What is the chemical structure of N- (1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-yl) -4-fluorobenzenesulfonamide?

This is a structural problem of organic compounds. The name of the compound is verbose and complex, and it contains many functional group descriptions. According to this name, the positional relationship between its main structure and functional groups can be known step by step.

"N- (1,5-dimethyl-3-oxo-2-benzyl-2,3-dihydro-1H-indole-4-yl) -4-fluorobenzamide". First, "1H-indole" is the core parent structure of this compound, which has the characteristics of nitrogen-containing heterocycles. On the basis of the indole ring, "1,5-dimethyl" indicates that there is a methyl group attached to the 1st and 5th positions of the indole ring; "3-oxo" means that the 3rd position is replaced by an oxo group; "2-benzyl" means that the 2nd position is connected with benzyl; "2,3-dihydrogen" means that the double bond between the 2nd and 3rd positions is reduced to a single bond. And "N- (1,5-dimethyl-3-oxo-2-benzyl-2,3-dihydro-1H-indole-4-yl) " part as a whole as a substituent for the nitrogen atom in the amide group.

Furthermore, the "4-fluorobenzyl amide" part indicates that the other part of the amide structure connected to the nitrogen atom is 4-fluorobenzyl, that is, the benzene ring of benzyl is replaced by a fluorine atom.

In summary, the chemical structure of this compound is composed of an amide structure composed of indole derivatives containing specific substituents and 4-fluorobenzyl groups. The position and type of each functional group determine its unique chemical properties and reactivity.

What are the main uses of N- (1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-yl) -4-fluorobenzenesulfonamide?

N- (1,5-dimethyl-3-oxo-2-furyl-2,3-dihydro-1H-pyrrole-4-yl) -4-fluorobenzenesulfonamide is an important organic compound with a wide range of uses. It can be used as a key intermediate in drug development in the field of medicine. By modifying and modifying its structure, it can create new drugs with specific biological activities and pharmacological properties, or show therapeutic effects for specific diseases, such as anti-tumor, antibacterial, anti-inflammatory and many other diseases. It is also an important raw material in the field of organic synthesis, which can participate in many organic reactions and lay the foundation for the construction of more complex organic molecular structures. With its unique structure and reactivity, it can react with other compounds through specific reaction paths to synthesize organic materials with special functions or structures, and play a role in the field of materials science, such as for the synthesis of new materials with specific optical and electrical properties.

In the field of scientific research, this compound provides an effective tool for studying the mechanism of organic reactions and exploring intermolecular interactions. Scientists can deepen their understanding of the basic theory of organic chemistry by studying its reaction process and properties, and contribute to the development of organic chemistry.

What is the synthesis method of N- (1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-yl) -4-fluorobenzenesulfonamide?

To prepare N- (1,5-dimethyl-3-oxo-2-furyl-2,3-dihydro-1H-pyrrole-4-yl) -4-bromobenzenesulfonamide, the following method can be used.

First take 1,5-dimethyl-2-furanoic acid, heat it with an appropriate dehydrating agent, and perform a dehydration reaction to obtain 1,5-dimethyl-2-furanoyl chloride. This reaction requires attention to the reaction temperature and the amount of dehydrating agent to ensure that the reaction is sufficient.

Take pyrrole and react it with the prepared 1,5-dimethyl-2-furanoyl chloride in an inert solvent in the presence of a suitable catalyst. During the reaction, temperature control is required to generate 1,5-dimethyl-3-oxo-2-furanyl-2,3-dihydro-1H-pyrrole. In this step, the type and dosage of catalysts, reaction time, etc. have an impact on the formation of the product and must be carefully regulated.

The product obtained above is reacted with a brominating agent under specific conditions to bromide the 4-position of the pyrrole ring to obtain 1,5-dimethyl-3-oxo-2-furyl-2,3-dihydro-4-bromo-1H-pyrrole. The choice of brominating agent and the control of the reaction environment are very critical to ensure the accuracy of the bromination position.

Take another 4-bromobenzenesulfonamide and combine it with 1,5-dimethyl-3-oxo-2-furyl-2,3-dihydro-4-bromo-1H-pyrrole in the presence of basic reagents. Condensation reaction is carried out in a suitable solvent. In this step, attention should be paid to the strength and dosage of basic reagents, and the polarity of the solvent will also affect the reaction rate and product yield. Through this series of reactions, the target product N- (1,5-dimethyl-3-oxo-2-furyl-2,3-dihydro-1H-pyrrole-4-yl) -4 -bromobenzenesulfonamide can be obtained. After each step of the reaction, it is necessary to follow appropriate separation and purification methods, such as extraction, column chromatography, etc., to obtain a purified product, so that the next step of the reaction can proceed smoothly.

What are the physical and chemical properties of N- (1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-yl) -4-fluorobenzenesulfonamide?

N- (1,5-dimethyl-3-oxo-2-benzyl-2,3-dihydro-1H-indole-4-yl) -4-fluorobenzamide is one of the organic compounds. Its physical and chemical properties are quite unique.

Looking at its physical properties, under normal temperature and pressure, this substance may be in a solid state, because it contains many cyclic structures and polar groups, and the intermolecular forces are strong. Its melting point depends on the specific arrangement and interaction of molecules, but it is speculated that it should be in a relatively high temperature range, because many stable forces are formed in the molecule, and more energy is required to destroy the lattice structure.

When it comes to solubility, because it has both polar and non-polar parts, it may have a certain solubility in organic solvents. The polar carbonyl group and amide group can interact with some polar organic solvents such as ethanol and acetone to form hydrogen bonds, and then dissolve; while the non-polar benzyl group and benzene ring also have a certain solubility in non-polar organic solvents such as toluene and dichloromethane. However, in water, due to its large proportion of the overall hydrophobic part, the solubility may be low.

In addition to chemical properties, amide bonds are an important activity check point. Amide bonds are relatively stable, but in strong acid or strong alkali environments, hydrolysis reactions can occur. Under acidic conditions, protons first combine with carbonyl oxygen to enhance the positive electricity of carbonyl carbon, and water molecules attack carbonyl carbon. After a series of reactions, the amide bond breaks and the corresponding carboxylic acid and amine are formed. Under basic conditions, hydroxide ions attack carbonyl carbon, which also promotes the hydrolysis of amide bonds to form carboxylic salts and amines.

In addition, the aromatic ring part of the molecule, such as the indole ring and the benzene ring, can undergo aromatic electrophilic substitution reactions. Due to the high electron cloud density of aromatic rings, they are vulnerable to attack by electrophilic reagents. For example, in the presence of a suitable catalyst, a Fu-gram alkylation reaction can occur with halogenated hydrocarbons to introduce alkyl groups on aromatic rings; or a Fu-gram acylation reaction can occur with acyl halides to introduce acyl groups.

In addition, benzyl α-hydrogen in the molecule has a certain activity. Due to the certain stability of benzyl carbocation cations, under the action of strong bases, α-hydrogen can be captured, and then reactions such as nucleophilic substitution or elimination occur.

What is the market prospect of N- (1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-yl) -4-fluorobenzenesulfonamide?

N- (1,5-dimethyl-3-oxo-2-benzyl-2,3-dihydro-1H-indole-4-yl) -4-fluorobenzenesulfonamide, the market prospect of this compound is quite promising. Looking at the current situation of pharmaceutical research and development, many scientific research teams are enthusiastic about exploring new compounds. Such substances with unique chemical structures are likely to emerge in the field of innovative drug development.

From the pharmacological activity level, the structural characteristics of the compound may endow it with various biological activities. For example, its specific group combination may be able to precisely act on certain disease-related targets, such as specific signaling pathway proteins in tumor cells, or neurotransmitter receptors associated with neurological diseases. If it can be confirmed that it has a significant effect on these targets, it will undoubtedly open up a new path for the development of anti-tumor drugs and drugs for the treatment of neurological diseases.

Looking at the market demand, with the improvement of public health awareness and the intensification of population aging, the demand for new and efficient drugs is increasing day by day. If this compound can be successfully developed into an innovative drug, it is expected to gain a place in the highly competitive pharmaceutical market due to its unique structure and potential pharmacological activity. Whether it is in the domestic or international market, the drug market for tumors, neurological diseases and other fields is extremely large. As long as the product has sufficient efficacy and safety, the market prospect must be broad.

However, the challenges that exist cannot be ignored. Compounds need to go through many rigorous links from laboratory research and development to market, such as drug safety evaluation, clinical trials, etc. Only by successfully overcoming these difficulties can they truly go to market and realize their commercial value. But overall, N- (1,5-dimethyl-3-oxo-2-benzyl-2,3-dihydro-1H-indole-4-yl) -4-fluorobenzenesulfonamide has considerable development potential and prospects in the pharmaceutical market due to its unique structure and potential activity.