What is the main use of 4- (1,1,2,3,3,3-heptafluoropropane-2-yl) -2-methylaniline?

The main use of 4 - (1,1,1,2,3,3,3-heptafluoropropane-2-yl) - 2-methylbenzofuran is in the matter of fire. Heptafluoropropane, which is often used for fire, has a high color, taste, low toxicity, good performance and does not contaminate the object to be protected.

In this compound, the presence of heptafluoropropane makes it effective in fire performance. The principle of fire is that heptafluoropropane can decompose free radicals at high temperatures, and these free radicals can be used to prevent combustion and reverse fire, and cause fire.

2-methylbenzofuran as a component of this compound, or its qualitative and physical properties have been affected, or its fire efficiency table in different environments has been adjusted. In particular, 4- (1,1,2,3,3,3-heptafluoropropane-2-yl) -2-methylbenzofuran is mainly used in the field of fire, with its unique chemical properties, exhibits good fire performance, and can be used in general need of effective fire and high environmental and protective materials requirements, such as buildings, buildings, museums, etc., to ensure its safety and protection from fire.

What are the physical properties of 4- (1,1,1,2,3,3,3-heptafluoropropane-2-yl) -2-methylaniline

4- (1,1,1,2,3,3,3, 3-heptafluoropropane-2-yl) - 2-methylfuranaldehyde, which is an organic compound. Its physical properties are quite critical and are related to many practical applications.

Looking at its state, it is mostly in a liquid state at room temperature and pressure. Due to the intermolecular forces, there is a certain van der Waals force between the molecules, which allows it to maintain a liquid state under these conditions. This state makes it fluid and easy to disperse uniformly in many reaction systems and participate in the reaction. < Br >
When it comes to boiling points, due to the presence of various groups in the molecular structure, such as methyl groups, furan rings, and fluorine-containing groups, these groups interact to cause their boiling points to have specific values. Fluorine-containing groups can enhance the intermolecular forces and increase the boiling point. The specific boiling point is determined by precise experiments, but the approximate range can be inferred from the characteristics of similar structural compounds. This boiling point characteristic is extremely important in the separation and purification of the compound, and can be separated according to the boiling point difference by means of distillation.

Melting point is also an important physical property, which depends on the arrangement regularity and interaction force of the molecules. The complexity of the molecular structure of the compound causes its molecules to be arranged in a specific way, which determines the melting point. The accurate determination of the melting point helps to distinguish the purity of the compound. If it contains impurities, the melting point often changes, or decreases, or the melting range becomes wider.

In terms of solubility, because its molecular structure contains polar and non-polar parts, it has good solubility in organic solvents, such as common ethanol, ether, etc. The polar aldehyde group and part of the non-polar carbon chain and fluorine-containing structure enable it to form intermolecular interactions with a variety of organic solvents, and then dissolve. This solubility can be used in organic synthesis to select suitable solvents to promote the reaction.

The density cannot be ignored either. Due to the molecular composition and structural characteristics, its density has a specific value. Density data is of great significance in chemical production, storage, etc. It is related to the conversion of material volume and quality, and affects the design of process flow.

What are the chemical properties of 4- (1,1,1,2,3,3,3-heptafluoropropane-2-yl) -2-methylaniline?

4 - (1,1,1,2,3,3,3, 3 - heptafluoropropane - 2 - yl) - 2 - methylpyridine, the chemical properties of this compound are quite complex.

Structurally, heptafluoropropane part endows it with unique physical and chemical properties. The electronegativity of fluorine atoms is large, which makes the molecule have high stability and low reactivity. The presence of heptafluoropropane changes the electron cloud distribution of the whole molecule and affects its polarity.

2 - methylpyridine part, the pyridine ring is aromatic, and the lone pair electrons of the nitrogen atom on the ring make it alkaline to a certain extent. The introduction of methyl groups further changes the electron cloud density and spatial structure of the molecule. Methyl as the power supply group can increase the electron cloud density of the pyridine ring, enhance its nucleophilicity, and affect its reactivity with electrophilic reagents.

In chemical reactions, this compound is relatively stable due to the aromatic stability of the pyridine ring, but it can also react under specific conditions, such as high temperature, strong acid base or when there is a suitable catalyst. Electrophilic substitution reactions can be carried out on the pyridine ring. Due to the positioning effect of methyl, the substitution check point will be selective. Although the heptafluoropropane part is stable, under extreme conditions, the fluorine atom may also undergo substitution or elimination reactions.

In terms of physical properties, due to the large number of fluorine atoms, the intermolecular forces are different from those of common organic compounds, affecting their boiling point, melting point and solubility. Fluorine-containing groups usually make compounds have low surface tension and good fat solubility, which may have good solubility in organic solvents.

What is the production method of 4- (1,1,1,2,3,3,3-heptafluoropropane-2-yl) -2-methylaniline?

To prepare 4- (1,1,1,2,3,3,3-heptafluoropropyl-2-methyl) -2-methylphenylboronic acid, the following ancient method can be used:

Take an appropriate amount of 1,1,2,3,3,3-heptafluoropropyl-2-methyl halogen and place it in a clean reactor. The kettle is pre-injected with an appropriate amount of anhydrous organic solvent, such as tetrahydrofuran, to ensure the uniformity and solubility of the reaction system. In this system, metal magnesium chips are slowly added, and at the same time, gentle stirring and appropriate heating are added to maintain the reaction temperature within a certain range, so that the halogen reacts with magnesium chips to generate 1, 1, 2, 3, 3-heptafluoropropyl-2-methylmagnesium halide. This reaction needs to be carried out under the protection of an inert gas, such as nitrogen or argon, to prevent the Grignard reagent from reacting adversely with water and oxygen in the air.

After the preparation of the Grignard reagent is completed, take another 2-methylphenylborate and slowly drop it into the reaction system containing the Grignard reagent above. The rate of the dropwise addition process needs to be carefully controlled to avoid excessive reaction. After the dropwise addition is completed, continue to stir the reaction for a period of time to promote the full reaction of the two to form the borate ester intermediate of the target product.

After the reaction is completed, the reaction mixture is cooled to room temperature, and then an appropriate amount of dilute acid solution, such as dilute hydrochloric acid or dilute sulfuric acid, is slowly added to hydrolyze the borate ester intermediate to obtain 4- (1,1,1,2,3,3-heptafluoropropyl-2-methyl) -2-methylphenylboronic acid. After the hydrolysis is completed, the reaction mixture is extracted with an organic solvent to separate the organic phase. After the organic phase is dried with a desiccant such as anhydrous sodium sulfate, the organic solvent is removed by reduced pressure distillation to obtain a crude product.

The crude product is further purified by column chromatography or recrystallization, and a suitable eluent or solvent system is selected to remove impurities, and finally a pure 4- (1,1,2,3,3,3-heptafluoropropyl-2-methyl) -2-methylphenylboronic acid is obtained. During the whole preparation process, the reaction conditions, including temperature, ratio of reactants, reaction time, etc. must be strictly controlled to ensure the smooth progress of the reaction and the high yield and purity of the product.

What are the precautions for using 4- (1,1,1,2,3,3,3-heptafluoropropane-2-yl) -2-methylaniline?

To prepare 4- (1,1,1,2,3,3,3-heptafluoropropane-2-yl) -2-methylphenylboronic acid, there are many points to be paid attention to in the preparation process.

The quality of the first raw material, the purity and stability of the raw material have a great impact on the product. It is necessary to carefully select suppliers and strictly check their quality. If the raw material is not good, the product will be difficult to purify and the reaction may not meet expectations.

The reaction conditions are also critical. Temperature must be precisely controlled, and different stages of the reaction have different temperature requirements. If the temperature is raised too fast or too slowly, the reaction will be biased towards side reactions and the yield of the main product will be reduced. For the preparation of 4- (1,1,1,2,3,3,3-heptafluoropropane-2-yl) -2-methylphenylboronic acid, a specific reaction stage may require a certain precise temperature range to ensure a smooth reaction. The same is true for pressure. Appropriate pressure can promote mass transfer and reaction process of substances. Improper pressure or abnormal reaction rate.

The choice and dosage of catalyst should not be underestimated. Choosing the right catalyst can greatly improve the reaction rate and selectivity, but the dosage needs to be cautious. Most may cause overreaction, and at least the catalytic effect is not good.

The reaction solvent is also exquisite. Its properties such as polarity and solubility are related to the dissolution of the reactants and the progress of the reaction. Suitable solvents can fully contact the reactants and improve the reaction efficiency. If the solvent is improper, or the reactants are unevenly dispersed, the reaction will be affected.

In addition, the cleaning and drying of the reaction equipment cannot be ignored. Impurities or moisture are mixed in, or side reactions are triggered, interfering with the main reaction, so the equipment must be thoroughly cleaned and dried before use.

The operation process should be rigorous. The order and speed of adding reagents are standardized, and they can be changed at will or cause the reaction to get out of control. And close monitoring is required during the reaction period, and the conditions should be adjusted in a timely manner according to the reaction process to ensure smooth preparation and obtain high-quality products.