What are the main application fields of 9,9-bis [4- (2-acryloxy ethoxy) phenyl] fluorene?

9,9-Bis [4- (2-methylphenoxyethoxy) phenyl] ethane, which has important applications in medicinal chemistry, materials science and other fields.

In the field of medicinal chemistry, it can be used as a drug intermediate. Because the structure of the compound contains specific functional groups and benzene ring structures, it can be chemically modified and transformed to construct molecules with specific pharmacological activities. If it is based on it, after structural optimization and modification, anti-tumor drugs can be developed. By modifying its side chain or benzene ring, the interaction between drug molecules and tumor cell targets can be adjusted to enhance the inhibitory effect on tumor cells. It can also be developed as a nervous system drug. With the help of structural modification, it has the characteristics of regulating neurotransmitter transmission and improving neural function, and is used in the treatment of neurodegenerative diseases.

In the field of materials science, it can be used as a polymer material monomer. In the structure of 9,9-bis [4- (2-methylphenoxyethoxy) phenyl] ethane, two phenyl rings are connected to a flexible ethoxy group, giving it unique physical and chemical properties. As a monomer, it can be polymerized with other compounds to prepare high-performance engineering plastics. Due to the introduction of this compound, such engineering plastics have excellent thermal stability, mechanical properties and electrical insulation, and are widely used in electronic appliances, automobile manufacturing and other industries. It can also be used to prepare optical materials, using its structural characteristics to prepare materials with specific optical properties, such as high transparency, low birefringence optical lens materials, etc.

What is the synthesis method of 9,9-bis [4- (2-acryloxy ethoxy) phenyl] fluorene?

To prepare 9%, 9-bis [4- (2-methylphenoxyethoxy) phenyl] acetylene, the method is as follows:

First take an appropriate amount of 4- (2-methylphenoxyethoxy) phenol as the starting material. In the clean reactor, fill an appropriate amount of protective gas, such as nitrogen, to create an inert environment to avoid oxidation of the raw materials and products. Subsequently, add an appropriate amount of alkali, such as potassium carbonate, which can assist in the subsequent reaction and enhance the nucleophilicity of the raw materials. < Br >
Add appropriate halogenated acetylene, the activity of the halogen atom can promote the nucleophilic substitution reaction with the base-activated 4- (2-methylphenoxyethoxy) phenol. Control the reaction temperature in a suitable range, generally between 60 and 80 degrees Celsius. This temperature range can not only ensure that the reaction has a certain rate, but also avoid side reactions due to excessive temperature. During the reaction process, continuous stirring is required to make the reactants fully contact and accelerate the reaction process.

After a period of reaction, the reaction process is monitored by thin-layer chromatography (TLC). When the raw material point is basically eliminated, the reaction is basically completed. Then, the reaction mixture is cooled to room temperature, and an appropriate amount of water is added to quench the unreacted base and other active substances. Next, the organic phase is extracted with an organic solvent, such as dichloromethane, and the organic phase is combined after multiple extractions.

The organic phase is dried with anhydrous sodium sulfate to remove the moisture contained in it. After that, the organic solvent is evaporated under reduced pressure to obtain a crude product. Finally, the crude product was purified by column chromatography, and an appropriate eluent, such as a mixed solvent of petroleum ether and ethyl acetate, was selected. According to the difference in the partition coefficient between the product and the impurity in the stationary phase and the mobile phase, the product and the impurity were separated to obtain a pure 9%, 9-bis [4 - (2 - methylphenoxy ethoxy) phenyl] acetylene. The whole process requires fine operation, strict control of each reaction condition and purification step, in order to obtain a high-purity target product.

What are the physical and chemical properties of 9,9-bis [4- (2-acryloxy ethoxy) phenyl] fluorene?

9,9-Bis [4- (2-methylphenoxyethoxy) phenyl] acetylene is an important compound in the field of organic synthesis. Its unique physical and chemical properties are of great significance for its in-depth study in the field of materials science and organic synthetic chemistry.

In terms of physical properties, this compound usually appears as a white to light yellow solid. Due to the long phenoxyethoxy side chain in the molecular structure, the intermolecular force is strong, resulting in a relatively high melting point. In view of its structure having a certain symmetry and rigidity, regular crystal structure, and large lattice energy, the melting point can be within a specific range, and the specific value will fluctuate due to factors such as purity. At the same time, the solubility of the compound is also very critical. Due to the presence of both the lipophilic benzene ring and the ethynyl group in the molecule, as well as a certain hydrophilic ethoxy chain segment, it has a certain solubility in organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF), etc. The lipophilic part makes it better soluble in non-polar or weakly polar organic solvents, and the ethoxy chain segment increases its solubility in some polar organic solvents.

In terms of chemical properties, the ethynyl group in this compound is highly reactive. For example, under the action of a suitable catalyst, the Sonogashira coupling reaction can be carried out to react with halogenated aromatics or halogenated olefins, thereby forming a carbon-carbon bond to expand the conjugate system of molecules, which is widely used in the synthesis of new photoelectric materials. The oxygen atom of the phenoxy ethoxy part has lone pair electrons, which can be used as a coordination atom to coordinate with metal ions to form metal complexes, which in turn changes the physical and chemical properties of the compound, showing potential application value in catalysis, molecular recognition and other fields. Furthermore, due to the presence of substituents on the benzene ring, the electron cloud density of the benzene ring will be affected, making the benzene ring more prone to electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. The molecular structure can be modified by such reactions to meet different application requirements.

What is the market price of 9,9-bis [4- (2-acryloxy ethoxy) phenyl] fluorene?

Looking at this question, I am inquiring about the price of 9,9-bis [4- (2-methoxyethoxy) phenyl] acetylene in the market. However, it is not easy to figure out its price.

The price of this substance often varies depending on various factors. First, whether the purity of the quality is related to the price. If the purity is very high, and the impurities are almost none, the price must be high; if the purity is slightly inferior, containing some impurities, the price may drop slightly. Second, the supply and demand of the market are also key. If there are many people who want it, and the supply is small, the price will rise; if the supply exceeds the demand, the price may fall. Third, the price varies depending on the producer. Well-known large factories, due to fine craftsmanship and strict quality control, the price of their products may be high; small factories offer, the price may be slightly lower.

This substance may be used in specific fields, such as pharmaceutical research and development, materials science, etc. Different fields have different needs, which also affect its price. In pharmaceutical research and development, if it is a key intermediate, it is related to the creation of new drugs, and the price may be high. In materials science, if it is a new material raw material, the price varies according to its performance and application prospects.

However, I have searched for ancient books all over, but I have not been able to get the exact price. If you want to know the details, you can consult chemical raw material suppliers, chemical reagent suppliers, or visit relevant professional trading platforms to get near real-time prices.

What are the manufacturers of 9,9-bis [4- (2-acryloxy ethoxy) phenyl] fluorene?

The manufacturer of 9,9-bis [4- (2-methacryloxyethoxy) phenyl] acetylene is not short of people in China. The world of chemical industry, with new skills, can be used by many people in this industry.

The first [manufacturer A], its factory has been in order for many years, specializing in the chemical industry. In the field of organic synthesis, he has deep attainments. Its exquisite technology, the production of 9,9-bis [4- (2-methacryloxyethoxy) phenyl] acetylene, with high quality and high purity, can be used in various industries, coatings, electronic materials and other industries, and has a great reputation. The factory takes science and technology as the guide, recruits talents, and often researches new techniques, so it can occupy a seat in the market.

The second is [manufacturer B], and it is also a leader in the industry. It upholds ingenuity and strictly grasps quality. In the production process, it is interlinked, and there are rules to follow. This product is made with excellent performance and can be customized to different specifications according to the special requirements of customers. The factory is based on integrity, trades all over the world, and interacts with various merchants, all of which are based on reputation, so its reputation is far-reaching.

Furthermore [manufacturer C], its factory has advanced equipment and complete management. In the manufacture of 9,9-bis [4- (2-methacryloxy ethoxy) phenyl] acetylene, the process is unique. The products it produces are not only of excellent quality, but also can adjust the production capacity in a timely manner with changes in the market. The factory focuses on environmental protection. During production, it strives to reduce pollution and consumption in order to meet the needs of today's green chemical industry.

All these factories are good producers of 9,9-bis [4- (2-methacryloxy ethoxy) phenyl] acetylene. Each has its own strengths, whether it is heavy technology, heavy quality, or heavy reputation. All add luster to the chemical industry to meet the needs of all parties.