What are the main uses of 2-fluoro-benzenemethanamin?

2-Fluoro-benzenemethanamine, Chinese name 2-fluorobenzamine, is an organic compound. It has a wide range of uses and is particularly critical in the field of medicinal chemistry.

In the process of drug development, 2-fluorobenzamine is often used as a key intermediate. Due to its unique chemical structure, it can combine with many bioactive molecules to assist in the synthesis of compounds with specific pharmacological activities. For example, it can be introduced into the molecular structure of a drug through a series of chemical reactions, thereby improving the absorption, distribution, metabolism and excretion characteristics of the drug, or enhancing the affinity between the drug and the target, and enhancing the efficacy of the drug. In the research and development of many new antidepressants and antihistamines, 2-fluorobenzamine has been seen, and its structural properties can be used to optimize drug properties.

Furthermore, in the field of materials science, 2-fluorobenzamine also has applications. Because it contains active amino groups and benzene ring structures, it can participate in a variety of polymerization reactions to prepare special polymer materials. Such materials may have unique electrical, optical or mechanical properties, and have applications in electronic devices, optical materials and other fields. For example, polymer materials prepared by polymerization with specific monomers may be used in organic Light Emitting Diodes (OLEDs) to improve their luminous efficiency and stability.

In addition, in the field of organic synthetic chemistry, 2-fluorobenzamine is a commonly used synthetic building block. Chemists can construct complex organic molecular structures by chemically modifying its phenyl ring and amino group. Through halogenation, alkylation, acylation, etc., different functional groups are introduced into its molecules to synthesize organic compounds with diverse structures, providing a rich material basis for the development of organic synthetic chemistry.

What are the physical properties of 2-fluoro-benzenemethanamin?

2-Fluorobenzamine is an organic compound. It has the following physical properties:
It is a colorless to light yellow liquid at room temperature and pressure. This state is determined by the molecular structure and intermolecular forces. The composition and arrangement of the molecules make it liquid at room temperature.
Smell, there is a special smell, but due to individual olfactory differences, the specific perception may be different. This smell is derived from the fluorine atom contained in the molecule and functional groups such as benzene ring and amino group, which interact to give it unique odor characteristics.
Measure its melting point, which is about -30 ° C. The low melting point is due to the weak intermolecular forces. Although the fluorine atom has a certain electronegativity, it can form a certain intermolecular force. However, the influence of the benzene ring and the amino group structure makes the overall intermolecular force insufficient to make the molecules closely arranged into a solid state at low temperature.
The boiling point is about 195-197 ° C. The higher boiling point is due to the presence of the benzene ring in the molecule. The conjugate system of the benzene ring makes the molecules have strong van der Waals forces; and the amino group can form hydrogen bonds, which further enhances the intermolecular forces. Therefore, a higher temperature is required to overcome these forces and make it boil.
On solubility, slightly soluble in water, soluble in organic solvents such as ethanol and ether. Due to the fact that the benzene ring in the molecule is a hydrophobic group, the fluorine atom has strong electronegativity, but it is connected to the benzene ring, which reduces the molecular polarity as a whole; while the amino group has a certain hydrophilicity, due to the influence of the benzene ring, its solubility in water is limited. Organic solvents such as ethanol and ether can form similar intermolecular forces, such as van der Waals forces, between molecules and 2-fluorobenzamine, so they are miscible. Its density is slightly larger than that of water, about 1.1g/cm ³. Due to the fact that the molecule contains fluorine atoms, the relative atomic mass of fluorine atoms is larger, and the molecular structure is tight, resulting in a unit volume mass greater than that of water.

What is the chemistry of 2-fluoro-benzenemethanamin?

2-Fluoro-aniline, this is an organic compound containing fluorine atoms and benzene ring and methylamine group. Its chemical properties are very interesting, let me talk about them one by one.

In terms of physical properties, it is liquid at room temperature or has a specific odor. Because it contains benzene ring and polar amine groups, it has good solubility in organic solvents, such as ethanol, ether, etc. Because its structure contains fluorine, or affects the boiling point and melting point, fluorine atoms have high electronegativity, or the intermolecular forces are different, causing the boiling point and melting point to be different from fluorine-free analogs.

From the perspective of chemical properties, amine groups are basic and can form salts with acids. 2-Fluoro-aniline meets inorganic acids such as hydrochloric acid, or forms corresponding salts. This reaction is neutralized by acid and base. It is often used in organic synthesis to prepare amine salts. The stability of amine salts is good, or it has different physical and chemical properties. It is useful in specific fields.

The benzene ring is an electron-rich system and is prone to electrophilic substitution. 2-The benzene ring of fluoro-aniline, the fluorine atom is an ortho-para-site locator. Although it has an electron-absorbing induction effect, it has an electron conjugation effect. The electrophilic substitution reaction mostly occurs in the ortho-site and the para-site of the fluorine atom. If with bromine in a suitable catalyst, the bromine atom or the substituted benzene ring ortho-

Furthermore, the amine group is nucleophilic and can participate in nucleophilic substitution reactions. If it reacts with halogenated hydrocarbons, the lone pair electron of the amine nitrogen atom attacks the carbon atom connected to the halogen in the halogenated hydrocarbon, and the halogen leaves to form a new nitrogen-containing compound. This is a common method for constructing carbon-nitrogen bonds, which is of great significance in the fields of drug synthesis and material preparation.

In addition, due to the special properties of fluorine atoms, 2-fluoro-aniline may have unique biological activities. The introduction of fluorine atoms into organic molecules often changes their fat solubility, metabolic stability, etc. In drug development, fluorine-containing compounds may more easily penetrate biofilms, enhance bioavailability, or have a stronger ability to bind to targets, laying the foundation for the creation of high-efficiency and low-toxicity new drugs.

What are 2-fluoro-benzenemethanamin synthesis methods?

To make 2-fluoro-aniline, there are various methods. First, you can start with 2-fluorobenzoic acid. First, the sulfinyl chloride is used to form 2-fluorobenzoyl chloride. This step is to make the carboxyl group into an acid chloride group. Sulfinyl chloride is active and reacts easily with the carboxyl group, and the by-products are all gases, which is easy to separate. After ammonia acts on 2-fluorobenzoyl chloride, the acid chloride reacts with ammonia, and the nitrogen of ammonia nucleophilic attacks the carbonyl carbon of the acid chloride, so 2-fluorobenzoamide is obtained. At the end, lithium aluminum hydride is used to reduce 2-fluorobenzamide in an appropriate solvent. Lithium aluminum hydride is a strong reducing agent, which can reduce the carbonyl group of the amide group to methylene, and finally obtain 2-fluoro-aniline.

Second, start with 2-fluorobrobenzyl. N - (2-fluorobenzyl) phthalimide was obtained by reacting with potassium phthalimide. After treatment with hydrazine hydrate, the bond between phthalimide and benzyl is broken through hydrazolysis reaction, and 2-fluoro-aniline is obtained.

Third, 2-fluorobenzaldehyde and methylamine can be reduced to amination. Under a suitable catalyst and hydrogen atmosphere, the carbonyl group of 2-fluorobenzaldehyde and the nitrogen of methylamine are first condensed to imine, and hydrogen reduces the imine under the action of the catalyst, and 2-fluoro-aniline can also be obtained. This method has its own advantages and disadvantages. The actual preparation needs to be weighed according to the availability of raw materials, the difficulty of reaction conditions, and the high and low yields.

2-fluoro-benzenemethanamin what are the precautions during use

2-Fluoro-aniline is an important compound in organic chemistry. There are many key precautions to keep in mind during use.

First, safety protection must be comprehensive. This compound is toxic and irritating, and can cause damage to the eyes, skin and respiratory tract. Therefore, when using, protective equipment is indispensable, such as goggles, gloves and gas masks. These equipment can effectively block the compound from contact with the human body and avoid harm. The operation should be carried out in a well-ventilated place, preferably in a fume hood, so that volatile gases can be discharged in time and the concentration of harmful substances in the air can be reduced.

Second, the chemical properties need to be understood in detail. 2-Fluoro-aniline contains an amine group and a benzene ring structure, and is chemically active. It can react with many compounds such as acids, acyl halides, and anhydrides. When using, be sure to avoid contact with incompatible substances to prevent violent reactions, such as explosions, fires, and other dangerous situations. Before use, it is necessary to fully understand its reaction characteristics with other substances and be prepared.

Third, storage conditions should not be ignored. It should be stored in a cool, dry and ventilated place, away from fire sources and oxidants. Because it is volatile, if stored improperly, it is easy to leak, which not only wastes resources, but also pollutes the environment and even causes safety accidents. The storage container must be well sealed and clearly labeled, indicating the name, nature and danger warning of the compound.

Fourth, the operation specification is very important. During the use process, the action should be precise and careful to avoid spilling. After use, the remaining compounds should be properly disposed of and must not be dumped at will. Experimental instruments should also be cleaned in time to remove residual substances for next use.

In short, when using 2-fluoro-aniline, safety is the first consideration. In-depth understanding of its properties, standardized operation and proper storage can ensure the safety of the use process and avoid accidents.