What is the chemical structure of (E) -3- (2-chlorophenyl) -2- (4-fluorophenyl) propenal?

(E) - 3 - (2 - chlorophenyl) - 2 - (4 - fluorophenyl) acronaldehyde, an organic compound with a unique chemical structure.

The main structure of this compound is acronaldehyde, with specific groups connected at both ends of the double bond of acronaldehyde. At position 3, there is 2 - chlorophenyl. The 2 - chlorophenyl group, that is, on the benzene ring, has a chlorine atom at the ortho-position of the carbon connected to acronaldehyde. At position 2, there is a 4 - fluorophenyl group, that is, the para-position of the carbon connected to acronaldehyde on the benzene ring, with a fluorine atom. < Br >
Its configuration is (E) type, which is determined according to the priority order of the groups connected by the double bond. When the preferred groups at both ends of the double bond are on the opposite side of the double bond, it is the (E) configuration. This structural characteristic makes the compound exhibit specific activity and selectivity in chemical reactions. In the field of organic synthesis, it can be used as a key intermediate to participate in various reactions to prepare more complex organic compounds.

What are the main uses of (E) -3- (2-chlorophenyl) -2- (4-fluorophenyl) propenal?

(E) - 3 - (2 - chlorophenyl) - 2 - (4 - fluorophenyl) acronaldehyde is a key compound in the field of organic synthesis. Its uses are quite extensive, in the field of medicinal chemistry, it is often used as a key intermediate to create various specific drugs. Due to its unique molecular structure, it contains specific functional groups such as chlorine and fluorine, which can be chemically modified to precisely adjust drug activity and bioavailability, and help the research and development of new anti-cancer and antibacterial drugs.

In the field of materials science, it also plays a role that cannot be ignored. It can participate in the synthesis of specific polymers or functional materials, giving materials unique optical, electrical or mechanical properties. For example, through specific polymerization reactions, polymer materials with special photoelectric response can be prepared, which has great potential for application in frontier fields such as photoelectric display and sensors.

Furthermore, in the study of organic synthesis methodologies, (E) -3- (2-chlorophenyl) -2- (4-fluorophenyl) acronaldehyde is often an important substrate for exploring novel and efficient synthesis pathways and reaction mechanisms. Chemists use this to deeply explore the laws of organic reactions, expand the boundaries of organic synthesis, and promote the continuous progress of organic chemistry.

In summary, this compound occupies an important position in many fields such as medicine, materials, and organic synthesis, and has made significant contributions to the development of related fields.

What are the physical properties of (E) -3- (2-chlorophenyl) -2- (4-fluorophenyl) propenal?

(E) - 3 - (2 - chlorophenyl) - 2 - (4 - fluorophenyl) acronaldehyde, which is an organic compound. Its physical properties are of great value for investigation, and let me tell you one by one.

Looking at its appearance, it is often in a solid state, or a powder, or a crystalline state, just like a crystal-clear micro-substance, or has a unique luster under light, just like the spirit of nature, hidden in the microscopic world.

When it comes to melting point, it melts in a specific temperature range. This temperature range is actually its inherent property, just like human character traits, specific and unique. This melting point temperature often varies slightly due to subtle factors such as purity, but the approximate range is relatively stable. This is one of the important signs for identifying this substance.

The boiling point is also an important physical characteristic. Under specific pressure conditions, the compound reaches a boiling point and changes from a liquid state to a gaseous state. This process is like a change in sublimation, from a liquid state to a gaseous state. The boiling point value is also affected by factors such as environmental pressure. When the pressure changes, the boiling point also varies.

Solubility cannot be ignored. In organic solvents, such as common ethanol, ether, etc., (E) -3- (2-chlorophenyl) -2- (4-fluorophenyl) acronaldehyde may dissolve to varying degrees. In ethanol, it can slowly dissolve to form a uniform solution, just like salt fused into water, invisible but real; in ether, its dissolution rate and degree may be different from that in ethanol, due to the different interactions between compounds and solvent molecules.

Density is also one of its physical properties. Its density value reflects the mass of a substance per unit volume, just like the scale of measuring the "weight" of an object. Under certain conditions, the density is relatively stable, providing an important reference for the study of its physical behavior.

The physical properties of this compound are its unique "business card", which helps researchers to accurately identify and deeply explore its mysteries in the complex chemical world.

What are the synthesis methods of (E) -3- (2-chlorophenyl) -2- (4-fluorophenyl) propenal?

(E) - 3 - (2 - chlorophenyl) - 2 - (4 - fluorophenyl) acronaldehyde synthesis method, there are many wonderful methods, the following is your way.

First, it can be a suitable aromatic halide and alkenaldehyde derivatives by metal catalytic coupling. First take chlorine-containing aryl halogens, such as 2-chloroiodobenzene, and fluorinated styrene aldehyde derivatives, with the help of palladium or nickel and other metal catalysts, in a suitable solvent, such as N, N-dimethylformamide, control the temperature, or between 60-80 degrees Celsius, after careful separation and purification, the target product can be obtained. Among them, the metal catalyst activates the halogenated aromatic hydrocarbon to couple it with the carbon-carbon double bond of the alkenal to form the required carbon-carbon bond, which is the key to the synthesis.

Second, the method of hydroxyaldehyde condensation can also be used. First, 2-chlorobenzaldehyde and 4-fluorobenzophenone are used as raw materials, and the hydroxyaldehyde condensation reaction is carried out in an alkaline catalyst, such as sodium hydroxide or potassium hydroxide alcohol solution. The alkaline environment prompts the dissociation of α-hydrogen of acetophenone, generating negative carbon ions, which attack the carbonyl carbon of benzaldehyde to form β-hydroxyketone intermediates, and then dehydrate to obtain α, β-unsaturated aldose. However, the reaction conditions need to be carefully regulated. The strength of alkalinity and temperature are all related to the yield and purity of the product. If the alkalinity is too strong, or side reactions occur, the product is complex; if the temperature is too high, the dehydration step may be out of control, which affects the product configuration.

Third, there is a way to obtain the coupling reaction of aryl boronic acid and halogenated alkenaldehyde through Suzuki-Miyaura. Select 2-chlorophenylboronic acid and halogenated alkenaldehyde containing 4-fluorophenyl group to react in an organic solvent in the presence of palladium catalyst, base and suitable ligand. The ligand and palladium catalyst cooperate to improve the reaction activity and selectivity. The type and amount of alkali have a great influence on the reaction process. Inorganic bases such as potassium carbonate and sodium carbonate are commonly used to react at 50-70 degrees Celsius. After extraction, column chromatography and other purification methods, (E) -3- (2-chlorophenyl) -2- (4-fluorophenyl) acronaldehyde is finally obtained.

(E) What are the precautions during storage and transportation of -3- (2-chlorophenyl) -2- (4-fluorophenyl) propenal?

(E) - 3 - (2 - chlorophenyl) - 2 - (4 - fluorophenyl) acronaldehyde, when storing and transporting, many matters should be paid attention to.

First storage, this substance should be placed in a cool and dry place. Due to its chemical properties, it is easy to deteriorate due to heat or moisture, so it must be avoided in places with high temperature and humidity. If stored in a warm and humid place, or cause chemical reactions, damage its quality. And it should be stored in a well-ventilated place to prevent the accumulation of harmful gases and endanger safety.

Furthermore, when storing, it should be separated from oxidants, acids, bases and other substances. This is because of its chemical activity, contact with the above-mentioned substances, or violent reaction, or even cause ignition and explosion, resulting in a disaster. At the same time, the storage container must be tightly sealed to prevent it from coming into contact with the air to prevent oxidation and other reactions.

As for transportation, the transportation vehicle should ensure that it is clean, dry, and free of other chemicals left behind, so as not to mix with it and cause adverse consequences. During transportation, it is necessary to closely monitor the temperature and humidity to maintain a suitable environment. In case of bad weather, such as heavy rain and high temperature, proper protective measures should be taken, such as covering the rain cloth and controlling the temperature of the carriage.

In addition, transportation personnel must undergo professional training and be familiar with the characteristics of this substance and emergency treatment methods. In the event of an unexpected situation such as a leak during transportation, it can be disposed of quickly and correctly to reduce the hazard.

In short, (E) -3- (2-chlorophenyl) -2- (4-fluorophenyl) acronaldehyde is stored and transported, from environmental conditions to item isolation, from container sealing to professional personnel, all details should not be ignored to ensure safety.