What is the chemical structure of 3- (difluoromethyl) -1-methyl-1H-pyrazole-4-carboxylic acid?

3 - (difluoromethyl) - 1 - methyl - 1H - pyrazole - 4 - carboxylic acid, this is an organic compound. Looking at its name, its structure can be deduced according to chemical nomenclature.

"pyrazole" is a five-membered heterocyclic compound containing two adjacent nitrogen atoms. In the "1H - pyrazole" structure, the hydrogen atom is attached to one of the nitrogen atoms. "1 - methyl" means methyl (-CH) attached to the nitrogen atom at position 1 of the pyrazole ring. " 3- (difluoromethyl) "indicates that the difluoromethyl (-CHF ²) is attached to the carbon atom at position 3 of the pyrazole ring." 4-carboxylic acid "indicates that the carboxyl group (-COOH) is located at position 4 of the pyrazole ring.

Therefore, the chemical structure of 3- (difluoromethyl) -1-methyl-1H-pyrazole-4-carboxylic acid is: with the pyrazole ring as the core, No. 1 azilylmethyl, No. 3 carbyldifluoromethyl, and No. 4 carbylcarboxyl. This structure gives it specific chemical activity and physical properties, and may have important uses in fields such as organic synthesis and medicinal chemistry.

What are the main uses of 3- (difluoromethyl) -1-methyl-1H-pyrazole-4-carboxylic acid?

3- (difluoromethyl) -1-methyl-1H-pyrazole-4-carboxylic acid has a wide range of uses. In the field of medicine, it is often used as a key intermediate. Taking the development of new antibacterial drugs as an example, with its unique chemical structure, it can precisely bind to specific bacterial targets, interfere with the normal physiological activities of bacteria, and achieve antibacterial effect; in the development of antiviral drugs, it can also play a role in inhibiting viral replication through specific mechanisms, providing a new way for antiviral therapy.

In the field of pesticides, its importance cannot be ignored. As a synthetic high-efficiency insecticide raw material, it can specifically act on the nervous system or physiological metabolism of pests, causing physiological dysfunction of pests, thus effectively controlling pests, and is relatively friendly to the environment, which is in line with the current development needs of green agriculture. At the same time, in the synthesis of fungicides, it can destroy the cell wall of pathogenic bacteria or interfere with their energy metabolism by virtue of its chemical properties, prevent and control plant diseases, help the healthy growth of crops, and ensure the agricultural harvest.

In the field of materials science, this compound has also emerged. Because of its special chemical properties, it can be used to prepare functional materials. For example, in the modification of some polymer materials, the addition of this substance can optimize the material properties, enhance its stability, corrosion resistance or optical properties, provide new opportunities for the innovation and development of materials science, and promote the progress of related industries.

What are the synthesis methods of 3- (difluoromethyl) -1-methyl-1H-pyrazole-4-carboxylic acid?

To prepare 3 - (difluoromethyl) - 1 - methyl - 1H - pyrazole - 4 - carboxylic acid, there are many methods, and the following are common synthesis paths.

First, 1 - methyl - 1H - pyrazole - 4 - carboxylic acid can be used as the starting material. Shilling 1 - methyl - 1H - pyrazole - 4 - carboxylic acid reacts with difluoromethylation reagent. Commonly used reagents such as difluoromethyl halide, under the action of alkali, the base can take away the hydrogen in the specific position of 1-methyl-1H-pyrazole-4-carboxylic acid to generate carbon negative ions, which then undergo nucleophilic substitution reaction with difluoromethyl halide, thereby introducing difluoromethyl to obtain the target product.

Second, start with a pyrazole ring precursor containing a suitable substituent. For example, a specific substituted pyrazole derivative is selected, and its substituent is converted into difluoromethyl and carboxyl groups through a series of reactions. Halogenated at a specific position on the pyrazole ring to obtain halogenated pyrazoles, and then reacted with a reagent containing difluoromethyl through a metal-organic reagent, such as Grignard's reagent or an organolithium reagent, to introduce difluoromethyl. After oxidation, another suitable substituent is converted into a carboxyl group to obtain 3- (difluoromethyl) -1 -methyl-1H -pyrazole-4 -carboxylic acid.

Third, a cyclization strategy can also be used. The chain-like compound containing fluorine and suitable functional groups such as nitrogen and carbon is used as raw material, and the molecular endocyclization reaction is carried out under suitable conditions. By controlling the reaction conditions and the ratio of reactants, the chain compound is cyclized to form a pyrazole ring, and difluoromethyl and carboxyl groups are introduced at the same time to obtain the target product. This process requires precise control of the reaction conditions, such as temperature, catalyst type and dosage, to ensure the smooth progress of the cyclization reaction and the selectivity of the product.

What are the physical properties of 3- (difluoromethyl) -1-methyl-1H-pyrazole-4-carboxylic acid?

3 - (difluoromethyl) - 1 - methyl - 1H - pyrazole - 4 - carboxylic acid, this is an organic compound with unique physical properties. Looking at its morphology, at room temperature and pressure, it is mostly white to white crystalline powder, just like finely crushed snow powder, delicate and pure. Its melting point is in a specific range, about [X] ° C to [X] ° C. This characteristic is like its "body temperature mark". When the temperature limit is reached, the material state gradually changes, from solid state to liquid state, like ice and snow melting gradually when warm.

When it comes to solubility, this compound shows different degrees of solubility in organic solvents, such as methanol, ethanol, dichloromethane, etc. In methanol, like ice crystals in warm water, it can be better dissolved to form a uniform solution, just like ice and snow integrated into a stream, which is seamless; in water, the solubility is poor, because the interaction between molecular structure and water molecules is limited, just like oil and water are difficult to melt, and only a very small amount can be dispersed.

Furthermore, its stability is also an important physical property. Under conventional environmental conditions, such as room temperature, room pressure and no special chemical reagents, the structure is relatively stable, like a solid fortress, and it is not prone to spontaneous chemical changes. However, if placed in extreme environments such as high temperature, strong acid or strong alkali, like a strong fortress encountered fierce artillery fire, its molecular structure may be damaged, triggering chemical reactions, resulting in changes in properties.

In addition, the density, odor and other properties of the compound also have their own characteristics. The density is similar to that of common organic compounds, giving it a specific mass and volume relationship; the smell is weak, without pungent or special strong odor, like quiet air, quietly exists in the environment. These physical properties are of key significance in many fields such as organic synthesis and drug development, laying the foundation for exploring its chemical uses and characteristics.

What is the market price of 3- (difluoromethyl) -1-methyl-1H-pyrazole-4-carboxylic acid?

Today, there is a question about the price of 3- (difluoromethyl) -1 -methyl-1H -pyrazole-4 -carboxylic acid in the market. However, I have searched all over the ancient books, but I have not found the exact price of this product on the market. Because the market conditions are fickle, the price changes with the wind, and the price of this compound may vary greatly due to differences in use, purity, supply and demand.

If it is used as a raw material for fine chemical synthesis, the price of high purity is high; if it is used for general experimental research, the price of ordinary purity is slightly lower. And in different places, the supply and demand are different, and the price is also different. In prosperous cities, the chemical industry is prosperous, and the demand is high, but the supply is also sufficient, and the price may be stable; in remote places, transportation is difficult, the supply is scarce, and the price may rise.

Furthermore, market fluctuations, raw material costs, policies and regulations are all affected. If the price of raw materials prepared rises sharply, or encounters new environmental protection regulations, production is limited, the price will rise. On the contrary, if raw materials are abundant, production technology is advanced, costs are reduced, and prices may drop.

Although the exact price of this product has not been explicitly stated, those who want to know the price of this product can visit the chemical product trading platform, consult merchants, or consult with people in the chemical industry, and must obtain the approximate market price of its recent market price for reference.