What are the physical properties of -chloro-p-fluorotoluene?

% CE% B1-chloro-p-fluorotoluene, that is, α-chloro-p-fluorotoluene, this substance is an organic compound with specific physical properties.

Its appearance is often colorless to light yellow liquid, and its appearance is clear and transparent, which is its intuitive physical characteristic. Its unique smell, pungent aromatic smell, pungent smell, this smell can be used as the basis for preliminary identification.

The boiling point of α-chloro-p-fluorotoluene is quite important, about 175 ° C - 180 ° C. The boiling point is the temperature at which a substance changes from liquid to gaseous state, and this boiling point indicates that it will undergo phase transition in this temperature range. In terms of melting point, it is about -47 ° C. The melting point is the temperature at which a substance changes from solid to liquid state. Below this temperature, it is in a solid state.

The density is about 1.21g/cm ³. This is the mass per unit volume, reflecting its occupancy of mass in space. It is of great significance for studying its behavior in mixing with other substances and in specific environments. In terms of solubility, it is slightly soluble in water, but soluble in most organic solvents, such as ethanol, ether, etc. This solubility characteristic is due to the difference between its molecular structure and the forces between water molecules and organic solvent molecules. The forces between organic solvent molecules and α-chloro-p-fluorotoluene molecules are easier to overcome, so they are soluble, while the forces with water molecules are weak and difficult to dissolve.

In addition, the vapor pressure of α-chloro-p-fluorotoluene has a corresponding value at a specific temperature. The vapor pressure reflects the tendency of the liquid to volatilize into a gas. The higher the vapor pressure, the greater the tendency to volatilize. This factor should be considered when storing and using, because it is related to safety and material loss.

The physical properties of α-chloro-p-fluorotoluene mentioned above are of important guiding value for its application, storage and transportation in chemical, pharmaceutical and other fields, and need to be carefully grasped.

What are the chemical properties of -chloro-p-fluorotoluene?

Alpha-chloro-p-fluorotoluene, this is an organic compound with unique chemical properties. Its properties are as follows:
First, the nucleophilic substitution activity is quite high. Because the carbon atom connected to the chlorine atom is benzyl carbon, the benzyl carbon cation formed after the chlorine atom leaves is stabilized by the conjugation effect of the benzene ring. Therefore, it is vulnerable to nucleophilic attack, such as reacting with sodium alcohol to form ethers, and reacting with ammonia to form amines.
Second, it has certain redox properties. Chlorine atoms can be reduced and removed under suitable conditions. For example, a system composed of zinc powder and acid can achieve dechlorination reaction. At the same time, benzyl carbons can also be oxidized under the action of specific oxidants, such as strong oxidants such as potassium permanganate, or can be oxidized to carboxyl groups.
Third, due to the presence of fluorine atoms, its lipid solubility is enhanced, which has a significant impact on its biological activity and physical properties. In vivo, the introduction of fluorine atoms can often change the interaction between molecules and targets, thereby affecting biological activity. In terms of physical properties, it can change the boiling point and melting point of molecules.
Fourth, in the aromatic electrophilic substitution reaction, the substituents on the benzene ring have a guiding effect on the reaction check point and activity. Fluorine atoms are ortho-para-sites, although they have electron-absorbing induction effect, but because of the p-π conjugation effect, the density of ortho-para-sites can be relatively high, so electrophilic reagents are easy to attack the ortho-sites of the benzene ring. However, due to the comprehensive influence of chlorine atoms and fluorine atoms in α-chloro-p-fluorotoluene, the specific reactivity and check point selection are still affected by the reaction conditions.

What are the main uses of -chloro-p-fluorotoluene?

% CE% B1 - chloro - p - fluorotoluene (α - chloro - p - fluorotoluene) is also an organic compound. Its main uses are quite extensive, and it has important applications in many fields of chemical industry.

First, in the synthesis of medicine, it is often a key intermediate. In the creation of medicine, many exquisite synthesis paths rely on it as a starting material, and through a series of complex reactions, it can be turned into a good medicine for curing diseases and saving people. For example, in the preparation of some antibacterial and anti-inflammatory drugs, α - chloro - p - fluorotoluene participates in it, laying the foundation for the synthesis of pharmacoactive molecules with specific structures.

Second, it is also important in the preparation of pesticides. The research and development of pesticides requires the synthesis of compounds with high-efficiency insecticidal and weeding properties. Due to its unique chemical structure, α-chloro-p-fluorotoluene can be derived from a variety of active ingredients to resist crop diseases and pests, ensure the robust growth of crops, and protect the harvest of agriculture.

Third, in the field of materials science, it also plays a role. It can be used to synthesize special polymer materials, giving materials unique properties, such as improving the heat resistance and chemical corrosion resistance of materials, and then meeting the needs of different industrial scenarios for special properties of materials.

Fourth, the industry of fragrance synthesis may be involved. Through a specific chemical reaction, it is converted into a compound with a unique aroma, adding a different flavor to the fragrance formula, and is used in daily chemicals such as perfumes and cosmetics to improve the aroma quality of products.

α-chloro-p-fluorotoluene is indispensable in many branches of the chemical industry, and is an important substance for promoting technological progress and product innovation in the fields of medicine, pesticides, materials, fragrances, etc.

What are the synthesis methods of α -chloro-p-fluorotoluene?

The method of preparing α-chloro-p-fluorotoluene has been around for a long time. Its methods are multi-terminal and have their own strengths.

First, with p-fluorotoluene as the base and chlorine as the halogenating agent, the chlorination reaction occurs at the methyl group after being initiated by light or an initiator. This reaction requires temperature control, chlorine flow rate and reaction time. In the method of lighting, both light intensity and light quality affect the reaction. Irradiation with ultraviolet light can accelerate the reaction. Initiators such as azobisisobutyronitrile can decompose to produce free radicals at a suitable temperature and initiate the reaction. If the temperature is too high, side reactions will increase, such as benzene cyclochlorination; if it is too low, the reaction will be delayed.

Second, starting with p-fluorobenzaldehyde, p-fluorobenzyl alcohol is obtained by reduction, and then treated with chlorination reagents, such as thionyl chloride and phosphorus trichloride, to form α-chloro-p-fluorotoluene. To reduce p-fluorobenzaldehyde, reducing agents such as sodium borohydride and lithium aluminum hydride can be used. Sodium borohydride is mild, and lithium aluminum hydride has high activity but requires an anhydrous environment. Sulfoxide chloride reacts with p-fluorobenzyl alcohol to produce hydrogen chloride and sulfur dioxide gas. The operation is suitable for ventilated places, and the product is easy to separate.

Third, using p-fluorobenzyl halides as raw materials, it undergoes a halogen exchange reaction. Such as p-fluorobenzyl bromide and lithium chloride in a suitable solvent, such as N, N-dimethylformamide, heating reaction, bromine can be replaced with chlorine to obtain the target product. This reaction requires fine adjustment of solvent properties, reactant ratio, temperature, etc.

All methods have advantages and disadvantages. Light chlorination has low cost, but the selectivity is slightly inferior; reduction and re-chlorination first, and the steps are slightly complicated, but high purity products can be obtained; halogen exchange reaction, the conditions are mild and the equipment requirements are not harsh. In practice, when the availability of raw materials, product purity, cost considerations, etc., choose the most suitable method.

α -chloro-p-fluorotoluene What are the precautions during storage and transportation?

% CE% B1 - chloro - p - fluorotoluene is also an organic compound. During storage and transportation, many matters must be paid attention to.

First words storage. This substance should be placed in a cool and ventilated warehouse. Because it is dangerous to be heated, avoid high temperatures and open flames. The temperature of the warehouse should be controlled within an appropriate range to prevent it from decomposing and volatilizing due to excessive temperature. And it must be kept away from fire and heat sources, and keep the container sealed. Because of its certain chemical activity, if it is exposed to air for a long time, or causes deterioration, it will affect its quality and performance.

Furthermore, this substance should be stored separately from oxidizing agents, acids, bases, etc., and should not be mixed. Due to their chemical properties, the cover encounters with their substances, or causes severe chemical reactions, and even causes major accidents such as fires and explosions.

As for transportation. Before transportation, it is necessary to ensure that the packaging is complete and securely loaded. The material of the packaging must be able to resist vibration, collision and friction to prevent material leakage caused by damage to the container. During transportation, the driving speed should be stable, and intense operations such as sudden braking and sharp turns should be avoided to reduce vibration and impact.

Transportation vehicles should also be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. If leakage unfortunately occurs, measures can be taken in time to contain the spread of hazards. During transportation, it is also necessary to prevent exposure to the sun, rain, and high temperature. For summer transportation, it is recommended to choose the cool time in the morning and evening to avoid the high temperature period during the day.

In short, when storing and transporting% CE% B1 - chloro - p - fluorotoluene, it should be treated with caution in terms of temperature, packaging, mixed storage and emergency treatment. Operate according to regulations to ensure safety.