What are the main uses of 5-bromo-2- (aminomethyl) -1,3-difluorobenzene?

5-Hydroxy-2- (ethylamino) -1,3-dialkane, although this substance has not been directly described in ancient books, it has a wide range of uses in today's scientific view.

In the field of medicine, it is often the key intermediate for the synthesis of many drugs. The unique structure of the geine can be cleverly spliced with other compounds through specific chemical reactions to form molecules with specific pharmacological activities. For example, some drugs with neuromodulation function, 5-hydroxy- 2 - (ethylamino) - 1,3-dioxane as the starting material, through multi-step reaction conversion, generate active ingredients that can precisely act on the targets of the nervous system, or help relieve the symptoms of psychiatric diseases.

In the chemical industry, it also has extraordinary performance in the synthesis of polymer materials. It can be used as a polymerization monomer or a crosslinking agent. When polymerized with other monomers, its own special structure is introduced into the polymer chain to improve material properties. For example, it is used to make special engineering plastics to enhance the mechanical strength, heat resistance and chemical stability of plastics, so that plastic products can adapt to more severe environments, such as high temperature, strong acid and alkali erosion.

In addition, in the manufacture of fine chemicals, 5-hydroxyl-2- (ethylamino) -1,3-diethane is often used in the preparation of fragrances and cosmetic additives. Due to its unique chemical properties, or imparting a special flavor to fragrances, it can be used in cosmetics or exert moisturizing, antibacterial and other effects to improve product quality and performance, and meet consumers' diverse needs for fine chemicals.

What are the synthesis methods of 5-bromo-2- (aminomethyl) -1,3-difluorobenzene

To prepare 5-bromo-2- (ethylamino) -1,3-distyrene, there are three methods.

First, with 2- (ethylamino) -1,3-distyrene as the substrate, the substitution reaction occurs with the bromine source under suitable conditions. This reaction requires the selection of suitable solvents, such as dichloromethane, chloroform, etc., so that the substrate can be fully mixed and contacted with the bromine source. At the same time, the reaction temperature and time should be precisely controlled. If the temperature is too high or the time is too long, the by-product of polybromide will be feared; if the temperature is too low or the time is too short, the reaction will be incomplete. Usually, at a low temperature (e.g. 0-10 ° C), a bromine source, such as liquid bromine or N-bromosuccinimide (NBS), is slowly added dropwise and stirred for several hours to achieve efficient conversion.

Second, the benzene ring is brominated to obtain bromobenzene-containing derivatives, and then ethylamino is introduced through a series of reactions to construct a diphenyl structure. Bromobenzene can be used as a raw material and reacted with bromine under the catalysis of Lewis acid to obtain bromobenzene. Bromobenzene is prepared by nitration, reduction and other steps to obtain amino bromobenzene, and then reacted with haloethane to introduce ethylamino. Then the distyrene structure is constructed by Wittig reaction or Heck reaction. This process is complicated and requires fine control of the reaction conditions at each step to ensure the yield and purity of each step to meet the requirements of the final product.

Third, the transition metal catalytic coupling reaction strategy is adopted. For example, using ethylaminobenzene boronic acid derivatives and bromostyrene derivatives as raw materials, under the action of transition metal catalysts and ligands such as palladium and nickel, Suzuki-Miyaura coupling reaction occurs under basic conditions. The method has mild conditions and high selectivity, but the cost of catalysts and ligands is high. It is very important to choose the right catalyst, ligand and base, such as tetra (triphenylphosphine) palladium as catalyst, potassium carbonate as base, and heat the reaction in a suitable solvent (such as dioxane-water mixed solvent) to obtain the target product. Pay attention to deoxygenation during the reaction to prevent the catalyst from deactivation.

What are the physical properties of 5-bromo-2- (aminomethyl) -1,3-difluorobenzene

5 + -Hydroxy-2- (ethylamino) -1,3 -diene benzene, its physical properties are as follows:

This substance is mostly liquid at room temperature, with a special smell, its taste or pungent feeling. Looking at its color, it is usually colorless to light yellow, and the transparency is quite high, like clear water.

Its density is slightly smaller than that of water. If placed in water, it can float on the water surface. The boiling point of this substance is about a certain range. When heated to the corresponding temperature, it will vaporize into a gaseous state. The melting point also has a fixed value. Under a specific low temperature environment, it will solidify from a liquid state to a solid state.

5 + -Hydroxy-2- (ethylamino) -1,3-dienylbenzene has unique solubility. It can be well miscible in organic solvents such as ethanol and ether, as if fish enter water and blend seamlessly. However, in water, its solubility is poor, just like oil and water, which are difficult to mix.

In addition, the substance is also volatile. When placed in the air for a while, it will slowly evaporate, just like water vapor evaporates and gradually disappears into invisibility. Its refractive index is also a specific constant. When light passes through, it will be refracted at a specific angle, showing different optical properties. These physical properties are of crucial significance when considering identification, separation, and related chemical reactions.

What is the market price of 5-bromo-2- (aminomethyl) -1,3-difluorobenzene?

5 + -ether-2- (hydroxymethyl) -1,3-divinylbenzene, this product is in the market, and its price is difficult to determine. The fluctuation of the price often depends on many reasons.

First, the price of raw materials changes. If the price of all the raw materials required to make this product rises, in order to ensure profitability, the manufacturer must raise the price of this product; on the contrary, if the price of raw materials falls, the price may also drop.

Second, the complexity of the process is related to the cost. If the preparation technique is complicated, requires a lot of utensils and manpower, and the energy consumption is also huge, the cost will be high and the price will be high; if the process is refined, the cost will decrease, and the price may decrease.

Third, the city's supply and demand determine its price. If the city has strong demand for this product, but the supply is limited, the demand exceeds the supply, and the price will rise; if the supply exceeds the demand, the merchant will sell the goods, or reduce the price to compete for the market.

Fourth, changes in the current situation also have an impact. Such as government decrees, trade policies, or the purchase of raw materials is difficult to change, or the tax-related increases or decreases, can make the price fluctuate.

Therefore, in order to know the real price of 5 + -ether-2- (hydroxymethyl) -1,3-divinylbenzene in the market, it is necessary to carefully observe the raw material market, process conditions, supply and demand conditions and timely government orders. In combination, a more accurate price can be obtained.

Precautions for storage and transportation of 5-bromo-2- (aminomethyl) -1,3-difluorobenzene

5-Hydroxy- 2 - (ethylamino) - 1,3-divinylbenzene, during storage and transportation, there should be many precautions.

This compound has specific chemical activity, and when storing, the first environment should be selected. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Due to heat, it is easy to cause chemical changes, or reactions such as decomposition and polymerization, which endanger safety. And it is necessary to avoid direct sunlight. Strong light may promote photochemical reactions and damage its quality.

Furthermore, the choice of storage container is also key. It is necessary to use corrosion-resistant and well-sealed materials, such as glass or specific plastic containers, to prevent them from reacting with the container material, causing leakage or deterioration. Labels must be clear, with detailed compound names, properties, hazards and emergency disposal methods, so as to identify and respond to emergencies.

During transportation, strictly abide by relevant regulations and standards. According to its dangerous characteristics, choose suitable transportation methods and tools. During transportation, ensure that the container is stable and avoid damage caused by collision and vibration. And transport personnel should be familiar with its characteristics and emergency treatment. In case of leakage, they can deal with it quickly and properly.

In case of leakage, do not panic. First, evacuate the surrounding personnel, set up a warning area, and prohibit unrelated people from approaching. Emergency personnel need professional protective equipment to avoid direct contact. Depending on the amount of leakage, either absorb it with inert materials such as sand and vermiculite, or neutralize it with suitable chemical reagents. The collected leaks should be properly disposed of according to regulations and should not be discarded at will, so as not to pollute the environment.