What are the main uses of m-Fluorobenzenethiol?

M-Fluorobenzenethiol (m-Fluorobenzenethiol) is also an organic compound. It has a wide range of uses and has important applications in various fields of chemical industry.

First, in the synthesis of medicine, m-Fluorobenzenethiol can be a key intermediate. When doctors make some specific drugs, they often rely on this compound to build the specific structure of drug molecules. Because of its fluorine atoms and thiophenol groups, it can endow drugs with unique biological activities and pharmacological properties. For example, it can affect the ability of drugs to bind to targets in vivo, thereby improving the efficacy and selectivity of drugs, and helping to create more precise and effective therapeutic drugs.

Second, in the field of materials science, m-Fluorobenzenethiol also plays an important role. When preparing special functional materials, it can be used as a modifier or reactive monomer. For example, when preparing optoelectronic materials, the introduction of m-fluoro-thiophenol structure can adjust the electron cloud distribution of the material and the interaction between molecules, thereby optimizing the photoelectric properties of the material, such as fluorescence emission, charge transport and other characteristics, so that the material shows better application potential in optoelectronic devices, such as organic Light Emitting Diodes, solar cells and other fields.

Third, in the field of organic synthetic chemistry, m-fluoro-thiophenol is a commonly used reagent. Chemists can participate in many organic reactions, such as nucleophilic substitution and oxidative coupling, by taking advantage of its active reactivity of thiophenol groups. Therefore, complex organic molecular structures can be constructed, providing a powerful tool for the development of organic synthetic chemistry, assisting in the synthesis of new organic compounds, and expanding the research boundaries of organic chemistry.

What are the physical properties of m-Fluorobenzenethiol?

M-Fluorobenzenethiol, or m-Fluorobenzenethiol, is an organic compound with unique physical properties.

It is mostly liquid at room temperature, and its appearance may be colorless to light yellow transparent liquid. Due to the structure of thiophenol, it emits a special and pungent smell, similar to the odor of common thiophenol compounds, which can be detected by those with a keen sense of smell.

The boiling point of m-Fluorobenzenethiol is about 195-197 ° C, which is determined by intermolecular forces and relative molecular mass. Its melting point is about -15 ° C, and it may solidify at low temperatures.

In terms of solubility, m-Fluorobenzenethiol is slightly soluble in water. Because the phenyl ring in the molecule is connected to the sulfur atom, it is a non-polar or weakly polar structure, which is very different from the polarity of water molecules. According to the principle of "similar miscibility", it is difficult to dissolve in water. However, it is soluble in a variety of organic solvents, such as ethanol, ether, dichloromethane, etc. The polarity of these organic solvents is similar to that of m-fluorothiophenol or can form intermolecular forces with it to promote its dissolution.

The density of m-fluorothiophenol is about 1.24 g/cm ³, which is heavier than water. If mixed with water and insoluble, it will sink to the bottom of the water.

The vapor pressure has a corresponding value at a specific temperature. Although the vapor pressure is not high, due to the volatile existence, a certain vapor concentration may be formed in the air, and the pungent smell should be paid attention to ventilation when using.

In addition, m-fluorothiophenol has certain chemical activity. The sulfur atom in the thiophenol group has lone pair electrons, which is easy to participate in chemical reactions, such as nucleophilic substitution, oxidation, etc. It is an important intermediate in the field of organic synthesis.

What is the chemistry of m-Fluorobenzenethiol?

M-Fluorobenzenethiol, or m-fluorobenzenethiol, is a family of organic compounds. It is active and has special chemical properties because it contains a thiohydrogen group (-SH).

From the perspective of reactivity, the sulfur atom in the -SH group has lone pair electrons, which are easy to participate in chemical reactions. This group is more acidic than the alcohol hydroxyl group. Because the radius of the sulfur atom is larger than that of the oxygen atom, the binding force on the hydrogen atom is weak, so the hydrogen atom is more likely to dissociate and exhibit acidity. In an alkaline environment, it is easy to react with bases to form corresponding salts.

Nucleophilicity is also its important property. The lone pair electrons on the sulfur atom make it nucleophilic and can undergo nucleophilic substitution reactions with electrophil If it reacts with halogenated hydrocarbons, thioether compounds are formed. This property makes it a key intermediate for the construction of sulfur-containing compounds in organic synthesis.

In addition, the fluorine atom in isafluorothiophenol also affects its properties. Fluorine atoms have strong electronegativity and can absorb electrons, which decreases the electron cloud density of the phenyl ring and changes the activity of the phenyl ring electrophilic substitution reaction. Compared with unfluorinated thiophenol, the electrophilic substitution reaction of isafluorothiophenol may be more difficult to occur, and the reaction check point may vary due to the localization effect of fluorine atoms.

In terms of oxidation reactions, the -SH group can be oxidized by a variety of oxidants. Under mild oxidation conditions, disulfides can be formed; when strong oxidants act, they can be further oxidized to sulfoxides or sulfones.

In short, m-Fluorobenzenethiol has unique chemical properties due to its -SH group and fluorine atom. It may have potential application value in organic synthesis, materials science and other fields. It can be used as a raw material for the synthesis of special functional materials and pharmaceutical intermediates, assisting chemists in creating new compounds and expanding the boundaries of organic chemistry research.

What are m-Fluorobenzenethiol synthesis methods?

The method of preparing m-fluorothiophenol follows several paths. One is to start with fluorine-containing aromatic hydrocarbons and make them respond to sulfur sources. If m-fluorobromobenzene is used as the substrate, under suitable conditions, it is heated and refluxed in the solvent with sulfur sources such as sodium hydrosulfide or thiourea, and the process of nucleophilic substitution can obtain m-fluorothiophenol. Among these, the properties of the solvent, the control of temperature, and the ratio of the reactants are all important factors. The selection of suitable polar aprotic solvents, such as N, N-dimethylformamide (DMF), can promote the progress of the reaction. The temperature setting, depending on the properties of the substrate and the reagent, is usually between 60 and 120 ° C. If the temperature is too low, the reaction rate is slow; if it is too high, the side reaction will occur.

Another method starts with m-fluorobenzoic acid, first converts to the corresponding acyl halide, and then reacts with thioreagents, and then obtains it through reduction steps. For example, m-fluorobenzoic acid reacts with thionyl chloride to form m-fluorobenzoyl chloride, and then reacts with thiol or thiourea to form sulfur-containing intermediates, and finally reacts with reducing agents such as lithium aluminum hydride to obtain m-fluorobenzoic phenol. There are many steps in this way, but the selectivity of each step is excellent.

Furthermore, the method of aryl diazonium salt can be used. The diazonium salt is first prepared from m-fluoroaniline, and then rearranged and hydrolyzed with thioreagents such as potassium thiocyanate or sodium thiosulfate to obtain m-fluorothiophenol. This process requires control of the reaction conditions, because the diazonium salt is active and easy to decompose. The reaction temperature is usually at low temperature, 0-5 ℃ is appropriate, and a suitable stabilizer is added to maintain the stability of the diazonium salt, and then promote the reaction to obtain the required m-fluorothiophenol.

What are the precautions in storage and transportation of m-Fluorobenzenethiol?

M-fluorothiophenol is an organic compound, and many matters need to be paid attention to during storage and transportation.

First, storage, because of its certain chemical activity and volatility, must choose a cool and ventilated warehouse. High temperature can promote its volatilization to accelerate, and even cause chemical reactions, causing deterioration or danger. The temperature of the warehouse should be controlled within a specific range to prevent accidents. And it must be kept away from fire and heat sources. Open flames and hot topics can cause it to burn or explode, which is the key. Furthermore, it should be stored separately from oxidants, acids, etc., which come into contact with it or react violently. Due to its irritation and toxicity, the storage area should be equipped with emergency treatment equipment and suitable containment materials in order to deal with emergencies such as leaks.

As for transportation, it is necessary to choose the appropriate means of transportation and packaging methods according to its dangerous characteristics. The packaging must be tight, anti-leakage, rain protection and high temperature protection. During transportation, drivers and escorts must be familiar with its characteristics and emergency treatment methods, so as to drive smoothly, avoid bumps and collisions, and prevent package damage. Transportation vehicles should also follow designated routes to avoid densely populated areas and important facilities.

In short, m-fluorothiophenol has strict regulations on environmental conditions, isolation requirements, packaging and transportation, and personnel operation during storage and transportation, so as to ensure safety and avoid dangerous accidents.