What is the chemical structure of (3R, 5S, 6E) -methyl-7- (4- (4-fluorophenyl) -6-isopropyl-2- (N-methylmethylsulfonamido) pyrimidin-5-yl) -3, 5-dihydroxyhept-6-enoate?

There is a substance called\ ((3R, 5S, 6E) \) -methyl-7 -\ ((4 - (4 - fluorophenyl) -6 - isopropyl - 2 - (N - methylmethylsulfonamido) pyrimidin - 5 - yl) -3,5 - dihydroxyhept - 6 - enoate\). To know its chemical structure, let me tell you in detail.

In the structure of this substance, "methyl" clearly shows a methyl group. " 3,5 - dihydroxyhept - 6 - enoate ", the main chain of the" hept "table contains seven carbon atoms," 6 - ene "shows a carbon-carbon double bond at position 6," 3,5 - dihydroxy "indicates a hydroxyl group at position 3 and position 5," oate "implies the presence of an ester group and is connected to the main chain.

Look at the" 7 -\ ((4- (4 - fluorophenyl) -6 - isopropyl - 2 - (N - methylmethylsulfonamido) pyrimidin - 5 - yl) \) "part, where" pyrimidin "is a pyrimidin ring, which is connected to the main chain at position 5." 4 - (4 - fluorophenyl) "indicates that the pyrimidine ring is connected with a 4-fluorophenyl group at the 4th position," 6 - isopropyl "indicates that the 6 position is connected with an isopropyl group, and" 2 - (N - methylmethylsulfonamido) "means that the 2 position is connected with a\ (N -\) methylmethylsulfonamide group.

In summary, the chemical structure of this compound is composed of a seven-carbon backbone containing carbon-carbon double bonds, hydroxyl groups, and ester groups, and a pyrimidine ring with a specific substituent.

What are the physical properties of (3R, 5S, 6E) -methyl-7- (4- (4-fluorophenyl) -6-isopropyl-2- (N-methylmethylsulfonamido) pyrimidin-5-yl) -3, 5-dihydroxyhept-6-enoate?

(3R, 5S, 6E) -methyl-7- (4- (4-fluorophenyl) -6-isopropyl-2- (N-methylmethylsulfonamido) pyrimidine-5-yl) -3,5-dihydroxyheptyl-6-enoate The physical properties of this product are particularly important, which is related to its performance and application in various situations.

Looking at its properties, it often takes a specific form, or is a crystalline solid with a specific crystalline structure and color, which may be due to its molecular arrangement and interaction. The melting point is one of the key physical properties. The value of the melting point reflects the strength of the intermolecular force, which is related to the temperature node of the substance from the solid state to the liquid state. It has a guiding effect in the process of purification and identification.

Solubility is also a property that cannot be ignored. In different solvents, the degree of solubility of this substance varies. In organic solvents, it may exhibit different degrees of solubility, or it is easily soluble in a certain type of organic solvent. This property affects its reaction, separation and preparation process in the solution system.

In addition, density is also a factor that characterizes its physical properties. Its density value reflects the mass of the substance per unit volume, providing important basic data in material calculation, storage and transportation planning. The refractive index of

also reflects the refractive characteristics of light propagating in it, and is related to the molecular structure and electron cloud distribution. When analyzing and identifying this object, it can be used as a unique marker to help researchers identify and confirm.

The various physical properties of this (3R, 5S, 6E) -methyl-7- (4- (4-fluorophenyl) -6-isopropyl-2- (N-methylmethylsulfonamido) pyrimidine-5-yl) -3,5-dihydroxyheptyl-6-enoate have their own uses and are indispensable factors for chemical research, pharmaceuticals and other fields.

What is the synthesis method of (3R, 5S, 6E) -methyl-7- (4- (4-fluorophenyl) -6-isopropyl-2- (N-methylmethylsulfonamido) pyrimidin-5-yl) -3, 5-dihydroxyhept-6-enoate?

To prepare (3R, 5S, 6E) -methyl-7- (4- (4-fluorophenyl) -6-isopropyl-2- (N-methylsulfonamido) pyrimidine-5-yl) -3,5-dihydroxyheptyl-6-enoate, the synthesis method is quite complicated and requires multiple and delicate reactions.

The first step is to carefully construct the structure of the pyrimidine ring with suitable starting materials and specific reaction conditions. In this process, it is necessary to choose fluorobenzene-containing compounds and isopropyl-containing reagents, skillfully combine them, and through various reactions such as condensation and cyclization, the pyrimidine ring can be formed. In this process, the temperature, pH and the ratio of the reactants must be carefully adjusted to make the reaction proceed in the expected direction and ensure that the substituents on the pyrimidine ring are in the correct position.

In the next step, the methylsulfonamide group is introduced at a suitable check point for the obtained pyrimidine derivative. This step requires finding a suitable sulfonylation reagent, and using its reactivity with specific atoms on the pyrimidine ring, under mild conditions, the access of N-methylsulfonamide group is realized. During the reaction, care should be taken to avoid unnecessary side reactions at other check points, so the reaction system needs to be closely monitored and regulated.

Furthermore, the heptenate moiety containing dihydroxyl groups can be constructed. It can be achieved by selective hydroxylation of unsaturated ester compounds. This process relies on efficient catalytic systems, such as specific metal catalysts and ligands, to achieve precise control of stereochemistry and ensure the formation of (3R, 5S) configurations.

Finally, the prepared pyrimidine moiety and the heptenate moiety containing dihydroxyl groups are connected by a coupling reaction. This reaction requires the selection of appropriate coupling reagents and reaction conditions to make the two precisely docked to form the target product. After the reaction is completed, various post-processing steps such as separation and purification are required to obtain high-purity (3R, 5S, 6E) -methyl-7- (4- (4-fluorophenyl) -6-isopropyl-2 - (N-methylsulfonamide) pyrimidine-5-yl) -3,5-dihydroxyheptyl-6-enoate.

During the entire synthesis process, every step requires great care, and the control of reaction conditions and the purity of intermediates are required to be extremely high. Only in this way can this target product be obtained.

What are the application fields of (3R, 5S, 6E) -methyl-7- (4- (4-fluorophenyl) -6-isopropyl-2- (N-methylmethylsulfonamido) pyrimidin-5-yl) -3, 5-dihydroxyhept-6-enoate?

(3R, 5S, 6E) -methyl-7- (4- (4-fluorophenyl) -6-isopropyl-2- (N-methylmethylsulfonamido) pyrimidine-5-yl) -3,5-dihydroxyheptyl-6-enoate is widely used in the field of medicine. It is a key intermediate of statins and is related to the ability to lower blood lipids.

The disease of blood lipids is often caused by the metabolism of lipids in the body. Lipid components such as cholesterol and triglycerides accumulate in the blood vessels, causing atherosclerosis and increasing the risk of cardiovascular diseases. Statins can inhibit hydroxymethylglutaryl-coenzyme A reductase, which is the key to cholesterol synthesis and inhibits its activity. Cholesterol synthesis decreases, lipid concentration in the blood vessels decreases, and blood vessels are unobstructed to protect cardiovascular health.

(3R, 5S, 6E) -methyl-7- (4- (4-fluorophenyl) -6-isopropyl-2- (N-methylmethylsulfonamido) pyrimidine-5-yl) -3,5-dihydroxyheptyl-6-enoate, which plays a key role in the synthesis of statins. Based on it, through series transformation, various good statins, such as atorvastatin, can be prepared, which is a great contribution to lowering blood lipids and preventing cardiovascular diseases.

What is the market prospect of (3R, 5S, 6E) -methyl-7- (4- (4-fluorophenyl) -6-isopropyl-2- (N-methylmethylsulfonamido) pyrimidin-5-yl) -3, 5-dihydroxyhept-6-enoate?

Guanfu (3R, 5S, 6E) -methyl-7 - (4 - (4 - fluorophenyl) -6 - isopropyl - 2 - (N - methylmethylsulfonamido) pyrimidin - 5 - yl) -3,5 - dihydroxyhept - 6 - enoate This product, its market prospects, are related to many.

In today's world, medical technology is booming, and many diseases are in urgent need of good solutions. This compound may have extraordinary potential in the field of medicine. Viewed from its unique chemical structure, it may be able to target specific diseases and play a wonderful role. If it is used to develop new drugs for cardiovascular, metabolic and other diseases, it may become a good remedy for the world.

However, the road ahead in the market is not smooth. New drug research and development is time-consuming and laborious, with huge capital consumption, and it must go through many rigorous tests. From basic research in the laboratory to the layers of clinical trials, if there is a slight mistake, it will fall short. Furthermore, the pharmaceutical market is fiercely competitive, and there are many similar drugs or potential competitors. It is not easy to stand out.

However, opportunities also exist. With the in-depth understanding of diseases, the demand for precision medicine is increasing. If this compound can accurately act on specific diseases and demonstrate excellent efficacy, it will surely attract the attention of pharmaceutical companies and receive R & D investment. And the aging of the global population is increasing, and the demand for innovative drugs is surging, which is also an opportunity for it to open up the market.

In summary, the market prospects of (3R, 5S, 6E) -methyl-7- (4- (4-fluorophenyl) -6-isopropyl-2- (N-methylmethylsulfonamido) pyrimidin-5-yl) -3,5-dihydroxyhept-6-enoate, although there are many challenges, there are also many opportunities. It depends on whether it can overcome obstacles and shine on the road of research and development.