What is the chemical structure of (8α, 9R, 8α, 9R) -1,1 '- [ (2,3,5,6-tetrafluoro-1,4-phenylene) bis (methylene) ] bis (6' -methoxyoctinine-1-onium-9-ol) dibromide?

The chemical structure of (8α, 9R, 8'α, 9'R) -1,1 '- [ (2,3,5,6-tetrahydro-1,4-benzylidene) bis (ethylene) ] bis (6' -ethoxybenzodihydropyran-1-heptyl-9-ene) dichloride resembles an ancient secret map containing many delicate mechanisms.

In this structure, the places marked by 8α and 9R are like the key hubs in the secret map, which determine the direction of their space and form the framework of their foundation, and 8'α and 9'R also echo it, like distant echoes, to build a complex spatial structure. 1,1 '-bit is like a central artery, connecting [ (2,3,5,6-tetrahydro-1,4-benzylidene) bis (ethylene) ], this part is like a winding dragon body, 2,3,5,6-tetrahydro structure is like a ring that has passed through the years, and 1,4-benzylidene is like the backbone of the dragon, giving it a tough structure. Bis (ethylene) is like a dragon's whisker that extends, adding agility and change.

Furthermore, the bi (6 '-ethoxybenzodihydropyran-1-heptyl-9-ene) part is like the mysterious treasure box on both sides of the secret map. 6' -ethoxy is like the delicate lock on the box, benzodihydropyran structure is like the box body, fusing ancient charm and delicacy, 1-heptyl-9-ene is like the mysterious rune on the box, giving it unique activity. The dichloride part, like the stars scattered in the secret map, although small, affects the overall electrical and reactive activity, like the power of the stars affects the world. Such a structure is like an ancient artifact, hiding endless mysteries in it, waiting for explorers to decipher.

(8α, 9R, 8α, 9R) -1,1 '- [ (2,3,5,6-tetrafluoro-1,4-phenylene) bis (methylene) ] bis (6' -methoxyoctanine-1-onium-9-ol) What are the main application fields of dibromide?

(8α, 9R, 8'α, 9'R) - 1,1 '- [ (2,3,5,6-tetrahydro-1,4-naphthylene) bis (ethylene) ] bis (6' -ethoxybenzoxazine-1-ketone-9-ester) dihalides, the main application fields of this compound are medicinal chemistry, because of its complex group combination in the structure, or can be used as a potential pharmaceutical active ingredient, rationally modified and developed for the synthesis of drugs for specific diseases; in the field of materials science, its unique molecular structure endows materials with specific physical and chemical properties, which can be applied to the preparation of high-performance polymer materials to improve the Mechanical properties, thermal stability, etc.; in the field of organic synthesis, as an important organic synthesis intermediate, with its bis (ethylene) and benzoxazine structures, it can participate in the construction of various complex organic compounds, providing a foundation for the synthesis of new organic materials and drugs.

(8α, 9R, 8'α, 9'R) -1,1 '- [ (2,3,5,6-tetrafluoro-1,4-phenylene) bis (methylene) ] bis (6' -methoxyoctinine-1-onium-9-ol) What is the synthesis method of dibromide?

(8α, 9R, 8'α, 9'R) -1,1 '- [ (2,3,5,6-tetrahydro-1,4-diazanaphthalene) bis (ethylene) ] bis (6' -methoxybenzodihydropyran-1-one-9-carboxylic acid) diester compounds are synthesized as follows:

The starting material should be selected with the corresponding substituent group of diazanaphthalene derivatives and benzodihydropyrone carboxylic acid esters.

In the first step, in a suitable reaction vessel, in an inert gas-protected atmosphere, the diazonaphthalene derivative is incorporated into an organic solvent, such as anhydrous tetrahydrofuran, dichloromethane, etc. An appropriate amount of alkali, such as potassium carbonate, sodium carbonate, etc., is added to this solution to regulate the pH of the reaction environment. After stirring evenly, slowly add the reagent containing the active substituent of ethylene. The dropwise addition process needs to control the rate to avoid the reaction being too violent. Maintain a certain temperature, usually between room temperature and 50 ° C, and continue to stir the reaction for several hours. With the help of thin-layer chromatography (TLC), the reaction progress is monitored in real time until the raw material point basically disappears, that is, it is determined that this step of the reaction < Br >
Next step, the product obtained in the first step is separated and purified by column chromatography or recrystallization. After that, the purified product is put into a new reaction system, and another benzodihydropyrone carboxylate derivative is added, and a suitable catalyst is added, such as an organotin catalyst. This reaction is also carried out in a high-boiling organic solvent such as toluene under the protection of inert gas, in a specific temperature range, generally 80 ° C - 120 ° C. During the reaction, continue to stir. After several hours of reaction, the progress of the reaction is monitored again by TLC. When the reaction is complete, the reaction mixture is cooled.

Last step, the separation and purification of the final product are carried out. The organic solvent was first removed by reduced pressure distillation, and then by column chromatography, silica gel was used as the stationary phase, and petroleum ether and ethyl acetate were mixed as the mobile phase in a specific ratio to carry out elution separation, and the eluent containing the target product was collected. The solvent was removed by rotary evaporation to obtain pure (8α, 9R, 8'α, 9'R) -1,1 '- [ (2,3,5,6-tetrahydro-1,4-diazanaphthalene) bis (ethylene) ] bis (6' -methoxybenzodihydropyran-1-ketone-9-carboxylic acid) diesters. After each step of the reaction, the structure and purity of the product need to be accurately tested to ensure that it meets expectations before proceeding to the next step of the reaction, so as to obtain the target product.

What are the physical properties of (8α, 9R, 8α, 9R) -1,1 '- [ (2,3,5,6-tetrafluoro-1,4-phenylene) bis (methylene) ] bis (6' -methoxyoctinine-1-onium-9-ol) dibromide?

(8α, 9R, 8'α, 9'R) -1,1 '- [ (2,3,5,6-tetrahydro-1,4-benzylidene) bis (ethylene) ] bis (6' -acetoxybenzodihydropyran-1-heptyl-9-ol) dichloride What are the physical properties of (8α, 9R, 8'α, 9'R) -1,1 '- [ (2,3,5,6-tetrahydro-1,4-benzylidene) bis (6' -acetoxybenzodihydropyran-1-heptyl-9-ol) dichloride?

This is a rather complex organic compound. Among its physical properties, the melting point is one of the important properties. However, due to its complex structure and diverse intermolecular forces, its melting point is difficult to predict simply, or it needs to be accurately determined through experiments. Generally speaking, the melting point of such organic compounds may be in a certain temperature range. At this temperature, the thermal motion of the molecule is sufficient to overcome the lattice energy, so as to realize the transition from solid to liquid state.

Furthermore, solubility is also a key physical property. In view of the fact that the molecule contains both polar groups such as acetoxy groups and non-polar parts such as benzylidene and benzodihydropyran, its solubility in solvents is relatively unique. In polar solvents, such as water and alcohols, polar groups can interact with solvent molecules to form hydrogen bonds, or have a certain solubility; in non-polar solvents, such as alkanes, the interaction of non-polar parts is dominant, and it may also have a certain solubility. The overall solubility depends on the specific solvent and the structural details of the compound.

In addition, density is also one of the physical properties. The density of this compound is closely related to the molecular weight and the way of molecular packing. The complex structure makes the molecular packing or more compact, and its density may be relatively large, but the exact value still needs to be determined by experimental measurement. At the same time, the compound may have a specific refractive index, which is related to the molecular structure and electron cloud distribution, which can be used to identify the purity and structural characteristics of the compound.

What are the catalytic properties of (8α, 9R, 8α, 9R) -1,1 '- [ (2,3,5,6-tetrafluoro-1,4-phenylene) bis (methylene) ] bis (6' -methoxyoctinine-1-onium-9-ol) dibromide in the reaction?

(8α, 9R, 8'α, 9'R) -1,1 '- [ (2,3,5,6-tetrahydro-1,4-benzylidene) bis (ethylene) ] bis (6' -acetyl-chroman-1-naphthalene-9-phenol) disulfide How is the catalytic performance in the reaction? This compound has a complex structure and is explained in classical Chinese from the perspective of "Tiangong Kaiwu". Its catalytic performance is similar to the ancient study of physical property changes.

Looking at this compound, it is like an exquisite formula in ancient times, and the atomic groups are cleverly combined like all kinds of materials. This disulfide is in the process of reaction, or like the medicinal induction of alchemy in ancient times, it affects the whole body and has a significant impact on the reaction process. Its catalytic ability, if properly controlled, can be like a good craftsman, making the reaction smooth and the product excellent; if there is a slight error, it will be like misplacing medicinal stones and causing disordered reactions.

In the reaction system, this disulfide may reduce the energy required for the reaction, just like opening a path, making it easy for the reactants to move forward and accelerating the change of chemical synthesis and decomposition. However, its catalytic activity is also affected by many factors, such as temperature, the proportion of reactants, and it is like the right time and place, and it needs to be properly prepared in order to exert its maximum effectiveness.

It can be compared to the ancient brewing method. The amount of koji and the temperature of fermentation are all related to the quality of the wine. This disulfide also needs to be precisely adjusted in order to gain insight into its catalysis, so that the reaction can be achieved according to people's wishes, and its unique catalytic efficiency can be demonstrated.