What is the chemical structure of 3-fluoro-4- (5- (hydroxymethyl) benzofuran-7-yl) picolinonitrile?

This is the name of an organic compound, and its chemical structure is derived according to its name. It needs to be resolved according to the naming rules of organic chemistry. "3-fluoro-4- (5- (hydroxymethyl) benzofuran-7-yl) picolinonitrile", "3-fluoro" shows that the pyridine ring has a fluorine atom substituted at the 3rd position; "picolinonitrile" is a pyridine nitrile, and the pyridine ring is connected to the cyanyl group. "4 - (5- (hydroxymethyl) benzofuran-7-yl) " epipyridine ring has a benzofuran group at the 4th position, and this benzofuran group has a hydroxymethyl substitution at the 5th position, and the 7th position is connected to the pyridine ring.

In ancient Chinese, this compound is involved in the field of organic synthesis, and the structure of its structure depends on the nomenclature of Western organic chemistry. "3-fluoro", which refers to the three-digit pyridine ring, which is replaced by the fluorine atom; "picolinonitrile", which is the phase of the pyridine ring and the cyano group. And "4 - (5- (hydroxymethyl) benzofuran - 7 - yl) ", the tetraposition of the pyridine ring, which is connected with the group of benzofuran, the five-position of this benzofuran, which is attached to the hydroxymethyl group, and the seven-position is connected to the pyridine ring. Viewing its name and inferring its structure is a skill that must be known to organic chemistry students, which can clarify the molecular structure and explore its properties and reaction rules.

What are the physical properties of 3-fluoro-4- (5- (hydroxymethyl) benzofuran-7-yl) picolinonitrile

3 - fluoro - 4 - (5- (hydroxymethyl) benzofuran - 7 - yl) picolinonitrile is an organic compound. The physical properties of this compound can be viewed from the following aspects.

First of all, its melting point is the temperature at which a substance changes from a solid state to a liquid state. However, the specific melting point of this substance needs to be determined by precise experiments. Generally speaking, the melting point of organic compounds is affected by factors such as intermolecular forces and crystal structures. This compound contains fluorine, cyano, hydroxyl and other functional groups, intermolecular or intermolecular hydrogen bonds, van der Waals forces, etc., or the melting point has a certain range.

The boiling point is the temperature when the saturated vapor pressure of a liquid is equal to the external atmospheric pressure. In view of the characteristics of the functional groups in the structure of the compound, the intermolecular force may be strong, and the boiling point may be relatively high. However, the specific value also needs to be measured accurately by experiment.

In terms of solubility, due to the hydrophilic hydroxymethyl group, it may have a certain solubility in polar solvents such as water and alcohols. However, the benzofuran ring and the pyridinonitrile part have certain hydrophobicity, so the solubility in non-polar solvents such as alkanes may be limited.

In appearance, it is speculated that it may be a solid, because the atoms in the molecule are connected by covalent bonds to form a relatively stable structure, coupled with intermolecular forces, it may be solid at room temperature and pressure. Its color may vary due to the existence of a conjugated system, or it may be a colorless to light yellow solid. < Br >
Density is also an important physical property. Although the specific value is difficult to give exactly, it can be roughly inferred according to its molecular composition and relative molecular mass. The relative molecular mass is larger and the structure is compact, and the density may be larger; otherwise, it is smaller.

The physical properties of this compound are affected by the arrangement of functional groups and atoms in its molecular structure, and the exact properties need to be accurately determined by experiments.

What are the main uses of 3-fluoro-4- (5- (hydroxymethyl) benzofuran-7-yl) picolinonitrile?

3-Fluoro-4- (5- (hydroxymethyl) benzofuran-7-yl) pyridinecarbonitrile, an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry.

From the perspective of pharmaceutical research and development, this compound can lay the foundation for the creation of new drugs. Due to its specific chemical structure or unique biological activity, it can target specific disease-related targets. For example, in the development of anti-tumor drugs, researchers can modify the structure of the compound to optimize its ability to bind to tumor cell targets in order to effectively inhibit tumor cell proliferation; in the exploration of drugs for the treatment of neurological diseases, it may participate in the construction of molecular structures that regulate neurotransmitter activity, bringing hope for the alleviation of diseases.

In the field of materials science, it also has potential applications. Due to its chemical properties, it may participate in the preparation of special functional materials. For example, after a specific process, it can be integrated into the optical material system to endow the material with unique optical properties, such as fluorescence properties, which can be used in the field of optical sensing to perform highly sensitive detection of specific substances; or in the preparation of electronic materials, with its structural properties, optimize the electrical properties of materials, and help the research and development of new electronic devices.

Furthermore, in the field of organic synthetic chemistry, it can participate in the construction of a series of complex organic molecules as an intermediate. Chemists can use its activity check point to introduce different functional groups through various organic reactions, such as nucleophilic substitution, coupling reactions, etc., to build organic compounds with diverse structures and functions, greatly enriching the library of organic compounds, providing the possibility for further exploration of new substances and new properties.

What are the synthesis methods of 3-fluoro-4- (5- (hydroxymethyl) benzofuran-7-yl) picolinonitrile

There are several methods for the synthesis of 3-fluoro-4- (5- (hydroxymethyl) benzofuran-7-yl) picolinonitrile. According to the description of "Tiangong Kaiwu", although it is not directly related to this product, the technical ideas may be useful for reference.

To synthesize this product, first, you can first prepare the raw material containing benzofuran structure. Or you can follow the ancient method of starting with a specific plant extract, chemically modified, and adding hydroxymethyl to the 5-position of benzofuran. For example, the ancient method of processing medicinal materials, extracting them with appropriate solvents to obtain crude products containing related structures, and then purifying them by precision fractionation and recrystallization to obtain pure 5- (hydroxymethyl) benzofuran raw materials.

Second, prepare the part containing fluorine and pyridinonitrile structure. This may be modeled after the mineral extraction method in Tiangong Kaiwu, starting from the ore or compound containing fluorine and nitrogen. After a multi-step reaction, fluorine atoms are introduced into the 3-position of the pyridine ring, and a suitable reaction check point is reserved at the 4-position, and cyanyl groups are introduced to form the pyridinitrile structure.

Third, connect the above two parts. This step may need to learn from the ingenious combination of ancient methods, select appropriate catalysts and reaction conditions, so that the two parts are connected by covalent bonds to generate 3-fluoro-4- (5- (hydroxymethyl) benzofuran-7-yl) picolinonitrile. After the reaction is completed, traditional separation methods such as filtration, washing, and drying are used to remove impurities and obtain pure products.

However, there are many difficulties in the synthesis. The reaction conditions need to be precisely controlled, such as temperature, pH, etc. A slight difference will affect the yield and purity. And the selection and treatment of raw materials need to be carefully considered. The rigor of ancient methods is still the essence of today's synthetic chemistry.

What are the precautions for using 3-fluoro-4- (5- (hydroxymethyl) benzofuran-7-yl) picolinonitrile?

3 - fluoro - 4 - (5 - (hydroxymethyl) benzofuran - 7 - yl) picolinonitrile is a complex organic compound. During use, all precautions are essential.

Bear the brunt, and safety protection must not be ignored. The characteristics of this compound may be unknown, and contact with it must be strictly selected protective equipment. Wear appropriate protective gloves to prevent it from touching the skin and causing allergies or other adverse reactions; wear protective glasses to protect your eyes from accidental splashing; wear protective clothing to prevent it from coming into contact with the body in all directions. If you operate in a poorly ventilated place, you need to prepare respiratory protective equipment to prevent its volatiles from entering the body.

Secondly, the operating specifications must be strictly followed. When taking it, measure it accurately, and take it according to the amount required by the experiment or production to avoid waste and excess risk. Stirring, heating and other operations, according to the established procedures, control the temperature and speed, keep the reaction stable, and avoid emergencies. And during the operation, focus not to be distracted to prevent misoperation.

Furthermore, storage conditions are also critical. Choose the storage environment according to its physical and chemical properties, usually in a cool, dry place to avoid high temperature and humidity. If it is sensitive to light, it needs to be stored in a dark container. Different compounds are placed separately to prevent mutual reaction.

Repeat, waste treatment should not be ignored. Waste containing this compound generated from experiment or production should not be discarded at will. According to relevant regulations and environmental protection requirements, classify and collect, and hand it over to professional institutions for treatment to reduce environmental hazards.

Finally, first aid knowledge is indispensable. In the event of an accident, such as skin contact, rinse with plenty of water immediately and seek medical attention; if splashed into the eye, immediately open the eyelid and rinse, and rush to medical attention. Those who inhale, move to a well-ventilated place, perform artificial respiration and seek medical attention if necessary. Those who take it orally, do not induce vomiting, and seek medical attention immediately. Only by paying attention to everything can you ensure safe use and avoid accidents and hazards.