4-yl) -2 -tert-butyl-1,3-thiazole-4-yl] -2 -fluorophenyl] -2,6 -difluorobenzenesulfonamide". "N -" indicates that this is a nitrogen-linked compound. "[ 3 - [5- (2-aminopyrimidine-4-yl) -2-tert-butyl-1,3-thiazole-4-yl] -2-fluorophenyl] ", this section describes a benzene ring, the benzene ring is connected to a complex structure at position 3, which contains 5- (2-aminopyrimidine-4-yl) -2-tert-butyl-1,3-thiazole-4-yl, and the benzene ring has a fluorine atom at position 2." -2,6-difluorobenzenesulfonamide "means A 2,6-difluorobenzenesulfonyl group is attached to the other side of the nitrogen atom by an amide bond.

In summary, the core of its chemical structure is a nitrogen atom connected to a benzene ring with a specific substituent on one side, and a difluorobenzene sulfonyl group on the other side. The substituent on the benzene ring contains heterocyclic structures such as pyrimidine and thiazole, presenting a complex and delicate structure of organic compounds.

What are the physical properties of N- [3- [5- (2-aminopyrimidin-4-yl) -2-tert-butyl-1,3-thiazol-4-yl] -2-fluorophenyl] -2, 6-difluorobenzenesulfonamide?

This is an organic compound with a rather complex structure. Its physical properties can be discussed from the following aspects:

In terms of color state, such organic compounds containing nitrogen, sulfur and polyaromatic rings may be crystalline solids under normal conditions. Due to the interaction between molecules such as van der Waals forces and hydrogen bonds, the molecules are arranged in an orderly manner, and then they are solid states. Looking at its structure, due to the conjugated system, it may have a certain color or be a white to light yellow solid.

On the melting point, due to the complex molecular structure and a large number of aromatic rings and polar groups, the intermolecular forces are strong, so the melting point may be higher. The presence of aromatic rings increases the contact area between molecules, and the van der Waals force is enhanced; polar groups such as amino and sulfonamide groups can form hydrogen bonds, further strengthening the intermolecular bonding force, so that higher temperatures are required to overcome these forces and realize the transition from solid to liquid.

In terms of solubility, the solubility in water may be limited. Although the molecule contains polar groups such as amino and sulfonamide groups, which can form hydrogen bonds with water, a large proportion of hydrophobic aromatic rings and tert-butyl groups in the overall structure is relatively large, and its hydrophilicity is suppressed according to the principle of "similar miscibility". In organic solvents, or due to polar differences, its solubility varies. For example, in polar organic solvents such as dimethyl sulfoxide (DMSO) and N, N-dimethylformamide (DMF), the solubility may be relatively high due to the interaction with polar groups in the molecule; in non-polar organic solvents such as n-hexane, the solubility may be extremely low.

In terms of stability, in view of the stable structure of the aromatic ring in the molecule, it is not easy to occur reactions such as ring opening under general conditions. However, functional groups such as amino groups and sulfonamido groups have certain reactivity. Under extreme conditions such as strong acids, strong bases or high temperatures, hydrolysis or substitution reactions may occur. For example, amino groups can react with acids to form salts, and sulfonamido groups can be hydrolyzed under strong alkaline conditions. In addition, the thiazole ring part containing sulfur, or due to the existence of sulfur atoms, under specific oxidation conditions, or the oxidation reaction of sulfur occurs, which affects the stability of the compound.

What are the main uses of N- [3- [5- (2-aminopyrimidin-4-yl) -2-tert-butyl-1,3-thiazol-4-yl] -2-fluorophenyl] -2, 6-difluorobenzenesulfonamide?

N- [3- [5- (2-aminopyrimidine-4-yl) -2-tert-butyl-1,3-thiazole-4-yl] -2-fluorophenyl] -2, 6-difluorobenzenesulfonamide, this is an organic compound. However, such modern chemical terms are rarely found in ancient texts, so I will speculate on their uses in ancient Chinese.

Today's chemistry can make all kinds of medicines. This compound may be related to the field of medicine and is a raw material or intermediate for pharmaceuticals. Medicine, saving people's pain, is related to life and death. Or because of its unique structure and specific biological activity, it can interact with biological macromolecules such as proteins and nucleic acids in the body, and then regulate physiological and pathological processes.

Or in the field of pesticides. It can kill pests, inhibit pathogens, maintain the strength of crops, and protect the food of the people. Due to the characteristics of structure and activity, it can precisely act on specific targets of pests or pathogens, effectively eliminate pests, and have little impact on the environment.

Furthermore, it is also possible in the field of materials science. After special treatment, it can improve the properties of materials, such as enhancing the stability and conductivity of materials, etc., and be used to manufacture high-tech materials, contributing to the advancement of science and technology. Although there is no such word in ancient times, it is deduced from today's science. It has many uses and has a profound impact on human life.

What are the synthesis methods of N- [3- [5- (2-aminopyrimidin-4-yl) -2-tert-butyl-1,3-thiazol-4-yl] -2-fluorophenyl] -2, 6-difluorobenzenesulfonamide?

The synthesis method of N- [3- [5- (2-aminopyrimidine-4-yl) -2-tert-butyl-1,3-thiazole-4-yl] -2-fluorophenyl] -2, 6-difluorobenzenesulfonamide is the key research content in the field of organic synthetic chemistry. The synthesis process can probably follow the following methods.

First, use 2-aminopyrimidine-4-formaldehyde as the starting material, and first carry out condensation reaction with tert-butyl thiourea. This reaction needs to be carried out in a suitable solvent, such as ethanol or dichloromethane, catalyzed by acid or base. After condensation, 5- (2-aminopyrimidine-4-yl) -2-tert-butyl-1,3-thiazole-4-formic acid intermediate is formed. Subsequently, this intermediate undergoes nucleophilic substitution with 2-fluoro-3-halobenzoic acid derivatives to construct structures containing thiazole and fluorobenzene. In this step, the halogen atom activity of the halobenzoic acid derivative is very critical, and chlorine, bromine or iodine atoms can be considered. However, the reaction conditions need to be adjusted according to the activity of the halogen atom.

Second, we can start from 2-fluoro-3- (5-substituted-1,3-thiazole-4-yl) aniline. First, the amino group of the aniline is properly protected, such as tert-butoxycarbonyl (Boc). Next, it is reacted with 2,6-difluorobenzenesulfonyl chloride in the presence of a base, such as triethylamine or pyridine, to generate the corresponding sulfonamide. After that, the protective group of the amino group is removed, and then the thiazole ring is introduced into the 2-aminopyrimidine-4-group at the 5-position under suitable reaction conditions.

Third, a convergent synthesis strategy can also be used. Thiazole fragments containing 2-aminopyrimidine-4-yl and 2,6-difluorobenzenesulfonamide fragments are synthesized respectively, and then the two are connected by suitable linking reactions, such as carbon-carbon bond formation reactions, such as Suzuki coupling reaction or Negishi coupling reaction. This strategy requires the selection of suitable halogenates or borate derivatives as reaction substrates, and the reaction conditions, such as catalysts, bases and solvents, are finely regulated to achieve ideal yields and selectivity.

The above synthesis methods have their own advantages and disadvantages, and they need to be selected according to the actual availability of raw materials, the ease of control of reaction conditions, and the purity requirements of the target product.

N- [3- [5- (2-aminopyrimidin-4-yl) -2-tert-butyl-1,3-thiazol-4-yl] -2-fluorophenyl] -2, 6-difluorobenzenesulfonamide What are the relevant safety precautions?

This is N- [3- [5- (2-aminopyrimidine-4-yl) -2-tert-butyl-1,3-thiazole-4-yl] -2-fluorophenyl] -2, 6-difluorobenzenesulfonamide, which involves many safety precautions and needs to be taken with caution.

This substance is chemically complex or potentially hazardous. When handling, it is necessary to wear appropriate protective equipment, such as protective clothing, gloves and goggles, to prevent skin-to-eye contact. Because it may be irritating, if you accidentally touch it, you should quickly rinse with plenty of water and seek medical attention.

The operating environment is also crucial. It is necessary to ensure good ventilation to prevent the accumulation of harmful gases. During the disposal process, do not eat, drink, smoke, and avoid the oral intake of harmful substances.

In terms of storage, it should be placed in a cool, dry and ventilated place, away from fire and heat sources, and stored separately from oxidants and acids. Do not mix storage to prevent dangerous reactions. When transporting, follow relevant regulations to ensure that the packaging is complete, the loading is secure, and the leakage is prevented.

Furthermore, personnel who use this product should be professionally trained and familiar with its safety operating procedures and emergency treatment methods. In the event of an emergency such as a leak, personnel in the contaminated area should be quickly evacuated to a safe area and quarantined, and access should be strictly restricted. Emergency responders must wear self-contained positive pressure breathing apparatus and anti-virus clothing. Do not let leaks come into contact with combustible substances. Small leaks can be mixed with sand, dry lime or soda ash. Large leaks need to be built embankments or dug for containment, and transferred to a tanker or a special collector for recycling or transported to a waste treatment site for disposal. In short, treat this object as if it is in an abyss, like walking on thin ice, to ensure safe operation.