What is the main use of 4- (difluoromethoxy) -3-isopropoxybenzamide?

4- (diethylamino) -3 -isopropoxyphenylacetamide has a wide range of main uses.

This substance is often used as a key intermediate in the field of medicine. Due to its structural properties, a variety of compounds with specific pharmacological activities can be derived through a series of chemical reactions. For example, in the development of neurological drugs, it may participate in the construction of drug molecules that regulate the transmission function of neurotransmitters and help relieve neurological diseases such as anxiety and depression.

In the field of organic synthetic chemistry, it is also of important value. It can be used as a starting material. With its different functional groups, such as ethylamino and isopropoxy, various organic reactions, such as substitution reactions, addition reactions, etc., can be used to construct complex organic molecular structures. Chemists can use this to synthesize materials with unique physical and chemical properties, or to develop new materials, such as special optical materials, polymer materials, etc.

In addition, in the study of the structure-activity relationship of pharmaceutical chemistry, 4- (diethylamino) -3 -isopropoxy phenylacetamide can provide a good model for studying the relationship between molecular structure and biological activity due to its various substituents. By adjusting the type, location and quantity of its substituents, researchers explore the impact on biological activity, and then lay the foundation for the design and development of high-efficiency and low-toxicity drugs.

What are the chemical properties of 4- (difluoromethoxy) -3-isopropoxybenzamide?

4- (diethylamino) -3 -isopropoxyphenylacetamide, this is an organic compound. Its chemical properties are unique and closely related to many reactions.

First of all, its molecule contains amino and amide groups, which give it a certain degree of alkalinity. The nitrogen atom in the amino group has a lone pair of electrons and can accept protons, thus exhibiting alkaline characteristics. In acidic media, amino groups easily combine with protons to form positively charged ammonium ions.

Furthermore, amide groups have certain stability, but under certain conditions, such as in strong acids or bases and in heated environments, hydrolysis reactions can occur. Under acidic conditions, hydrolysis produces corresponding carboxylic acids and amines; under basic conditions, hydrolysis produces carboxylic salts and amines.

In addition, the ethoxy group and isopropoxy group in the molecule belong to the alkoxy group. The oxygen atom in the alkoxy group is connected to the benzene ring. Due to the electronic effect of the oxygen atom, the electron cloud distribution of the benzene ring is affected, which in turn changes the reactivity of the benzene ring. In the electrophilic substitution reaction, the alkoxy group is an ortho and para-site group, which helps the electrophilic reagent to attack the ortho and para-sites of the benzene ring.

At the same time, the alkyl moiety in the compound, such as ethyl and isopropyl, This results in differences in the solubility of the whole molecule in different solvents. The solubility is relatively high in non-polar or weakly polar solvents, while the solubility is low in polar solvents.

Because of the coexistence of multiple functional groups in its structure, each functional group affects each other, resulting in 4- (diethylamino) - 3 - isopropoxyphenylacetamide can be used as a current or intermediate in the field of organic synthesis, participating in the preparation of many complex organic compounds.

What is the synthesis method of 4- (difluoromethoxy) -3-isopropoxybenzamide?

To prepare 4- (diethylamino) -3 -isopropoxyacetophenone, you can do it as follows.

First take an appropriate amount of phenolic compounds, such as resorcinol, as the reaction starter. Use an appropriate base, such as potassium carbonate, as an acid binding agent, in an organic solvent, such as N, N -dimethylformamide (DMF), with isopropyl halide, such as isopropyl bromide, for nucleophilic substitution. This step aims to convert one of the phenolic hydroxyl groups into isopropoxy. During the reaction, control the temperature in a moderate range, about 50-80 ° C, and continue to stir for a number of times to make the reaction fully proceed. After monitoring the reaction process, when the raw materials are exhausted, the phenolic intermediate containing isopropoxy is obtained by conventional separation methods, such as extraction and column chromatography.

The intermediate is then reacted with diethylamine under appropriate conditions. With a suitable catalyst, such as the catalytic system composed of cuprous iodide and corresponding ligands, in an alkaline environment, such as cesium carbonate as a base, in an organic solvent, heated to 80-120 ℃, the phenolic hydroxyl group and diethylamine undergo nucleophilic substitution to form 4- (diethylamino) phenolic derivatives. After the reaction is completed, the pure 4- (diethylamino) phenolic products are obtained by separation and purification. < Br >
Then, the product is combined with an acetyl halide, such as acetyl chloride, in the presence of a Lewis acid catalyst, such as anhydrous aluminum trichloride, at a low temperature, such as 0-5 ° C. This step can be completed in inert organic solvents such as dichloromethane. Care should be taken to isolate water vapor during the reaction to ensure a smooth reaction. After the reaction is completed, the target product 4 - (diethylamino) -3 - isopropoxyacetophenone can be obtained through hydrolysis, neutralization, extraction, drying, and column chromatography. After each step of the reaction, the purity and structure of the product should be accurately analyzed to ensure that it meets expectations, so as to facilitate subsequent reactions.

What is the price range of 4- (difluoromethoxy) -3-isopropoxybenzamide in the market?

Nowadays, there is dihydroxyethyl-3-isopropoxyphenylacetic acid in the market. What is its price?

This dihydroxyethyl-3-isopropoxyphenylacetic acid is an organic compound and is often used as a raw material in the field of medicine and chemical industry. Its market value depends on many factors, the first of which is purity. If the purity is extremely high, almost pharmaceutical grade, and there are few impurities, this is suitable for fine pharmaceutical synthesis, and the price must be high. Because its preparation requires fine technology, strict control of impurities, and huge labor and material resources, its price may reach tens or even hundreds of yuan per gram.

Furthermore, market supply and demand also affect its price. If there is a sudden increase in demand for drugs with this structure in current pharmaceutical research and development, the demand will exceed the supply, and the price will also rise. On the contrary, if the supply exceeds the demand, the manufacturer will sell its goods or reduce the price.

In addition, the scale of production also has an impact. In large-scale production, due to the scale effect, the unit cost is reduced, and the price may become more affordable; in small-scale production, the cost is high, and the price is also high.

In addition, the price varies depending on the region. In prosperous cities, with convenient transportation, well-informed information, and fierce competition, the price may be relatively reasonable; in remote areas, the transportation cost is high, and the information is not smooth, and the price may be slightly higher.

Overall, the price of dihydroxyethyl-3-isopropoxyphenylacetic acid is between a few and a hundred yuan per gram in the city, but this is only an approximate number. The actual price depends on the specific situation.

What are the safety and toxicity of 4- (difluoromethoxy) -3-isopropoxybenzamide?

The safety and toxicity of 4- (diethylamino) -3 -isobutoxy phenylacetamide are related to many aspects. The pharmacological and chemical properties of this substance have an impact on its safety and toxicity.

Looking at its chemical structure, the existence of diethylamino and isobutoxy may affect its metabolism, distribution and interaction in organisms. From a safety perspective, if this substance is used in medicine or other fields, after it enters the organism, it is necessary to consider its impact on various organs and systems. If it is in the nervous system, it may affect the transmission of neurotransmitters due to the characteristics of the groups in the structure, resulting in abnormal nervous system function. In the cardiovascular system, it may also interfere with ion channels, affect cardiac rhythm and vascular tension.

When it comes to toxicity, its acute and chronic toxicity should be considered. Acute toxicity may be reflected in high-dose exposure in a short period of time, causing severe adverse reactions in the body, such as breathing difficulties, convulsions, etc. Chronic toxicity may gradually appear during long-term low-dose exposure, such as affecting normal cell metabolism, causing cell mutation, carcinogenesis, or interfering with the endocrine system, causing reproductive and developmental abnormalities.

Because it is an organic compound, it may be difficult to degrade in the environment, or it may cause harm to the ecosystem. When discharged into the natural environment, it may accumulate in organisms and be transmitted through the food chain, affecting many biological populations, thereby destroying the ecological balance.

In summary, the safety and toxicity of 4- (diethylamino) -3 -isobutoxy phenylacetamide are complex, and it is necessary to explore in depth from various aspects to clarify its latent risk and ensure its safe use.