What are the main uses of 3-Chloro-4-fluorobenzenethiol?

3-Chloro-4-fluorothiophenol is an important chemical substance in the field of organic synthesis. It has a wide range of main uses and is a key intermediate in the field of medicinal chemistry. The unique activity of the structure of gointhiophenol can react with many compounds to build complex drug molecular structures. It can often be seen in the synthesis of many antibacterial, anti-inflammatory and anti-cancer drugs. For example, it can be coupled with nitrogen-containing heterocyclic compounds through specific chemical reactions to prepare new drug molecules with inhibitory activity against specific cancer cells.

In the field of materials science, 3-chloro-4-fluorothiophenol also has extraordinary performance. First, in the preparation of functional polymer materials, it can participate in the reaction as a modifier. Through the combination of thiophenol and polymer skeleton, the material is endowed with properties such as anti-oxidation and anti-ultraviolet, and the stability and durability of the material are improved. Second, in the self-assembled monolayer technology, this substance can form an orderly arrangement of monolayers on the metal surface by virtue of the strong adsorption of sulfur atoms on the metal surface, providing an effective way for the surface modification and functionalization of the material, thereby improving the surface properties of the material, such as wettability and conductivity.

In addition, in the field of pesticide chemistry, 3-chloro-4-fluorothiophenol also plays an important role. It can be used as a raw material for the synthesis of new pesticides, and reacts with other organic reagents to generate compounds with high insecticidal, bactericidal or herbicidal activities. Compared with traditional products, such pesticides often have higher biological activity and lower environmental toxicity, which can effectively meet the needs of modern agriculture for green and environmentally friendly pesticides.

What are the physical properties of 3-Chloro-4-fluorobenzenethiol?

3-Chloro-4-fluorothiophenol is one of the organic compounds. Its physical properties are quite important and are the basis for our understanding of this substance.

Looking at its properties, at room temperature, it is mostly liquid, colored or light yellow, or nearly colorless and transparent, with an oily texture, flowing but not stagnant. Its odor is pungent and unpleasant, and this odor characteristic is also one of its physical properties.

When it comes to the boiling point, the boiling point of this substance is quite high, due to the intermolecular forces. After accurate experimental determination, its boiling point can reach a certain value (the specific value varies slightly according to the experimental conditions). The boiling phenomenon under this high temperature condition reflects the strong bonding force between molecules, and requires more energy to convert it from liquid to gaseous.

In terms of melting point, it is relatively low and lies in a specific temperature range. Under this temperature, the substance is solid and the structure is relatively stable; if the temperature rises slightly and exceeds the melting point, it melts into a liquid state, showing the characteristics of solid-liquid transformation.

Solubility is also an important physical property. In organic solvents, such as common ethanol, ether, etc., 3-chloro-4-fluorothiophenol has good solubility and can be miscible with it to form a uniform solution. However, in water, its solubility is very little, almost insoluble, which is due to the lipophilic hydrophobicity of its molecular structure.

In terms of density, it is heavier than water. When it is mixed with water, it can be seen that it sinks to the bottom of the water. This density difference is also a unique manifestation of its physical properties. In many practical applications and separation operations, this property is of great significance.

In summary, the physical properties of 3-chloro-4-fluorothiophenol, such as properties, odor, melting point, solubility and density, are interrelated, and together constitute a physical understanding of this substance, providing a solid foundation for its application in chemical industry, scientific research and other fields.

What are the chemical properties of 3-Chloro-4-fluorobenzenethiol?

3-Chloro-4-fluorothiophenol is also an organic compound. It has unique chemical properties and is widely used in many fields.

On its chemical properties, the first is the characteristics of its functional groups. The benzene ring is a stable conjugated system, and the chlorine atom and the fluorine atom are connected to it, and each has its own influence. The chlorine atom has a certain electronegativity, although it can absorb electrons, its induction effect is relatively weak; the fluorine atom has extremely strong electronegativity, and the electron absorption induction effect is significant. The two together affect the electron cloud density of the benzene ring, resulting in uneven distribution of the electron cloud of the benzene ring. The change of this electron cloud has a great impact on the reactivity of the compound.

The thiophenyl group is an important functional group, and the solitary pair electrons of the sulfur atom can participate in the chemical reaction, making this compound nucleophilic. Because the sulfur-hydrogen bond energy is lower than that of the hydrogen-oxygen bond, the acidity of thiophenol is slightly stronger than that of the corresponding phenols, and it is easier to lose protons and generate thiophenol negative ions. This negative ion can be used as a nucleophilic reagent to participate in nucleophilic substitution reactions.

In the nucleophilic substitution reaction, 3-chloro-4-fluorophenylthiophenol can react with halogenated hydrocarbons, acyl halides and other electrophilic reagents. Taking halogenated hydrocarbons as an example, the sulfur atom of the thiophenol negative ion attacks the carbon atom of This reaction is a common method for constructing carbon-sulfur bonds in organic synthesis.

It can also participate in oxidation reactions. Thiophenols are easily oxidized and can be converted into disulfides under the action of mild oxidants. In case of stronger oxidants, sulfur atoms can be further oxidized to form sulfoxides or sulfones.

3-chloro-4-fluorobenzothiophenol also has physical properties due to the presence of chlorine and fluorine atoms. Its boiling point and melting point are affected by intermolecular forces. The presence of chlorine and fluorine atoms changes the intermolecular forces, which in turn affects its melting and boiling point. At the same time, its solubility is also affected by functional groups and benzene rings, and its solubility is better in organic solvents, but poor in water.

The unique chemical properties of 3-chloro-4-fluorothiophenol provide an important basis for organic synthesis, materials science and other fields, and are of great significance in chemical production and scientific research.

What are 3-Chloro-4-fluorobenzenethiol synthesis methods?

The synthesis method of 3-chloro-4-fluorobromothiophenol is often involved in the field of organic synthesis. There are many ways to synthesize it.

First, it can be started from halogenated aromatics. First, 3-chloro-4-fluorobromobenzene is used as a raw material and refluxed with thiourea in a suitable solvent such as ethanol or acetone. In this reaction, the sulfur atom of thiourea nucleophilically attacks the halogenated atom of halogenated aromatics to form an intermediate. Subsequently, the intermediate is hydrolyzed under basic conditions, such as treated with sodium hydroxide solution, to obtain 3-chloro-4-fluorothiophenol. < Br >
Second, 3-chloro-4-fluoroaniline is used as the starting material. First, it is diazotized, and the amino group is converted into a diazo salt by reacting with sodium nitrite and hydrochloric acid at a low temperature (such as 0-5 ° C). After that, the diazo salt reacts with thiocyanate, such as potassium thiocyanide, to form the corresponding thiocyanide. Finally, the target product can be obtained through a reduction step, such as zinc powder and hydrochloric acid treatment. 3-chloro-4-fluorobenzoic acid is used as the starting material.

Third, 3-chloro-4-fluorobenzoic acid is used as the starting material. It is first converted into an acyl chloride and treated with thionyl chloride to obtain it. The acyl chloride is then reacted with a mercaptan reagent, such as sodium hydride, in an appropriate solvent to introduce sulfur atoms. After appropriate reduction and decarboxylation steps, 3-chloro-4-fluorothiophenol can also be obtained.

All synthetic methods have their own advantages and disadvantages. In practical applications, it is necessary to weigh the availability of raw materials, the difficulty of reaction conditions, the yield and purity.

3-Chloro-4-fluorobenzenethiol need to pay attention to when storing and transporting

3-Chloro-4-fluorothiophenol is an organic compound. During storage and transportation, many matters need to be paid attention to.

First words storage. This compound should be stored in a cool, dry and well-ventilated place. Because of its volatility and chemical activity, high temperature and humidity can easily cause it to deteriorate or cause chemical reactions. Therefore, the warehouse temperature should be carefully controlled, generally not exceeding 30 degrees Celsius, and the humidity should be maintained at a relatively low level to prevent moisture from dissolving. And it must be kept away from fire and heat sources. Because it may be flammable, there is a risk of combustion and explosion in case of open flames and hot topics. Furthermore, it should be stored separately from oxidizing agents, acids, alkalis, etc. Because 3-chloro-4-fluorothiophenol is chemically active, contact with the above substances, or cause violent chemical reactions, endangering safety.

Second talk about transportation. When transporting, the packaging must be strong and tight to prevent leakage. The packaging materials used must be able to withstand the chemical attack of the compound, and have certain pressure resistance and shock resistance. Transportation vehicles should also be equipped with corresponding fire fighting equipment and leakage emergency treatment equipment for emergencies. During driving, drivers should be cautious and avoid violent operations such as sudden braking and sharp turns to prevent package damage. At the same time, transportation routes should try to avoid sensitive areas such as densely populated areas and water conservation areas. If a leak occurs, effective measures should be taken promptly to evacuate the surrounding population, prevent the spread of pollution, and promptly clean up the leakage to avoid serious harm to the environment.