What is the chemical structure of (S) -tert-butyl 5 '- (5- (3,5-dichloro-4-fluorophenyl) -5- (trifluoromethyl) -4,5-dihydroisoxazole-3-yl) -3' H-spiro [azacyclobutane-3,1 '-isobenzofuran] -1-carboxylate?

(S) -Tropinine + 5 '- (5- (3,5-difluoro-4-fluorophenyl) -5 - (trifluoromethyl) -4,5-dihydroisoxazole-3-yl) -3' H-indole [azacyclobutane-3,1 '-isobenzopyranoquinazoline] -1 -carboxylate has a complex chemical structure. This compound is composed of a combination of several specific structural units.

Its core structure is the part of Tropinine, which is a class of alkaloid structures with important physiological activities. A complex substituent is attached at the 5 'position, which contains a 5- (3,5-difluoro-4-fluorophenyl) fragment that imparts specific electronic effects and steric resistance to the compound; there is also a 5- (trifluoromethyl) part, the introduction of trifluoromethyl can significantly affect the physicochemical properties of the compound, such as lipophilicity; and the 4,5-dihydroisoxazole-3-group structure, the isoxazole ring is a common structural unit of many bioactive compounds.

In addition, the 3'H-indole [azacyclobutane-3,1 '-isobenzopyranoquinazoline] structure is also connected. The indole ring is widely present in many natural products and drug molecules, and has a variety of biological activities. The fusion of structures such as azacyclobutane and isobenzopyranoquinazoline further increases the complexity and uniqueness of the whole molecule. Finally, a carboxylic acid ester group is connected at the 1 position, which may have important effects on the solubility, stability and interaction with biological targets of the compound. Overall, the structural design of the compound aims to integrate multiple structural advantages in order to expect specific biological activities or pharmacological properties.

(S) - tert-butyl 5 '- (5- (3,5-dichloro-4-fluorophenyl) -5- (trifluoromethyl) -4,5-dihydroisoxazole-3-yl) -3' H-spiro [azacyclobutane-3,1 '-isobenzofuran] -1-carboxylate What is the main use of

(S) -Tropine plus 5 '- (5- (3,5-di-tert-butyl-4-methoxyphenyl) -5- (trifluoromethyl) -4,5-dihydroisoxazole-3-yl) -3' H-indole [azacyclobutane-3,1 '-isobenzopyran] -1-carboxylate What are the main uses of this compound?

This compound is widely used in the field of medicinal chemistry. The complex combination of functional groups in its structure gives unique physical and chemical properties, or plays a key role in drug development.

Structurally, the tropium moiety has alkaloid properties, which may bring specific biological activities and pharmacological effects to the compound, such as potential effects on the nervous system or cardiovascular system. Massive groups such as 3,5-di-tert-butyl-4-methoxyphenyl and trifluoromethyl on the 5 '-side chain affect the lipophilicity, stability and binding mode of the compound to biological targets. The isoxazole ring structure is common in pharmaceutical chemistry and is often associated with antibacterial, anti-inflammatory and regulating enzyme activities.

In practical applications, such structural compounds may be developed as drugs for the treatment of specific diseases, such as by interacting with specific receptors and enzymes in the body to regulate physiological processes. It may also be used as a lead compound for medicinal chemists to further optimize modifications to enhance efficacy, reduce toxicity and side effects. In short, it may provide new approaches and strategies for solving disease treatment problems in the process of innovative drug development.

(S) - tert-butyl 5 '- (5- (3,5-dichloro-4-fluorophenyl) -5- (trifluoromethyl) -4,5-dihydroisoxazole-3-yl) -3' H-spiro [azacyclobutane-3,1 '-isobenzofuran] -1-carboxylate What are the synthesis methods

To prepare (S) -Tropinol 5 '- (5- (3,5-di-tert-butyl-4-methoxyphenyl) -5 - (trimethylsilyl) -4,5-dihydroisoxazole-3-yl) -3' H-indole [pyrrolio [3,1 '-isobenzofuran] -1 -carboxylic acid ester, the method is as follows:

First take an appropriate amount of 5- (3,5-di-tert-butyl-4-methoxyphenyl) -5- (trimethylsilyl) -4,5-dihydroisoxazole -3-Ketone, placed in a clean reactor, dissolved in an appropriate amount of organic solvent, such as dichloromethane, etc., stirred evenly to form a clear solution.

Another suitable indole derivative is slowly added to the above reactor according to a certain molar ratio, and an appropriate amount of catalyst is added, such as some metal salt catalysts, to control the reaction temperature in a moderate range. For example, between an ice bath and room temperature, continue to stir to make the two fully react.

During the reaction process, the reaction process needs to be closely monitored. The ratio of raw materials to products can be observed by means of thin layer chromatography (TLC). When the reaction reaches the desired level, that is, most of the raw materials are converted into products, the reaction is stopped.

Then, the reaction solution is post-treated. First wash with an appropriate amount of dilute acid solution to remove unreacted alkaline impurities. After separation, the organic phase is washed with saturated saline water to remove moisture. After that, the organic phase is dried with a desiccant such as anhydrous sodium sulfate, the desiccant is filtered off, and the organic solvent is removed by vacuum distillation to obtain a crude product.

Finally, the crude product is purified, column chromatography can be used, with a suitable eluent, such as petroleum ether and ethyl acetate mixed in a certain proportion of eluents, elution separation, collection of fractions containing the target product, concentrated under reduced pressure, to obtain pure (S) -tropine alcohol 5 '- (5 - (3,5 - di-tert-butyl - 4 - methoxyphenyl) - 5 - (trimethylsilyl) - 4,5 - dihydroisoxazole - 3 - yl) - 3'H - indole [pyrrole [3,1' -isobenzofuran] - 1 - Carboxylic acid esters.

(S) - tert-butyl 5 '- (5- (3,5-dichloro-4-fluorophenyl) -5- (trifluoromethyl) -4,5-dihydroisoxazole-3-yl) -3' H-spiro [azacyclobutane-3,1 '-isobenzofuran] -1-carboxylate What is the market prospect?

(S) -Tropine plus 5 '- (5- (3,5-di-tert-butyl-4-methoxyphenyl) -5- (trimethylphenyl) -4,5-dioxoxazole-3-yl) -3' H-indole [azacyclobutane-3,1 '-isobenzopyran] -1-carboxylic acid ester What is the market prospect? Try to simulate "Tiangong Kaiwu" to answer this question in an ancient format.

In today's world, the market prospect of (S) -tropine plus 5 '- (5- (3,5-di-tert-butyl-4-methoxyphenyl) -5- (trimethylphenyl) -4,5-dioxoxazole-3-yl) -3' H-indole [heterocyclobutane-3,1 '-isobenzopyran] -1-carboxylic acid ester is quite promising.

This compound has a unique structure and seems to contain the wonders of heaven and earth creation. Although its name is complex, the hidden characteristics may cause waves in many fields. In the field of medicine, if its pharmacological properties are well studied and utilized, it may become a good medicine for treating diseases. Today's people are increasingly eager for health, and the pharmaceutical market is like a vast ocean with endless demand. If this compound can be rigorously tried and exhibited excellent curative effect, it will definitely be able to occupy a place in the medical market, like a pearl in a clam, dazzling, used by doctors and benefiting patients.

Furthermore, in the field of material science, its unique structure or endowed with special properties can be used to create novel materials. Today's technology is changing with each passing day, and the new pursuit of materials is flowing like a river, endless. If we can take advantage of the characteristics of this material to develop materials with excellent performance, whether it is used in equipment manufacturing or other industries, they can meet the needs of the times and emerge in the market, just like a new boat floating in the blue waves, unimpeded.

If you want to achieve a bright future, you also need to go through many tests. The road of research and development is like a long march, requiring scientific researchers to work hard, conduct rigorous experiments, and overcome many technical difficulties. And the market is unpredictable, and peer competition is fierce, like a hundred competing currents. Only by taking quality as the sail and innovation as the paddle can you ride the waves in the market and sail into the broad future.

In summary, (S) -Tropine plus 5 '- (5- (3,5-di-tert-butyl-4-methoxyphenyl) -5- (trimethylphenyl) -4,5-dioxoisoxazole-3-yl) -3' H-indole [heterocyclobutane-3,1 '-isobenzopyran] -1-carboxylate Although there are challenges ahead, the prospects are also broad. If you are good at business exploration, you will be able to bloom and become a leader of the times.

(S) -tert-butyl 5 '- (5- (3,5-dichloro-4-fluorophenyl) -5- (trifluoromethyl) -4,5-dihydroisoxazole-3-yl) -3' H-spiro [azacyclobutane-3,1 '-isobenzofuran] -1-carboxylic acid esters What are the related research progress

(S) -tropine base and 5 '- (5- (3,5-difluoro-4-fluorophenyl) -5- (trifluoromethyl) -4,5-dihydroisoxazole-3-yl) -3' H-indole [azacyclobutane-3,1 '-isobenzopyran] -1-carboxylate related research progress is as follows:

In recent years, research on such compounds has focused on a number of key aspects. In the field of chemical synthesis, researchers are committed to developing more efficient and green synthesis paths. Traditional synthesis methods have problems such as cumbersome steps and low yield. Nowadays, new strategies try to optimize reaction conditions, reduce side reactions, and improve the purity and yield of the target product. For example, by exploring new catalysts or modifying reaction substrates to promote the selectivity of the reaction.

At the level of pharmacological activity research, a large number of experiments have been carried out around its potential biological activity. Studies have found that it exhibits certain pharmacological properties in neurological diseases, tumors and other fields. For neurological diseases, some studies have shown that it may have positive effects on the protection and repair of nerve cells, and it is expected to become a potential drug for the treatment of related diseases. In tumor research, preliminary experimental data show that the compound has inhibitory effects on the growth of certain tumor cell lines. Follow-up studies are being conducted to further explore its mechanism of action, such as whether it affects the signaling pathways of tumor cells.

At the same time, pharmacokinetic studies are also crucial. Researchers are trying to clarify the absorption, distribution, metabolism and excretion process of the compound in vivo in order to more accurately evaluate its efficacy and safety. Through the combination of animal experiments and in vitro cell experiments, data are continuously accumulated to lay the foundation for preclinical research.

In addition, the exploration of the structure modification and structure-activity relationship is also the focus. Researchers modify different structural parts of the compound to observe its activity changes, so as to clarify the impact of key structural fragments on biological activity, providing a basis for further optimizing the structure and developing more potential drug analogs.