Name | 1-(chloromethyl)-4-fluorobenzene |
Molecular Formula | C7H6ClF |
Molecular Weight | 144.573 g/mol |
Appearance | Colorless to light yellow liquid |
Boiling Point | 170 - 172 °C |
Density | 1.199 g/cm³ at 25 °C |
Flash Point | 56 °C |
Solubility In Water | Insoluble |
Logp | 2.99 |
Refractive Index | 1.501 - 1.503 |
Chemical Formula | C7H6ClF |
Molar Mass | 144.573 g/mol |
Appearance | Colorless to light yellow liquid |
Boiling Point | 174 - 176 °C |
Density | ~1.19 g/cm³ |
Flash Point | 62 °C |
Solubility In Water | Insoluble |
Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
Vapor Pressure | Low vapor pressure at room temperature |
Odor | Pungent odor |
Chemical Formula | C7H6ClF |
Molar Mass | 144.573 g/mol |
Appearance | Colorless to light yellow liquid |
Boiling Point | 173 - 175 °C |
Density | 1.19 g/cm³ |
Flash Point | 63 °C |
Solubility In Water | Insoluble |
Refractive Index | 1.504 |
What are the main uses of 1- (chloromethyl) -4-fluorobenzene?
(1- (cyanomethyl) -4-cyanonaphthalene) is widely used and has important applications in many fields.
In the field of materials science, it is often used to prepare high-performance organic optoelectronic materials. Due to the special molecular structure of (1- (cyanomethyl) -4-cyanonaphthalene), it can endow materials with excellent optoelectronic properties and effectively improve the luminous efficiency and stability of materials, so it plays an indispensable role in the fabrication of organic Light Emitting Diodes (OLEDs) and other devices. As a new generation of display technology, OLED is widely used in the manufacture of display screens such as mobile phones and TVs. (1- (cyanomethyl) -4-cyanonaphthalene) provides key support for achieving high resolution, high contrast and wide color gamut display.
In the field of organic synthetic chemistry, (1- (cyanomethyl) -4-cyanonaphthalene) is also an extremely important intermediate. With its unique chemical activity, it can be skillfully combined with other organic compounds through a series of chemical reactions, resulting in the synthesis of more complex and diverse organic compounds with more unique structures and functions. The synthesis process of many biologically active drug molecules and functional materials with special optical or electrical properties is often inseparable from the reaction path of (1- (cyanomethyl) -4-cyanonaphthalene) as the starting material or key intermediate, which lays a solid foundation for the development of organic synthetic chemistry and the creation of new compounds.
In addition, at the level of scientific research and exploration, (1- (cyanomethyl) -4-cyanonaphthalene) also provides an excellent model for scientists to study the relationship between molecular structure and properties. Through structural modification and performance testing, researchers can gain in-depth insight into how small changes in molecular structure affect overall performance, providing theoretical basis and practical guidance for the design and development of more advanced functional materials and compounds.
What are the physical properties of 1- (chloromethyl) -4-fluorobenzene?
1 - (cyanomethyl) - 4 - cyanonaphthalene is one of the organic compounds. Its physical properties are quite unique, and I will describe them in detail for you.
Looking at its appearance, under normal temperature and pressure, 1 - (cyanomethyl) - 4 - cyanonaphthalene is often white to light yellow crystalline powder. This form is easy to observe and handle, and it is easy to operate in many experimental and industrial processes.
When it comes to melting point, the melting point of this compound is within a certain range. The characteristics of melting point play a key role in its state transition under different temperature conditions. Knowing the melting point allows the temperature to be adjusted reasonably during production, storage and use to ensure that it exists in the desired state.
Furthermore, solubility is also one of the important physical properties. 1- (cyanomethyl) -4-cyanonaphthalene exhibits a certain solubility in some organic solvents. For example, in common organic solvents such as dichloromethane, N, N-dimethylformamide, etc., it can dissolve to form a uniform solution. In water, its solubility is poor. This difference in solubility is of great significance in terms of separation, purification and choice of reaction medium. If you want to carry out a chemical reaction, you need to choose a suitable solvent according to its solubility to promote the smooth progress of the reaction.
In addition, the density of 1- (cyanomethyl) -4-cyanonaphthalene is also one of its physical properties. Although the specific value needs to be accurately measured, the density parameter also has a non-negligible role in operations such as mixing and separation of substances. For example, in the process of liquid stratification separation, the difference in density can stratify different substances, and then achieve the purpose of separation.
In summary, the physical properties of 1- (cyanomethyl) -4-cyanonaphthalene, including appearance, melting point, solubility and density, are interrelated and play their respective roles. They are all indispensable factors in chemical research, industrial production and other fields.
What are the chemical properties of 1- (chloromethyl) -4-fluorobenzene?
(1) The property of this compound is
1 - (cyanomethyl) - 4 - cyanobenzene, which is an organic compound. Its properties are chemically active and are quite important in the field of organic synthesis.
(2) Chemical properties
1. ** Nucleophilic substitution **: The cyanyl group in this compound has nucleophilic properties and can perform nucleophilic substitution reactions with electrophilic reagents such as halogenated hydrocarbons. For example, when encountering halogenated alkanes, the carbon atoms in the cyanyl group can attack the alpha-carbon atoms of the halogenated alkanes, and the halogenated atoms leave to form carbon-carbon bonds, resulting in new compounds containing cyanide groups. This reaction is commonly used in the construction of complex organic molecular structures, and is an important way to grow carbon chains and introduce functional groups.
2. ** Hydrolysis reaction **: Cyanyl groups can be hydrolyzed under acid or base catalysis conditions. In acidic hydrolysis, Mr. Amide is formed, and then hydrolyzed to carboxylic acids and ammonia (or ammonium salts). Base catalyzed hydrolysis produces carboxylic salts and ammonia. If in sodium hydroxide solution, 1- (cyanomethyl) -4-cyanobenzene is hydrolyzed, and the cyanyl group is gradually converted to obtain the corresponding carboxylate products. This hydrolysis property can be used to prepare compounds containing carboxyl groups, which are of practical value in organic synthesis and chemical production.
3. ** Addition reaction **: The carbon-nitrogen triple bond in the cyanyl group is unsaturated and can be added to certain reagents. If it is hydrogenated with hydrogen under the action of a catalyst, the cyanyl group can be hydrogenated and reduced to an amino group to form an amino-containing compound. This addition reaction is an important means of introducing amino groups in organic synthesis, and can prepare many bioactive and industrial compounds.
4. ** Polymerization reaction **: If the molecular structure is suitable, under specific conditions, 1 - (cyanomethyl) - 4 - cyanobenzene may participate in the polymerization reaction. Cyanyl groups can be used as a reactive check point to interact with other monomers with active groups to form polymers. This polymerization reaction may be used to prepare polymer materials with special properties, which has potential applications in the field of materials science.
What are the preparation methods of 1- (chloromethyl) -4-fluorobenzene?
The method of preparing 1- (cyanomethyl) -4-cyanonaphthalene has been known in ancient times. The method is as follows:
First, using naphthalene as the base, 4-bromonaphthalene is obtained by bromination. The 4-bromonaphthalene is co-heated with cuprous cyanide in a high-boiling solvent, such as dimethylformamide, and the two are combined to obtain 4-cyanonaphthalene. After formaldehyde and sodium cyanide are used as agents, under appropriate conditions, 4-cyanonaphthalene is reacted with both to obtain 1- (cyanomethyl) -4-cyanonaphthalene. In this process, when brominating, it is necessary to control the temperature moderately, and the properties of the solvent and the length of the reaction are the main factors, which are related to the purity and quantity of the product.
Second, the naphthalene is first taken, and the acylation reaction is carried out with acetyl chloride and anhydrous aluminum trichloride as the medium to obtain 4-acetylnaphthalene. After that, the 4-acetylnaphthalene is reduced by Huangminglong to remove the carbonyl oxygen to obtain 4-methylnaphthalene. Then the 4-methylnaphthalene and bromine are substituted with free radicals with the help of light or initiators to obtain 4-bromomethylnaphthalene. Following the reaction with an alcoholic solution of sodium cyanide, bromomethyl is replaced by a cyanyl group to obtain 1- (cyanomethyl) -4-cyanonaphthalene. In this path, the selection of acylation agents, reduction conditions, and substitution environment all need to be carefully controlled to obtain good results.
Third, start with 4-naphthalene formaldehyde. First, 4-naphthalene formaldehyde interacts with sodium cyanide and hydrochloric acid to obtain 4- (aminocyanomethyl) naphthalene by Straker reaction, and then dehydrates to obtain 1- (cyanomethyl) -4-cyanonaphthalene. In this process, the acid-base environment of the reaction and the method of dehydration are all key, and whether the operation is accurate or not affects the quality of the product.
All these methods have their own advantages and disadvantages, and they need to be based on the actual situation, such as the availability of raw materials, the ownership of equipment, and the consideration of cost. Only by choosing the best one can achieve the purpose of preparation.
What are the precautions for using 1- (chloromethyl) -4-fluorobenzene?
1 - (hydroxymethyl) - 4 - hydroxynaphthalene needs to pay attention to many things during use.
First of all, it is related to its physical and chemical properties. 1 - (hydroxymethyl) - 4 - hydroxynaphthalene has specific chemical activity and is more sensitive to temperature and humidity. Under high temperature, it may cause its chemical structure to change, which will affect its performance. Therefore, it should be stored in a cool, dry place, away from heat and fire sources to prevent accidental reaction or combustion.
Furthermore, from the perspective of operating specifications. When taking it, be sure to follow strict operating procedures. Because it may be irritating, direct contact with the skin, eyes, or cause discomfort, it is necessary to wear appropriate protective equipment, such as gloves, goggles, etc., when operating. If accidentally exposed, rinse immediately with plenty of water and seek medical attention according to the specific situation.
At the same time, this substance plays a key role in chemical reactions, and dosage control is particularly important. Improper dosage, or cause an imbalance in the reaction, and cannot achieve the desired effect, so precise measurement is required, and strict operation is required according to the reaction requirements and formula.
In addition, 1- (hydroxymethyl) -4-hydroxynaphthalene should be checked regularly for packaging integrity during storage. If the package is damaged, it is easy to absorb moisture and oxidize, which affects the quality. Once the abnormal packaging is detected, it needs to be dealt with in time, or the packaging needs to be replaced to ensure its stability and quality.
Finally, the disposal of its waste cannot be ignored. It cannot be discarded at will, and should be properly disposed of in accordance with relevant environmental regulations to avoid pollution to the environment. Only by paying attention to the above matters in all directions can 1- (hydroxymethyl) -4-hydroxynaphthalene be used safely and effectively to avoid latent risks and achieve the intended purpose of use.