This product 4- [ (2E) -3- (3,5-dichloro-4-fluorophenyl) -4,4,4-trifluorobutyl-2-enoyl] -N- [ (4R) -2-ethyl-3-oxo-1,2-oxazolidine-4-yl] -2-methylbenzamide What is the main use of

The name of this drug is 4- [ (2E) -3 - (3,5-difluoro-4-allyl) -4,4,4-trifluorobutyl-2-alkynyl] -N - [ (4R) -2 -methyl-3-oxo-1,2-benzoisothiazole-4-yl] -2 -methylbenzamide. Although its main use was not available in ancient times mentioned in Tiangong Kaiwu, it can be explained in this way from a scientific perspective and an analogy of medical use today.

In the field of current medicine, such compounds may play a key role in the treatment of specific diseases. Or used for targeted treatment of some difficult diseases, such as specific tumor diseases. Due to its unique chemical structure, it can precisely act on specific targets of diseased cells, interfering with abnormal cell metabolism or proliferation processes, in order to control the disease and relieve symptoms.

Or it may emerge in the treatment of immunoregulation-related diseases. With its structural properties, it regulates the activity and function of the body's immune cells, corrects immune imbalances, and helps the immune system restore its normal ability to resist diseases.

It may also make a difference in the treatment of neurodegenerative diseases. By regulating the microenvironment of nerve cells, nerve cells are protected from damage, disease progression is delayed, and patients' cognitive and motor functions are improved. Although it is difficult to describe the use of this drug in "Tiangong Kaiwu", from the perspective of current medical development, such complex compounds are mostly focused on the precise treatment of diseases and the regulation of key physiological processes of the body, etc., to escort human health.

4- [ (2E) -3- (3,5-dichloro-4-fluorophenyl) -4,4,4-trifluorobutyl-2-enoyl] -N- [ (4R) -2-ethyl-3-oxo-1,2-oxazolidine-4-yl] -2-methylbenzamide What are the chemical properties of

4 - [ (2E) - 3 - (3,5 - dioxy - 4 - hydroxybenzyl) - 4,4,4 - trifluorobutyl - 2 - alkynyl] - N - [ (4R) - 2 - ethyl - 3 - oxo - 1,2 - oxazolidine - 4 - yl] - 2 - methylbenzylbenzoate This compound has the following chemical properties:

Its structure contains a number of special functional groups, giving it a unique chemical activity. For example, the alkynyl group in the molecule has strong unsaturation and can undergo a variety of addition reactions. Under suitable catalysts and reaction conditions, it can be added to hydrogen and gradually converted into olefins or even alkanes; it can also be added to electrophilic reagents such as hydrogen halides to generate halogenated olefin derivatives.

Trifluorobutyl in the molecule has high chemical stability and unique electronic effects due to the strong electronegativity of fluorine atoms. This not only affects the polarity of the molecule as a whole, but also acts as a stable structural unit in some reactions, affecting the selectivity and rate of the reaction. At the same time, the existence of trifluoromethyl also makes the solubility of the compound in some organic solvents show particularity.

Oxygen-containing heterocyclic structures such as dioxy and oxazolidinone. These heterocyclic rings can participate in cyclization, ring opening and other reactions under certain conditions. For example, under acidic or basic conditions, the oxazolidinone ring may open the ring and react with nucleophiles to form new nitrogen and oxygen-containing compounds, thereby changing the structure and properties of the molecule.

And the benzyl benzoate part, the benzene ring in the benzyl group has aromatic properties and can undergo electrophilic substitution reactions, such as halogenation, nitration, sulfonation, etc.; the benzoate structure can be hydrolyzed under basic or acidic conditions to produce benzoic acid and corresponding alcohols. In organic synthesis, this kind of hydrolysis reaction can be used to modify the structure of molecules or to realize the gradual transformation and functionalization of compounds under specific conditions.

What is the production process of 4- [ (2E) -3- (3,5-dichloro-4-fluorophenyl) -4,4,4-trifluorobutyl-2-enoyl] -N- [ (4R) -2-ethyl-3-oxo-1,2-oxazolidine-4-yl] -2-methylbenzamide?

To prepare 4- [ (2E) -3 - (3,5 - difluoro - 4 - ethoxyphenyl) - 4,4,4 - trifluorobutyl - 2 - alkynyl] - N - [ (4R) -2 - methyl - 3 - oxo - 1,2 - benzisoxazole - 4 - yl] - 2 - methylphenylacetamide, the preparation process is as follows:

First take a suitable reaction vessel and prepare the required raw materials and reagents, such as (2E) -3 - (3,5 - difluoro- 4-Ethoxyphenyl) -4,4,4-trifluorobutyl-2-alkyne, (4R) -2-methyl-3-oxo-1,2-benzisoxazole-4-amine, 2-methylphenylacetyl halogen, etc.

In the reaction vessel, according to a certain stoichiometric ratio, add (2E) -3 - (3,5-difluoro-4-ethoxyphenyl) -4,4,4-trifluorobutyl-2-alkyne and (4R) -2-methyl-3-oxo-1,2-benzisoxazole-4-amine, dissolve in an appropriate amount of organic solvent, such as dichloromethane, N, N-dimethylformamide, etc., so that the two are fully mixed. < Br >
Add suitable bases, such as triethylamine, potassium carbonate, etc., to adjust the pH of the reaction system and promote the progress of the reaction. Control the reaction temperature, usually at room temperature or under moderate heating conditions, stir the reaction for a certain period of time. During this process, nucleophilic substitution and other reactions occur between the raw material molecules, and the precursor of the target product is gradually formed.

Then, 2-methylphenylacetyl halide is added to the reaction system to continue the reaction. This step of the reaction aims to introduce 2-methylphenylacetyl group to finally construct a complete target molecular structure. During the reaction, the reaction process needs to be closely monitored, and the reaction can be determined by analysis methods such as thin-layer chromatography and liquid chromatography.

After the reaction is completed, the reaction solution is post-processed. Generally, the reaction is quenched with an appropriate amount of water, and then extracted with an organic solvent to collect the organic phase. The moisture in the organic phase is removed with a desiccant such as anhydrous sodium sulfate, and the desiccant is filtered to remove the desiccant. The organic solvent is removed by vacuum distillation to obtain a crude product.

The crude product is purified by means of column chromatography, using a suitable silica gel column and eluent to separate and purify the crude product, and finally obtain a high purity of 4- [ (2E) -3 - (3,5 -difluoro-4 -ethoxyphenyl) -4,4,4 -trifluorobutyl-2 -alkynyl] -N - [ (4R) -2 -methyl-3 -oxo-1,2 -benzisoxazole-4-yl] -2 -methylphenylacetamide product. The entire preparation process requires strict control of the reaction conditions and operation details to ensure the yield and purity of the product.

4- [ (2E) -3- (3,5-dichloro-4-fluorophenyl) -4,4,4-trifluorobutyl-2-enoyl] -N- [ (4R) -2-ethyl-3-oxazolidine-4-yl] -2-methylbenzamide What are the Quality Standards

4 - [ (2E) - 3 - (3,5 - dioxy - 4 - ethylphenyl) - 4,4,4 - trifluorobutyl - 2 - alkynyl] - N - [ (4R) - 2 - ethyl - 3 - oxo - 1,2 - oxazolidine - 4 - yl] - 2 - methylphenylacetamide is an organic compound. The Quality Standard for this compound is not directly contained in Tiangong Kaiwu, but it can be deduced according to the concept of ancient pharmaceutical and technological records.

View the ancient pharmaceuticals and processes, and the purity of the first raw materials. The raw materials for this compound, such as (2E) -3- (3,5-dioxo-4-ethylphenyl), etc., need to be selected with excellent texture and no impurities. When picking, choose according to the solar terms and the origin. For example, when picking herbs, harvest their buds in spring, harvest their leaves in summer, harvest their fruits in autumn, and harvest their roots in winter, according to the time, to obtain the best properties of raw materials. The origin of raw materials is also important. Different regions have different water and soil climates, and the properties of products are also different. It is necessary to choose those produced in suitable places.

Secondly, the preparation process needs to be precisely controlled. The temperature, time, and material ratio of the reaction are all key. Although the ancient process did not have modern accurate equipment, it can be obtained by experience and observation. For example, alchemy and cooking medicine, in terms of heat, simmering slowly and frying quickly, each has its own use. The preparation of this compound also needs to control the temperature and time according to the reaction characteristics, so that the reaction is sufficient and not excessive. The material ratio also needs to be strictly followed. One point more is too much, and one point less is not enough to obtain a pure product.

Furthermore, the purity and impurity content of the product need to be checked. Although there are no modern precision testing instruments in ancient times, it can be roughly judged by methods such as appearance, smell, and solubility. The product should be uniform in color and odor, and has good solubility in specific solvents. If the appearance is variegated, the smell is pungent or the solubility is abnormal, the product is known to be impure and needs to be refined again.

As for the content determination, the ancient or simple means such as gravimetric method and volumetric method can be used. Although it is not as accurate as modern high-performance liquid chromatography, it is still possible to obtain a rough estimate. Taking the gravimetric method as an example, if the theoretical yield of the product is known, the actual product weight can be weighed. In comparison, it is known whether the content is up to standard.

In summary, although "Tiangong Kaiwu" does not detail 4- [ (2E) -3- (3,5-dioxy-4-ethylphenyl) -4,4,4-trifluorobutyl-2-alkynyl] -N - [ (4R) -2-ethyl-3-oxo-1,2-oxazolidine-4-yl] - 2 -methylphenylacetamide Quality Standard, but according to the ancient process concept, from the raw materials, preparation, testing, etc., can build a set to ensure its quality Law.

What are the market prospects for 4- [ (2E) -3- (3,5-dichloro-4-fluorophenyl) -4,4,4-trifluorobutyl-2-enoyl] -N- [ (4R) -2-ethyl-3-oxoxazolidine-4-yl] -2-methylbenzamide?

4 - [ (2E) - 3 - (3,5 - dioxy - 4 - ethylphenyl) - 4,4,4 - trifluorobutyl - 2 - alkynyl] - N - [ (4R) - 2 - methyl - 3 - oxo - 1,2 - oxazolidine - 4 - yl] - 2 - methylphenylacetamide, the market prospect of this product is related to many aspects.

View its structure, complex and unique, or with specific physical and chemical properties and biological activities. In the field of medicine, if it shows good affinity and inhibitory or excitatory effects on specific disease targets, the development of therapeutic drugs will have promising prospects. For example, many innovative drugs today can overcome difficult diseases with their unique chemical structures and win a broad market.

In terms of pesticides, if they are highly toxic to pests or interfere with their growth and development, they can become new pesticides and find opportunities in the development of green agriculture. At present, there is a growing demand for environmentally friendly and efficient pesticides. If this compound meets the requirements, the market potential is huge.

However, its market expansion also faces challenges. The synthesis process may be complex, the cost is high, and large-scale production and application are restricted. And new compounds need to undergo strict safety and effectiveness assessments, with long cycles and high costs. Only by successfully overcoming these obstacles can we gain a firm foothold in the market and gain considerable profits and development space.