What are the main uses of 3-fluoro-4-iodopyridine-2-carbonitrile?

3-Fluoro-4-iodopyridine-2-formonitrile has a wide range of uses. In the field of medicinal chemistry, it is a key intermediate, and many new drug research and development depend on it. The special structure of the geinpyridine ring and fluorine, iodine, and cyano groups endows the compound with unique physical and biological activities, which is conducive to interacting with specific biological targets to achieve therapeutic effects. For example, in the development of anti-tumor drugs, this structure can precisely interfere with the signal pathway of tumor cell proliferation and inhibit tumor growth.

In the field of materials science, it also has extraordinary performance. Because of its stable structure and specific electronic properties, it can be used to prepare organic optoelectronic materials. For example, in the manufacture of organic Light Emitting Diode (OLED), it can optimize the luminous efficiency and stability of the material and improve the display performance.

In the field of pesticide chemistry, it is also an important part. Through rational design and modification, high-efficiency, low-toxicity and environmentally friendly pesticides can be created. By binding to specific enzymes or receptors in pests, it interferes with the normal physiological activities of pests and realizes the purpose of pest control.

In short, 3-fluoro-4-iodopyridine-2-formonitrile shows great application potential in many fields such as medicine, materials, and pesticides, and promotes technological innovation and development in various fields.

What are 3-fluoro-4-iodopyridine-2-carbonitrile synthesis methods?

The synthesis method of 3-fluoro-4-iodine-pyridine-2-formonitrile covers a variety of paths. Common ones can be started from pyridine derivatives.

First, a suitable pyridine nitrile is used as a raw material, and fluorine atoms are introduced first. In this case, fluorine-containing reagents, such as potassium fluoride, can be selected. Under suitable reaction conditions, such as in a specific organic solvent, the temperature and reaction time can be controlled to make fluorine atoms replace hydrogen atoms at specific positions on the pyridine ring to obtain fluoropyridine-containing pyridine nitrile derivatives.

Then, iodine atoms are introduced. This step often requires an iodine source, such as iodine elemental matter, with a suitable catalyst, such as a copper salt catalyst. In the presence of a specific base, the reaction is heated in a suitable solvent, so that the iodine atom replaces the hydrogen at the target position on the pyridine ring, and then 3-fluoro-4-iodine pyridine-2-formonitrile is obtained.

Second, the pyridine ring can also be constructed first. Appropriate nitrile compounds and fluorine-containing and iodine-containing reagents are cyclized to form a pyridine ring structure through multi-step reactions. For example, the fluorine-containing intermediate is formed by the addition reaction of nitriles and fluoroalkene-containing compounds first, and then the intermediate is further cyclized with the help of suitable reaction conditions, and iodine atoms are introduced at the same time, so as to obtain the target product.

Third, there is another strategy, which is to use halogenated pyridine as the starting material. First, the nucleophilic substitution reaction is used to replace the halogen atom with cyanyl group, and the cyanyl group is introduced to obtain the pyridine formonitrile derivative. Then, fluorine atoms and iodine atoms are introduced in sequence. The introduction method is similar to the above. By controlling the reaction conditions and the amount of reagents, the synthesis of 3-fluoro-4-iodopyridine-2-formonitrile can be achieved.

Each method has its own advantages and disadvantages, and it is necessary to comprehensively consider the availability of raw materials, the difficulty of reaction, the purity and yield of the product, etc., in order to choose the optimal synthesis path.

What are the physical properties of 3-fluoro-4-iodopyridine-2-carbonitrile?

3-Fluoro-4-iodopyridine-2-formonitrile, this is an organic compound. Its physical properties are quite critical and are of great significance in both chemical research and industrial applications.

First, let's talk about the appearance. Under normal conditions, 3-fluoro-4-iodopyridine-2-formonitrile is mostly solid, and its solid form is often white to light yellow in color and fine in texture, like a carefully ground powder. This appearance feature is convenient for researchers to observe and operate in experiments.

Melting point is also one of the important physical properties. After experimental determination, its melting point is in a specific temperature range, which is crucial for the purity identification of compounds. If the compound has high purity, the melting point range is relatively narrow and approaches the theoretical value; if it contains impurities, the melting point will be reduced and the range will be wider. Knowing the melting point allows researchers to precisely control the temperature during synthesis and purification to obtain high-purity products.

In terms of solubility, 3-fluoro-4-iodopyridine-2-formonitrile has different solubility in common organic solvents. In some polar organic solvents, such as dimethyl sulfoxide (DMSO) and N, N-dimethylformamide (DMF), it has good solubility and can be uniformly dispersed to form a uniform solution. This property provides convenience for its participation in various organic reactions, because many organic reactions need to be carried out in a solution environment. However, in non-polar organic solvents such as n-hexane, its solubility is poor, insoluble or only slightly soluble.

In addition, the density of the compound is also a specific value. Density, as a basic physical property of a substance, is crucial in the conversion of mass and volume, and is indispensable in the material measurement and reaction system design of chemical production.

Furthermore, the stability of 3-fluoro-4-iodopyridine-2-formonitrile also belongs to the category of physical properties. Under normal temperature and pressure and without special chemical environment interference, the compound is relatively stable and can maintain its own chemical structure and properties. However, when exposed to high temperature, strong acid and base or specific chemical reaction conditions, chemical changes may occur. This stability feature reminds researchers and producers to choose suitable conditions according to their characteristics when storing and using to ensure their quality and performance.

What are the chemical properties of 3-fluoro-4-iodopyridine-2-carbonitrile?

3-Fluoro-4-iodopyridine-2-formonitrile is an organic compound with a variety of unique chemical properties, which has attracted much attention in the field of organic synthesis.

It has a nitrile group (-CN), which has high functional group activity. The nitrile group can be hydrolyzed, and under the catalysis of acid or base, it can be gradually converted into an amide, which then becomes a carboxylic acid. For example, in an alkaline environment, the cyanyl group is first added to water to obtain an amide intermediate, and then further hydrolyzed to form a carboxylic acid.

Halogen atoms (fluorine and iodine) also give the compound specific properties. Fluorine atoms have high electronegativity, which can affect the distribution of molecular electron clouds, enhance molecular polarity, and have a significant Although iodine atoms have lower electronegativity than fluorine, they have higher reactivity due to their large atomic radius and relatively small C-I bond energy. In nucleophilic substitution reactions, iodine atoms are easily replaced by nucleophiles, which is an important check point for organic synthesis to construct new carbon-carbon bonds or carbon-hetero bonds. For example, in palladium-catalyzed cross-coupling reactions, the iodine atoms of 3-fluoro-4-iodopyridine-2-formonitrile can react with carbon-containing nucleophiles to achieve carbon chain growth on the pyridine ring or introduce other functional groups. The presence of the

pyridine ring also adds to the properties of this compound. The pyridine ring is aromatic, and its nitrogen atom makes the distribution of the ring electron cloud uneven. The electron cloud density of the adjacent and para-sites of the nitrogen atom is relatively low, and the meta-site is relatively high. This makes the electrophilic substitution reaction more likely to occur in the meta-site, while the nucleophilic substitution reaction tends to be in the adjacent and para-site. 3-fluoro-4-iodopyridine-2-formonitrile has a more complex electron cloud distribution due to the substitution of nitrile groups, fluorine atoms and iodine atoms, and the reaction activity and selectivity are also affected.

3-fluoro-4-iodopyridine-2-formonitrile exhibits rich chemical properties due to the interaction of nitrile groups, halogen atoms and pyridine rings. It is used as a key intermediate in organic synthesis, medicinal chemistry and other fields to construct complex organic molecules with diverse structures.

What is the price of 3-fluoro-4-iodopyridine-2-carbonitrile in the market?

3-Fluoro-4-iodopyridine-2-formonitrile is in the market, and its price is difficult to determine. Due to the changeable market conditions, the supply and demand situation, the difficulty of preparation, and the high and low quality all affect its price.

In the past, the source of the material and the simplicity of the process are all variables of the price. If the material is easily available, the preparation technique is simple and familiar, and the price may be slightly flat; on the contrary, if the material is rare and dilute and the preparation is complicated, the price will be high.

In addition, the distinction of quality is also heavy. For high purity, due to the difficulty of refining, the price is often high; for less, the price is low. And the state of supply and demand is changing rapidly. There are many people who want it, and there are few people who supply it, so the price will rise; if the supply exceeds the demand, the price will drop.

However, at this time, it is difficult to determine the price without knowing the certainty of the market. To know the details, you need to explore the chemical industry market and consult various merchants before you can get a near-real price. Or in the concentration of chemical materials, observe the prices of each merchant in detail, or visit the industry, listen to the changes in their prices, and have the opportunity to get a real price.