What is the chemical structure of 3- (4-Fluorobenzene) -1- (1-methylethyl) -1-H-indole?

This substance is called 3- (4-fluorophenyl) -1- (1-methylethyl) -1H-indole. Its chemical structure can be as follows:

Indole ring is the core structure of this compound, 1H-indole means that the hydrogen atom at position 1 on the indole ring is still present. 1- (1-methylethyl), that is, isopropyl, is connected to the 1 position of the indole ring, and this isopropyl is the substituent of the 1 position of the indole ring. And 3- (4-fluorophenyl) indicates that a 4-fluorophenyl is connected to the 3 position of the indole ring. 4-Fluorophenyl, that is, the 4-position on the benzene ring is replaced by a fluorine atom, and this benzene ring is connected to the 3-position of the indole ring.

In this compound structure, the indole ring has a conjugated system, which endows it with certain stability and special chemical properties. The introduction of fluorine atoms will affect the electron cloud distribution of the molecule due to the high electronegativity of fluorine, changing its physical and chemical properties, such as affecting the polarity and lipophilicity of the compound. The presence of isopropyl also affects the spatial structure and electronic effects of the molecule, and has an effect on the solubility and reactivity of the compound. The interaction between these substituents and the indole ring jointly determines the unique chemical properties and potential application characteristics of 3- (4-fluorophenyl) -1- (1-methylethyl) -1H-indole.

What are the physical properties of 3- (4-Fluorobenzene) -1- (1-methylethyl) -1-H-indole?

3 - (4 - fluorobenzene) - 1 - (1 - methylethyl) - 1 - H - indole is one of the organic compounds. Its physical properties are quite important, let me tell you in detail.

First of all, its appearance, this compound is often in a solid state, mostly white or white powder-like substances, fine texture, and it is quite textured.

Describe its melting point. The characteristics of this material's melting point are one of the key indicators to determine its purity and quality. After many experimental investigations, its melting point is roughly in a specific temperature range, but it may be slightly different due to slight differences in experimental conditions. Knowing the melting point is of great help in the purification and identification of this compound.

Furthermore, when it comes to solubility, its solubility varies in organic solvents. In some polar organic solvents, such as dichloromethane, N, N-dimethylformamide, etc., it has good solubility and can be uniformly dispersed to form a clear solution. In water, its solubility is poor and insoluble in it. This solubility property has an important impact on its application in chemical reactions and the process of separation and purification.

has density. Although its density data may not be well known to everyone, it is also an indispensable physical property parameter in chemical production and specific experimental operations. The density of this compound makes it occupy a specific space in the relevant liquid system, which affects the physical state and behavior of the system.

In addition, its boiling point is also an important physical property. The level of boiling point depends on its volatilization characteristics under heating conditions. The specific boiling point determines the temperature at which the compound will transform from liquid to gas, which is particularly critical in separation operations such as distillation. The physical properties of 3- (4-fluorobenzene) -1- (1-methylethyl) -1-H-indoles, such as appearance, melting point, solubility, density and boiling point, are interrelated and play a pivotal role in many fields such as organic synthesis, drug development, materials science, etc., providing a solid foundation for scientists to further study and rationally apply this compound.

What are the common uses of 3- (4-Fluorobenzene) -1- (1-methylethyl) -1-H-indole?

3- (4-fluorobenzene) -1- (1-methylethyl) -1-H-indole is an organic compound. Its common uses are quite extensive, in the field of medicinal chemistry, and it is mostly a key intermediate for drug research and development. The structure of Geinindole is widely present in many bioactive molecules, and the introduction of fluorine atoms and isopropyl groups can significantly change the physical, chemical and biological properties of compounds. For example, the strong electronegativity of fluorine atoms can enhance the interaction between molecules and biological targets, improve the affinity and selectivity of drugs; while isopropyl can adjust the lipid solubility of molecules, affecting the absorption, distribution, metabolism and excretion of drugs in the body.

In the field of materials science, this compound also has applications. Because of its specific electronic structure and optical properties, it can be used as a building block for organic optoelectronic materials. In the field of organic Light Emitting Diodes (OLEDs), compounds containing indole structures often exhibit unique luminescent properties. By reasonably modifying the fluorine atom on the benzene ring and the isopropyl group on the indole nitrogen atom, the luminescent color and efficiency of the compound can be regulated, providing the possibility for the preparation of high-performance OLED materials.

In addition, it is also an important synthetic building block in organic synthetic chemistry. With its activity check point on the indole ring, other functional groups can be further introduced through various organic reactions, such as nucleophilic substitution, electrophilic substitution, coupling reaction catalyzed by transition metals, etc., to construct organic molecules with more complex and diverse structures, providing a rich material basis for the development of organic synthetic chemistry.

What are the synthesis methods of 3- (4-Fluorobenzene) -1- (1-methylethyl) -1-H-indole?

The synthesis method of 3- (4-fluorophenyl) -1- (1-methylethyl) -1H-indole is described in your present.

First, it can be started with 4-fluorobenzophenone. First, it is condensed with acrylonitrile through Knoevenagel to obtain the corresponding unsaturated nitrile. This reaction needs to be catalyzed by a weak base, such as pyridine, at a suitable temperature, or at 50 to 80 degrees Celsius. When the reaction number, a higher yield product can be obtained. The obtained unsaturated nitrile is carefully reduced with metal hydride, such as lithium aluminum hydride, in an anhydrous organic solvent, such as anhydrous ether, to obtain unsaturated amines. This step requires a low temperature, about 0 to 5 degrees Celsius, and a slow dropwise addition of the reducing agent to prevent overreaction. Unsaturated amines are cyclized within the molecule, or heated to 120 to 150 degrees Celsius in the presence of an acidic catalyst, such as p-toluenesulfonic acid, to obtain the target 3- (4-fluorophenyl) -1- (1-methylethyl) -1H-indole.

Second, use 1- (1-methylethyl) -1H-indole as raw material. First, it is treated at a low temperature, such as -78 degrees Celsius, with a strong base, such as n-butyl lithium, to deprotonate the indole nitrogen atom. Then 4-fluorobrombenzene is added to undergo a nucleophilic substitution reaction. This reaction needs to be in an anhydrous and oxygen-free environment, using anhydrous tetrahydrofuran as a solvent. When the reaction is over, 4-fluorophenyl can be introduced to obtain the target product. After the reaction is completed, the reaction is quenched with dilute acid, and then separated and purified by extraction, column chromatography, etc.

Third, 4-fluorobenzoic acid and 1- (1-methylethyl) -1H-indole are used as the starting materials. 4-Fluorobenzoic acid is first converted into an acyl chloride, which can be co-heated with dichlorosulfoxide. The obtained acyl chloride is catalyzed by 1- (1-methylethyl) -1H-indole in Lewis acid, such as aluminum trichloride. The intermediate product can be obtained by reacting in anhydrous dichloromethane solvent at room temperature or slightly heated. Then with a suitable reducing agent, such as zinc amalgam and concentrated hydrochloric acid (Clemmensen reduction method), or hydrazine and potassium hydroxide (Wolff-Kishner reduction method), the carbonyl group is reduced to methylene, and the final product is 3 - (4 - fluorophenyl) - 1 - (1 - methethyl) - 1H - indole.

What is the market outlook for 3- (4-Fluorobenzene) -1- (1-methylethyl) -1-H-indole?

3 - (4 - fluorobenzene) - 1 - (1 - methylethyl) - 1 - H - indole, this substance is quite impressive in the current pharmaceutical market scene.

Looking at the current tide of pharmaceutical research and development, the need for innovation is urgent. Due to its unique molecular structure, this compound is gradually emerging in the field of new drug creation. It is often a key intermediate in the field of organic synthetic chemistry, just like the coincidence in Luban's hands, paving the way for the construction of many complex drug molecules.

From the perspective of pharmacological research, compounds with similar structures often have the potential to regulate specific biological targets, or may involve multiple pharmacological activities such as anti-tumor and neuroprotection. In terms of tumor diseases, there are many people suffering from this disease at present, and the medical community is seeking new cures. If the drought is looking at Yunni, this compound may be able to open up new paths for the development of anti-cancer drugs, such as the boat of night walking, which is led by the morning star.

Furthermore, from the perspective of market supply and demand, with the increasing global demand for innovative drugs, the demand for 3- (4-fluorobenzene) -1- (1-methylethyl) -1-H-indole, an important raw material for new drug research and development, is also on the rise. Pharmaceutical companies are competing for the highlands of new drug research and development, and their demand for it is like chasing the Central Plains. As a result, this product is in the chemical raw material market, with its value increasing and its transactions becoming more and more complex. It is like a pearl in the market, and everyone is paying attention.

However, the prospects of its market are not without twists and turns. The complexity of the synthesis process and the control of costs are all hanging over the sword of its market development. In order to navigate the market, process optimization and cost reduction are the only way to go. If you want to cross the river, you must build a strong ship. Although there may be thorns in the road ahead, its potential is huge. In the rivers and lakes of medicine and chemical industry, it can eventually ride the wind and waves and become a great cause.