What is the chemical structure of (−) -trans-4- (4 '-fluorophenyl) -3-hydroxymethyl-N-methylpiperidine

The chemical structure of (−) -trans-4- (4 '-fluorophenyl) -3-hydroxymethyl-N-methylpiperidine is as follows.

Piperidine is a six-membered heterocyclic compound containing nitrogen. The nitrogen atom in the ring has a pair of lone pair electrons. In this compound, the piperidine ring is its core structure.

At the 4th position of the piperidine ring, there is a 4' -fluorophenyl group attached. The so-called 4 '-fluorophenyl group, that is, at the relative position (4th position) of the benzene ring and the carbon atom connected to the piperidine ring, there is a fluorine atom substituted. The introduction of this fluorine atom can significantly affect the electron cloud distribution, steric hindrance and physicochemical properties of the compound.

At the 3rd position of the piperidine ring, there is a hydroxymethyl group. The hydroxymethyl group is composed of a carbon atom connected to a hydroxyl group and a hydrogen atom. The high electronegativity of the oxygen atom in the hydroxyl group makes the hydroxymethyl group have a certain polarity and can participate in many chemical reactions such as hydrogen bond formation.

And there are methyl groups attached to the nitrogen atom of the piperidine ring. The existence of methyl groups changes the electron cloud density and the spatial environment around the nitrogen atom.

The spatial configuration of this compound is the (−) -trans configuration. " Trans "indicates that the relevant substituent is on the opposite side of the plane of the piperidine ring, while" (−) "reveals that it has optical rotation, causing the polarized light to turn left. Such a chemical structure endows the compound with unique physical, chemical and biological properties.

What are the main uses of (−) -trans-4- (4 '-fluorophenyl) -3-hydroxymethyl-N-methylpiperidine

(−) -Trans-4- (4 ′ -fluorophenyl) -3-hydroxymethyl-N-methylpiperidine is an important compound in organic chemistry. It has a wide range of main uses and has outstanding performance in various fields such as medicinal chemistry and organic synthesis.

In the field of medicinal chemistry, this compound is often a key intermediate for the creation of new drugs. Due to its specific chemical structure, it can be combined with specific targets in organisms and exhibit unique biological activities. For example, studies have found that it may inhibit some disease-related protein kinases, which play an important role in the occurrence and development of diseases. Therefore, based on this compound, reasonable structural modification and optimization may be able to develop specific drugs for the treatment of major diseases such as cancer and cardiovascular diseases.

In the field of organic synthesis, (−) -trans-4- (4 ′ -fluorophenyl) -3-hydroxymethyl-N-methylpiperidine is also a valuable synthetic building block. It has multiple active functional groups, such as hydroxyl groups and methyl groups, which can participate in a variety of organic chemical reactions. With such reactions, chemists can construct more complex and novel organic molecules, expand the variety and function of organic compounds, and is of great significance to promote the progress of organic synthetic chemistry.

To sum up, (−) -trans-4- (4 ′ -fluorophenyl) -3-hydroxymethyl-N-methylpiperidine has key uses in the fields of medicine and organic synthesis, and has broad prospects. It is an important object for researchers to further explore and apply.

What are the synthesis methods of (−) -trans-4- (4 '-fluorophenyl) -3-hydroxymethyl-N-methylpiperidine

The synthesis method of (−) -trans-4- (4 '-fluorophenyl) -3-hydroxymethyl-N-methylpiperidine is quite complicated and delicate. In the past, various scholars have developed their talents in the synthesis of this compound and explored various paths.

One method is to first take an aromatic halide with a specific structure and a compound containing a piperidine parent nucleus precursor, and with the help of a catalyst, make it undergo nucleophilic substitution. This catalyst needs to be highly active and selective in order to guide the reaction in the expected direction. After this step, the key intermediate can be obtained, and the precise construction of its structure is the foundation for subsequent reactions. < Br >
Then, for the modification of intermediates. Under suitable reaction conditions, a hydroxymethyl group is introduced at a specific position. In this process, the choice of solvent and the regulation of temperature are all important. The solvent needs to be able to dissolve the reactants well without additional side reactions with the reaction system; the temperature is related to the reaction rate and the selectivity of the product. When accurately grasped, the hydroxymethyl group can be integrated in an ideal stereochemical manner to obtain the desired spatial configuration.

Furthermore, the nitrogen atom on the piperidine ring is methylated. In this step, an appropriate methylating agent, such as iodomethane, needs to be selected, and a suitable base is matched to promote the smooth occurrence of the reaction. The strength and dosage of the base will affect the efficiency of methylation and the purity of the product.

There are other methods, using natural products or compounds with similar skeletons as starting materials. After multi-step functional group conversion, the structure of the target molecule is gradually constructed. First, the specific functional groups of the starting material are activated to make it prone to subsequent reactions. Then, by rearrangement, addition and other reaction types, the carbon skeleton and functional group layout of the molecule are delicately constructed. After each reaction step, separation and purification are required to ensure the purity of the intermediate and provide an excellent substrate for the next reaction. So many steps of reaction, interlocking, such as the craftsman's carving of beautiful jade, the final result is (−) -trans-4- (4 '-fluorophenyl) -3-hydroxymethyl-N-methylpiperidine, an exquisite compound.

What are the physical properties of (−) -trans-4- (4 '-fluorophenyl) -3-hydroxymethyl-N-methylpiperidine

The physical properties of (-) -trans-4- (4 '-fluorophenyl) -3-hydroxymethyl-N-methylpiperidine are crucial. This compound has a certain melting point, but the exact value will vary slightly depending on the degree of purification and test conditions. Generally speaking, its melting point is in a certain range. At this temperature, the compound gradually melts from solid to liquid, which is an important sign of the transformation of the state of a substance.

Its boiling point is also an important physical property. The boiling point characterizes the temperature required for the substance to change from liquid to gas under a specific pressure. External pressure has a great influence on its boiling point, and the boiling point at standard atmospheric pressure is generally used as a common reference value.

In terms of solubility, this compound has certain solubility properties in organic solvents. Common organic solvents such as ethanol and dichloromethane have different solubility due to the interaction between solvent and solute molecules. In ethanol, or due to inter-molecular hydrogen bonds, it exhibits moderate solubility; in dichloromethane, it also shows a specific degree of solubility due to the principle of similar miscibility.

Density is also a physical property that cannot be ignored. Its density reflects the mass of the substance per unit volume. This value is of great significance for the calculation of material dosage and the evaluation of system properties in many chemical operations such as mixing and separation.

In appearance, (-) -trans-4- (4 '-fluorophenyl) -3-hydroxymethyl-N-methylpiperidine often takes a specific form, or is a white crystalline powder with uniform texture and pure color. This appearance characteristic can be used as an important basis for preliminary identification and quality judgment.

What is the market availability of (−) -trans-4- (4 '-fluorophenyl) -3-hydroxymethyl-N-methylpiperidine?

There are （ - ） - trans - 4 - (4 '-fluorophenyl) - 3 - hydroxymethyl - N - methylpiperidine in the market today. What is the supply of it? This is a very crucial question. In the ancient and elegant words of "Tiangong Kaiwu", although there is no direct statement of this thing, it can be deduced one or two according to its insight into the world.

The supply and demand of the city is related to all kinds of things. First, if this thing is the key raw material for rare medicines, doctors hope that it can help patients to get rid of diseases, and drug dealers must be thirsty for it, and the supply may be tight. The workshop of pharmaceuticals is operated day and night, hoping to obtain this material to make good medicines and help the sick people in the world.

Second, if it is used in the industry of exquisite chemicals, which is the foundation of the synthesis of exotic materials, chemical giants should also compete. In the workshop, craftsmen regard it as a treasure, and want to use it to create novel things for the needs of the world.

However, the supply is also limited by many parties. If it is difficult to extract this material, it is not easy to obtain materials, and even if the demand is like a tide, the supply will also be difficult to increase rapidly. Deep mountain remote soil, or hide its source, then mining and refining techniques, or need time to refine, can be widely supplied to the world.

Furthermore, the situation in the four directions also has an impact. The trade of neighboring countries and the leniency of decrees can cause changes in supply. When trade is open, the goods of all parties may be widely accepted, and the supply is abundant; if there are changes, the checkpoints are numerous, and the supply is like a trickle, and it is difficult to respond to the flood.

Therefore （ - ） - the supply of trans-4- (4 '-fluorophenyl) -3-hydroxymethyl-N-methylpiperidine in the city, it is necessary to carefully observe the requirements of the pharmaceutical and chemical industry, the difficulty of raw material extraction, and the change of the trade situation.