What is the main use of (Z) -3- (3-chloro-2-fluoro-phenyl) -2- (4-chloro-2-fluoro-phenyl) acrylonitrile?

(Z) -3- (3-chloro-2-fluorophenyl) -2 - (4-chloro-2-fluorophenyl) acrylonitrile, this is an organic compound. Its main use is quite extensive, and it is often used as a key intermediate in the field of medicinal chemistry. Take the creation of new antibacterial drugs as an example. The compound can be converted into a substance with antibacterial activity through a specific chemical reaction. Due to the chlorine and fluorine atoms in its molecular structure, it has unique chemical and physical properties, which can interact with specific bacterial targets, interfere with the normal physiological activities of bacteria, and achieve antibacterial effect.

In the field of materials science, it also shows important uses. In the preparation of some functional polymer materials, this compound structural unit will be introduced. Due to its special structure, it can improve the thermal stability, chemical stability and mechanical properties of polymer materials. For example, it is used to make high-performance engineering plastics, which can maintain good properties under high temperature and chemical corrosion environments, and broaden its application scenarios, such as aerospace, automobile manufacturing and other fields that require strict material properties.

Furthermore, in the field of organic synthetic chemistry, it is an important synthetic building block. Chemists use various reactions on it, such as nucleophilic substitution, addition reactions, etc., to build more complex organic molecules. By ingeniously designing reaction routes, compounds with specific functions and structures can be synthesized, providing a rich material basis for the development of new drugs and the creation of new materials. Overall, (Z) -3- (3-chloro-2-fluorophenyl) -2 - (4-chloro-2-fluorophenyl) acrylonitrile has significant uses in many fields, which is of great significance for promoting the development of related fields.

What are the synthesis methods of (Z) -3- (3-chloro-2-fluoro-phenyl) -2- (4-chloro-2-fluoro-phenyl) acrylonitrile

The method of synthesizing (Z) -3- (3-chloro-2-fluorophenyl) -2- (4-chloro-2-fluorophenyl) acrylonitrile can follow the following path.

Starting material, when taking aromatic hydrocarbons containing specific substituents. First, 3-chloro-2-fluorobenzaldehyde and 4-chloro-2-fluorophenylacetonitrile are used as raw materials, and the two are in an alkaline medium. Knoevenagel condensation reaction is carried out. The alkaline environment can be provided by weak bases such as pyridine and piperidine, and the reaction temperature should be controlled in a moderate range, usually between room temperature and 60 ° C. In this process, the aldehyde group is condensed with the active hydrogen of acetonitrile to form unsaturated nitrile intermediates.

Or another way is to start from halogenated aromatics. Using 3-chloro-2-fluorohalobenzene and 4-chloro-2-fluorohalobenzene as the starting material, a metal-catalyzed coupling reaction is used to form a carbon-carbon bond. For example, palladium-catalyzed cross-coupling reactions, such as Suzuki coupling, Stille coupling, etc. For Suzuki coupling, a suitable boric acid or borate ester reagent is required, and the ligand cooperates with the palladium catalyst to react under basic conditions. The reaction solvent can be selected from dioxane, toluene, etc. The temperature is adjusted between 80 and 120 ° C according to the specific reagent and reaction process.

After the reaction is completed, the crude product may contain impurities and needs to be purified. Common methods such as column chromatography use silica gel as the stationary phase, select an appropriate eluent, and separate according to the polarity difference between the product and the impurities. Recrystallization can also be used to select an appropriate solvent, so that the product is dissolved in a hot solvent, and pure crystals are precipitated after cooling. In this way, after multiple operations, the target product (Z) -3- (3-chloro-2-fluorophenyl) -2- (4-chloro-2-fluorophenyl) acrylonitrile can be obtained.

What are the physical properties of (Z) -3- (3-chloro-2-fluoro-phenyl) -2- (4-chloro-2-fluoro-phenyl) acrylonitrile

(Z) - 3 - (3 - chloro - 2 - fluorophenyl) - 2 - (4 - chloro - 2 - fluorophenyl) acrylonitrile, which is an organic compound. Its physical properties are very critical, related to its application in various scenarios.

Looking at its properties, it may be a solid under normal circumstances, due to the intermolecular force. The molecule contains halogen atoms such as chlorine and fluorine, which increases the intermolecular van der Waals force and promotes the substance to appear in a solid state. Its melting and boiling point also has characteristics. Due to the introduction of halogen atoms, the molecular polarity is enhanced and the intermolecular force increases, so the melting and boiling point is relatively high. For accurate determination, the melting point meter, boiling point meter, etc. should be used in the laboratory according to experimental means, and the exact value can be obtained under suitable conditions.

In terms of solubility, because it is an organic compound and has a certain polarity, it may have good solubility in polar organic solvents, such as dichloromethane, N, N-dimethylformamide, etc. according to the principle of similarity dissolution. The solubility in water may not be good. Although the polarity of water is strong, the carbon skeleton of the compound is large, and the halogen atom does not exist in the form of easy hydrogen bonding with water, so it is difficult to dissolve in water.

Density is also one of the important physical properties, which can be determined experimentally, such as using the bottle specific gravity method. Due to the presence of heavy atoms of chlorine and fluorine in the molecule, its density may be greater than that of common organic solvents. The specific value needs to be accurately measured experimentally.

The color state of the compound may be colorless to light yellow. Although there is no typical chromophore in the molecular structure, it may be slightly yellow due to factors such as the conjugated system or a few impurities. Its odor may be weak and irritating. The presence of halogen atoms and nitrile groups makes it emit a special odor, and long-term contact or irritation of human respiratory tract, skin and other parts.

The above are all speculations based on its structural characteristics. The exact physical properties need to be verified experimentally.

What are the chemical properties of (Z) -3- (3-chloro-2-fluoro-phenyl) -2- (4-chloro-2-fluoro-phenyl) acrylonitrile

(Z) - 3 - (3 - chloro - 2 - fluorophenyl) - 2 - (4 - chloro - 2 - fluorophenyl) acrylonitrile is an organic compound. Its chemical properties are quite complex and closely related to the molecular structure.

First talk about its stability. In this compound, due to the stability of the benzene ring structure, the cyano group (-CN), as an electron-absorbing group, is connected to the carbon-carbon double bond, which affects the electron cloud distribution of the molecule through the conjugation effect, enhancing the stability of the molecule to a certain extent. However, the existence of the carbon-carbon double bond makes the molecule have a certain reactivity.

Let's look at its reactivity. The carbon-carbon double bond can undergo an addition reaction, such as addition with hydrogen. Under the action of a suitable catalyst, the double bond can be hydrogenated to form a saturated carbon-carbon single bond, which can be converted into the corresponding alkane derivative. With the addition of halogen elements, halogens such as chlorine and bromine can be added with double bonds to form dihalides. At the same time, cyanide groups can also participate in the reaction, such as hydrolysis under acidic or alkaline conditions, hydrolysis under acidic conditions to form carboxylic acids and ammonium salts, and hydrolysis under alkaline conditions to form carboxylic salts and ammonia.

From the perspective of the substituent effect, the chlorine atom and fluorine atom on the benzene ring are electron-withdrawing groups, which will reduce the electron cloud density of the benzene ring, reduce the electrophilic substitution activity on the benzene ring, and the position of the substituent will affect the regioselectivity of the reaction.

In terms of solubility, the compound should have a certain solubility in polar organic solvents such as dimethyl sulfoxide (DMSO) and N, N-dimethylformamide (DMF), but its solubility in water is low, because the overall polarity of the molecule is not particularly strong, and it contains a large hydrophobic aromatic ring structure.

What is the price of (Z) -3- (3-chloro-2-fluoro-phenyl) -2- (4-chloro-2-fluoro-phenyl) acrylonitrile in the market?

I don't know the price of (Z) -3- (3-chloro-2-fluoro-phenyl) -2- (4-chloro-2-fluoro-phenyl) acrylonitrile in the market. This is a fine chemical, and its price is affected by many factors.

First, the cost of production. The price of raw materials and the simplicity of the preparation process are all affected. If raw materials are scarce and difficult to find, or the preparation requires complex steps and high-end technology, the cost will be high, and the price will also rise.

Second, the supply and demand of the market. If the demand is strong and the supply is limited, the merchant may raise the price due to the shortage of supply; conversely, if the supply exceeds the demand, the price may drop.

Third, the level of quality. High purity and high quality, the price is often higher than that of ordinary products.

Fourth, the region and channel of sales. The market environment, transportation costs, and sales channels in different regions can all lead to differences in prices.

However, I have not found the exact price data. If you want to know the details, you can consult chemical product suppliers, distributors, or check the information of chemical product trading platforms to get more accurate prices.